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Menopausal age and sex hormones in postmenopausal women with alcoholic and non-alcoholic liver disease.

Abstract：

:In order to evaluate age at menopause and serum sex hormone profiles in postmenopausal women with stable chronic liver disease, six non-cirrhotic alcoholics, 13 with alcoholic cirrhosis, eight with non-alcoholic cirrhosis, and 46 healthy controls were studied. In all three groups, patients were significantly (p less than 0.05) younger at the time of natural menopause than controls. Compared to controls, non-cirrhotic alcoholic women had significantly (p less than 0.05) reduced levels of DHAS, significantly (p less than 0.05) more alcoholic cirrhotic women had detectable oestradiol concentrations, elevated concentrations of oestrone and sex hormone binding globulin (SHBG) and reduced levels of 5 alpha-dihydrotestosterone (DHT), while women with non-alcoholic cirrhosis had significantly elevated concentrations of SHBG and reduced levels of oestrone sulphate, DHT, androstenedione and dehydroepiandrosterone sulphate (DHAS) (p less than 0.05). The observed changes may be a consequence of liver disease since similar changes were observed in patients with alcoholic and non-alcoholic liver disease, but an additional effect of alcohol cannot be excluded.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Becker U,Gluud C,Farholt S,Bennett P,Micic S,Svenstrup B,Hardt F

doi

10.1016/0168-8278(91)90859-a

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

25-32

issue

1

eissn

0168-8278

issn

1600-0641

pii

0168-8278(91)90859-A

journal_volume

13

pub_type

杂志文章

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