The function of serotonin within the liver.

abstract：BACKGROUND/AIMS:The aim of this prospective randomized controlled trial was to investigate the need for prophylactic antibiotherapy in patients with cirrhosis and hepatocellular carcinoma who underwent transarterial embolization and to establish the parameters that determine the development of fever > 38 degrees C afte...

journal_title：Journal of hepatology

authors： Castells A,Bruix J,Ayuso C,Brú C,Montanyà X,Boix L,Rodès J

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND/AIMS:We have previously shown that an abnormality in cardiac autonomic reflexes (AN) is an independent predictor of mortality in patients with chronic liver disease. Aim of this study was to determine whether there was an association between prolonged QTc interval and cardiac AN. METHODS:Cardiac AN and QTc ...

journal_title：Journal of hepatology

authors： Puthumana L,Chaudhry V,Thuluvath PJ

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND/AIMS:The impact of dietary fatty acids on the development of cancers is highly controversial. We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in hepatocytes. In this study, we investigated whether unsa...

journal_title：Journal of hepatology

authors： Vinciguerra M,Carrozzino F,Peyrou M,Carlone S,Montesano R,Benelli R,Foti M

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND/AIM:A low-titered hepatitis B virus infection without immunological markers was identified in a prospective study in the serum of a kidney transplant recipient by PCR. The aim of this study was to analyze HBV genomes and their biological significance. METHODS:The genome was amplified in two overlapping frag...

journal_title：Journal of hepatology

authors： Schories M,Peters T,Rasenack J

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND & AIMS:Recent research has suggested that dietary fructose intake may increase serum uric acid (UA) concentrations. Both UA concentration and fructose consumption maybe also increase in NAFLD. It is not known whether dietary fructose consumption and UA concentration are independently associated with non-alco...

journal_title：Journal of hepatology

authors： Mosca A,Nobili V,De Vito R,Crudele A,Scorletti E,Villani A,Alisi A,Byrne CD

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND/AIMS:The chemokine receptor CX3CR1 and its specific ligand fractalkine (CX3CL1) are known to modulate inflammatory and fibroproliferative diseases. Here we investigate the role of CX3CR1/fractalkine in HCV-induced liver fibrosis. METHODS:A genotype analysis of CX3CR1 variants was performed in 211 HCV-infect...

journal_title：Journal of hepatology

authors： Wasmuth HE,Zaldivar MM,Berres ML,Werth A,Scholten D,Hillebrandt S,Tacke F,Schmitz P,Dahl E,Wiederholt T,Hellerbrand C,Berg T,Weiskirchen R,Trautwein C,Lammert F

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND/AIMS:Phase I/II studies of 4 weeks duration have confirmed the ALT lowering effect of glycyrrhizin in Western chronic hepatitis C patients. Our aim was to determine the dose frequency of glycyrrhizin required to maintain the ALT response beyond 4 weeks and evaluate its effect on liver histology and quality o...

journal_title：Journal of hepatology

authors： Orlent H,Hansen BE,Willems M,Brouwer JT,Huber R,Kullak-Ublick GA,Gerken G,Zeuzem S,Nevens F,Tielemans WC,Zondervan PE,Lagging M,Westin J,Schalm SW

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND/AIMS:Von Willebrand factor (vWf) is found in high levels in plasma of patients with acute and chronic liver disease. The role of vWf in liver injury and repair is unknown. We studied the effect of liver mass and remodeling on plasma and tissue vWf after partial hepatectomy. METHODS:Rats were sacrificed post...

journal_title：Journal of hepatology

authors： Baruch Y,Neubauer K,Shenkar L,Sabo E,Ritzel A,Wilfling T,Ramadori G

更新日期：2002-10-01 00:00:00

abstract：:Hepatitis C virus genotype and the amounts of circulating HCV RNA are the most important factors in determining the efficacy of interferon therapy for chronic hepatitis C. To clarify the correlation of these two factors to the progression of liver disease, we classified 148 Japanese patients with type C chronic liver ...

journal_title：Journal of hepatology

authors： Mita E,Hayashi N,Kanazawa Y,Hagiwara H,Ueda K,Kasahara A,Fusamoto H,Kamada T

更新日期：1994-09-01 00:00:00

abstract：:The clinical course of cirrhosis is mostly determined by the progressive increase of portal hypertension, hyperdynamic circulation, bacterial translocation and activation of systemic inflammation. Different disease states, encompassing compensated and decompensated cirrhosis and a late decompensated state, are related...

journal_title：Journal of hepatology

authors： D'Amico G,Morabito A,D'Amico M,Pasta L,Malizia G,Rebora P,Valsecchi MG

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND/AIM:Smooth muscle antibodies and antinuclear antibodies characterize type 1 autoimmune hepatitis. Our aim was to correlate the appearance and disappearance of these autoantibodies with clinical and histological events. METHODS:One hundred and seven patients were evaluated successively over 128+/-9 months. A...

