Myofibroblasts and hepatocellular carcinoma: an in vivo and in vitro study.

abstract：:The present study was conducted to evaluate if the increased rate of apoptosis previously reported in the liver of ethanol-treated rats was accompanied by increased cell renewal. A quantitative analysis of apoptosis was performed in rats fed an ethanol-containing liquid diet for 5 weeks. S-phase cells were demonstrate...

journal_title：Journal of hepatology

authors： Baroni GS,Marucci L,Benedetti A,Mancini R,Jezequel AM,Orlandi F

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND/AIMS:Multidrug resistance-associated protein 3 (MRP3) is a carrier-type transport protein belonging to the ABC transporters. It is expressed in normal tissues, and enhanced expression in many cancers has been reported. In this study, we investigated the usefulness of MRP3 as a target antigen in immunotherapy...

journal_title：Journal of hepatology

authors： Mizukoshi E,Honda M,Arai K,Yamashita T,Nakamoto Y,Kaneko S

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND/AIMS:We evaluated the test performance profile (TPP) of blood tests of liver fibrosis. METHODS:Three hundred and fifty-six patients with C chronic hepatitis were included in two centers. Metavir staging of liver specimens by two independent pathologists and the following tests were evaluated: Fibrotest (FT)...

journal_title：Journal of hepatology

authors： Halfon P,Bacq Y,De Muret A,Penaranda G,Bourliere M,Ouzan D,Tran A,Botta D,Renou C,Bréchot MC,Degott C,Paradis V

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Eastern American woodchuck (Marmota monax), naturally infected with woodchuck hepatitis virus, a virus similar to human hepatitis B virus, develops liver cancer with a high prevalence. AIMS:The aim of this work was to assess Marmota monax as a model of human hepatocellular carcinoma, especially to assess ne...

journal_title：Journal of hepatology

authors： Gouillat C,Manganas D,Zoulim F,Vitrey D,Saguier G,Guillaud M,Ain JF,Duque-Campos R,Jamard C,Praves M,Trepo C

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to determine whether there is an increased infectious risk following liver biopsy in liver transplant patients with choledochojejunostomy. METHODS:We evaluated the incidence of liver-biopsy-related sepsis in a consecutive series of 27 patients who underwent choledochojejunostomy, eithe...

journal_title：Journal of hepatology

authors： Ben-Ari Z,Neville L,Rolles K,Davidson B,Burroughs AK

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND & AIMS:Tumor shrinkage has been considered a fundamental surrogate efficacy measure for new cancer treatments. However, in patients treated with sorafenib for advanced hepatocellular carcinoma (HCC), tumor shrinkage rarely accompanies increased survival, thereby questioning the prognostic value of imaging-ba...

journal_title：Journal of hepatology

authors： Personeni N,Bozzarelli S,Pressiani T,Rimassa L,Tronconi MC,Sclafani F,Carnaghi C,Pedicini V,Giordano L,Santoro A

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND/AIMS:The natural history of chronic hepatitis C (HCV) is not completely understood. This study was aimed to evaluate the long-term outcome of the disease over a prolonged period of time and to identify factors associated with progression. METHODS:One hundred and sixteen patients with non-cirrhotic chronic n...

journal_title：Journal of hepatology

authors： Forns X,Ampurdanès S,Sanchez-Tapias JM,Guilera M,Sans M,Sánchez-Fueyo A,Quintó L,Joya P,Bruguera M,Rodés J

更新日期：2001-08-01 00:00:00

abstract：:To evaluate the expression of hepatocyte HLA Class I and II antigens and the infiltration of CD8-positive lymphocytes in patients with chronic hepatitis, cells obtained by the technique of fine-needle aspiration were compared with those obtained by percutaneous liver biopsy. In general, correlation between cytological...

journal_title：Journal of hepatology

authors： Krawitt EL,Zannier A,Chossegros P,Gerard F,Chevallier M,Mutin M,Trepo C,Touraine JL

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND/AIMS:Intrahepatic cholestasis of pregnancy is characterized by pruritus and increased levels of serum bile acids, and is often associated with premature delivery, fetal distress, and perinatal mortality. The aims of the present study were: (i) to better define the serum bile acid profile in intrahepatic chol...

journal_title：Journal of hepatology

authors： Brites D,Rodrigues CM,Oliveira N,Cardoso M,Graça LM

更新日期：1998-01-01 00:00:00

abstract：:The high incidence of non-anastomotic biliary strictures (NAS) after transplantation of livers from extended criteria donors is currently a major barrier to widespread use of these organs. This review provides an update on the most recent advances in the understanding of the etiology of NAS. These new insights give re...

