当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7.

Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7.

Abstract：

BACKGROUND/AIMS:The oral administration of the major transplant immunosuppressants cyclosporine A and tacrolimus leads to unpredictable drug levels requiring drug monitoring. Hepatic and extrahepatic metabolism of cyclosporine A and tacrolimus by cytochrome P450 proteins has been analyzed but metabolism and inactivation by glucuronidation has not been investigated. METHODS:Cyclosporine A and tacrolimus glucuronidation was measured in hepatic and gastrointestinal microsomal protein, and with 11 recombinant hepatic and extrahepatic family 1 and 2 UDP-glucuronosyltransferases. UDP-glucuronosyltransferase transcripts were determined by polymerase chain reaction. RESULTS:Significant cyclosporine and tacrolimus glucuronidation activity was present in endoplasmic reticulum from liver, duodenum, jejunum, ileum and colon, but was absent in stomach. Specific cyclosporine A glucuronidation activity was highest in liver and colon, tacrolimus glucuronidation was highest in liver. Analyses using recombinant UDPglucuronosyltransferases identified UGT2B7 as a human UDP-glucuronosyltransferase with specific activity toward cyclosporine A and tacrolimus. The hepato-gastrointestinal distribution of immunosuppressant glucuronidation activity corresponded to the differential expression pattern of UGT2B7 mRNA. CONCLUSIONS:This study provides conclusive evidence of hepatic and extrahepatic immunosuppressant glucuronidation by human UGT2B7 which was identified to be differentially expressed in the human hepatogastrointestinal tract. Hepatic and extrahepatic glucuronidation may influence the therapeutic efficacy of transplant immunosuppressants.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Strassburg CP,Barut A,Obermayer-Straub P,Li Q,Nguyen N,Tukey RH,Manns MP

doi

10.1016/s0168-8278(01)00040-x

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

865-72

issue

6

eissn

0168-8278

issn

1600-0641

pii

S016882780100040X

journal_volume

34

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Inositol phosphate responses in portal veins from portal hypertensive rats: receptor- and nonreceptor-mediated responses.

    abstract：BACKGROUND/AIMS:Venous hyporesponsiveness in portal hypertension has been reported previously by us. The present study was undertaken to investigate possible changes of phosphoinositide signal transduction pathway in the portal veins from portal hypertensive rats METHODS:Portal hypertension was induced by partial port...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80055-4

    authors： Huang YT,Chang SP,Lin HC,Yang MC,Hong CY

    更新日期：1997-02-01 00:00:00

  • Evaluation of a bioartificial liver based on a nonwoven fabric bioreactor with porcine hepatocytes in pigs.

    abstract：BACKGROUND/AIMS:We developed a bioartificial liver (BAL) based on a direct hemoperfusion typed nonwoven fabric bioreactor containing porcine hepatocytes. In this study, the efficacy of our BAL was evaluated with a pig fulminant hepatic failure (FHF) model. METHODS:FHF was induced with intravenous administration of D-g...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.08.006

    authors： Li LJ,Du WB,Zhang YM,Li J,Pan XP,Chen JJ,Cao HC,Chen Y,Chen YM

    更新日期：2006-02-01 00:00:00

  • Inhibition of hepatitis C virus gene expression by adenoviral vectors encoding antisense RNA in vitro and in vivo.

    abstract：BACKGROUND & AIMS:In this study, adenoviral vectors encoding an antisense RNA complementary to the 5' non-coding region (5'NCR) of the HCV-genome were generated to inhibit HCV-RNA gene expression in cell culture and in vivo. METHODS:First and second-generation (with E4-deletion) adenoviruses encoding the HCV5'NCR in a...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.11.010

    authors： González-Carmona MA,Vogt A,Heinicke T,Quasdorff M,Hoffmann P,Yildiz Y,Schneider C,Serwe M,Bartenschlager R,Sauerbruch T,Caselmann WH

    更新日期：2011-07-01 00:00:00

  • β7-Integrin and MAdCAM-1 play opposing roles during the development of non-alcoholic steatohepatitis.

