Cholestatic liver injury after glimepiride therapy.

abstract：:The present study investigated the hemodynamic effects of nicardipine, a new calcium channel blocker, and placebo in 14 patients with cirrhosis. Sixty minutes after nicardipine administration (20 mg orally; n = 8), there was a significant increase in hepatic blood flow (25 +/- 21%; p < 0.05) and azygos blood flow (33 ...

journal_title：Journal of hepatology

authors： García-Pagán JC,Feu F,Luca A,Fernández M,Pizcueta P,Bosch J,Rodés J

更新日期：1994-06-01 00:00:00

abstract：:Ultrastructural changes were observed in 23 consecutive patients who died from fulminant hepatic failure due to hepatitis B virus (4 cases), sporadic non-A, non-B (7), or paracetamol (acetaminophen) overdose (12) and in 3 patients with subacute hepatic necrosis of unknown cause. The findings are described in detail in...

journal_title：Journal of hepatology

authors： McCaul TF,Fagan EA,Tovey G,Portmann B,Williams R,Zuckerman AJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:Statins are widely used to treat hypercholesterolemia. Statins may prevent hepatocellular carcinoma (HCC), but have not yet been fully studied, particularly in patients at high risk. Therefore, we investigated the risk of HCC after statin use in the whole general population and evaluated the effects o...

journal_title：Journal of hepatology

authors： Kim G,Jang SY,Nam CM,Kang ES

更新日期：2018-03-01 00:00:00

abstract：:In the human fetal liver, CYP3A7 is expressed as early as the 13th week of gestation. This continues to the perinatal period when it is sharply repressed prior to birth. Concomitantly, the expression of CYP3A4, not detectable in the fetus, sharply increases in the perinatal period to remain elevated throughout adultho...

journal_title：Journal of hepatology

authors： Ourlin JC,Jounaïdi Y,Maurel P,Vilarem MJ

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND & AIMS:Weak hepatitis C virus (HCV) specific immunity in peripheral blood has been shown to be partially controlled by regulatory T cells (Treg). However, little is known about Treg present in livers of HCV-infected patients, their association with clinical parameters, and immunopathology resulting in diseas...

journal_title：Journal of hepatology

authors： Claassen MA,de Knegt RJ,Tilanus HW,Janssen HL,Boonstra A

更新日期：2010-03-01 00:00:00

abstract：:The high incidence of non-anastomotic biliary strictures (NAS) after transplantation of livers from extended criteria donors is currently a major barrier to widespread use of these organs. This review provides an update on the most recent advances in the understanding of the etiology of NAS. These new insights give re...

journal_title：Journal of hepatology

authors： Weeder PD,van Rijn R,Porte RJ

更新日期：2015-07-01 00:00:00

abstract：:A total of 37 patients with histologically confirmed chronic viral hepatitis B and presence of HBV-DNA and HBsAg in the serum were treated in a randomized, prospectively controlled multicenter trial either with recombinant IFN alpha-2b alone or a combination of IFN alpha-2b and recombinant IL-2. Twenty-two patients fr...

journal_title：Journal of hepatology

authors： Bruch HR,Korn A,Klein H,Markus R,Malmus K,Baumgarten R,Müller R

更新日期：1993-01-01 00:00:00

abstract：:Lactitol is a disaccharide analogue of lactulose which is available as a pure crystalline powder. The efficacy of lactitol in the treatment of chronic hepatic encephalopathy was assessed in 9 cirrhotic patients in a randomised, double-blind, cross-over comparison with lactulose. The sugars were dispensed in solutions,...

journal_title：Journal of hepatology

authors： Morgan MY,Hawley KE,Stambuk D

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND/AIMS:To study the effect of short-term cholestasis on glycogen metabolism. METHODS:Rats were bile duct ligated (BDL) for 4 or 8 days and compared to sham-operated control rats pair-fed to BDL (pair-fed CON) or fed ad libitum (ad libitum-fed CON). RESULTS:Four days after surgery, the hepatic glycogen conten...

journal_title：Journal of hepatology

authors： Lang C,Schäfer M,Varga L,Zimmermann A,Krähenbühl S,Krähenbühl L

更新日期：2002-01-01 00:00:00

abstract：:The influence of hepatitis C virus and its subtypes on the clinical course of liver disease in alcoholics was assessed. Hepatitis C virus infection was confirmed by a reverse transcription and polymerase chain reaction method for the hepatitis C virus NS-5 region in the sera of alcoholics with various stages of histol...

journal_title：Journal of hepatology

authors： Yokoyama H,Ishii H,Moriya S,Nagata S,Watanabe T,Kamegaya K,Takahashi H,Maruyama K,Haber P,Tsuchiya M

