当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial.

Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial.

Abstract：

BACKGROUND/AIMS:Silymarin has protective effects in different experimental conditions, but its efficacy in human liver cirrhosis has not been completely established. Therefore, this study was carried out to determine the effect of silymarin in alcoholics with liver cirrhosis with respect to survival and clinical and laboratory changes. METHODS:From February 1986 to June 1989, we enrolled 200 alcoholics with histologically or laparoscopically proven liver cirrhosis in a randomized, double-blind multicenter trial comparing 450 mg of silymarin (150 mg/ three times per day) with placebo. The primary outcome was time to death, and the secondary outcome was the progression of liver failure. Additional analyses were also performed in 75 patients in whom anti-hepatitis C virus antibodies were measured after completion of the trial. RESULTS:One hundred and three patients were assigned to receive silymarin and 97 to receive placebo. The two groups were well matched for demographic and baseline clinical and laboratory features. A 2-year study period was completed in 125 patients (57 receiving silymarin and 68 receiving placebo). Twenty-nine patients (15 receiving silymarin, and 14 receiving placebo) died during the trial. Survival was similar in patients receiving silymarin or placebo. The effect of silymarin on survival was not influenced by sex, the persistence of alcohol intake, the severity of liver dysfunction or by the presence of alcoholic hepatitis in the liver biopsy. Silymarin did not have any significant effect on the course of the disease. No relevant side-effects were observed in any group. CONCLUSIONS:The results of this study indicate that silymarin has no effect on survival and the clinical course in alcoholics with liver cirrhosis.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Parés A,Planas R,Torres M,Caballería J,Viver JM,Acero D,Panés J,Rigau J,Santos J,Rodés J

doi

10.1016/s0168-8278(98)80285-7

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

615-21

issue

4

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(98)80285-7

journal_volume

28

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Pancreatic Duodenal Homeobox-1 de novo expression drives cholangiocyte neuroendocrine-like transdifferentiation.

    abstract：BACKGROUND & AIMS:Reactive cholangiocytes acquire a neuroendocrine-like phenotype, with synthesis and local release of neuropeptides and hormones. The mechanism that drives such phenotypical changes is still undefined. Pancreatic Duodenal Homeobox-1 (PDX-1) is a transcription factor required for pancreatic development,...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.04.022

    authors： Marzioni M,Saccomanno S,Candelaresi C,Rychlicki C,Agostinelli L,Shanmukhappa K,Trozzi L,Pierantonelli I,De Minicis S,Benedetti A

    更新日期：2010-10-01 00:00:00

  • Replicating and virion secreting hepatitis B mutant virus unable to produce preS2 protein.

    abstract：:Mutant HBV genomes unable to produce preS2 protein were identified in the serum of a highly viremic chronic carrier. By direct sequencing of the amplified preS region and by sequencing of 50 cloned amplified preS DNA fragments all molecules were found to have deleted the preS2 translation initiation codon and three am...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90036-b

    authors： Fernholz D,Stemler M,Brunetto M,Bonino F,Will H

    更新日期：1991-01-01 00:00:00

  • Evolutionary biology of human hepatitis viruses.

    abstract：:Hepatitis viruses are major threats to human health. During the last decade, highly diverse viruses related to human hepatitis viruses were found in animals other than primates. Herein, we describe both surprising conservation and striking differences of the unique biological properties and infection patterns of human...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2018.11.010

    authors： Rasche A,Sander AL,Corman VM,Drexler JF

    更新日期：2019-03-01 00:00:00

  • Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing.

    abstract：BACKGROUND/AIMS:The aim of our study was to evaluate the proportion of patients with severe alcoholic cirrhosis who would need orthotopic liver transplantation (OLT) and to determine the optimal delay to evaluate an abstinent patient for transplantation. METHODS:Survival without OLT, improvement in liver function and ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00228-8

    authors： Veldt BJ,Lainé F,Guillygomarc'h A,Lauvin L,Boudjema K,Messner M,Brissot P,Deugnier Y,Moirand R