    abstract：BACKGROUND & AIMS:Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease in Western countries. It is unclear how infiltrating leukocytes affect NASH-development. Our study aims to investigate the role of the homing/receptor, pair mucosal addressin cell adhesion molecule-1 (MAdCAM-1)/β7-Integri...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.02.001

    authors： Drescher HK,Schippers A,Clahsen T,Sahin H,Noels H,Hornef M,Wagner N,Trautwein C,Streetz KL,Kroy DC

    更新日期：2017-06-01 00:00:00

  • Global liver disease burdens and research trends: Analysis from a Chinese perspective.

    abstract：:Liver diseases affect millions of people worldwide. In most developed countries, the incidence of viral hepatitis is waning as a result of modern advances in disease prevention, diagnosis, and therapies. Expanded programmes for systematic immunisation against hepatitis B virus have also significantly brought down the ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2019.03.004

    authors： Xiao J,Wang F,Wong NK,He J,Zhang R,Sun R,Xu Y,Liu Y,Li W,Koike K,He W,You H,Miao Y,Liu X,Meng M,Gao B,Wang H,Li C

    更新日期：2019-07-01 00:00:00

  • Defective aggregation in cirrhosis is independent of in vivo platelet activation.

    abstract：BACKGROUND/AIMS:Platelet function abnormalities contribute to the hemostatic defect in patients with cirrhosis. In this study we evaluated the occurrence of in vivo platelet activation as a possible mechanism of defective platelet aggregation in patients with cirrhosis. METHODS:Nine patients with severe (Child B-C) ci...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80164-4

    authors： Laffi G,Cinotti S,Filimberti E,Ciabattoni G,Caporale R,Marra F,Melani L,Grossi A,Carloni V,Gentilini P

    更新日期：1996-04-01 00:00:00

  • Cytokeratin 7 staining of hepatocytes predicts progression to more severe fibrosis in alcohol-fed baboons.

    abstract：BACKGROUND/AIMS:Not all alcoholic patients develop severe liver disease with fibrosis progressing to cirrhosis. It is of practical importance to determine whether some markers can predict progression of liver fibrosis. METHODS:We used a baboon model that mimics human alcoholic liver disease. Cytokeratin 7 and 19 expre...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00144-2

    authors： Ren C,Paronetto F,Mak KM,Leo MA,Lieber CS

    更新日期：2003-06-01 00:00:00

  • Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival.

    abstract：BACKGROUND/AIMS:Members of the CD44 family are transmembrane glycoproteins which act mainly as receptors for hyaluronan. We have examined the expression of CD44s and several CD44v and the relationship between these and hepatocellular carcinoma (HCC) grade, clinicopathological parameters, p53 expression, and patient sur...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80192-0

    authors： Endo K,Terada T

    更新日期：2000-01-01 00:00:00

  • Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors.

    abstract：BACKGROUND/AIMS:Thrombin and MC tryptase, which are agonists for proteinase-activated receptors-1 and -2, respectively, are both increased in injured liver. We have examined if rat stellate cells express these receptors and if receptor agonists influence stellate cell activation. METHODS:Expression of mRNA for protein...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00285-9

    authors： Gaça MD,Zhou X,Benyon RC

    更新日期：2002-03-01 00:00:00

  • The lung in patients with cirrhosis.

    abstract：:To summarize, nowadays it seems clear that in patients with cirrhosis: (a) the pulmonary circulation is usually markedly dilated. (b) This vasodilation is due to a loss of vascular tone and it is characterized by a poor (or even absent) vascular reactivity in front of the hypoxic stimulus. (c) This abnormal behaviour ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/0168-8278(90)90061-u

    authors： Agustí AG,Roca J,Bosch J,Rodriguez-Roisin R

    更新日期：1990-03-01 00:00:00

  • Omega 3 - Omega 6: What is right for the liver?

