Transarterial embolization for hepatocellular carcinoma. Antibiotic prophylaxis and clinical meaning of postembolization fever.

abstract：BACKGROUND & AIMS:Histopathology is the gold standard in the diagnosis of liver diseases but may be complicated by sampling error and bleeding. Confocal laser endomicroscopy (CLE) is a novel imaging modality providing in vivo histology. Previous studies using CLE for liver microscopy suffered from limited imaging depth...

journal_title：Journal of hepatology

authors： Goetz M,Deris I,Vieth M,Murr E,Hoffman A,Delaney P,Galle PR,Neurath MF,Kiesslich R

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND/AIMS:Interleukin-12 (IL-12), a cytokine with antitumor activity, was examined for the suppressive effect on hepatocellular carcinoma (HCC) in mouse model, and its mechanism of antitumor activity was analyzed. METHODS:Mice implanted with MIH-2 HCC cells were treated with recombinant mouse IL-12 (500 ng/mouse...

journal_title：Journal of hepatology

authors： Komita H,Homma S,Saotome H,Zeniya M,Ohno T,Toda G

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND/AIMS:In this study, a detailed morphometrical analysis of the hepatic microvasculature in the different zones of hepatic parenchyma was performed in normal and cirrhotic rat liver (CCl4-induced). The aims were to detect, in CCl4-induced cirrhosis, the real presence of the "capillarization" of hepatic sinusoi...

journal_title：Journal of hepatology

authors： Onori P,Morini S,Franchitto A,Sferra R,Alvaro D,Gaudio E

更新日期：2000-10-01 00:00:00

abstract：:A 36-year-old woman was admitted for hepatosplenomegaly and anemia. Bone marrow cytology showed "sea-blue histiocytes", vacuolated macrophages and plasma cells. As primary liver disease, malignancy or hematologic disorders were excluded, and plasma chitotriosidase activity was increased 27-fold over control, the prese...

journal_title：Journal of hepatology

authors： vom Dahl S,Harzer K,Rolfs A,Albrecht B,Niederau C,Vogt C,van Weely S,Aerts J,Müller G,Häussinger D

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND/AIMS:Repetitive indomethacin administration induces down-regulation of hepatic cytochrome P450 (CYP) enzymes. We tested the hypothesis that an increase in intestinal permeability by indomethacin-induced intestinal injury leads to entry of bacterial endotoxin and reaching into liver via the portal vein, resul...

journal_title：Journal of hepatology

authors： Masubuchi Y,Horie T

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND/AIMS:IgM antibodies to hepatitis C virus have been found in a variable proportion of patients with chronic hepatitis C. We have evaluated whether IgM anti-core antibodies correlate with viraemia or hepatic injury in chronic hepatitis C. METHODS:Serum from 106 patients with chronic hepatitis C with varying s...

journal_title：Journal of hepatology

authors： Martinelli AL,Brown D,Braun HB,Michel G,Dusheiko GM

更新日期：1996-01-01 00:00:00

abstract：:Hepatitis A virus (HAV) infection in adults is often symptomatic and disabling. The present article summarizes our experience with phase 2 studies of an inactivated hepatitis A virus vaccine. Pre- and post-exposure prophylaxis with immune globulin (IG) is only effective for 4-6 months. We compared the safety, tolerabi...

journal_title：Journal of hepatology

authors： Shouval D,Ashur Y,Adler R,Lewis JA,Miller W,Kuter B,Brown L,Nalin DR

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:A 4977-base pair deletion has been detected in the hepatic mitochondrial DNA of alcoholic patients with microvesicular steatosis, a lesion ascribed to impaired mitochondrial beta-oxidation. However, only a single deletion had been looked for in this previous study, and it could not be determined whether...

journal_title：Journal of hepatology

authors： Mansouri A,Fromenty B,Berson A,Robin MA,Grimbert S,Beaugrand M,Erlinger S,Pessayre D

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND & AIMS:Non-selective beta blockers (NSBBs) have been shown to have deleterious outcomes in patients with refractory ascites, alcoholic hepatitis and spontaneous bacterial peritonitis leading many physicians to stop the drug in these cases. Acute-on-chronic liver failure (ACLF) is characterized by systemic in...

journal_title：Journal of hepatology

authors： Mookerjee RP,Pavesi M,Thomsen KL,Mehta G,Macnaughtan J,Bendtsen F,Coenraad M,Sperl J,Gines P,Moreau R,Arroyo V,Jalan R,CANONIC Study Investigators of the EASL-CLIF Consortium.

