当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Interferon-gamma produced by interleukin-12-activated tumor infiltrating CD8+T cells directly induces apoptosis of mouse hepatocellular carcinoma.

Interferon-gamma produced by interleukin-12-activated tumor infiltrating CD8+T cells directly induces apoptosis of mouse hepatocellular carcinoma.

Abstract：

BACKGROUND/AIMS:Interleukin-12 (IL-12), a cytokine with antitumor activity, was examined for the suppressive effect on hepatocellular carcinoma (HCC) in mouse model, and its mechanism of antitumor activity was analyzed. METHODS:Mice implanted with MIH-2 HCC cells were treated with recombinant mouse IL-12 (500 ng/mouse). Involvement of CD4(+), CD8(+), NK cells and interferon (IFN)-gamma on tumor suppression by IL-12 was examined by treatment of mice with each antibody. Interferon-gamma (IFN-gamma) production by tumor infiltrating cells was analyzed by immunofluorescence microscopy and flow cytometric analysis. Signal transduction for apoptosis induction was examined by immunoblot analysis. RESULTS:The growth of implanted MIH-2 tumors was significantly suppressed by IL-12 and the suppression was inhibited by depletion of CD8(+)T cells. IL-12 treatment caused numerous IFN-gamma-producing CD8(+)T cells to infiltrate into MIH-2 tumors. Antitumor activity of IL-12 was blocked by treating mice with anti-IFN-gamma mAb. CD8(+)T cells from IL-12-treated mice attached to MIH-2 cells and produced IFN-gamma in vitro. Cell attachment might be associated with intercellular adhesion molecule-1 induced by IFN-gamma. In vitro treatment with IFN-gamma induced apoptosis of MIH-2 cells via a mitochondria-dependent pathway. CONCLUSIONS:IL-12 suppressed HCC growth in mouse model. IFN-gamma produced by IL-12-activated tumor-infiltrating CD8(+)T cells directly induced apoptosis of HCC cells.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Komita H,Homma S,Saotome H,Zeniya M,Ohno T,Toda G

doi

10.1016/j.jhep.2006.05.018

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

662-72

issue

5

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(06)00303-5

journal_volume

45

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis.

    abstract：BACKGROUND AND AIMS:Fatty acid translocase CD36 (CD36) is a membrane protein with multiple immuno-metabolic functions. Palmitoylation has been suggested to regulate the distribution and functions of CD36, but little is known about its significance in non-alcoholic steatohepatitis (NASH). METHODS:Human liver tissue sam...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2018.04.006

    authors： Zhao L,Zhang C,Luo X,Wang P,Zhou W,Zhong S,Xie Y,Jiang Y,Yang P,Tang R,Pan Q,Hall AR,Luong TV,Fan J,Varghese Z,Moorhead JF,Pinzani M,Chen Y,Ruan XZ

    更新日期：2018-09-01 00:00:00

  • A multicentre randomized controlled trial of moderate hypothermia to prevent intracranial hypertension in acute liver failure.

    abstract：BACKGROUND & AIMS:Animal models and human case series of acute liver failure (ALF) suggest moderate hypothermia (MH) to have protective effects against cerebral oedema (CO) development and intracranial hypertension (ICH). However, the optimum temperature for patient management is unknown. In a prospective randomized co...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jhep.2016.03.003

    authors： Bernal W,Murphy N,Brown S,Whitehouse T,Bjerring PN,Hauerberg J,Frederiksen HJ,Auzinger G,Wendon J,Larsen FS

    更新日期：2016-08-01 00:00:00

  • The heart in liver transplantation.

    abstract：:The heart and liver are organs that are closely related in both health and disease. Patients who undergo liver transplantation may suffer from heart disease that is: (a) related to the original cause of the liver disease such as hemochromatosis, (b) related to the liver disease itself, or (c) related to other associat...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2010.11.003

    authors： Ripoll C,Yotti R,Bermejo J,Bañares R

    更新日期：2011-04-01 00:00:00

  • Liver resection for hepatocellular carcinoma in patients with metabolic syndrome: A multicenter matched analysis with HCV-related HCC.

