Calcium in pig livers following ischemia and reperfusion.

abstract：BACKGROUND/AIMS:The mechanism of action of recombinant interferon-alpha (rIFN alpha) treatment in chronic hepatitis C is not fully understood, and may include modulation of the immune system as well as a direct antiviral effect. We have therefore evaluated the plasma concentrations of pro- and anti-inflammatory cytokin...

journal_title：Journal of hepatology

authors： Naveau S,Emilie D,Borotto E,Portier A,Lazizi Y,Giraud V,Grangeot-Keros L,Capron F,Galanaud P,Chaput JC

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND & AIMS:Direct-acting antiviral (DAA) therapy is used in patients with HCV-related decompensated cirrhosis with the expectation of improving hepatic function. However, little is known about the long-term hepatic benefit of successful antiviral treatment. METHODS:Patients with advanced/decompensated cirrhosis...

journal_title：Journal of hepatology

authors： Verna EC,Morelli G,Terrault NA,Lok AS,Lim JK,Di Bisceglie AM,Zeuzem S,Landis CS,Kwo P,Hassan M,Manns MP,Vainorius M,Akushevich L,Nelson DR,Fried MW,Reddy KR

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND/AIMS:Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate ...

journal_title：Journal of hepatology

authors： Werner M,Almer S,Prytz H,Lindgren S,Wallerstedt S,Björnsson E,Bergquist A,Sandberg-Gertzén H,Hultcrantz R,Sangfelt P,Weiland O,Danielsson A

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND & AIMS:To develop an in situ molecular signature to predict postsurgical recurrence in hepatocellular carcinoma (HCC) patients. METHODS:Immunohistochemistry was performed using tissue microarrays containing both tumoral and peri-tumoral regions of the advancing tumor edge from 336 HCC patients (289 were pos...

journal_title：Journal of hepatology

authors： Xu J,Ding T,He Q,Yu XJ,Wu WC,Jia WH,Yun JP,Zhang Y,Shi M,Shao CK,Pan WD,Yin XY,Min J,Zhuang SM,Zheng L

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND & AIMS:γδ T cells comprise a substantial proportion of tissue-associated lymphocytes. However, our current understanding of human γδ T cells is primarily based on peripheral blood subsets, while the immunobiology of tissue-associated subsets remains largely unclear. Therefore, we aimed to elucidate the T cel...

journal_title：Journal of hepatology

authors： Hunter S,Willcox CR,Davey MS,Kasatskaya SA,Jeffery HC,Chudakov DM,Oo YH,Willcox BE

更新日期：2018-09-01 00:00:00

abstract：:In this Grand Round presentation, the case of a man with decompensated liver disease is described. He subsequently developed a fatal pulmonary embolism, which may not have occurred if he had been prescribed prophylactic anticoagulation to prevent venous thromboembolic disease. The burden of thrombotic disease in those...

journal_title：Journal of hepatology

authors： Dhar A,Mullish BH,Thursz MR

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND/AIMS:Circulatory abnormalities with activation of vasoconstrictor systems after large-volume paracentesis are generally considered secondary to an increased extravasation of fluid from the intravascular compartment to the extravascular space with subsequent reduction in plasma volume. To test this hypothesis...

journal_title：Journal of hepatology

authors： Saló J,Ginès A,Ginès P,Piera C,Jiménez W,Guevara M,Fernández-Esparrach G,Sort P,Bataller R,Arroyo V,Rodés J

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND & AIMS:Glucagon-like peptide-1 (GLP-1), a gut-derived peptide degraded by dipeptidyl peptidase-4 (DPP4), stimulates insulin secretion in response to nutrients, yet its direct effect on the liver is controversial. We investigated the effects of GLP-1 on hepatic fat and glucose metabolism and elucidated its me...

journal_title：Journal of hepatology

authors： Ben-Shlomo S,Zvibel I,Shnell M,Shlomai A,Chepurko E,Halpern Z,Barzilai N,Oren R,Fishman S

更新日期：2011-06-01 00:00:00

abstract：:This article summarizes the current state of antiviral therapy of hepatitis B with special attention given to areas that remain controversial or poorly defined. Strict adherence to liver association practice guidelines may result in missed opportunities to treat patients with significant underlying liver disease. In p...

journal_title：Journal of hepatology

authors： Zoulim F,Perrillo R

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:Whether GB virus C and hepatitis G virus participate in fulminant hepatic failure is controversial. We studied the prevalence of the viral RNA in 48 patients. There were possible routes of infection, including blood transfusion, in 22 patients (group 1), and no risk factors in the other 26 (group 2). M...