journal_title：Journal of hepatology

authors： Weeder PD,van Rijn R,Porte RJ

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF phenotype (AD-ACLF) defined by organ failure(s). Precipitants may induce AD. This multicenter, prospective, observational PREDICT study (NCT03056612) analyzes and characterizes the pr...

journal_title：Journal of hepatology

authors： Trebicka J,Fernandez J,Papp M,Caraceni P,Laleman W,Gambino C,Giovo I,Uschner FE,Jansen C,Jimenez C,Mookerjee R,Gustot T,Albillos A,Bañares R,Jarcuska P,Steib C,Reiberger T,Acevedo J,Gatti P,Shawcross DL,Zeuzem S,

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND/AIMS:Many Concanavalin A-binding glycoproteins have been proposed to influence cholesterol crystallization in human bile. This has been studied mainly by addition of the Concanavalin A-binding fraction to model bile. The physiological relevance of the proteins in native bile is not yet known. The aim of this...

journal_title：Journal of hepatology

authors： Keulemans YC,Mok KS,Gouma DJ,Groen AK

更新日期：1997-12-01 00:00:00

abstract：:Serotonin or 5-hydroxytryptamine (5-HT) is known to regulate several key aspects of liver biology and these functions include hepatic blood flow, innervation and wound healing. Given the importance of these functions it is surprising that relatively little time has been dedicated to studying the precise function and m...

journal_title：Journal of hepatology

authors： Ruddell RG,Mann DA,Ramm GA

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND & AIMS:Living donor liver transplantation (LDLT) provides a timely alternative to deceased donor liver transplantation (DDLT) for patients with hepatitis C virus-related (HCV-related) diseases in the circumstances of severe organ dearth. However, the patient and graft outcomes, and recurrence of HCV after LD...

journal_title：Journal of hepatology

authors： Hu A,Liang W,Zheng Z,Guo Z,He X

更新日期：2012-12-01 00:00:00

abstract：:The aim of the present study was to identify the cell types that express collagen alpha 1(I), alpha 1(III) and alpha 1(IV), fibronectin and laminin B1 genes in normal rat liver. Parenchymal, sinusoidal endothelial, Kupffer and fat-storing (Ito) cells were isolated and purified. Total RNA of the freshly isolated cells ...

journal_title：Journal of hepatology

authors： Geerts A,Greenwel P,Cunningham M,De Bleser P,Rogiers V,Wisse E,Rojkind M

更新日期：1993-08-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Journal of hepatology

authors： Arai T,Kato Y,Ishimoto K,Kanai M,Shinjo S,Sayama K,Suzuki T,Doi T,Johnson RS,Suematsu M,Goda N

更新日期：2015-02-10 00:00:00

abstract：:In a rat model of chronic portal hypertension we studied ethanol-induced gastric mucosal damage and the effects of pretreatment by propranolol and sucralfate. Susceptibility to ethanol was increased in chronic portal hypertensive rats compared with sham-operated rats (55 +/- 8% vs. 25 +/- 4%). Both acute pretreatment ...

journal_title：Journal of hepatology

authors： Geoffroy P,Duchateau A,Thiéfin G,Zeitoun P

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND/AIMS:Liver macrophages play an essential role in necro-inflammatory liver damage which leads to fibrosis and cirrhosis. The aim of the present study was to compare the mediator release and the DNA synthesis of macrophages at an early and at a later stage of liver cirrhosis induced by thioacetamide. METHODS:...

journal_title：Journal of hepatology

authors： Vogl S,Junker U,Vogelsang H,Dargel R

更新日期：1997-05-01 00:00:00

abstract：:Ten patients with non-alcoholic cirrhosis and ten control subjects were studied in basal conditions and after ingestion of a standard mixed test meal. Plasma somatostatin, blood glucose, plasma insulin, C-peptide and glucagon were determined before and 15, 30, 45, 60, 90, 120 and 180 min after the start of the meal. B...

journal_title：Journal of hepatology

authors： Barreca T,Franceschini R,Cataldi A,Rolandi E

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND & AIMS:Prevalence data for hepatitis B and C and an evaluation of a guideline based screening in the primary care setting are not yet available. We therefore implemented a hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) screening and developed guideline based screening strategies. METHO...

journal_title：Journal of hepatology

authors： Wolffram I,Petroff D,Bätz O,Jedrysiak K,Kramer J,Tenckhoff H,Berg T,Wiegand J,German Check-Up 35+ Study Group.