    abstract：BACKGROUND & AIMS:The incidence of metabolic syndrome-related hepatocellular carcinoma (MS-HCC) is increasing worldwide. High resection risks are anticipated because of underlying steatohepatitis, but long-term results are unknown. To clarify the outcomes following liver resection in patients with MS-HCC and to compare...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jhep.2015.01.024

    authors： Viganò L,Conci S,Cescon M,Fava C,Capelli P,D'Errico A,Torzilli G,Di Tommaso L,Giuliante F,Vecchio FM,Salizzoni M,David E,Pinna AD,Guglielmi A,Capussotti L

    更新日期：2015-07-01 00:00:00

  • Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients.

    abstract：BACKGROUND & AIMS:Innate sensing of viral infection activates a global defense response including type I interferon (IFN) and IFN-stimulated genes (ISGs) expression. We previously reported that HCV NS3/4A protease, an essential protein in viral polyprotein processing, can abrogate antiviral signaling pathways and effec...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2011.07.017

    authors： Jouan L,Chatel-Chaix L,Melançon P,Rodrigue-Gervais IG,Raymond VA,Selliah S,Bilodeau M,Grandvaux N,Lamarre D

    更新日期：2012-01-01 00:00:00

  • Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: the HEmochromatosis FAmily Study.

    abstract：BACKGROUND/AIMS:In families of patients with clinically detected hereditary hemochromatosis (HH) early screening has been suggested to prevent morbidity and mortality. Here, we aim to identify determinants for iron overload in first-degree family members of C282Y homozygous probands with clinically detected HH. METHOD...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.08.014

    authors： Jacobs EM,Hendriks JC,van Deursen CT,Kreeftenberg HG,de Vries RA,Marx JJ,Stalenhoef AF,Verbeek AL,Swinkels DW

    更新日期：2009-01-01 00:00:00

  • Blood analysis for liver cirrhosis.

    abstract：:Liver fibrosis is one of the most important factors of disturbed liver function, but could not be measured by simple blood tests until recently. Among several parameters used for this purpose, the aminoterminal procollagen type III peptide (PIIIP) appears to be the most widely accepted. Studies conducted in several cl...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(85)80069-6

    authors： Hahn EG

    更新日期：1985-01-01 00:00:00

  • The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.

    abstract：BACKGROUND/AIMS:The organic anion transporting polypeptides (OATPs) mediate the uptake of numerous amphipathic compounds into hepatocytes. Our aim was to study the expression and regulation of OATP8 (OATP1B3, SLC21A8/SLCO1B3) and OATP-C (OATP1B1, SLC21A6/SLCO1B1) in hepatocellular carcinomas (HCC). METHODS:RNA and pro...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2003.10.008

    authors： Vavricka SR,Jung D,Fried M,Grützner U,Meier PJ,Kullak-Ublick GA

    更新日期：2004-02-01 00:00:00

  • Analysis of the cost of population screening for haemochromatosis using biochemical and genetic markers.

    abstract：AIMS:To estimate the cost of population screening for haemochromatosis in Australia and to compare the cost of alternative screening strategies. METHODS:The costs of screening for haemochromatosis were analysed in a hypothetical study using transferrin saturation as the primary screening test, with confirmation of the...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80357-1

    authors： Bassett ML,Leggett BA,Halliday JW,Webb S,Powell LW

    更新日期：1997-09-01 00:00:00

  • Antitumor effect of the nucleoside analogs 2-chlorodeoxyadenosine and 2',2'-difluorodeoxycytidine on human hepatoma HepG2 cells.

    abstract：BACKGROUND/AIMS:Hepatocellular carcinoma is one of the most malignant tumors in the world. Although a wide range of therapeutic options is available, the efficacy of these methods and the prognosis of hepatocellular carcinoma are still very poor. The nucleoside analogs 2-chlorodeoxyadenosine (Cladribine, 2-CdA) and 2',...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(98)80326-7

    authors： Graziadei I,Kelly T,Schirmer M,Geisen FH,Vogel W,Konwalinka G

    更新日期：1998-03-01 00:00:00

  • Elevation of the serum bilirubin diconjugate fraction provides an early marker for cholestasis in the rat.