    abstract：:Linoleic and alpha-linolenic acids are the fatty acids designated as "essential" since they are not synthesized by mammalian cells and must be provided in the diet. The recent dietary shift towards the consumption of n-6 (omega-6) at the expense of n-3 (omega-3) polyunsaturated fatty acids (PUFAs) is thought to be a p...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2007.08.005

    authors： El-Badry AM,Graf R,Clavien PA

    更新日期：2007-11-01 00:00:00

  • Is surgery for large hepatocellular carcinoma justified?

    abstract：BACKGROUND/AIMS:Most hepatocellular carcinomas are still discovered at an advanced stage and are left untreated as large hepatocellular carcinomas are contraindications to liver transplantation and percutaneous ethanol injection and are usually considered as poor indications for liver resection. The aim of this study w...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80319-5

    authors： Régimbeau JM,Farges O,Shen BY,Sauvanet A,Belghiti J

    更新日期：1999-12-01 00:00:00

  • Norfloxacin primary prophylaxis of bacterial infections in cirrhotic patients with ascites: a double-blind randomized trial.

    abstract：BACKGROUND/AIMS:Norfloxacin is useful to prevent infections in hospitalized cirrhotic patients with low ascitic fluid protein concentrations. It is also effective in preventing the recurrence of spontaneous bacterial peritonitis. The aim of our study was to determine the efficacy of norfloxacin in the primary prophylax...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0168-8278(98)80061-5

    authors： Grangé JD,Roulot D,Pelletier G,Pariente EA,Denis J,Ink O,Blanc P,Richardet JP,Vinel JP,Delisle F,Fischer D,Flahault A,Amiot X

    更新日期：1998-09-01 00:00:00

  • Hepatobiliary transport.

    abstract：:The alterations of hepatobiliary transport that occur in cholestasis can be divided into primary defects, such as mutations of transporter genes or acquired dysfunctions of transport systems that cause defective canalicular or cholangiocellular secretion, and secondary defects, which result from biliary obstruction. T...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-8278(00)80411-0

    authors： Kullak-Ublick GA,Beuers U,Paumgartner G

    更新日期：2000-01-01 00:00:00

  • A multicentre randomized controlled trial of moderate hypothermia to prevent intracranial hypertension in acute liver failure.

    abstract：BACKGROUND & AIMS:Animal models and human case series of acute liver failure (ALF) suggest moderate hypothermia (MH) to have protective effects against cerebral oedema (CO) development and intracranial hypertension (ICH). However, the optimum temperature for patient management is unknown. In a prospective randomized co...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jhep.2016.03.003

    authors： Bernal W,Murphy N,Brown S,Whitehouse T,Bjerring PN,Hauerberg J,Frederiksen HJ,Auzinger G,Wendon J,Larsen FS

    更新日期：2016-08-01 00:00:00

  • The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin.

    abstract：BACKGROUND/AIMS:Selective cyclooxygenase (COX)-2 inhibitors do not adversely affect renal function in experimental cirrhosis. In the current study, we investigated the molecular mechanisms underlying the effects of the selective COX-2 inhibitor, celecoxib, and assessed the influence of albumin on its actions. METHODS:...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.09.011

    authors： López-Parra M,Clària J,Titos E,Planagumà A,Párrizas M,Masferrer JL,Jiménez W,Arroyo V,Rivera F,Rodés J

    更新日期：2005-01-01 00:00:00

  • Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats.

    abstract：BACKGROUND/AIMS:To assess the effect of lactoferrin on oxidative liver damage and its mechanism, we used Long-Evans Cinnamon (LEC) rats that spontaneously develop fulminant-like hepatitis and lethal hepatic failure. METHODS:Four-week-old female LEC rats were divided into the untreated and treated groups. The latter wa...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2007.11.013

    authors： Tsubota A,Yoshikawa T,Nariai K,Mitsunaga M,Yumoto Y,Fukushima K,Hoshina S,Fujise K

