Prognostic significance of portal hemodynamics in patients with compensated cirrhosis.

abstract：:The addition of protease inhibitors, boceprevir or telaprevir, to peginterferon+ribavirin (PegIFN/RBV) increases the frequency as well as the severity, and hence, clinical relevance of anemia, which has now become one of the major complications associated with triple therapy. Most significant factors associated with a...

journal_title：Journal of hepatology

authors： Romero-Gómez M,Berenguer M,Molina E,Calleja JL

更新日期：2013-12-01 00:00:00

abstract：:Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and microRNAs. They can originate from both healthy and stressed cells, and provide a snapshot of the cell of origin in physiological and pathological circumstances. Various processes that may give rise to the release of extracellular...

journal_title：Journal of hepatology

authors： Thietart S,Rautou PE

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Serum carbohydrate deficient transferrin is a marker of chronic alcohol consumption; it increases above normal in healthy individuals after a daily alcohol intake of more than 60 g/d for more than 2 weeks. The influence of liver disease itself on carbohydrate deficient transferrin levels has not been suffici...

journal_title：Journal of hepatology

authors： Radosavljevic M,Temsch E,Hammer J,Pfeffel F,Mayer G,Renner F,Pidlich J,Muller C

更新日期：1995-12-01 00:00:00

abstract：:Ciprofloxacin, a fluorinated quinolone, is a powerful antibiotic widely used for its broad spectrum of activity in ambulatory and long-term care setting. Until now, ciprofloxacin administration has been associated with a few cases of acute, sometimes cholestatic jaundice or fulminant hepatic failure believed mainly re...

journal_title：Journal of hepatology

authors： Bataille L,Rahier J,Geubel A

更新日期：2002-11-01 00:00:00

abstract：:Experimental autoimmune hepatitis was induced in C57BL/6 mice by immunization with syngeneic liver protein and adjuvant. Hepatitis was characterized by marked cellular infiltrates, but hepatic necrosis was mild to moderate. A small dose of endotoxin (25 micrograms/mouse) produced lethal hepatitis with elevation of ser...

journal_title：Journal of hepatology

authors： Ogawa M,Mori Y,Ueda S,Mori T,Makino Y,Hori J,Ohto M,Wakashin M

更新日期：1993-11-01 00:00:00

abstract：:Abnormalities of carbohydrate metabolism, including hyperinsulinaemia and insulin resistance, are well recognised complications of cirrhosis. While diabetes mellitus can be explained in many instances on the basis of coincident pancreatic disease, in most the characteristic glucose intolerance of cirrhosis is not read...

journal_title：Journal of hepatology

authors： Allison ME,Wreghitt T,Palmer CR,Alexander GJ

更新日期：1994-12-01 00:00:00

abstract：:Since the first tests for antibodies to components of the hepatitis C virus became widely available there has been considerable interest in evidence linking HCV infection with autoimmune liver diseases and other autoimmune conditions. With respect to autoimmune hepatitis, it is now clear that the early tests were quit...

journal_title：Journal of hepatology

authors： Eddleston AL

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIMS:Not all alcoholics develop liver disease (ALD). Thus, excessive ethanol consumption is necessary, but not sufficient, to induce alcoholic steatohepatitis (ASH) and ALD. Since endotoxemia is present in patients with ALD, it has been proposed that gut-derived, circulating endotoxin is the necessary co-fac...

journal_title：Journal of hepatology

authors： Keshavarzian A,Farhadi A,Forsyth CB,Rangan J,Jakate S,Shaikh M,Banan A,Fields JZ

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND/AIMS:In families of patients with clinically detected hereditary hemochromatosis (HH) early screening has been suggested to prevent morbidity and mortality. Here, we aim to identify determinants for iron overload in first-degree family members of C282Y homozygous probands with clinically detected HH. METHOD...

journal_title：Journal of hepatology

authors： Jacobs EM,Hendriks JC,van Deursen CT,Kreeftenberg HG,de Vries RA,Marx JJ,Stalenhoef AF,Verbeek AL,Swinkels DW

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF phenotype (AD-ACLF) defined by organ failure(s). Precipitants may induce AD. This multicenter, prospective, observational PREDICT study (NCT03056612) analyzes and characterizes the pr...

journal_title：Journal of hepatology

authors： Trebicka J,Fernandez J,Papp M,Caraceni P,Laleman W,Gambino C,Giovo I,Uschner FE,Jansen C,Jimenez C,Mookerjee R,Gustot T,Albillos A,Bañares R,Jarcuska P,Steib C,Reiberger T,Acevedo J,Gatti P,Shawcross DL,Zeuzem S,