    abstract：AIMS/METHODS:During cholestasis, components normally excreted into bile, e.g. bilirubin, accumulate in liver cells and biliary passages. In order to assess the conjugation of bilirubin retained in the hepatocyte during cholestasis, we analyzed the pattern of bilirubin pigments in rat serum and bile, using reversed phas...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80330-3

    authors： Mesa VA,De Vos R,Fevery J

    更新日期：1997-11-01 00:00:00

  • Endpoints and design of clinical trials in patients with decompensated cirrhosis: Position paper of the LiverHope Consortium.

    abstract：:Management of decompensated cirrhosis is currently geared towards the treatment of complications once they occur. To date there is no established disease-modifying therapy aimed at halting progression of the disease and preventing the development of complications in patients with decompensated cirrhosis. The design of...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.08.009

    authors： Solà E,Pose E,Campion D,Piano S,Roux O,Simon-Talero M,Uschner F,de Wit K,Zaccherini G,Alessandria C,Beuers U,Caraceni P,Francoz C,Mookerjee RP,Trebicka J,Vargas V,Serra M,Torres F,Montagnese S,Krag A,Hernaez R,K

    更新日期：2021-01-01 00:00:00

  • DAA therapy and long-term hepatic function in advanced/decompensated cirrhosis: Real-world experience from HCV-TARGET cohort.

    abstract：BACKGROUND & AIMS:Direct-acting antiviral (DAA) therapy is used in patients with HCV-related decompensated cirrhosis with the expectation of improving hepatic function. However, little is known about the long-term hepatic benefit of successful antiviral treatment. METHODS:Patients with advanced/decompensated cirrhosis...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.03.031

    authors： Verna EC,Morelli G,Terrault NA,Lok AS,Lim JK,Di Bisceglie AM,Zeuzem S,Landis CS,Kwo P,Hassan M,Manns MP,Vainorius M,Akushevich L,Nelson DR,Fried MW,Reddy KR

    更新日期：2020-09-01 00:00:00

  • Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein.

    abstract：BACKGROUND & AIMS:Disturbance in lipid metabolism is one of the features of chronic hepatitis C, being a crucial determinant of the progression of liver fibrosis. Experimental studies have revealed that the core protein of hepatitis C virus (HCV) induces steatosis. METHODS:The activities of fatty acid metabolizing enz...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.07.039

    authors： Miyoshi H,Moriya K,Tsutsumi T,Shinzawa S,Fujie H,Shintani Y,Fujinaga H,Goto K,Todoroki T,Suzuki T,Miyamura T,Matsuura Y,Yotsuyanagi H,Koike K

    更新日期：2011-03-01 00:00:00

  • A comparison of fibrosis progression in chronic liver diseases.

    abstract：BACKGROUND/AIMS:No study has compared the liver fibrosis progression rates among chronic liver diseases and the risk factors in order to better organize screening strategies. METHODS:A total of 4852 patients were retrospectively studied (chronic hepatitis C (HCV) [n=2313], human immunodeficiency virus (HIV)-HCV co-inf...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(02)00413-0

    authors： Poynard T,Mathurin P,Lai CL,Guyader D,Poupon R,Tainturier MH,Myers RP,Muntenau M,Ratziu V,Manns M,Vogel A,Capron F,Chedid A,Bedossa P,PANFIBROSIS Group.

    更新日期：2003-03-01 00:00:00

  • S-adenosylmethionine protects post-ischemic mitochondrial injury in rat liver.

    abstract：BACKGROUND/AIMS:S-adenosylmethionine (SAM) is a thiol-containing compound with known therapeutic affects on cholestasis and hepatotoxicity. The aim of this study was to investigate the effect of SAM on the prevention of mitochondrial injury induced by hepatic ischemia and reperfusion. METHODS/RESULTS:Rats were subject...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)00045-3

    authors： Jeon BR,Lee SM

    更新日期：2001-03-01 00:00:00

  • Prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic disease.