更新日期：2016-03-01 00:00:00

abstract：:In order to document the incidence of hepatitis delta virus (HDV) replication markers and their relationship to HBV replication, 91 HBsAg chronic carriers were studied. Of these, 51 were anti-HD-positive (19 HBeAg-positive and 32 anti-HBe-positive). Liver HDAg was found in 75% of anti-HD-positive patients. Of the 19 p...

journal_title：Journal of hepatology

authors： Bas C,Bartolomé J,La Banda F,Porres JC,Quiroga JA,Mora I,Carreño V

更新日期：1988-04-01 00:00:00

abstract：:The risk of HCV transmission by blood and blood products has been greatly reduced since the early 1980's. Selection of non-remunerated donors, donor selection to prevent HIV transmission, initial surrogate testing in some regions, and introduction of anti-HCV testing have all contributed to this. ALT surrogate testing...

journal_title：Journal of hepatology

authors： van der Poel CL

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND & AIMS:Living donor liver transplantation (LDLT) provides a timely alternative to deceased donor liver transplantation (DDLT) for patients with hepatitis C virus-related (HCV-related) diseases in the circumstances of severe organ dearth. However, the patient and graft outcomes, and recurrence of HCV after LD...

journal_title：Journal of hepatology

authors： Hu A,Liang W,Zheng Z,Guo Z,He X

更新日期：2012-12-01 00:00:00

abstract：:Hepatitis viruses are major threats to human health. During the last decade, highly diverse viruses related to human hepatitis viruses were found in animals other than primates. Herein, we describe both surprising conservation and striking differences of the unique biological properties and infection patterns of human...

journal_title：Journal of hepatology

authors： Rasche A,Sander AL,Corman VM,Drexler JF

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND/AIMS:The organic anion transporting polypeptides (OATPs) mediate the uptake of numerous amphipathic compounds into hepatocytes. Our aim was to study the expression and regulation of OATP8 (OATP1B3, SLC21A8/SLCO1B3) and OATP-C (OATP1B1, SLC21A6/SLCO1B1) in hepatocellular carcinomas (HCC). METHODS:RNA and pro...

journal_title：Journal of hepatology

authors： Vavricka SR,Jung D,Fried M,Grützner U,Meier PJ,Kullak-Ublick GA

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND & AIMS:Ventriculo-arterial coupling (VAC) reflects the interaction between ventricular performance and effective arterial load. Current criteria for cirrhotic cardiomyopathy focus only on cardiac function without addressing the effect of hyperdynamic, low-resistance circulation. We investigated alterations i...

journal_title：Journal of hepatology

authors： Shin WJ,Song JG,Jun IG,Moon YJ,Kwon HM,Jung K,Kim SO,Hwang GS

更新日期：2017-02-01 00:00:00

abstract：:The high incidence of non-anastomotic biliary strictures (NAS) after transplantation of livers from extended criteria donors is currently a major barrier to widespread use of these organs. This review provides an update on the most recent advances in the understanding of the etiology of NAS. These new insights give re...

journal_title：Journal of hepatology

authors： Weeder PD,van Rijn R,Porte RJ

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic steatosis is an important factor in pathogenesis, progression and response to treatment in hepatitis C. We aimed to investigate differences in hepatic lipid composition in liver biopsies from patients with chronic hepatitis C using proton magnetic resonance spectroscopy ((1)H MRS) and to trans...

journal_title：Journal of hepatology

authors： Cobbold JF,Patel JH,Goldin RD,North BV,Crossey MM,Fitzpatrick J,Wylezinska M,Thomas HC,Cox IJ,Taylor-Robinson SD

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:Liver carbohydrate metabolism and blood flow are regulated by hepatic nerves and hormones such as glucagon, insulin or catecholamines. Acute and chronic application of alcohol are known to depress the function of central and peripheral nerves. The extent of inhibition of the autonomic nervous system is ...

journal_title：Journal of hepatology

authors： Kucera T,Stümpel F,Jungermann K

更新日期：1997-01-01 00:00:00

abstract：:The effect of a single bolus of somatostatin on oesophageal variceal pressure has been studied in 7 patients with cirrhosis and 5 patients with non-cirrhotic portal hypertension using a non-invasive variceal pressure gauge. Both groups of patients demonstrated similar reductions in variceal pressure with all subjects ...

journal_title：Journal of hepatology

authors： Clements D,Rhodes JM,Elias E

更新日期：1986-01-01 00:00:00

abstract：:Advances in the management of the pulmonary complications of cystic fibrosis may result in an increasing prevalence of patients with chronic liver disease which may, therefore, become more important in the long-term management of cystic fibrosis patients. However, no simple and reliable test is available for the diagn...

journal_title：Journal of hepatology

authors： Williams SG,Evanson JE,Barrett N,Hodson ME,Boultbee JE,Westaby D

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND/AIMS:Lipid peroxidation has been found to be associated with Ito cell activation. Ito cells are the principal collagen-producing cells and the main storage sites of retinoids. However, the relationship between retinoids and hepatic fibrosis is complex. The aim of this study was to elucidate the role of retin...