更新日期：2020-11-20 00:00:00

abstract：:Hypergammaglobulinemia, mainly due to increased serum immunoglobulin M concentrations, is a common and distinctive feature of primary biliary cirrhosis. T-B cell cooperation plays a pivotal role in the regulation of immunoglobulin secretion. In this paper, the production of regulatory B lymphokines by T cells, as well...

journal_title：Journal of hepatology

authors： Menéndez-Caro JL,Alvarez-Mon M,Girón JA,Manzano L,Garrido A,Abreu L,Albillos A,Durántez A

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND/AIMS:IgM antibodies to hepatitis C virus have been found in a variable proportion of patients with chronic hepatitis C. We have evaluated whether IgM anti-core antibodies correlate with viraemia or hepatic injury in chronic hepatitis C. METHODS:Serum from 106 patients with chronic hepatitis C with varying s...

journal_title：Journal of hepatology

authors： Martinelli AL,Brown D,Braun HB,Michel G,Dusheiko GM

更新日期：1996-01-01 00:00:00

abstract：:Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver, and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. However, the data on which this conclusion is based is incomplete. There is inadequate ascertainme...

journal_title：Journal of hepatology

authors： Sherman M

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND & AIMS:It is widely recognized that in the early stages of liver regeneration after partial hepatectomy, the hepatocytes accumulate a significant amount of lipids. The functional meaning of this transient steatosis and its effect on hepatocellular proliferation are not well defined. In addition, the basic me...

journal_title：Journal of hepatology

authors： Pauta M,Rotllan N,Vales F,Fernandez-Hernando A,Allen RM,Ford DA,Marí M,Jiménez W,Baldán A,Morales-Ruiz M,Fernández-Hernando C

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND & AIMS:HCV related liver disease is one of the most important complications in persons with HIV, with accelerated fibrosis progression in coinfected persons compared to those with HCV alone. We hypothesized that HCV-HIV coinfection increases HCV related hepatocyte apoptosis and that HCV and HIV influence TRA...

journal_title：Journal of hepatology

authors： Jang JY,Shao RX,Lin W,Weinberg E,Chung WJ,Tsai WL,Zhao H,Goto K,Zhang L,Mendez-Navarro J,Jilg N,Peng LF,Brockman MA,Chung RT

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND/AIMS:Adrenomedullin recently discovered in human pheochromocytoma is a potent vasodilatory peptide mainly derived from vascular endothelial and smooth muscle cells. Hyperdynamic circulation, ultimately leading to ascites formation, has been attributed to peripheral vasodilatation in liver cirrhosis. However,...

journal_title：Journal of hepatology

authors： Kojima H,Tsujimoto T,Uemura M,Takaya A,Okamoto S,Ueda S,Nishio K,Miyamoto S,Kubo A,Minamino N,Kangawa K,Matsuo H,Fukui H

更新日期：1998-05-01 00:00:00

abstract：:We describe a PFIC2 patient with a good response to ursodeoxycholic acid for 9 years. We found two novel ABCB11 gene mutations in the patient, i.e. I498T and 2098delA. The correlation of the patient's genotypes with the clinical course supports the existence of a phenotypic continuum between BRIC2 and PFIC2. ...

journal_title：Journal of hepatology

authors： Lam CW,Cheung KM,Tsui MS,Yan MS,Lee CY,Tong SF

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND & AIMS:The advent of new chronic hepatitis C virus (HCV) therapies requires characterization of patients in order to predict adequate treatment. A good candidate marker is Programmed Cell Death-1 (PD-1) which is involved in progression of HCV infection. The aim of this study was to analyse the effect of seve...

journal_title：Journal of hepatology

authors： Vidal-Castiñeira JR,López-Vázquez A,Alonso-Arias R,Moro-García MA,Martinez-Camblor P,Melón S,Prieto J,López-Rodriguez R,Sanz-Cameno P,Rodrigo L,Pérez-López R,Pérez-Álvarez R,López-Larrea C

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND & AIMS:It was recently shown that semi-annual surveillance for hepatocellular carcinoma (HCC) in cirrhotic patients provides a prognostic advantage over the annual program; however, its cost-effectiveness (CE) in the general cirrhotic population still needs to be defined. METHODS:A Markov model was built to...

journal_title：Journal of hepatology

authors： Cucchetti A,Trevisani F,Cescon M,Ercolani G,Farinati F,Poggio PD,Rapaccini G,Nolfo MAD,Benvegnù L,Zoli M,Borzio F,Giannini EG,Caturelli E,Chiaramonte M,Pinna AD,Italian Liver Cancer (ITA.LI.CA) Group.