    abstract：BACKGROUND/AIMS:The aims were to study: 1) the prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic liver disease, 2) viral and host immunogenetic factors that may predispose to diabetes, and 3) liver transplantation outcome in patients with or without d...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80065-3

    authors： Zein NN,Abdulkarim AS,Wiesner RH,Egan KS,Persing DH

    更新日期：2000-02-01 00:00:00

  • Randomized placebo controlled phase I/II trial of alpha-galactosylceramide for the treatment of chronic hepatitis C.

    abstract：BACKGROUND/AIMS:The glycosphingolipid alpha-galactosylceramide has been shown to activate invariant natural killer T cells when presented in the context of CD1d and induces powerful antiviral immune responses via the production of inflammatory cytokines. The aim of this study was to investigate the safety and the antiv...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jhep.2007.04.018

    authors： Veldt BJ,van der Vliet HJ,von Blomberg BM,van Vlierberghe H,Gerken G,Nishi N,Hayashi K,Scheper RJ,de Knegt RJ,van den Eertwegh AJ,Janssen HL,van Nieuwkerk CM

    更新日期：2007-09-01 00:00:00

  • Pregnancy-associated acute liver disease and acute viral hepatitis: differentiation, course and outcome.

    abstract：BACKGROUND/AIMS:Pregnant women with acute viral hepatitis (VH) and those with pregnancy associated acute liver disease (PAALD) including acute fatty liver disease of pregnancy, hemolysis elevated liver enzyme and low platelet syndrome present with similar clinical features and liver tests abnormalities. Accurate differ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.07.030

    authors： Devarbhavi H,Kremers WK,Dierkhising R,Padmanabhan L

    更新日期：2008-12-01 00:00:00

  • Machine perfusion in liver transplantation as a tool to prevent non-anastomotic biliary strictures: Rationale, current evidence and future directions.

    abstract：:The high incidence of non-anastomotic biliary strictures (NAS) after transplantation of livers from extended criteria donors is currently a major barrier to widespread use of these organs. This review provides an update on the most recent advances in the understanding of the etiology of NAS. These new insights give re...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2015.03.008

    authors： Weeder PD,van Rijn R,Porte RJ

    更新日期：2015-07-01 00:00:00

  • Multiple voxel 1H MR spectroscopy of phosphorylase-b kinase deficient patients (GSD IXa) showing an accumulation of fat in the liver that resolves with aging.

    abstract：BACKGROUND/AIMS:Phosphorylase-b deficient patients suffer from glycogen storage disease (GSD IXa) leading to liver enlargement which usually resolves during puberty and adolescence. This pathology has not yet been documented by (1)H MR spectroscopy (MRS) investigation. METHODS:MRS of eight GSD IXa patients was perform...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.06.021

    authors： Sijens PE,Smit GP,Borgdorff MA,Kappert P,Oudkerk M

    更新日期：2006-12-01 00:00:00

  • Lymphoblastoid interferon therapy of chronic HBV infection. A comparison of 12 vs. 24 weeks of thrice weekly treatment.

    abstract：:This study set out to examine the relative effectiveness and tolerability of 12- versus 24-week courses of thrice weekly intramuscular lymphoblastoid interferon in the treatment of hepatitis B 'e' antigen (HBeAg)-positive chronic hepatitis B virus (HBV) infection, and to identify pretreatment factors predicting the ou...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(87)80061-2

    authors： Scully LJ,Shein R,Karayiannis P,McDonald JA,Thomas HC

    更新日期：1987-08-01 00:00:00

  • The prognostic role of hepatic venous pressure gradient in cirrhotic patients undergoing elective extrahepatic surgery.

    abstract：BACKGROUND & AIMS:Surgery in cirrhosis is associated with a high morbidity and mortality. Retrospectively reported prognostic factors include emergency procedures, liver function (MELD/Child-Pugh scores) and portal hypertension (assessed by indirect markers). This study assessed the prognostic role of hepatic venous pr...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jhep.2019.07.007

    authors： Reverter E,Cirera I,Albillos A,Debernardi-Venon W,Abraldes JG,Llop E,Flores A,Martínez-Palli G,Blasi A,Martínez J,Turon F,García-Valdecasas JC,Berzigotti A,de Lacy AM,Fuster J,Hernández-Gea V,Bosch J,García-Pagán JC