更新日期：1995-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is among the most prevalent human malignancies worldwide with rising incidence in industrialised countries, few therapeutic options and poor prognosis. To expand and improve therapeutic strategies, identification of drug targets involved in several liver cancer-related pathways is crucia...

journal_title：Journal of hepatology

authors： Beck M,Schirmacher P,Singer S

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND/AIMS:The liver is the major source of collagen XVIII (C18), the precursor of the angiogenesis inhibitor endostatin. In human liver C18 is mainly expressed by hepatocytes. However, its quantitative and temporospatial expression patterns during liver fibrogenesis are unknown. METHODS:We used RNA quantificatio...

journal_title：Journal of hepatology

authors： Jia JD,Bauer M,Sedlaczek N,Herbst H,Ruehl M,Hahn EG,Riecken EO,Schuppan D

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic background may affect liver damage in patients with non-alcoholic fatty liver disease (NAFLD). The main outcomes of the study were to assess whether IL28B rs12979860 and rs8099917 polymorphisms, together with PNPLA3 rs738409 C>G polymorphism, are associated with lobular inflammation and fibros...

journal_title：Journal of hepatology

authors： Petta S,Grimaudo S,Cammà C,Cabibi D,Di Marco V,Licata G,Pipitone RM,Craxì A

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND & AIMS:SIRT1 is a class III histone deacetylase that plays diverse roles in various cancers. However, the clinical significance of SIRT1 in hepatocellular carcinoma (HCC) remains unknown. METHODS:We analysed p53 mutations and the activation of SIRT1 in 252 hepatitis B virus-positive HCC cases. None of the p...

journal_title：Journal of hepatology

authors： Zhang ZY,Hong D,Nam SH,Kim JM,Paik YH,Joh JW,Kwon CH,Park JB,Choi GS,Jang KY,Park CK,Kim SJ

更新日期：2015-01-01 00:00:00

abstract：:In order to evaluate age at menopause and serum sex hormone profiles in postmenopausal women with stable chronic liver disease, six non-cirrhotic alcoholics, 13 with alcoholic cirrhosis, eight with non-alcoholic cirrhosis, and 46 healthy controls were studied. In all three groups, patients were significantly (p less t...

journal_title：Journal of hepatology

authors： Becker U,Gluud C,Farholt S,Bennett P,Micic S,Svenstrup B,Hardt F

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic graft hepatitis occurs in 20-30% adults after liver transplantation but the prevalence and causes in children are not known. In adults, hepatitis C virus infection is prevalent prior to transplantation and recurrent infection is a frequent cause of graft dysfunction. The significance of the rece...

journal_title：Journal of hepatology

authors： Davison SM,Skidmore SJ,Collingham KE,Irving WL,Hubscher SG,Kelly DA

更新日期：1998-05-01 00:00:00

abstract：:Advances in the management of the pulmonary complications of cystic fibrosis may result in an increasing prevalence of patients with chronic liver disease which may, therefore, become more important in the long-term management of cystic fibrosis patients. However, no simple and reliable test is available for the diagn...

journal_title：Journal of hepatology

authors： Williams SG,Evanson JE,Barrett N,Hodson ME,Boultbee JE,Westaby D

更新日期：1995-05-01 00:00:00

abstract：:Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and microRNAs. They can originate from both healthy and stressed cells, and provide a snapshot of the cell of origin in physiological and pathological circumstances. Various processes that may give rise to the release of extracellular...

journal_title：Journal of hepatology

authors： Thietart S,Rautou PE

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND/AIMS:Little is known about the role of fractalkine (CX3CL1) in the liver. The aim of this study was to investigate the expression patterns of fractalkine and its receptor CX3CR1 in normal human liver and in conditions of injury. METHODS:Distribution and expression of fractalkine and its receptor were invest...

journal_title：Journal of hepatology

authors： Efsen E,Grappone C,DeFranco RM,Milani S,Romanelli RG,Bonacchi A,Caligiuri A,Failli P,Annunziato F,Pagliai G,Pinzani M,Laffi G,Gentilini P,Marra F

更新日期：2002-07-01 00:00:00

abstract：:Since interferons are reported to inhibit collagen synthesis in vivo and in vitro, they are possible anti-fibrogenic drugs. However, little is known about the effect of interferons on connective tissue metabolism in liver disease. To investigate the effect, serum concentrations of the aminoterminal domain of procollag...

journal_title：Journal of hepatology

authors： Hayasaka A,Kohen H,Yoshikawa N,Iida S,Ohto M

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND/AIMS:In 2002, the first reported outbreak of hepatitis A virus (HAV) infection involving mostly intravenous drug users (IDU) occurred in Italy. We attempted a thorough evaluation of the outbreak, including epidemiological, clinical and virological analyses. METHODS:We conducted an epidemiological investigat...