    更新日期：2002-01-01 00:00:00

  • Increased IgM B cell differentiation lymphokine production by T lymphocytes from patients with primary biliary cirrhosis.

    abstract：:Hypergammaglobulinemia, mainly due to increased serum immunoglobulin M concentrations, is a common and distinctive feature of primary biliary cirrhosis. T-B cell cooperation plays a pivotal role in the regulation of immunoglobulin secretion. In this paper, the production of regulatory B lymphokines by T cells, as well...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80488-x

    authors： Menéndez-Caro JL,Alvarez-Mon M,Girón JA,Manzano L,Garrido A,Abreu L,Albillos A,Durántez A

    更新日期：1994-04-01 00:00:00

  • Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids.

    abstract：BACKGROUND & AIMS:Chronic liver disease is characterized by fibrosis that may progress to cirrhosis. Nucleotide oligomerization domain 2 (Nod2), a member of the Nod-like receptor (NLR) family of intracellular immune receptors, plays an important role in the defense against bacterial infection through binding to the lig...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.02.012

    authors： Wang L,Hartmann P,Haimerl M,Bathena SP,Sjöwall C,Almer S,Alnouti Y,Hofmann AF,Schnabl B

    更新日期：2014-06-01 00:00:00

  • Caspase 8 differentially controls hepatocytes and non-parenchymal liver cells during chronic cholestatic liver injury in mice.

    abstract：BACKGROUND & AIMS:Receptor mediated cell death through the activation of caspases has been identified as an important mechanism to control life and death in various tissues and is thus crucial for the maintenance of liver tissue homeostasis. Here we investigated how caspase 8 (Casp8) differentially regulates immune-med...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.07.026

    authors： Chaudhary K,Liedtke C,Wertenbruch S,Trautwein C,Streetz KL

    更新日期：2013-12-01 00:00:00

  • A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump.

    abstract：BACKGROUND/AIMS:Progressive familial intrahepatic cholestasis type 2 (PFIC-2) patients have a defect in the hepatocanalicular bile salt secretion. The disease is caused by mutations in the bile salt export pump (BSEP). Ten different missense mutations have been described. In this study, we analysed the effect of the D4...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00483-5

    authors： Plass JR,Mol O,Heegsma J,Geuken M,de Bruin J,Elling G,Müller M,Faber KN,Jansen PL

    更新日期：2004-01-01 00:00:00

  • The antimitochondrial antibody anti-M9. A marker for the diagnosis of early primary biliary cirrhosis.

    abstract：:The clinical relevance of a new antimitochondrial antibody, anti-M9, reacting with an outer membrane-associated antigen on liver mitochondria is described. Sera from 22 anti-M2-negative patients with histologically proven primary biliary cirrhosis (PBC) who had been followed for 5-15 years were tested for anti-M9 in t...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(88)80046-1

    authors： Klein R,Klöppel G,Fischer R,Fintelmann V,Müting D,Berg PA

    更新日期：1988-06-01 00:00:00

  • The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.

    abstract：BACKGROUND/AIMS:The organic anion transporting polypeptides (OATPs) mediate the uptake of numerous amphipathic compounds into hepatocytes. Our aim was to study the expression and regulation of OATP8 (OATP1B3, SLC21A8/SLCO1B3) and OATP-C (OATP1B1, SLC21A6/SLCO1B1) in hepatocellular carcinomas (HCC). METHODS:RNA and pro...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2003.10.008

    authors： Vavricka SR,Jung D,Fried M,Grützner U,Meier PJ,Kullak-Ublick GA

    更新日期：2004-02-01 00:00:00

  • PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.

    abstract：INTRODUCTION:Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF phenotype (AD-ACLF) defined by organ failure(s). Precipitants may induce AD. This multicenter, prospective, observational PREDICT study (NCT03056612) analyzes and characterizes the pr...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.11.019

    authors： Trebicka J,Fernandez J,Papp M,Caraceni P,Laleman W,Gambino C,Giovo I,Uschner FE,Jansen C,Jimenez C,Mookerjee R,Gustot T,Albillos A,Bañares R,Jarcuska P,Steib C,Reiberger T,Acevedo J,Gatti P,Shawcross DL,Zeuzem S,