journal_title：Journal of hepatology

authors： Tanaka M,Nishiguchi S,Tanaka T,Enomoto M,Fukuda K,Takeda T,Nakajima S,Shiomi S,Kuroki T,Monna T,Yano Y,Otani S

更新日期：1997-12-01 00:00:00

abstract：:As growth hormone possesses anabolic properties that are active on protein metabolism, and thus of potential benefit to patients with chronic liver disease, we determined the metabolic effects of recombinant human growth hormone on insulin-like growth factor-I (IGF-I) its specific binding proteins, and liver function....

journal_title：Journal of hepatology

authors： Møller S,Becker U,Grønbaek M,Juul A,Winkler K,Skakkebaek NE

更新日期：1994-11-01 00:00:00

abstract：:Intracellular ion homeostasis in liver cell is accomplished through the concerted action of ion pumps, carriers and channels. Description of these elements includes the Na+/K+-ATPase, Na+/H+- and Cl-/ HCO3(-)-exchange and Na+-HCO-3(-)- and Na(+)-K(+)-2 Cl(-)-cotransport as well as K+-, Cl(-)-, Na+ and nonselective cat...

journal_title：Journal of hepatology

authors： Graf J,Häussinger D

更新日期：1996-01-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Journal of hepatology

authors： Arai T,Kato Y,Ishimoto K,Kanai M,Shinjo S,Sayama K,Suzuki T,Doi T,Johnson RS,Suematsu M,Goda N

更新日期：2015-02-10 00:00:00

abstract：BACKGROUND/AIMS:Suppressor of cytokine signaling (SOCS)-1, a negative feedback regulator of cytokine signaling pathway, also has a tumor suppressor activity, the silencing of its gene by hypermethylation is suggested to contribute to hepatocarcinogenesis. We studied the effect of the core protein of hepatitis C virus (...

journal_title：Journal of hepatology

authors： Miyoshi H,Fujie H,Shintani Y,Tsutsumi T,Shinzawa S,Makuuchi M,Kokudo N,Matsuura Y,Suzuki T,Miyamura T,Moriya K,Koike K

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIMS:The number of perisinusoidal myofibroblasts has been shown to be increased in hepatocellular carcinoma, as compared to cirrhosis. This increase might suggest a cooperative relationship between tumour cells and myofibroblasts. To assess this relationship, we undertook: (a) an immunohistochemical study to...

journal_title：Journal of hepatology

authors： Nhieu JT,Brochériou I,Préaux AM,Mallat A,Cherqui D,Zafrani ES,Mavier P

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND/AIMS:Little is known about the nucleotide excision repair (NER) pathway in the resistance of human hepatocellular carcinoma (HCC) to chemotherapeutics. We investigated expression of several NER genes in human HCC and matching non-tumor tissue (NT) and in normal liver. METHODS:Expression of CSA, CSB, XPC, hH...

journal_title：Journal of hepatology

authors： Fautrel A,Andrieux L,Musso O,Boudjema K,Guillouzo A,Langouët S

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatobiliary malignancies are frequently seen in primary sclerosing cholangitis (PSC) and they complicate the evaluation of patients and timing of liver transplantation. METHODS:Data from all Nordic PSC patients listed for liver transplantation during 1990-2001 were recorded prospectively. Predictors ...

journal_title：Journal of hepatology

authors： Brandsaeter B,Isoniemi H,Broomé U,Olausson M,Bäckman L,Hansen B,Schrumpf E,Oksanen A,Ericzon BG,Höckerstedt K,Mäkisalo H,Kirkegaard P,Friman S,Bjøro K

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIM:Endothelin-1 plays an important role in the regulation of portal hypertension; endothelin antagonists have been extensively studied in portal hypertensive animals. We aimed to evaluate the efficacy of highly selective endothelin antagonists in partial portal vein ligated (PPVL) rats. METHODS:Four groups...

journal_title：Journal of hepatology

authors： De Gottardi A,Shaw S,Sägesser H,Reichen J

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIMS:Albumin administration prevents renal failure and improves survival in spontaneous bacterial peritonitis. This study characterizes the mechanisms of action of albumin in this condition. METHODS:Systemic and splanchnic hemodynamics, plasma renin activity and plasma concentration of interleukin-6, serum ...

journal_title：Journal of hepatology

authors： Fernández J,Navasa M,Garcia-Pagan JC,G-Abraldes J,Jiménez W,Bosch J,Arroyo V

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND & AIMS:Repair from biliary damages requires the biliary specification of hepatic progenitor cells and the remodeling of ductular reactive structures into branching biliary tubules. We hypothesized that the morphogenetic role of Notch signaling is maintained during the repair process and have addressed this h...