    更新日期：2008-03-01 00:00:00

  • Multiple voxel 1H MR spectroscopy of phosphorylase-b kinase deficient patients (GSD IXa) showing an accumulation of fat in the liver that resolves with aging.

    abstract：BACKGROUND/AIMS:Phosphorylase-b deficient patients suffer from glycogen storage disease (GSD IXa) leading to liver enlargement which usually resolves during puberty and adolescence. This pathology has not yet been documented by (1)H MR spectroscopy (MRS) investigation. METHODS:MRS of eight GSD IXa patients was perform...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.06.021

    authors： Sijens PE,Smit GP,Borgdorff MA,Kappert P,Oudkerk M

    更新日期：2006-12-01 00:00:00

  • Lack of decline in hepatitis C virus incidence among HIV-positive men who have sex with men during 1990-2014.

    abstract：BACKGROUND & AIMS:Hepatitis C virus (HCV) incidence among HIV-positive men who have sex with men (MSM) has increased since 2000, although there are regional differences. We aimed to 1) estimate trends in HCV incidence among HIV-positive MSM, 2) assess the association between incidence and geographical region, age and H...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.03.038

    authors： van Santen DK,van der Helm JJ,Del Amo J,Meyer L,D'Arminio Monforte A,Price M,Béguelin CA,Zangerle R,Sannes M,Porter K,Geskus RB,Prins M,CASCADE Collaboration in EuroCoord.

    更新日期：2017-08-01 00:00:00

  • Heterogeneity of hepatitis B virus C-gene sequences: implications for amplification and sequencing.

    abstract：:Occasionally direct sequencing of amplified hepatitis B virus DNA leads to weak signals on autoradiograms. Using amplified C-gene sequences we investigated whether this is due to sequence heterogeneity of virus populations and use of inappropriate primers for direct sequencing. High C-gene sequence heterogeneity (poin...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80009-1

    authors： Miska S,Günther S,Vassilev M,Meisel H,Pape G,Will H

    更新日期：1993-04-01 00:00:00

  • Microsteatosis may not interact with macrosteatosis in living donor liver transplantation.

    abstract：BACKGROUND & AIMS:The insignificance of pure microsteatosis (MiS) was reported in living donor liver transplantation (LDLT). However, since steatosis is mostly found in a mixed form of microsteatosis (MiS) and macrosteatosis (MaS), we aimed to determine the importance of MiS mixed with MaS in LDLT. METHODS:Donor match...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.10.027

    authors： Han S,Ha SY,Park CK,Joh JW,Kwon CH,Kwon GY,Kim G,Gwak MS,Jeong WK,Ko JS

    更新日期：2015-03-01 00:00:00

  • Complete removal of the tumor-bearing portal territory decreases local tumor recurrence and improves disease-specific survival of patients with hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:Anatomic resection (AR) of the tumor-bearing portal territory has been reported to be associated with a decreased recurrence of hepatocellular carcinoma (HCC). However, because of the heterogeneity of the study populations, its oncologic advantage remains controversial. The objective of the present st...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.10.015

    authors： Shindoh J,Makuuchi M,Matsuyama Y,Mise Y,Arita J,Sakamoto Y,Hasegawa K,Kokudo N

    更新日期：2016-03-01 00:00:00

  • Fulminant hepatitis. An ultrastructural study.

    abstract：:Ultrastructural changes were observed in 23 consecutive patients who died from fulminant hepatic failure due to hepatitis B virus (4 cases), sporadic non-A, non-B (7), or paracetamol (acetaminophen) overdose (12) and in 3 patients with subacute hepatic necrosis of unknown cause. The findings are described in detail in...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80087-3

    authors： McCaul TF,Fagan EA,Tovey G,Portmann B,Williams R,Zuckerman AJ

    更新日期：1986-01-01 00:00:00

  • Roles of alcohol consumption in fatty liver: a longitudinal study.

