The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin.

abstract：BACKGROUND/AIMS:The impact of heterozygous HFE mutations on the course of chronic hepatitis C and iron indices was studied. METHODS:Ferritin, transferrin saturation (TS), serum iron, C282Y and H63D mutations were determined in 401 patients with chronic hepatitis C virus (HCV) infection and 295 healthy controls. Liver ...

journal_title：Journal of hepatology

authors： Erhardt A,Maschner-Olberg A,Mellenthin C,Kappert G,Adams O,Donner A,Willers R,Niederau C,Häussinger D

更新日期：2003-03-01 00:00:00

abstract：:Our understanding of the process whereby replicating Hepatitis B virus is eradicated has been substantially modified by the development of highly sensitive assays of viral replication, such as the detection of HBV-DNA in serum. The implications of these developments on our therapeutic approach in terms of both timing ...

journal_title：Journal of hepatology

authors： Williams R,Alexander GJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:Thrombopoietin receptor agonists are a new class of compounds licenced for the treatment of immune thrombocytopenic purpura. They are currently being studied for patients with thrombopenia in advanced liver disease or under therapy for hepatitis C. There are indications that the risk for development o...

journal_title：Journal of hepatology

authors： Dultz G,Kronenberger B,Azizi A,Mihm U,Vogl TJ,Sarrazin U,Sarrazin C,Zeuzem S,Hofmann WP

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND/AIMS:Interferon (IFN) with ribavirin combination therapy (CT) was proposed for the treatment of hepatitis C recurring in liver transplants. We assessed the efficacy of two protocols of CT in transplanted patients with recurrent severe hepatitis C virus (HCV) hepatitis. METHODS:Fifty-seven patients (68% geno...

journal_title：Journal of hepatology

authors： Lavezzo B,Franchello A,Smedile A,David E,Barbui A,Torrani M,Ottobrelli A,Zamboni F,Fadda M,Bobbio A,Salizzoni M,Rizzetto M

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND/AIMS:Except for bleeding complications, other serious adverse reactions of coumarin anticoagulants such as hepatotoxicity or skin necrosis are comparatively rare. Nonetheless, a small number of coumarin-induced (sub-) acute liver failures has been published. METHODS:A retrospective analysis was performed of...

journal_title：Journal of hepatology

authors： Schimanski CC,Burg J,Möhler M,Höhler T,Kanzler S,Otto G,Galle PR,Lohse AW

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND/AIMS:Leptin has a particular profibrogenic role in the liver. We investigated whether IFN-alpha influences leptin production in patients with chronic hepatitis B (CHB) and C (CHC). Leptin was determined in serial samples from 63 CHB and 42 CHC IFN-alpha treated patients. Furthermore, we evaluated whether lep...

journal_title：Journal of hepatology

authors： Zografos TA,Rigopoulou EI,Liaskos C,Togousidis E,Zachou K,Gatselis N,Germenis A,Dalekos GN

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND & AIMS:Low levels of toll-like receptor 3 (TLR3) in patients with hepatocellular carcinoma (HCC) are associated with poor prognosis, primarily owing to the loss of inflammatory signaling and subsequent lack of immune cell recruitment to the liver. Herein, we explore the role of TLR3-triggered apoptosis in HC...

journal_title：Journal of hepatology

authors： Bonnin M,Fares N,Testoni B,Estornes Y,Weber K,Vanbervliet B,Lefrançois L,Garcia A,Kfoury A,Pez F,Coste I,Saintigny P,Viari A,Lang K,Guey B,Hervieu V,Bancel B,Bartoch B,Durantel D,Renno T,Merle P,Lebecque S

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND & AIMS:Toll-like receptor 4 (TLR4) plays an essential role in mediating organ injury in acute liver failure (ALF) and acute-on-chronic liver failure (ACLF). Herein, we assess whether inhibiting TLR4 signaling can ameliorate liver failure and serve as a potential treatment. METHODS:Circulating TLR4 ligands a...

journal_title：Journal of hepatology

authors： Engelmann C,Sheikh M,Sharma S,Kondo T,Loeffler-Wirth H,Zheng YB,Novelli S,Hall A,Kerbert AJC,Macnaughtan J,Mookerjee R,Habtesion A,Davies N,Ali T,Gupta S,Andreola F,Jalan R

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND/AIMS:Local ablation methods are an effective treatment for hepatocellular carcinoma (HCC). The rate of recurrence or development of intra-hepatic metastases may be lowered by antitumoral immune responses. Since HCCs are in general only weakly immunogenic, cell injury induced by local tumor ablation (PEI/RFTA...

journal_title：Journal of hepatology

authors： Ali MY,Grimm CF,Ritter M,Mohr L,Allgaier HP,Weth R,Bocher WO,Endrulat K,Blum HE,Geissler M

更新日期：2005-11-01 00:00:00

abstract：:Data derived from population, case-control, and cohort studies conducted in several Euro-Mediterranean and African countries disclose impressive similarities in the age and modes of hepatitis B virus (HBV) transmission and in the prevalence, duration, and outcome of the four phases of the natural history of chronic in...