journal_title：Journal of hepatology

authors： Czaja AJ

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND/AIMS:HCV infection recurs almost in all HCV-positive patients receiving liver transplantation and carries a poor prognosis. Aim of this study was to analyze efficacy and effect on survival of antiviral therapy in this clinical setting. METHODS:Pegylated-interferon alpha-2b and ribavirin were administered at...

journal_title：Journal of hepatology

authors： Picciotto FP,Tritto G,Lanza AG,Addario L,De Luca M,Di Costanzo GG,Lampasi F,Tartaglione MT,Marsilia GM,Calise F,Cuomo O,Ascione A

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND/AIM:Since patients with high viral load and HCV subtype 1b are known to respond poorly to interferon (IFN) therapy, the viral dynamics of HCV RNA after initiation of interferon therapy were examined in the present study with respect to two different administration regimens, once vs. twice a day. METHODS:Twe...

journal_title：Journal of hepatology

authors： Shiratori Y,Perelson AS,Weinberger L,Imazeki F,Yokosuka O,Nakata R,Ihori M,Hirota K,Ono N,Kuroda H,Motojima T,Nishigaki M,Omata M

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND/AIMS:Pregnant women with acute viral hepatitis (VH) and those with pregnancy associated acute liver disease (PAALD) including acute fatty liver disease of pregnancy, hemolysis elevated liver enzyme and low platelet syndrome present with similar clinical features and liver tests abnormalities. Accurate differ...

journal_title：Journal of hepatology

authors： Devarbhavi H,Kremers WK,Dierkhising R,Padmanabhan L

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND/AIMS:Terlipressin is a long-acting vasopressin analogue that has been proved useful in the treatment of variceal haemorrhage. This study investigates the time profile of the haemodynamic effects of terlipressin on portal hypertension as well as the efficacy in decreasing portal-pressure and collateral blood ...

journal_title：Journal of hepatology

authors： Escorsell A,Bandi JC,Moitinho E,Feu F,García-Pagan JC,Bosch J,Rodés J

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND/AIMS:Members of the CD44 family are transmembrane glycoproteins which act mainly as receptors for hyaluronan. We have examined the expression of CD44s and several CD44v and the relationship between these and hepatocellular carcinoma (HCC) grade, clinicopathological parameters, p53 expression, and patient sur...

journal_title：Journal of hepatology

authors： Endo K,Terada T

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND & AIMS:Evidence on the efficacy of antiviral treatment in chronic hepatitis C (CHC) patients with hepatocellular carcinoma (HCC) after curative treatment is scarce. We aimed to evaluate the efficacy and safety of pegylated interferon-alpha plus ribavirin (pegIFN/RBV) combination therapy in these patients, co...

journal_title：Journal of hepatology

authors： Huang JF,Yu ML,Huang CF,Chiu CF,Dai CY,Huang CI,Yeh ML,Yang JF,Hsieh MY,Hou NJ,Lin ZY,Chen SC,Wang LY,Chuang WL

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Fatty acid translocase CD36 (CD36) is a membrane protein with multiple immuno-metabolic functions. Palmitoylation has been suggested to regulate the distribution and functions of CD36, but little is known about its significance in non-alcoholic steatohepatitis (NASH). METHODS:Human liver tissue sam...

journal_title：Journal of hepatology

authors： Zhao L,Zhang C,Luo X,Wang P,Zhou W,Zhong S,Xie Y,Jiang Y,Yang P,Tang R,Pan Q,Hall AR,Luong TV,Fan J,Varghese Z,Moorhead JF,Pinzani M,Chen Y,Ruan XZ

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIMS:To relate severity of intoxication with allyl alcohol and acetaminophen to modulated hepatic gene expression of liver functions and regeneration. METHODS:Rats fasted for 12 h received acetaminophen 3.5 or 5.6 g per kg body weight, or allyl alcohol 100 or 125 microl by gastric tube, doses producing no a...

journal_title：Journal of hepatology

authors： Tygstrup N,Jensen SA,Krog B,Dalhoff K

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic background may affect liver damage in patients with non-alcoholic fatty liver disease (NAFLD). The main outcomes of the study were to assess whether IL28B rs12979860 and rs8099917 polymorphisms, together with PNPLA3 rs738409 C>G polymorphism, are associated with lobular inflammation and fibros...

journal_title：Journal of hepatology

authors： Petta S,Grimaudo S,Cammà C,Cabibi D,Di Marco V,Licata G,Pipitone RM,Craxì A