    更新日期：2020-11-20 00:00:00

  • Deriving the optimal limit of detection for an HCV point-of-care test for viraemic infection: Analysis of a global dataset.

    abstract：BACKGROUND & AIMS:Affordable point-of-care tests for hepatitis C (HCV) viraemia are needed to improve access to treatment in low- and middle-income countries. Our aims were to determine the target limit of detection (LOD) necessary to diagnose the majority of people with HCV eligible for treatment, and identify charact...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.02.011

    authors： Freiman JM,Wang J,Easterbrook PJ,Horsburgh CR,Marinucci F,White LF,Kamkamidze G,Krajden M,Loarec A,Njouom R,Nguyen KV,Shiha G,Soliman R,Solomon SS,Tsertsvadze T,Denkinger CM,Linas B

    更新日期：2019-07-01 00:00:00

  • A comparison of fibrosis progression in chronic liver diseases.

    abstract：BACKGROUND/AIMS:No study has compared the liver fibrosis progression rates among chronic liver diseases and the risk factors in order to better organize screening strategies. METHODS:A total of 4852 patients were retrospectively studied (chronic hepatitis C (HCV) [n=2313], human immunodeficiency virus (HIV)-HCV co-inf...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(02)00413-0

    authors： Poynard T,Mathurin P,Lai CL,Guyader D,Poupon R,Tainturier MH,Myers RP,Muntenau M,Ratziu V,Manns M,Vogel A,Capron F,Chedid A,Bedossa P,PANFIBROSIS Group.

    更新日期：2003-03-01 00:00:00

  • Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice.

    abstract：BACKGROUND & AIM:Hydrogen peroxide-inducible clone-5 (Hic-5), also named as transforming growth factor beta-1-induced transcript 1 protein (Tgfb1i1), was found to be induced by TGF-β. Previous studies have shown that TGF-β is a principal mediator of hepatic stellate cell (HSC) activation in liver fibrosis. However, thi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.08.026

    authors： Lei XF,Fu W,Kim-Kaneyama JR,Omoto T,Miyazaki T,Li B,Miyazaki A

    更新日期：2016-01-01 00:00:00

  • Treatment of acute hepatic porphyria with hematin.

    abstract：:The efficacy of hematin has been evaluated in eight patients with acute intermittent porphyria: six with acute attacks and two with chronic subacute symptoms. Hematin suppressed the chemical signs of porphyria in all patients and the symptoms in those with acute attacks. The clinical response to hematin occurred unifo...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(88)80456-2

    authors： Bissell DM

    更新日期：1988-02-01 00:00:00

  • Prolonged QTc interval and its relationship to autonomic cardiovascular reflexes in patients with cirrhosis.

    abstract：BACKGROUND/AIMS:We have previously shown that an abnormality in cardiac autonomic reflexes (AN) is an independent predictor of mortality in patients with chronic liver disease. Aim of this study was to determine whether there was an association between prolonged QTc interval and cardiac AN. METHODS:Cardiac AN and QTc ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00217-3

    authors： Puthumana L,Chaudhry V,Thuluvath PJ

    更新日期：2001-12-01 00:00:00

  • Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells--a potential mechanism for targeting liver anti-fibrotic therapeutics.

    abstract：BACKGROUND/AIMS:Hepatic stellate cells are pivotal to fibrogenesis in the liver and many potential anti-fibrotic therapeutics are required to act on targets within hepatic stellate cells. The aim of this study was to generate a human antibody fragment to hepatic stellate cells. METHODS:Phage display was used to genera...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.01.028

    authors： Elrick LJ,Leel V,Blaylock MG,Duncan L,Drever MR,Strachan G,Charlton KA,Koruth M,Porter AJ,Wright MC