journal_title：Journal of hepatology

authors： Hadziyannis SJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND/AIMS:Primary sclerosing cholangitis (PSC) is associated with a high risk of cholangiocarcinoma. Our aim was to evaluate the diagnostic value of trypsinogen-1, trypsinogen-2, tumour-associated trypsin inhibitor, human chorionic gonadotropin beta and trypsin-2-alpha(1)-antitrypsin for cholangiocarcinoma and to...

journal_title：Journal of hepatology

authors： Lempinen M,Isoniemi H,Mäkisalo H,Nordin A,Halme L,Arola J,Höckerstedt K,Stenman UH

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND/AIMS:The glycosphingolipid alpha-galactosylceramide has been shown to activate invariant natural killer T cells when presented in the context of CD1d and induces powerful antiviral immune responses via the production of inflammatory cytokines. The aim of this study was to investigate the safety and the antiv...

journal_title：Journal of hepatology

authors： Veldt BJ,van der Vliet HJ,von Blomberg BM,van Vlierberghe H,Gerken G,Nishi N,Hayashi K,Scheper RJ,de Knegt RJ,van den Eertwegh AJ,Janssen HL,van Nieuwkerk CM

更新日期：2007-09-01 00:00:00

abstract：:The implications of hepatitis B virus (HBV) reinfection after liver transplantation were studied in 29 patients followed for 1.7-15 years. Of 20 patients with HBV infection alone, nine were HBeAg and HBV DNA seronegative and 11 had evidence of HBV replication as measured by HBeAg or HBV DNA seropositivity. Nine patien...

journal_title：Journal of hepatology

authors： O'Grady JG,Smith HM,Davies SE,Daniels HM,Donaldson PT,Tan KC,Portmann B,Alexander GJ,Williams R

更新日期：1992-01-01 00:00:00

abstract：:The aim of the present study was to identify the cell types that express collagen alpha 1(I), alpha 1(III) and alpha 1(IV), fibronectin and laminin B1 genes in normal rat liver. Parenchymal, sinusoidal endothelial, Kupffer and fat-storing (Ito) cells were isolated and purified. Total RNA of the freshly isolated cells ...

journal_title：Journal of hepatology

authors： Geerts A,Greenwel P,Cunningham M,De Bleser P,Rogiers V,Wisse E,Rojkind M

更新日期：1993-08-01 00:00:00

abstract：:A case of HIV superinfection observed in an HBsAg/HBeAg-positive male homosexual with chronic persistent hepatitis is described. Soon after the appearance of clinical and serological features of acute HIV infection, a rapid fall to a normal value of ALT was noted with simultaneous recrudescence of HBV replication last...

journal_title：Journal of hepatology

authors： Pastore G,Santantonio T,Monno L,Milella M,Luchena N,Angarano G

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND/AIMS:Although 6-thioguanine (6-TG) has been suggested as an effective treatment option for patients with inflammatory bowel disease (IBD), the recent description of its hepatotoxicity has led to the recommendation not to consider this drug. We initiated a multicenter safety study in IBD-patients treated with...

journal_title：Journal of hepatology

authors： Seiderer J,Zech CJ,Reinisch W,Lukas M,Diebold J,Wrba F,Teml A,Chalupna P,Stritesky J,Schoenberg SO,Schima W,Göke B,Ochsenkühn T

更新日期：2005-08-01 00:00:00

abstract：:Recently, we have shown that taurocholate transport is impaired in hepatocytes isolated from CCl4 cirrhotic rats. Na+,K+-ATPase activity depends on the lipid composition of the surrounding membrane. Therefore, we performed this study in order to detect differences in plasma membrane composition and membrane functions ...

journal_title：Journal of hepatology

authors： Krähenbühl S,Meier-Abt PJ,Reichen J

更新日期：1989-07-01 00:00:00

abstract：:The effect of glucagon on the relation between urea synthesis and blood amino acid concentration was studied in seven healthy volunteers. Alanine was given as prime-continuous infusions and, after 1 hr for equilibration, the urea nitrogen synthesis rate was measured in two periods of about 2 hrs as urinary excretion c...

journal_title：Journal of hepatology

authors： Vilstrup H,Hansen BA,Almdal TP

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIM:A low-titered hepatitis B virus infection without immunological markers was identified in a prospective study in the serum of a kidney transplant recipient by PCR. The aim of this study was to analyze HBV genomes and their biological significance. METHODS:The genome was amplified in two overlapping frag...

journal_title：Journal of hepatology

authors： Schories M,Peters T,Rasenack J

更新日期：2000-11-01 00:00:00

abstract：:An HBV strain isolated from a patient lacking conventional serological markers of HBV infection was characterized. The complete nucleotide sequence was determined following PCR amplification. Only 22 nucleotide substitutions were found relative to the reported sequence of the ayw subtype. Five of these point mutations...

journal_title：Journal of hepatology

authors： Kremsdorf D,Garreau F,Duclos H,Thiers V,Schellekens H,Petit MA,Bréchot C