    abstract：BACKGROUND & AIMS:Roles of alcohol consumption in non-alcoholic fatty liver disease are still controversial, although several cross-sectional studies have suggested the beneficial effect of light to moderate drinking on fatty liver. We analyzed the longitudinal relationship between drinking pattern and fatty liver. ME...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.11.025

    authors： Moriya A,Iwasaki Y,Ohguchi S,Kayashima E,Mitsumune T,Taniguchi H,Ando M,Yamamoto K

    更新日期：2015-04-01 00:00:00

  • Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells.

    abstract：BACKGROUND & AIMS:Sepsis is an acute systemic inflammatory response to infection associated with high patient mortality (28-40%). We hypothesized that interleukin (IL)-30, a novel cytokine protecting mice against liver injury resulting from inflammation, would generate a protective effect against systemic inflammation ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.12.020

    authors： Yan J,Mitra A,Hu J,Cutrera JJ,Xia X,Doetschman T,Gagea M,Mishra L,Li S

    更新日期：2016-05-01 00:00:00

  • Variability of splanchnic blood flow measurements using MR velocity mapping under fasting and post-prandial conditions--comparison with echo-Doppler.

    abstract：BACKGROUND/AIMS:The aim was to study the reproducibility of magnetic resonance velocity mapping, when measuring portal vein and superior mesenteric artery blood flow, under fasting and post-prandial conditions. Magnetic resonance flow measurements for the portal vein were compared with echo-Doppler measurements in the ...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(97)80045-1

    authors： Lycklama à Nijeholt GJ,Burggraaf K,Wasser MN,Schultze Kool LJ,Schoemaker RC,Cohen AF,de Roos A

    更新日期：1997-02-01 00:00:00

  • Effect of therapeutic paracentesis on plasma volume and transvascular escape rate of albumin in patients with cirrhosis.

    abstract：BACKGROUND/AIMS:Circulatory abnormalities with activation of vasoconstrictor systems after large-volume paracentesis are generally considered secondary to an increased extravasation of fluid from the intravascular compartment to the extravascular space with subsequent reduction in plasma volume. To test this hypothesis...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80081-5

    authors： Saló J,Ginès A,Ginès P,Piera C,Jiménez W,Guevara M,Fernández-Esparrach G,Sort P,Bataller R,Arroyo V,Rodés J

    更新日期：1997-10-01 00:00:00

  • Effects of ursodeoxycholic acid after 4 to 12 years of therapy in early and late stages of primary biliary cirrhosis.

    abstract：:Twenty-two patients with primary biliary cirrhosis were treated with ursodeoxycholic acid, 10 mg/kg per day. Fourteen patients with stages I/II were treated for 4-12 years (mean 7.5), and eight patients with stages III/IV for 5-12 years (mean 6.5). Twelve of 13 patients with early stages became asymptomatic. Aminotran...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0168-8278(94)80111-8

    authors： Leuschner U,Güldütuna S,Imhof M,Hübner K,Benjaminov A,Leuschner M

    更新日期：1994-10-01 00:00:00

  • Bile acid kinetics and biliary lipid composition in cystic fibrosis.

    abstract：AIMS/METHODS:Bile acid kinetics and biliary lipid composition were studied in seven patients, aged 17-70 years with cystic fibrosis. All patients were of normal height and weight, and were in good clinical condition. Ultrasonography indicated a small gallbladder in one and non-visualized gallbladder in two patients. Se...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80326-6

    authors： Strandvik B,Einarsson K,Lindblad A,Angelin B

    更新日期：1996-07-01 00:00:00

  • Liver biopsy in liver transplantation: no additional risk of infections in patients with choledochojejunostomy.

    abstract：BACKGROUND/AIMS:This study aimed to determine whether there is an increased infectious risk following liver biopsy in liver transplant patients with choledochojejunostomy. METHODS:We evaluated the incidence of liver-biopsy-related sepsis in a consecutive series of 27 patients who underwent choledochojejunostomy, eithe...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80012-2

    authors： Ben-Ari Z,Neville L,Rolles K,Davidson B,Burroughs AK

    更新日期：1996-03-01 00:00:00