    更新日期：2005-06-01 00:00:00

  • Prognostic significance of portal hemodynamics in patients with compensated cirrhosis.

    abstract：:The prognostic value of portal hemodynamics, measured by pulsed echo-Doppler, was prospectively evaluated, together with clinical, biochemical and endoscopic parameters, in a series of 50 consecutive patients with compensated cirrhosis. After a mean follow-up of 6 years, 25 patients had died, all from complications of...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80521-5

    authors： Zoli M,Iervese T,Merkel C,Bianchi G,Magalotti D,Marchesini G,Gatta A,Pisi E

    更新日期：1993-01-01 00:00:00

  • Mutations in DCDC2 (doublecortin domain containing protein 2) in neonatal sclerosing cholangitis.

    abstract：BACKGROUND & AIMS:Neonatal sclerosing cholangitis (NSC) is a severe neonatal-onset cholangiopathy commonly leading to liver transplantation (LT) for end-stage liver disease in childhood. Liver biopsy findings histopathologically resemble those in biliary atresia (BA); however, in NSC extrahepatic bile ducts are patent,...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2016.07.017

    authors： Grammatikopoulos T,Sambrotta M,Strautnieks S,Foskett P,Knisely AS,Wagner B,Deheragoda M,Starling C,Mieli-Vergani G,Smith J,University of Washington Center for Mendelian Genomics.,Bull L,Thompson RJ

    更新日期：2016-12-01 00:00:00

  • Targeted vaccination programme successful in reducing acute hepatitis B in men having sex with men in Amsterdam, the Netherlands.

    abstract：BACKGROUND & AIMS:In the Netherlands, transmission of hepatitis B virus occurs mainly within behavioural high-risk groups, such as in men who have sex with men. Therefore, a vaccination programme has targeted these high-risk groups. This study evaluates the impact of the vaccination programme targeting Amsterdam's larg...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.08.002

    authors： van Rijckevorsel G,Whelan J,Kretzschmar M,Siedenburg E,Sonder G,Geskus R,Coutinho R,van den Hoek A

    更新日期：2013-12-01 00:00:00

  • Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1.

    abstract：BACKGROUND & AIMS:Clinical evidence has indicated a close link between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, the underlying mechanism remains to be elucidated. This study aimed to explore a potential role of hepatocyte-derived extracellular vesicles (EVs) in endothelial in...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.09.014

    authors： Jiang F,Chen Q,Wang W,Ling Y,Yan Y,Xia P

    更新日期：2020-01-01 00:00:00

  • Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: the HEmochromatosis FAmily Study.

    abstract：BACKGROUND/AIMS:In families of patients with clinically detected hereditary hemochromatosis (HH) early screening has been suggested to prevent morbidity and mortality. Here, we aim to identify determinants for iron overload in first-degree family members of C282Y homozygous probands with clinically detected HH. METHOD...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.08.014

    authors： Jacobs EM,Hendriks JC,van Deursen CT,Kreeftenberg HG,de Vries RA,Marx JJ,Stalenhoef AF,Verbeek AL,Swinkels DW

    更新日期：2009-01-01 00:00:00

  • CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis.

    abstract：BACKGROUND AND AIMS:Fatty acid translocase CD36 (CD36) is a membrane protein with multiple immuno-metabolic functions. Palmitoylation has been suggested to regulate the distribution and functions of CD36, but little is known about its significance in non-alcoholic steatohepatitis (NASH). METHODS:Human liver tissue sam...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2018.04.006

    authors： Zhao L,Zhang C,Luo X,Wang P,Zhou W,Zhong S,Xie Y,Jiang Y,Yang P,Tang R,Pan Q,Hall AR,Luong TV,Fan J,Varghese Z,Moorhead JF,Pinzani M,Chen Y,Ruan XZ

    更新日期：2018-09-01 00:00:00

  • Efficacy and safety of oral naltrexone treatment for pruritus of cholestasis, a crossover, double blind, placebo-controlled study.