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND & AIMS:Alcoholic hepatitis is an acute life- and health-threatening disease that may be increasingly frequent. However, accurate and representative data on time trends in its incidence and prognosis are not available. This study aims to provide nationwide population-based estimates of alcoholic hepatitis inc...

journal_title：Journal of hepatology

authors： Sandahl TD,Jepsen P,Thomsen KL,Vilstrup H

更新日期：2011-04-01 00:00:00

abstract：:Hydroxyethyl starch (HES) has gained wide clinical acceptance as a colloidal plasma substitute. We were able to study the liver biopsies of two patients with renal failure who developed ascites after repeated infusions of HES. All types of liver cells displayed massive accumulation of HES with the morphologic resembla...

journal_title：Journal of hepatology

authors： Dienes HP,Gerharz CD,Wagner R,Weber M,John HD

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:Reactive cholangiocytes acquire a neuroendocrine-like phenotype, with synthesis and local release of neuropeptides and hormones. The mechanism that drives such phenotypical changes is still undefined. Pancreatic Duodenal Homeobox-1 (PDX-1) is a transcription factor required for pancreatic development,...

journal_title：Journal of hepatology

authors： Marzioni M,Saccomanno S,Candelaresi C,Rychlicki C,Agostinelli L,Shanmukhappa K,Trozzi L,Pierantonelli I,De Minicis S,Benedetti A

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The association between polyarteritis nodosa and viral hepatitis B infection is well established and still remains a therapeutic challenge. Famciclovir--a new nucleoside analog--has a broad spectrum of antiviral activity against herpes viruses and the human hepatitis B virus. CASE REPORT:A 56-year-old man w...

journal_title：Journal of hepatology

authors： Kruger M,Böker KH,Zeidler H,Manns MP

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND/AIMS:Modifications of the Child-Pugh classification of liver cirrhosis by incorporation of hyaluronan were tested to improve the prognostic power for long term evaluation of liver cirrhosis in 126 patients observed over a period of 10 years. METHODS:Serum concentrations of HA were determined at study entry....

journal_title：Journal of hepatology

authors： Körner T,Kropf J,Kosche B,Kristahl H,Jaspersen D,Gressner AM

更新日期：2003-12-01 00:00:00

abstract：:Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality. Prospective data to define ...

journal_title：Journal of hepatology

authors： Jalan R,Gines P,Olson JC,Mookerjee RP,Moreau R,Garcia-Tsao G,Arroyo V,Kamath PS

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND/AIMS:To examine the T-cell repertoire which is involved in the immunopathogenesis of chronic hepatitis, we analyzed the T-cell receptor Vbeta gene usage in liver-infiltrating lymphocytes by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical technique. METHODS:Complementary DNA ...

journal_title：Journal of hepatology

authors： Kashii Y,Shimizu Y,Nambu S,Minemura M,Okada K,Higuchi K,Watanabe A

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND & AIMS:The pool of HCV genotype 1 patients likely to be cured by peg-interferon and ribavirin remains to be quantified. METHODS:In 1045 patients treated with peg-interferon and ribavirin, two therapeutic strategies were confronted: the first one evaluated only baseline variables associated with sustained vi...

journal_title：Journal of hepatology

authors： Andriulli A,Di Marco V,Margaglione M,Ippolito AM,Fattovich G,Smedile A,Valvano MR,Calvaruso V,Gioffreda D,Milella M,Morisco F,Felder M,Brancaccio G,Fasano M,Gatti P,Tundo P,Barone M,Cozzolongo R,Angelico M,D'Andrea

更新日期：2014-01-01 00:00:00

abstract：:A quantitative immunohistochemical study of Kupffer cells in liver biopsies from alcoholics was carried out. Two markers were compared, lysozyme and an antimacrophage monoclonal antibody EMB/11. The results showed that there is no significant reduction in Kupffer cell numbers in acute and chronic alcoholic liver disea...

journal_title：Journal of hepatology

authors： Kelly PM,Heryet AR,McGee JO

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and obesity are epidemiologically correlated with each other but the causal inter-relationships between them remain incompletely understood. We aimed to explore the causal relationships between the 3 diseases. METHODS:Using both UK Biob...

journal_title：Journal of hepatology

authors： Liu Z,Zhang Y,Graham S,Wang X,Cai D,Huang M,Pique-Regi R,Dong XC,Chen YE,Willer C,Liu W

更新日期：2020-08-01 00:00:00