Abstract:
BACKGROUND/AIMS:Albumin administration prevents renal failure and improves survival in spontaneous bacterial peritonitis. This study characterizes the mechanisms of action of albumin in this condition. METHODS:Systemic and splanchnic hemodynamics, plasma renin activity and plasma concentration of interleukin-6, serum concentration of nitric oxide and ascitic fluid levels of nitric oxide and interleukin-6 were assessed at diagnosis and resolution of infection in 12 patients with spontaneous bacterial peritonitis treated with ceftriaxone plus albumin. At infection resolution there was a significant improvement in circulatory function, as indicated by a significant increase in mean arterial pressure (+8%, P=0.02), a fall in heart rate (-10%, P=0.01), a suppression of plasma renin activity (-67%, P=0.002) and a decrease in creatinine levels. These changes were related to both an increase in cardiac work (stroke work index: +18%, P=0.005) and in peripheral vascular resistance (+14%, P=0.05). The improvement in cardiac function was due to an increase in filling. No significant changes were observed in portal pressure or hepatic blood flow. CONCLUSIONS:These results indicate that the beneficial effects of albumin administration on systemic hemodynamics and renal function in spontaneous bacterial peritonitis are related to both an improvement in cardiac function and a decrease in the degree of arterial vasodilation.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Fernández J,Navasa M,Garcia-Pagan JC,G-Abraldes J,Jiménez W,Bosch J,Arroyo Vdoi
10.1016/j.jhep.2004.05.009subject
Has Abstractpub_date
2004-09-01 00:00:00pages
384-90issue
3eissn
0168-8278issn
1600-0641pii
S0168827804002314journal_volume
41pub_type
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pub_type: 杂志文章
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journal_title:Journal of hepatology
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journal_title:Journal of hepatology
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pub_type: 历史文章,杂志文章,评审
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pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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doi:10.1016/j.jhep.2008.08.014
更新日期:2009-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:Journal of hepatology
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更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
doi:10.1016/j.jhep.2012.05.016
更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-04-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2006.02.017
更新日期:2006-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-07-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Journal of hepatology
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更新日期:2019-04-01 00:00:00
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journal_title:Journal of hepatology
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:1999-02-01 00:00:00
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journal_title:Journal of hepatology
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更新日期:2013-06-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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