journal_title：Journal of hepatology

authors： Mizobuchi Y,Shimizu I,Yasuda M,Hori H,Shono M,Ito S

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND & AIMS:Despite the clinical and genetic significance of macrotrabecular-massive hepatocellular carcinoma (MTM-HCC), its characteristics on imaging have not been described. This study aimed to characterise MTM-HCC on gadoxetic acid-enhanced MRI and to evaluate the diagnostic accuracy and prognostic value of t...

journal_title：Journal of hepatology

authors： Rhee H,Cho ES,Nahm JH,Jang M,Chung YE,Baek SE,Lee S,Kim MJ,Park MS,Han DH,Choi JY,Park YN

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to sequence the precore region of HBV isolated from serum and tumorous and non-tumorous liver tissue from patients with hepatocellular carcinoma to identify mutations that might play a role in malignant transformation. METHODS:HBV DNA was extracted from 62 sera, 14 tumorous and...

journal_title：Journal of hepatology

authors： Kramvis A,Kew MC,Bukofzer S

更新日期：1998-01-01 00:00:00

abstract：:The purpose of the present study was to determine the effects of chronic portal diversion on antioxidant levels in the rat liver. Male Sprague-Dawley rats (n = 32) were used for these studies. An end-to-side portacaval anastomosis was constructed in 17 of the rats. Sham-operated rats (n = 15) served as controls. Two w...

journal_title：Journal of hepatology

authors： Benoit JN,Grisham MB,Mesh CL,Korthuis RJ,Granger DN

更新日期：1992-03-01 00:00:00

abstract：:We describe two cases of terbinafine-associated hepatic injury, in which a mixed cholestatic-hepatocellular type of hepatitis was present. In both cases extrahepatic cholestasis and viral hepatitis were excluded and involvement of other drugs was unlikely. In the first patient all abnormalities have disappeared, but i...

journal_title：Journal of hepatology

authors： van 't Wout JW,Herrmann WA,de Vries RA,Stricker BH

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of cirrhosis and subsequent development of organ dysfunction (OD) requiring intensive care unit (ICU) support is rising. Historically, critically ill cirrhotics are perceived as having poor prognosis and substantial cost of care. METHODS:The aim was to prospectively analyse resource uti...

journal_title：Journal of hepatology

authors： Shawcross DL,Austin MJ,Abeles RD,McPhail MJW,Yeoman AD,Taylor NJ,Portal AJ,Jamil K,Auzinger G,Sizer E,Bernal W,Wendon JA

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND/AIMS:The liver is the main source of circulating insulin-like growth factor binding proteins. In man, the cellular origin of insulin-like growth factor binding proteins has remained obscure. METHODS:Human hepatocytes isolated from surgical specimens were purified and cultured using a collagen gel immobiliza...

journal_title：Journal of hepatology

authors： Scharf JG,Schmidt-Sandte W,Pahernik SA,Koebe HG,Hartmann H

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND & AIMS:The liver is a crucial organ at the crossroads of iron and glucose metabolism. The aim of the study was to assess intra-hepatic iron in young patients with non-alcoholic fatty liver disease (NAFLD) and its association with insulin resistance and severity of liver damage. METHODS:Intrahepatic iron con...

journal_title：Journal of hepatology

authors： Manco M,Alisi A,Real JF,Equitani F,DeVito R,Valenti L,Nobili V

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells by the use of soluble factors, can model human liver function and toxicity. However, at present HLC maturity and whether any deficit represents a true fetal state or aberrant differentiation is unclear and compounded by compariso...

journal_title：Journal of hepatology

authors： Baxter M,Withey S,Harrison S,Segeritz CP,Zhang F,Atkinson-Dell R,Rowe C,Gerrard DT,Sison-Young R,Jenkins R,Henry J,Berry AA,Mohamet L,Best M,Fenwick SW,Malik H,Kitteringham NR,Goldring CE,Piper Hanley K,Vallier L,

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND/AIMS:The precise mechanism of formation and significance of Mallory bodies (MBs) are poorly understood. The endoplasmic reticulum (ER) is the organelle responsible for proper folding and elimination of unfolded proteins. Therefore, failure of this function increases defective proteins in the cell. METHODS:W...

journal_title：Journal of hepatology

authors： Hanada S,Harada M,Kumemura H,Bishr Omary M,Koga H,Kawaguchi T,Taniguchi E,Yoshida T,Hisamoto T,Yanagimoto C,Maeyama M,Ueno T,Sata M

更新日期：2007-07-01 00:00:00