    更新日期：2019-11-01 00:00:00

  • Expression of liver-specific functions in rat hepatocytes following sublethal and lethal acetaminophen poisoning.

    abstract：AIM:In order to study the short-term effect of moderate and severe reduction of liver function by acetaminophen poisoning of different severity on gene expression for liver-specific functions, rats were given 3.75 and 7.5 g per kg body weight acetaminophen intragastrically. The lower dose is associated with low mortali...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80072-9

    authors： Tygstrup N,Jensen SA,Krog B,Dalhoff K

    更新日期：1996-08-01 00:00:00

  • Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways.

    abstract：BACKGROUND & AIMS:miR-224 is up-regulated in human HCCs as compared to both paired peri-tumoral cirrhotic tissues and cirrhotic livers without HCC. Here, we have cloned the miR-224 regulatory region and characterized its transcriptional regulation by the NFκB-dependent inflammatory pathways. METHODS:Mature miRNA expre...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2011.11.017

    authors： Scisciani C,Vossio S,Guerrieri F,Schinzari V,De Iaco R,D'Onorio de Meo P,Cervello M,Montalto G,Pollicino T,Raimondo G,Levrero M,Pediconi N

    更新日期：2012-04-01 00:00:00

  • Calcium in pig livers following ischemia and reperfusion.

    abstract：:Calcium concentrations in pig livers were serially estimated following ischemia-reperfusion. Ischemia was produced by clamping the hepatic artery and the portal vein for 90 min (Group 1, n = 6) or for 180 min (Group 2, n = 6) during temporary side-to-side portacaval shunt performed before the induction of ischemia. Al...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80140-0

    authors： Uchida M,Takemoto Y,Nagasue N,Kimoto T,Dhar DK,Nakamura T

    更新日期：1994-06-01 00:00:00

  • THF gamma 2 stimulates cytokine release by peripheral blood mononuclear cells of patients with chronic hepatitis B virus infection.

    abstract：:A recent study indicated that thymic hormones have antiviral effects in human hepatitis B virus infection and woodchuck hepatitis virus infection. These hormones are known to exert immunomodulatory effects on lymphocyte maturation and function; because these are abnormal in patients with chronic hepatitis B virus infe...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(94)80010-3

    authors： Daniels HM,O'Toole A,Hussein MJ,Corridori S,Alexander GJ,Williams R

    更新日期：1994-03-01 00:00:00

  • Urinary 7alpha-hydroxy-3-oxochol-4-en-24-oic and 3-oxochola-4,6-dien-24-oic acids in infants with cholestasis.

    abstract：BACKGROUND/AIMS:Urinary 3-oxo-delta4 bile acids have been detected in infants who ultimately died of liver disease. We used qualitative and quantitative methods to compare urinary 3-oxo-delta4 bile acids in liver disease, determining their composition and evaluating the prognostic implication in patients of various age...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(88)80014-x

    authors： Kimura A,Suzuki M,Murai T,Kurosawa T,Tohma M,Sata M,Inoue T,Hoshiyama A,Nakashima E,Yamashita Y,Fujisawa T,Kato H

    更新日期：1998-02-01 00:00:00

  • The major histocompatibility complex influences the development of chronic liver disease in male children and young adults with cystic fibrosis.

    abstract：BACKGROUND/AIMS:Chronic liver disease is a well-recognised complication of cystic fibrosis. Recent reports suggest that its development is not determined by specific mutations within the cystic fibrosis gene; however, familial clustering of portal hypertension cases and inappropriate immune responses against liver memb...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80058-1

    authors： Duthie A,Doherty DG,Donaldson PT,Scott-Jupp R,Tanner MS,Eddleston AL,Mowat AP

    更新日期：1995-11-01 00:00:00

  • NAFLD: a multisystem disease.

    abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries that is predicted to become also the most frequent indication for liver transplantation by 2030. Over the last decade, it has been shown that the clinical burden of NAFLD is not only confined to liver-relat...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2014.12.012

    authors： Byrne CD,Targher G

    更新日期：2015-04-01 00:00:00