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND/AIMS:Silymarin has protective effects in different experimental conditions, but its efficacy in human liver cirrhosis has not been completely established. Therefore, this study was carried out to determine the effect of silymarin in alcoholics with liver cirrhosis with respect to survival and clinical and la...

journal_title：Journal of hepatology

authors： Parés A,Planas R,Torres M,Caballería J,Viver JM,Acero D,Panés J,Rigau J,Santos J,Rodés J

更新日期：1998-04-01 00:00:00

abstract：:The effect of a single bolus of somatostatin on oesophageal variceal pressure has been studied in 7 patients with cirrhosis and 5 patients with non-cirrhotic portal hypertension using a non-invasive variceal pressure gauge. Both groups of patients demonstrated similar reductions in variceal pressure with all subjects ...

journal_title：Journal of hepatology

authors： Clements D,Rhodes JM,Elias E

更新日期：1986-01-01 00:00:00

abstract：:To establish the effects of a meal on portal venous flow and the prognostic value of this parameter, 46 patients with chronic liver disease and 28 healthy subjects were examined with duplex Doppler before and after a meal. The measurements were completed in 40 patients and 21 healthy subjects. Postprandial portal veno...

journal_title：Journal of hepatology

authors： de Vries PJ,de Hooge P,Hoekstra JB,van Hattum J

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Eastern American woodchuck (Marmota monax), naturally infected with woodchuck hepatitis virus, a virus similar to human hepatitis B virus, develops liver cancer with a high prevalence. AIMS:The aim of this work was to assess Marmota monax as a model of human hepatocellular carcinoma, especially to assess ne...

journal_title：Journal of hepatology

authors： Gouillat C,Manganas D,Zoulim F,Vitrey D,Saguier G,Guillaud M,Ain JF,Duque-Campos R,Jamard C,Praves M,Trepo C

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND & AIMS:Recent research has suggested that dietary fructose intake may increase serum uric acid (UA) concentrations. Both UA concentration and fructose consumption maybe also increase in NAFLD. It is not known whether dietary fructose consumption and UA concentration are independently associated with non-alco...

journal_title：Journal of hepatology

authors： Mosca A,Nobili V,De Vito R,Crudele A,Scorletti E,Villani A,Alisi A,Byrne CD

更新日期：2017-05-01 00:00:00

abstract：:Twenty patients with paracetamol(acetaminophen)-induced acute liver damage of varying severity were studied longitudinally with assessment of clinical state, standard liver function tests and radiometric hyaluronate (HYA) assay (Pharmacia). In patients (n = 6) who developed coma, HYA rose rapidly with clinical deterio...

journal_title：Journal of hepatology

authors： Bramley PN,Rathbone BJ,Forbes MA,Cooper EH,Losowsky MS

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND/AIMS:To bridge acute liver failure (ALF) patients to orthotopic liver transplantation, several bioartificial liver (BAL) systems have been developed. The bio-component of most BAL systems consists mainly of porcine hepatocytes. Plasma or blood of ALF patients is perfused through the BAL thereby contacting po...

journal_title：Journal of hepatology

authors： van de Kerkhove MP,Germans MR,Deurholt T,Hoekstra R,Joziasse DH,van Wijk AC,van Gulik TM,Chamuleau RA,Roos A

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND & AIMS:Clinical evidence has indicated a close link between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, the underlying mechanism remains to be elucidated. This study aimed to explore a potential role of hepatocyte-derived extracellular vesicles (EVs) in endothelial in...

journal_title：Journal of hepatology

authors： Jiang F,Chen Q,Wang W,Ling Y,Yan Y,Xia P

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:The relationship between HCV RNA levels and the severity of HCV-related liver disease has been addressed in a few studies, which has led to conflicting results. To clarify this point, we studied serum HCV RNA levels in patients with HCV liver disease at various stages, using a second-generation branched...

journal_title：Journal of hepatology

authors： Duvoux C,Pawlotsky JM,Bastie A,Cherqui D,Soussy CJ,Dhumeaux D

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND & AIMS:Receptor mediated cell death through the activation of caspases has been identified as an important mechanism to control life and death in various tissues and is thus crucial for the maintenance of liver tissue homeostasis. Here we investigated how caspase 8 (Casp8) differentially regulates immune-med...

journal_title：Journal of hepatology

authors： Chaudhary K,Liedtke C,Wertenbruch S,Trautwein C,Streetz KL

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND/AIMS:The ability to transfer foreign genes into the biliary tract would be useful for the treatment of biliary tract diseases, including cancer, cystic fibrosis and other genetic diseases. To introduce a foreign gene precisely into the rat biliary epithelial cells, we developed a new technique, inserting a p...

journal_title：Journal of hepatology

authors： Uehara T,Honda K,Hatano E,Terao R,Iimuro Y,Yamamoto N,Yamamoto M,Kaneda Y,Yamaoka Y

更新日期：1999-05-01 00:00:00