journal_title：Journal of hepatology

authors： Spada E,Genovese D,Tosti ME,Mariano A,Cuccuini M,Proietti L,Giuli CD,Lavagna A,Crapa GE,Morace G,Taffon S,Mele A,Rezza G,Rapicetta M

更新日期：2005-12-01 00:00:00

abstract：:The aim of the present investigation was to study the number and acinar distribution of apoptotic bodies in normal liver as an approach to a better understanding of cell kinetics in the hepatic parenchyma. The material included 20 normal human needle liver biopsies and 20 normal male Sprague-Dawley rats. For each live...

journal_title：Journal of hepatology

authors： Benedetti A,Jézéquel AM,Orlandi F

更新日期：1988-12-01 00:00:00

abstract：:Eighty-eight dialysis patients were vaccinated with recombinant hepatitis B vaccine prepared in yeast. Fourty-nine patients were immunized 3 times (months 0, 1, 6) intragluteally with 40 micrograms hepatitis B surface antigen (HBsAg) per dose. Only 32 of them (65.3%) showed anti-HBs concentrations above 10 IU/l with a...

journal_title：Journal of hepatology

authors： Jilg W,Schmidt M,Weinel B,Küttler T,Brass H,Bommer J,Müller R,Schulte B,Schwarzbeck A,Deinhardt F

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cystathionine beta synthase (CBS) deficiency leads to severe hyperhomocysteinemia, which confers diverse clinical manifestations, notably fatty liver. Recently, abnormal lipid metabolism has been demonstrated in CBS-deficient mice, a murine model of severe hyperhomocysteinemia. To gain further insights ...

journal_title：Journal of hepatology

authors： Hamelet J,Demuth K,Paul JL,Delabar JM,Janel N

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND & AIMS:Serological markers of hepatocellular carcinoma (HCC) indicate its invasiveness. We aimed to investigate whether the prognostic impact of surgical resection (SR) and radiofrequency thermal ablation (RFA) on patients with single nodular HCC ⩽5cm were different regarding positive conditions of the follo...

journal_title：Journal of hepatology

authors： Ueno M,Hayami S,Shigekawa Y,Kawai M,Hirono S,Okada K,Tamai H,Shingaki N,Mori Y,Ichinose M,Yamaue H

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND & AIMS:γδ T cells comprise a substantial proportion of tissue-associated lymphocytes. However, our current understanding of human γδ T cells is primarily based on peripheral blood subsets, while the immunobiology of tissue-associated subsets remains largely unclear. Therefore, we aimed to elucidate the T cel...

journal_title：Journal of hepatology

authors： Hunter S,Willcox CR,Davey MS,Kasatskaya SA,Jeffery HC,Chudakov DM,Oo YH,Willcox BE

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIMS:Results of our previous studies supported the concept that in the human liver, the smallest ramification of the biliary tree, the bile ductules, might contain hepatic progenitor cells. An insufficient proliferative response and loss of bile ductules preceded bile duct loss whereas preservation of bile d...

journal_title：Journal of hepatology

authors： Gouw AS,van den Heuvel MC,Boot M,Slooff MJ,Poppema S,de Jong KP

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis C virus (HCV) evades humoral immunity and establishes chronic infections. Virus particles circulate in complex with lipoproteins facilitating antibody escape. Apolipoprotein E (ApoE) is essential for intracellular HCV assembly and for HCV cell entry. We aimed to explore if ApoE released from...

journal_title：Journal of hepatology

authors： Bankwitz D,Doepke M,Hueging K,Weller R,Bruening J,Behrendt P,Lee JY,Vondran FWR,Manns MP,Bartenschlager R,Pietschmann T

更新日期：2017-09-01 00:00:00

abstract：:The addition of protease inhibitors, boceprevir or telaprevir, to peginterferon+ribavirin (PegIFN/RBV) increases the frequency as well as the severity, and hence, clinical relevance of anemia, which has now become one of the major complications associated with triple therapy. Most significant factors associated with a...

journal_title：Journal of hepatology

authors： Romero-Gómez M,Berenguer M,Molina E,Calleja JL

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND/AIMS:To study whether the host's immune response determines viral clearance in chronic hepatitis C, virological markers and antigen-specific T cell reactions were analysed in 30 chronic HCV carriers followed up during interferon-alpha therapy, 11 untreated anti-HCV positive individuals and 10 healthy control...

journal_title：Journal of hepatology

authors： Löhr HF,Gerken G,Roth M,Weyer S,Schlaak JF,Meyer zum Büschenfelde KH

更新日期：1998-10-01 00:00:00