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Understanding liver immunology using intravital microscopy.

Abstract：

:The liver has come a long way since it was considered only a metabolic organ attached to the gastrointestinal tract. The simultaneous ascension of immunology and intravital microscopy evidenced the liver as a central axis in the immune system, controlling immune responses to local and systemic agents as well as disease tolerance. The multiple hepatic cell populations are organized in a vascular environment that promotes intimate cellular interactions, including initiation of innate and adaptive immune responses, rapid leukocyte recruitment, pathogen clearance and production of a variety of immune mediators. In this review, we focus on the advances in liver immunology supported by intravital microscopy in diseases such as isquemia/reperfusion, acute liver injury and infections.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Marques PE,Oliveira AG,Chang L,Paula-Neto HA,Menezes GB

doi

10.1016/j.jhep.2015.05.027

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

733-42

issue

3

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(15)00385-2

journal_volume

63

pub_type

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