Abstract:
BACKGROUND/AIMS:Von Willebrand factor (vWf) is found in high levels in plasma of patients with acute and chronic liver disease. The role of vWf in liver injury and repair is unknown. We studied the effect of liver mass and remodeling on plasma and tissue vWf after partial hepatectomy. METHODS:Rats were sacrificed postoperatively at intervals ranging from 60 min to 5 days, and vWf plasma levels were measured by enzyme-linked immunosorbent assay, using rabbit anti-human vWf, and by immunoperoxidase on cryosections, using rabbit anti-vWf/factor VIII. Northern blot hybridization was prepared with a complementary DNA specific to human vWf. RESULTS:vWf plasma levels increased early after sham operation and after 70% partial hepatectomy. The highest levels were reached at 24 h, remaining high for 5 days. Immunostaining showed intense staining of sinusoidal lining cells 4 h after partial hepatectomy, remaining so for 5 days. Non-significant changes in overall liver messenger RNA expression of vWf were seen over 5 days in sham operation and partial hepatectomy. CONCLUSIONS:After partial hepatectomy, plasma vWf is increased, probably due to both acute-phase reaction and decreased degradation. An increase in sinusoidal vWf immunostaining may suggest a role for this factor in tissue remodeling.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Baruch Y,Neubauer K,Shenkar L,Sabo E,Ritzel A,Wilfling T,Ramadori Gdoi
10.1016/s0168-8278(02)00215-5subject
Has Abstractpub_date
2002-10-01 00:00:00pages
471-7issue
4eissn
0168-8278issn
1600-0641pii
S0168827802002155journal_volume
37pub_type
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journal_title:Journal of hepatology
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更新日期:2015-03-01 00:00:00
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更新日期:2011-04-01 00:00:00
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更新日期:2007-03-01 00:00:00
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更新日期:1986-01-01 00:00:00
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更新日期:1996-01-01 00:00:00
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更新日期:2019-02-01 00:00:00
abstract:BACKGROUND & AIMS:Emricasan, an oral pan-caspase inhibitor, decreased portal pressure in experimental cirrhosis and in an open-label study in patients with cirrhosis and severe portal hypertension, defined as a hepatic venous pressure gradient (HVPG) ≥12 mmHg. We aimed to confirm these results in a placebo-controlled s...
journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-10-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-03-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2014.02.012
更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jhep.2017.08.023
更新日期:2017-09-21 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(05)80521-5
更新日期:1993-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2008.07.030
更新日期:2008-12-01 00:00:00
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更新日期:1987-06-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0168-8278(98)80186-4
更新日期:1998-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2005.08.011
更新日期:2006-05-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(86)80085-x
更新日期:1986-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
doi:10.1016/s0168-8278(00)80411-0
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND & AIMS:Weak hepatitis C virus (HCV) specific immunity in peripheral blood has been shown to be partially controlled by regulatory T cells (Treg). However, little is known about Treg present in livers of HCV-infected patients, their association with clinical parameters, and immunopathology resulting in diseas...
journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2009.12.013
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate demographic characteristics, liver histology and virological features of hepatitis C virus (HCV) carriers with normal alanine transaminase (ALT) levels. METHODS:A nationwide prospective study was started in 1997. Four Italian centres have participated in this study. RESULTS:Eight hundred a...
journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(02)00101-0
更新日期:2002-07-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.jhep.2010.12.030
更新日期:2011-07-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2016.12.018
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND AIMS:In hepatitis C there is controversy over the linearity of the rate of progression and the significance of gender, mode of infection and viral factors. METHODS:2313 untreated patients with a reliable estimated duration of infection and liver fibrosis were included. Fibrosis progression was calculated us...
journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(00)00097-0
更新日期:2001-05-01 00:00:00
abstract:AIM:In order to study the short-term effect of moderate and severe reduction of liver function by acetaminophen poisoning of different severity on gene expression for liver-specific functions, rats were given 3.75 and 7.5 g per kg body weight acetaminophen intragastrically. The lower dose is associated with low mortali...
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pub_type: 杂志文章
doi:10.1016/s0168-8278(96)80072-9
更新日期:1996-08-01 00:00:00