journal_title：Journal of hepatology

authors： Fiorotto R,Raizner A,Morell CM,Torsello B,Scirpo R,Fabris L,Spirli C,Strazzabosco M

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND/AIMS:As conditional knockout mice for stat3 are impaired in liver regeneration after partial hepatectomy while those for gp130 have defects in early STAT3 phosphorylation but have normal DNA synthesis, late STAT3 phosphorylation induced independently of gp130 seems to be essential for liver regeneration. Sin...

journal_title：Journal of hepatology

authors： Seki E,Kondo Y,Iimuro Y,Naka T,Son G,Kishimoto T,Fujimoto J,Tsutsui H,Nakanishi K

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND/AIMS:To review our experience of thrombolytic therapy in patients with acute Budd Chiari syndrome (BCS). METHODS:Records of 10 patients with BCS, treated by thrombolysis over a 12-year period were retrospectively analysed for demographics, clinical presentation/duration, primary disease, thrombolytic regime...

journal_title：Journal of hepatology

authors： Sharma S,Texeira A,Texeira P,Elias E,Wilde J,Olliff SP

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aims were to study: 1) the prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic liver disease, 2) viral and host immunogenetic factors that may predispose to diabetes, and 3) liver transplantation outcome in patients with or without d...

journal_title：Journal of hepatology

authors： Zein NN,Abdulkarim AS,Wiesner RH,Egan KS,Persing DH

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND/AIMS:Reactive oxygen species, proinflammatory cytokines, glutathione depletion and nitric oxide have all been implicated in the pathogenesis of fulminant hepatic failure. The aim of the present study was to examine the respective roles of these factors in the pathogenesis of thioacetamide-induced fulminant h...

journal_title：Journal of hepatology

authors： Bruck R,Aeed H,Shirin H,Matas Z,Zaidel L,Avni Y,Halpern Z

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND & AIMS:Number-needed-to-treat is used in assessing the effectiveness of a health-care intervention, and reports the number of patients who need to be treated to prevent one additional bad outcome. Although largely used in medical literature, there are no studies measuring the benefit of liver transplantation...

journal_title：Journal of hepatology

authors： Vitale A,Cucchetti A,Qiao GL,Cescon M,Li J,Ramirez Morales R,Frigo AC,Xia Y,Tuci F,Shen F,Cillo U,Pinna AD

更新日期：2014-06-01 00:00:00

abstract：:The liver has come a long way since it was considered only a metabolic organ attached to the gastrointestinal tract. The simultaneous ascension of immunology and intravital microscopy evidenced the liver as a central axis in the immune system, controlling immune responses to local and systemic agents as well as diseas...

journal_title：Journal of hepatology

authors： Marques PE,Oliveira AG,Chang L,Paula-Neto HA,Menezes GB

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic stellate cells (HSCs) are perisinusoidal pericytes which have receptors for vasoactive factors, such as endothelin-1, which can regulate cell contractility in an autocrine manner. It is unknown whether human HSCs have receptors for and are able to synthesize the vasodilator peptide adrenomedulli...

journal_title：Journal of hepatology

authors： Görbig MN,Ginès P,Bataller R,Nicolás JM,Garcia-Ramallo E,Cejudo P,Sancho-Bru P,Jiménez W,Arroyo V,Rodés J

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND/AIMS:Repetitive indomethacin administration induces down-regulation of hepatic cytochrome P450 (CYP) enzymes. We tested the hypothesis that an increase in intestinal permeability by indomethacin-induced intestinal injury leads to entry of bacterial endotoxin and reaching into liver via the portal vein, resul...

journal_title：Journal of hepatology

authors： Masubuchi Y,Horie T

更新日期：2003-09-01 00:00:00

abstract：:We have studied the roles of immunoprophylaxis, patient selection policy and coexistent hepatitis D virus infection in the outcome of 56 HBsAg-positive elective liver transplant recipients. Twenty-nine unselected patients not treated with immunoprophylaxis formed group 1 and were compared to a recent consecutive serie...

journal_title：Journal of hepatology

authors： Devlin J,Smith HM,O'Grady JG,Portmann B,Tan KC,Williams R

更新日期：1994-08-01 00:00:00

abstract：:The multidrug resistance genes encode plasma membrane glycoproteins named P-glycoproteins, that act as an ATP-dependent drug efflux pump and decrease the cytosolic concentration of chemotherapeutic agents. It has been hypothesized that in rat liver, this protein may have a physiological role as a biliary transporter o...

journal_title：Journal of hepatology

authors： Vollrath V,Wielandt AM,Acuña C,Duarte I,Andrade L,Chianale J

更新日期：1994-11-01 00:00:00