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Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver.

Abstract：

:The present study was conducted to evaluate if the increased rate of apoptosis previously reported in the liver of ethanol-treated rats was accompanied by increased cell renewal. A quantitative analysis of apoptosis was performed in rats fed an ethanol-containing liquid diet for 5 weeks. S-phase cells were demonstrated by immunohistochemistry, using the Bromodeoxyuridine/anti-Bromodeoxyuridine method. In ethanol-fed rats apoptosis was five times greater than in pair-fed controls. Bromodeoxyuridine-labelled hepatocytes increased from 0.07 +/- 0.009% in controls to 0.17 +/- 0.013% (p < 0.001) and Bromodeoxyuridine-labelled lipocytes (desmin-positive sinusoidal cells) increased from 3.43 +/- 0.28% to 6.60 +/- 1.04% (p < 0.001). The lobular distribution of labelled cells was modified with a shift towards the perivenular areas. The results of this study suggest that the replacement of liver cells lost by ethanol-induced apoptosis is not impaired in intact (non-operated) animals. The impaired regeneration following partial hepatectomy reported in ethanol-fed rats is possibly due to differences in the extent of parenchymal loss, to altered relationships between hepatocytes and blood supply and to the modalities of regeneration involved.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Baroni GS,Marucci L,Benedetti A,Mancini R,Jezequel AM,Orlandi F

doi

10.1016/s0168-8278(05)80498-2

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

508-13

issue

4

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(05)80498-2

journal_volume

20

pub_type

杂志文章

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