    abstract：BACKGROUND/AIMS:To assess the efficacy and safety of naltrexone for the short and long term treatment of pruritus of cholestasis. METHODS:Twenty patients with pruritus and cholestasis were included. A baseline pruritus score was obtained over 1 week. Patients were then randomized to receive 50 mg/day of naltrexone or ...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(02)00318-5

    authors： Terg R,Coronel E,Sordá J,Muñoz AE,Findor J

    更新日期：2002-12-01 00:00:00

  • Histological and virological features and follow-up of hepatitis C virus carriers with normal aminotransferase levels: the Italian prospective study of the asymptomatic C carriers (ISACC).

    abstract：BACKGROUND/AIMS:To evaluate demographic characteristics, liver histology and virological features of hepatitis C virus (HCV) carriers with normal alanine transaminase (ALT) levels. METHODS:A nationwide prospective study was started in 1997. Four Italian centres have participated in this study. RESULTS:Eight hundred a...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(02)00101-0

    authors： Puoti C,Castellacci R,Montagnese F,Zaltron S,Stornaiuolo G,Bergami N,Bellis L,Precone DF,Corvisieri P,Puoti M,Minola E,Gaeta GB

    更新日期：2002-07-01 00:00:00

  • A new life for bile acids.

    abstract：:TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- and loss-of-function studies invivo, we show here that TGR5 sign...

    journal_title：Journal of hepatology

    pub_type： 评论,杂志文章

    doi：10.1016/j.jhep.2010.02.003

    authors： Jansen PL

    更新日期：2010-06-01 00:00:00

  • Regulation of insulin-like growth factor-I and of insulin-like growth factor binding protein-1, -3 and -4 in cocultures of rat hepatocytes and Kupffer cells by interleukin-6.

    abstract：BACKGROUND/AIMS:Catabolism is associated with decreased serum concentrations of insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-3 associated with elevated IGFBP-3 protease activity and increased concentrations of IGFBP-1 and -4. The effects of the acute phase mediators interleu...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00170-2

    authors： Lelbach A,Scharf JG,Ramadori G

    更新日期：2001-11-01 00:00:00

  • Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.

    abstract：BACKGROUND & AIMS:Steatohepatitis (SH) is associated with mitochondrial dysfunction and excessive production of superoxide, which can then be converted into H(2)O(2) by SOD2. Since mitochondrial GSH (mGSH) plays a critical role in H(2)O(2) reduction, we explored the interplay between superoxide, H(2)O(2), and mGSH in n...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.05.024

    authors： von Montfort C,Matias N,Fernandez A,Fucho R,Conde de la Rosa L,Martinez-Chantar ML,Mato JM,Machida K,Tsukamoto H,Murphy MP,Mansouri A,Kaplowitz N,Garcia-Ruiz C,Fernandez-Checa JC

    更新日期：2012-10-01 00:00:00

  • Multiple voxel 1H MR spectroscopy of phosphorylase-b kinase deficient patients (GSD IXa) showing an accumulation of fat in the liver that resolves with aging.

    abstract：BACKGROUND/AIMS:Phosphorylase-b deficient patients suffer from glycogen storage disease (GSD IXa) leading to liver enlargement which usually resolves during puberty and adolescence. This pathology has not yet been documented by (1)H MR spectroscopy (MRS) investigation. METHODS:MRS of eight GSD IXa patients was perform...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.06.021

    authors： Sijens PE,Smit GP,Borgdorff MA,Kappert P,Oudkerk M

    更新日期：2006-12-01 00:00:00

  • Early increase in plasma parathyroid hormone levels following liver transplantation.

    abstract：BACKGROUND/AIMS:The pathogenesis of post-transplantation bone loss is poorly understood, although glucocorticoid therapy is believed to play an important role. In the present study we have measured plasma parathyroid hormone concentrations in the first few months after orthotopic liver transplantation, in order to exam...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80243-1

    authors： Compston JE,Greer S,Skingle SJ,Stirling DM,Price C,Friend PJ,Alexander G

    更新日期：1996-11-01 00:00:00