Abstract：
BACKGROUND/AIMS:Except for bleeding complications, other serious adverse reactions of coumarin anticoagulants such as hepatotoxicity or skin necrosis are comparatively rare. Nonetheless, a small number of coumarin-induced (sub-) acute liver failures has been published. METHODS:A retrospective analysis was performed of patients treated for liver disease between 1992 and 2002 at our department to evaluate the incidence, clinical findings and histopathology of coumarin-induced hepatotoxicity. RESULTS:The retrospective analysis revealed eight cases of phenprocoumon-induced hepatotoxicity, including three cases of (sub-) acute liver failure which resulted in two orthotopic liver transplantations and one fatal outcome. Five patients with phenprocoumon-induced hepatitis recovered well after anticoagulation was switched to another coumarin derivate or subcutaneous low molecular weight heparin. In all patients liver injury was predominantly of an hepatitic type. In the cases of (sub-) acute liver failure massive confluent liver cell necroses were histologically present, whereas among patients without liver failure mild portal to moderate active lobular hepatitis were observed. A retrospective analysis by BfArM (German Federal Institute for Drugs and Medical Devices) revealed 4390 cases of possible phenprocoumon-related adverse reactions since 1990, 2% of which had presented with hepatitis and 0.2% with liver failure. CONCLUSIONS:Phenprocoumon-induced liver disease is an uncommon complication, which can, however, cause (sub-) acute liver failure.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Schimanski CC,Burg J,Möhler M,Höhler T,Kanzler S,Otto G,Galle PR,Lohse AWdoi
10.1016/j.jhep.2004.03.010subject
Has Abstractpub_date
2004-07-01 00:00:00pages
67-74issue
1eissn
0168-8278issn
1600-0641pii
S0168827804001059journal_volume
41pub_type
杂志文章abstract：BACKGROUND:The association between polyarteritis nodosa and viral hepatitis B infection is well established and still remains a therapeutic challenge. Famciclovir--a new nucleoside analog--has a broad spectrum of antiviral activity against herpes viruses and the human hepatitis B virus. CASE REPORT:A 56-year-old man w...
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abstract：:The First European Consensus Conference on the Treatment of Chronic Hepatitis B and C in HIV Co-infected Patients aimed to produce recommendations that could be applied across Europe. However, some important differences exist around Europe, in terms of access to treatment and tests for monitoring. This short survey of...
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pub_type： 杂志文章,多中心研究
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abstract：BACKGROUND/AIMS:Patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) are at risk of early death due to end-stage liver failure. The aim of this study was to compare model of end-stage liver disease (MELD) and Child-Pugh scores as predictors of survival after TIPS. METHODS:We studied 140 cirrhotic p...
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更新日期：2002-04-01 00:00:00
abstract：:Chronic cholestatic diseases, whether occurring in infancy, childhood or adulthood, are characterized by defective bile acid transport from the liver to the intestine, which is caused by primary damage to the biliary epithelium in most cases. In this article, approaches to diagnosis and management of the main specific...
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abstract：BACKGROUND:Platelet cytosolic calcium is necessary for normal platelet function, and may reflect intracellular signalling in vascular smooth muscle cells. METHODS:The cytosolic calcium of platelets from patients with cirrhosis and control subjects was measured in contact with plasma from either source, using FURA 2AM....
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更新日期：2008-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：1988-10-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0168-8278(99)80160-3
更新日期：1999-07-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2004.07.031
更新日期：2004-11-01 00:00:00
abstract：:In situ hybridization with oligonucleotide probes has been used to localise hepatitis A virus RNA genomic sequences in formalin-fixed and routinely processed human liver biopsies from three patients. Using radiolabelled Sulphur-35 antisense probes, viral genomic sequences were found in all three cases, but signal inte...
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pub_type： 杂志文章
doi：10.1016/s0168-8278(94)80012-x
更新日期：1994-03-01 00:00:00
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更新日期：2016-05-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2004.04.017
更新日期：2004-08-01 00:00:00
abstract：:In order to document the incidence of hepatitis delta virus (HDV) replication markers and their relationship to HBV replication, 91 HBsAg chronic carriers were studied. Of these, 51 were anti-HD-positive (19 HBeAg-positive and 32 anti-HBe-positive). Liver HDAg was found in 75% of anti-HD-positive patients. Of the 19 p...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/s0168-8278(88)80033-3
更新日期：1988-04-01 00:00:00
abstract：BACKGROUND/AIMS:To study whether the host's immune response determines viral clearance in chronic hepatitis C, virological markers and antigen-specific T cell reactions were analysed in 30 chronic HCV carriers followed up during interferon-alpha therapy, 11 untreated anti-HCV positive individuals and 10 healthy control...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/s0168-8278(98)80146-3
更新日期：1998-10-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/s0168-8278(96)80200-5
更新日期：1996-10-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jhep.2012.07.015
更新日期：2012-12-01 00:00:00
abstract：:The addition of protease inhibitors, boceprevir or telaprevir, to peginterferon+ribavirin (PegIFN/RBV) increases the frequency as well as the severity, and hence, clinical relevance of anemia, which has now become one of the major complications associated with triple therapy. Most significant factors associated with a...
journal_title：Journal of hepatology
pub_type： 杂志文章,评审
doi：10.1016/j.jhep.2013.07.014
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND/AIMS:Cholangiocarcinoma comprises 5-20% of all primary malignant tumors of the liver. However, the lack of information about the genetic basis of cholangiocarcinoma has impeded characterization and understanding of its biological behavior. METHODS:In this study, genome-wide aberrations in 13 cases of cholan...
journal_title：Journal of hepatology
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更新日期：2002-11-01 00:00:00