更新日期：2012-06-01 00:00:00

abstract：:Occasionally direct sequencing of amplified hepatitis B virus DNA leads to weak signals on autoradiograms. Using amplified C-gene sequences we investigated whether this is due to sequence heterogeneity of virus populations and use of inappropriate primers for direct sequencing. High C-gene sequence heterogeneity (poin...

journal_title：Journal of hepatology

authors： Miska S,Günther S,Vassilev M,Meisel H,Pape G,Will H

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND & AIMS:Despite the clinical and genetic significance of macrotrabecular-massive hepatocellular carcinoma (MTM-HCC), its characteristics on imaging have not been described. This study aimed to characterise MTM-HCC on gadoxetic acid-enhanced MRI and to evaluate the diagnostic accuracy and prognostic value of t...

journal_title：Journal of hepatology

authors： Rhee H,Cho ES,Nahm JH,Jang M,Chung YE,Baek SE,Lee S,Kim MJ,Park MS,Han DH,Choi JY,Park YN

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND & AIMS:Virus-specific T cells capable of controlling HBV and eliminating hepatocellular carcinoma (HCC) expressing HBV antigens are deleted or dysfunctional in patients with chronic HBV or HBV-related HCC. The goal of this study was to determine if T cell receptor (TCR) gene transfer can reconstitute HBV-spe...

journal_title：Journal of hepatology

authors： Gehring AJ,Xue SA,Ho ZZ,Teoh D,Ruedl C,Chia A,Koh S,Lim SG,Maini MK,Stauss H,Bertoletti A

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND & AIMS:Ventriculo-arterial coupling (VAC) reflects the interaction between ventricular performance and effective arterial load. Current criteria for cirrhotic cardiomyopathy focus only on cardiac function without addressing the effect of hyperdynamic, low-resistance circulation. We investigated alterations i...

journal_title：Journal of hepatology

authors： Shin WJ,Song JG,Jun IG,Moon YJ,Kwon HM,Jung K,Kim SO,Hwang GS

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND & AIMS:Resveratrol, a polyphenol found in a variety of fruits, exerts a wide range of beneficial effects on the endothelium, regulates multiple vasoactive substances and decreases oxidative stress, factors involved in the pathophysiology of portal hypertension. Our study aimed at evaluating the effects of re...

journal_title：Journal of hepatology

authors： Di Pascoli M,Diví M,Rodríguez-Vilarrupla A,Rosado E,Gracia-Sancho J,Vilaseca M,Bosch J,García-Pagán JC

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND/AIMS:The aims were to study: 1) the prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic liver disease, 2) viral and host immunogenetic factors that may predispose to diabetes, and 3) liver transplantation outcome in patients with or without d...

journal_title：Journal of hepatology

authors： Zein NN,Abdulkarim AS,Wiesner RH,Egan KS,Persing DH

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND/AIMS:Many Concanavalin A-binding glycoproteins have been proposed to influence cholesterol crystallization in human bile. This has been studied mainly by addition of the Concanavalin A-binding fraction to model bile. The physiological relevance of the proteins in native bile is not yet known. The aim of this...

journal_title：Journal of hepatology

authors： Keulemans YC,Mok KS,Gouma DJ,Groen AK

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND/AIM:Endothelin-1 plays an important role in the regulation of portal hypertension; endothelin antagonists have been extensively studied in portal hypertensive animals. We aimed to evaluate the efficacy of highly selective endothelin antagonists in partial portal vein ligated (PPVL) rats. METHODS:Four groups...

journal_title：Journal of hepatology

authors： De Gottardi A,Shaw S,Sägesser H,Reichen J

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIMS:Adrenomedullin recently discovered in human pheochromocytoma is a potent vasodilatory peptide mainly derived from vascular endothelial and smooth muscle cells. Hyperdynamic circulation, ultimately leading to ascites formation, has been attributed to peripheral vasodilatation in liver cirrhosis. However,...

journal_title：Journal of hepatology

authors： Kojima H,Tsujimoto T,Uemura M,Takaya A,Okamoto S,Ueda S,Nishio K,Miyamoto S,Kubo A,Minamino N,Kangawa K,Matsuo H,Fukui H

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND & AIMS:CD4(+) CD25(+) Foxp3(+) regulatory T cells (Tregs) have a profound ability to control immune responses. We have previously shown that the liver is a major source of peripherally induced Tregs. Here, we investigate the liver cell types and molecular mechanisms responsible for hepatic Treg induction. M...

journal_title：Journal of hepatology

authors： Carambia A,Freund B,Schwinge D,Heine M,Laschtowitz A,Huber S,Wraith DC,Korn T,Schramm C,Lohse AW,Heeren J,Herkel J

更新日期：2014-09-01 00:00:00