Abstract:
BACKGROUND & AIMS:Thrombopoietin receptor agonists are a new class of compounds licenced for the treatment of immune thrombocytopenic purpura. They are currently being studied for patients with thrombopenia in advanced liver disease or under therapy for hepatitis C. There are indications that the risk for development of portal vein thrombosis in patients with advanced liver cirrhosis might be increased under therapy with thrombopoietin receptor agonists. We report a case of a patient with Child class B liver cirrhosis with concurrent immune thrombocytopenic purpura that developed portal vein thrombosis under therapy with the thrombopoietin receptor agonist romiplostim. METHODS:A 50-year-old woman with hepatitis C virus associated immune thrombocytopenic purpura and Child class B liver cirrhosis presented in our emergency with rapidly evolving hydropic decompensation and general malaise. For immune thrombocytopenic purpura, the patient was started on the thrombopoietin receptor agonist romiplostim nine months ago. RESULTS:During hospitalization, the platelet count was measured above 330,000/μl and partial portal vein thrombosis was diagnosed by imaging studies. The thrombotic event was assumed to be associated with the romiplostim treatment for immune thrombocytopenic purpura via excessive elevation of platelet count. After anticoagulation with heparin and cessation of romiplostim treatment, complete recanalisation of the portal vein was achieved. CONCLUSIONS:We conclude that romiplostim should be used with precaution in patients with hepatitis C-associated immune thrombocytopenic purpura and advanced liver cirrhosis as the risk for thrombotic complications may increase significantly.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Dultz G,Kronenberger B,Azizi A,Mihm U,Vogl TJ,Sarrazin U,Sarrazin C,Zeuzem S,Hofmann WPdoi
10.1016/j.jhep.2011.01.020subject
Has Abstractpub_date
2011-07-01 00:00:00pages
229-32issue
1eissn
0168-8278issn
1600-0641pii
S0168-8278(11)00090-0journal_volume
55pub_type
杂志文章abstract:BACKGROUND & AIMS:To follow the local tissue delivery of doxorubicin in HCC explants from patients embolized with drug-eluting beads and to compare it with histologic modifications. METHODS:Six patients with HCC underwent chemoembolization with doxorubicin-eluting beads (caliber 100-300 μm, dose 75-150 mg) followed by...
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更新日期:2012-08-01 00:00:00
abstract:Background & Aims:Liver enzyme abnormalities are common in patients with coronavirus disease 2019 (COVID-19). Whether or not severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to liver damage per se remains unknown. Herein, we reported the clinical characteristics and liver pathological man...
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pub_type: 临床试验,杂志文章
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更新日期:1994-10-01 00:00:00
abstract:BACKGROUND/AIMS:To compare carotid intima-media thickness (IMT) - an index of early atherosclerosis - among patients with non-alcoholic steatohepatitis (NASH), patients with chronic hepatitis B (HBV) or C (HCV) and control subjects. METHODS:We studied 60 consecutive patients with biopsy-proven NASH, 60 patients with H...
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更新日期:2007-06-01 00:00:00
abstract:BACKGROUND/AIMS:Norfloxacin is useful to prevent infections in hospitalized cirrhotic patients with low ascitic fluid protein concentrations. It is also effective in preventing the recurrence of spontaneous bacterial peritonitis. The aim of our study was to determine the efficacy of norfloxacin in the primary prophylax...
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0168-8278(98)80061-5
更新日期:1998-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
abstract:BACKGROUND/AIMS:The pathophysiology of binge drinking of ethanol and its potentiation of acetaminophen (APAP) toxicity has received very little attention. To evaluate if ethanol binging sensitizes hepatic sinusoidal endothelial cells (SEC) and liver to APAP toxicity. METHODS:The histopathological responses to APAP wer...
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pub_type: 杂志文章
doi:10.1016/j.jhep.2004.11.033
更新日期:2005-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jhep.2007.07.022
更新日期:2007-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0168-8278(05)80665-8
更新日期:1992-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0168-8278(99)80137-8
更新日期:1999-05-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1016/s0168-8278(00)00067-2
更新日期:2001-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0168-8278(05)80620-8
更新日期:1994-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0168-8278(97)80286-3
更新日期:1997-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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更新日期:2011-03-01 00:00:00
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更新日期:2000-02-01 00:00:00
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更新日期:2002-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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doi:10.1016/s0168-8278(99)80266-9
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0168-8278(85)80009-x
更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(85)80745-5
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND & AIMS:Cerebral oxidative stress plays an important role in the pathogenesis of hepatic encephalopathy (HE), but the underlying mechanisms are incompletely understood. Herein, we analyzed a role of heme oxygenase (HO)1, iron and NADPH oxidase 4 (Nox4) for the induction of oxidative stress and senescence in H...
journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2019.06.020
更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00