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND/AIMS:Urinary 3-oxo-delta4 bile acids have been detected in infants who ultimately died of liver disease. We used qualitative and quantitative methods to compare urinary 3-oxo-delta4 bile acids in liver disease, determining their composition and evaluating the prognostic implication in patients of various age...

journal_title：Journal of hepatology

authors： Kimura A,Suzuki M,Murai T,Kurosawa T,Tohma M,Sata M,Inoue T,Hoshiyama A,Nakashima E,Yamashita Y,Fujisawa T,Kato H

更新日期：1998-02-01 00:00:00

abstract：:We investigated the effects of the hapten trinitrobenzenesulfonic acid instilled into the rat biliary tree. The study included three groups of animals that received a single intracholedochal injection of either saline, 10% ethanol or 10 mg trinitrobenzenesulfonic acid dissolved in 10% ethanol. A fourth group of rats w...

journal_title：Journal of hepatology

authors： Mourelle M,Salas A,Vilaseca J,Guarner F,Malagelada JR

更新日期：1995-02-01 00:00:00

abstract：:Chronic cholestatic diseases, whether occurring in infancy, childhood or adulthood, are characterized by defective bile acid transport from the liver to the intestine, which is caused by primary damage to the biliary epithelium in most cases. In this article, approaches to diagnosis and management of the main specific...

journal_title：Journal of hepatology

authors： Poupon R,Chazouillères O,Poupon RE

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this prospective randomized controlled trial was to investigate the need for prophylactic antibiotherapy in patients with cirrhosis and hepatocellular carcinoma who underwent transarterial embolization and to establish the parameters that determine the development of fever > 38 degrees C afte...

journal_title：Journal of hepatology

authors： Castells A,Bruix J,Ayuso C,Brú C,Montanyà X,Boix L,Rodès J

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND/AIMS:The world-wide distribution of hepatitis B virus (HBV) genotypes follows a geographic pattern under the influence of ethnic background. METHODS:Forty eight core genes from four pacific islands were compared with the following findings. RESULTS:First, island-specific variant substitutions were found fo...

journal_title：Journal of hepatology

authors： Jazayeri MS,Basuni AA,Cooksley G,Locarnini S,Carman WF

更新日期：2004-07-01 00:00:00

abstract：AIM:In order to study the short-term effect of moderate and severe reduction of liver function by acetaminophen poisoning of different severity on gene expression for liver-specific functions, rats were given 3.75 and 7.5 g per kg body weight acetaminophen intragastrically. The lower dose is associated with low mortali...

journal_title：Journal of hepatology

authors： Tygstrup N,Jensen SA,Krog B,Dalhoff K

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND & AIMS:Emricasan, an oral pan-caspase inhibitor, decreased portal pressure in experimental cirrhosis and in an open-label study in patients with cirrhosis and severe portal hypertension, defined as a hepatic venous pressure gradient (HVPG) ≥12 mmHg. We aimed to confirm these results in a placebo-controlled s...

journal_title：Journal of hepatology

authors： Garcia-Tsao G,Bosch J,Kayali Z,Harrison SA,Abdelmalek MF,Lawitz E,Satapathy SK,Ghabril M,Shiffman ML,Younes ZH,Thuluvath PJ,Berzigotti A,Albillos A,Robinson JM,Hagerty DT,Chan JL,Sanyal AJ,IDN-6556-14 Investigators(‡).

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND/AIMS:Liver fibrosis is a dynamic state between matrix production and degradation. Since our report in 1974, many studies have examined collagenase and liver fibrosis, but not the identification of cells responsible for collagenase production in vivo. The aim of this study was to investigate the gene expressi...

journal_title：Journal of hepatology

authors： Watanabe T,Niioka M,Hozawa S,Kameyama K,Hayashi T,Arai M,Ishikawa A,Maruyama K,Okazaki I

更新日期：2000-08-01 00:00:00

abstract：:The establishment of robust HCV cell culture systems and characterization of the viral life cycle provided the molecular basis for highly innovative, successful years in HCV drug development. With the identification of direct-acting antiviral agents (DAAs), such as NS3/4A protease inhibitors, NS5A replication complex ...

journal_title：Journal of hepatology

authors： Welzel TM,Dultz G,Zeuzem S

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND & AIMS:Cholangiocarcinoma (CCA) carries a very poor prognosis due to a typically late clinical presentation and a poor response to current therapeutics. While these tumors commonly express PD-1 and PD-L1, the response to immune checkpoint inhibitors (ICI) is poor. Stimulating antigen-presenting cells includi...

journal_title：Journal of hepatology

authors： Diggs LP,Ruf B,Ma C,Heinrich B,Cui L,Zhang Q,McVey JC,Wabitsch S,Heinrich S,Rosato U,Lai W,Subramanyam V,Longerich T,Loosen SH,Luedde T,Neumann UP,Desar S,Kleiner D,Gores G,Wang XW,Greten TF

更新日期：2020-12-01 00:00:00