A predictive model of treatment outcome in patients with chronic HCV infection using IL28B and PD-1 genotyping.

Abstract:

BACKGROUND & AIMS:The advent of new chronic hepatitis C virus (HCV) therapies requires characterization of patients in order to predict adequate treatment. A good candidate marker is Programmed Cell Death-1 (PD-1) which is involved in progression of HCV infection. The aim of this study was to analyse the effect of several single nucleotide polymorphisms of PD-1 gene and several previously associated factors (IL28B and KIR receptors) on treatment responses. METHODS:407 HCV chronic infected patients treated with PEG-IFN-α and ribavirin were recruited and classified according to their response to treatment. They were genotyped for PD-1 and IL28B polymorphisms, killer immunoglobulin-like receptors (KIR) and HLA genes. A multivariate logistic regression analysis and a Chi-squared Automatic Interaction Detector (CHAID) prediction model of response included these and other clinical parameters. RESULTS:Our results showed that PD-1.3/A allele was significantly associated with sustained virological response (SVR) in a multivariate logistic regression analysis (p<0.01, OR=2.57). Additionally, IL28B C/C genotype was the most significant predictor of an SVR to treatment in all HCV genotypes (74.5%). In IL28B C/C patients, the presence of PD-1.3/A allele increased the probability of an SVR to 93.3%. Moreover, when this analysis was made only with patients infected by HCV-1, the predictive value of IL28B C/C genotype with PD-1.3/A allele was 90%. CONCLUSIONS:PD-1.3/A allele is associated with SVR to treatment and notably increases the predictive value of IL28B C/C genotype. Both markers in conjunction could be a useful tool, more relevant than HCV genotype in some cases, in clinical practice.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Vidal-Castiñeira JR,López-Vázquez A,Alonso-Arias R,Moro-García MA,Martinez-Camblor P,Melón S,Prieto J,López-Rodriguez R,Sanz-Cameno P,Rodrigo L,Pérez-López R,Pérez-Álvarez R,López-Larrea C

doi

10.1016/j.jhep.2012.01.011

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

1230-8

issue

6

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(12)00102-X

journal_volume

56

pub_type

杂志文章
  • Interleukin-1α deficiency attenuates endoplasmic reticulum stress-induced liver damage and CHOP expression in mice.

    abstract:BACKGROUND & AIMS:ER stress promotes liver fat accumulation and induction of inflammatory cytokines, which contribute to the development of steatohepatitis. Unresolved ER stress upregulates the pro-apoptotic CHOP. IL-1α is localized to the nucleus in apoptotic cells, but is released when these cells become necrotic and...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2015.05.012

    authors: Kandel-Kfir M,Almog T,Shaish A,Shlomai G,Anafi L,Avivi C,Barshack I,Grosskopf I,Harats D,Kamari Y

    更新日期:2015-10-01 00:00:00

  • Tumor-derived adenosine promotes macrophage proliferation in human hepatocellular carcinoma.

    abstract:BACKGROUND & AIMS:Macrophages (Mϕ) represent a major component of tumor tissues and play an important role in both tumor progression and therapeutic response. Although tumor Mϕ are generally considered to be derived from circulating monocytes, emerging evidence indicates that tissue Mϕ pools can be maintained by self-r...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.10.021

    authors: Wang J,Wang Y,Chu Y,Li Z,Yu X,Huang Z,Xu J,Zheng L

    更新日期:2020-10-31 00:00:00

  • Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis.

    abstract:BACKGROUND/AIMS:Hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. However, their origin is still unknown. We tested the hypothesis that bone marrow (BM) contributes to the population of HSCs. METHODS:Chimeric mice transplanted with donor BM from collagen alpha1(I)-GFP+ reporter mice were subjected...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2006.04.014

    authors: Kisseleva T,Uchinami H,Feirt N,Quintana-Bustamante O,Segovia JC,Schwabe RF,Brenner DA

    更新日期:2006-09-01 00:00:00

  • Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride.

    abstract:BACKGROUND/AIMS:Liver fibrosis is a dynamic state between matrix production and degradation. Since our report in 1974, many studies have examined collagenase and liver fibrosis, but not the identification of cells responsible for collagenase production in vivo. The aim of this study was to investigate the gene expressi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(00)80363-3

    authors: Watanabe T,Niioka M,Hozawa S,Kameyama K,Hayashi T,Arai M,Ishikawa A,Maruyama K,Okazaki I

    更新日期:2000-08-01 00:00:00

  • Comparison of no-touch multi-bipolar vs. monopolar radiofrequency ablation for small HCC.

    abstract:BACKGROUND & AIMS:The primary aim of this study was to compare the rate of global radiofrequency ablation (RFA) failure between monopolar RFA (MonoRFA) vs. no-touch multi-bipolar RFA (NTmbpRFA) for small hepatocellular carcinoma (HCC) ⩽5cm in cirrhotic patients. METHODS:A total of 362 cirrhotic patients were included ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jhep.2016.07.010

    authors: Hocquelet A,Aubé C,Rode A,Cartier V,Sutter O,Manichon AF,Boursier J,N'kontchou G,Merle P,Blanc JF,Trillaud H,Seror O

    更新日期:2017-01-01 00:00:00

  • Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.

    abstract:BACKGROUND/AIMS:Haematopoietic stem cells (HSC) have previously been shown in some studies to migrate to damaged and diseased liver where a small proportion will engraft. Such cells can promote liver repair in rodent models of liver injury and lead to improved liver function in uncontrolled clinical studies. In order t...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2009.06.021

    authors: Crosby HA,Lalor PF,Ross E,Newsome PN,Adams DH

    更新日期:2009-10-01 00:00:00

  • Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN.

    abstract:BACKGROUND/AIMS:The impact of dietary fatty acids on the development of cancers is highly controversial. We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in hepatocytes. In this study, we investigated whether unsa...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2009.01.027

    authors: Vinciguerra M,Carrozzino F,Peyrou M,Carlone S,Montesano R,Benelli R,Foti M

    更新日期:2009-06-01 00:00:00

  • The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease.

    abstract:BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population and signifies increased risk of liver fibrosis and cirrhosis, type 2 diabetes, and cardiovascular disease. Therapies are limited. Weight loss is of benefit but is difficult to maintain. We aimed at examining the effect of th...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.jhep.2013.02.012

    authors: Ryan MC,Itsiopoulos C,Thodis T,Ward G,Trost N,Hofferberth S,O'Dea K,Desmond PV,Johnson NA,Wilson AM

    更新日期:2013-07-01 00:00:00

  • Targeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease.

    abstract:BACKGROUND & AIMS:The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is affected by epigenetic factors as well as by genetic variation. METHODS:We performed targeted-bisulfite sequencing to determine the levels of DNA methylation of 4 CpG islands (CpG99, CpG71, CpG26, and CpG101) in the regulatory regions o...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2015.02.049

    authors: Kitamoto T,Kitamoto A,Ogawa Y,Honda Y,Imajo K,Saito S,Yoneda M,Nakamura T,Nakajima A,Hotta K

    更新日期:2015-08-01 00:00:00

  • β7-Integrin and MAdCAM-1 play opposing roles during the development of non-alcoholic steatohepatitis.

    abstract:BACKGROUND & AIMS:Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease in Western countries. It is unclear how infiltrating leukocytes affect NASH-development. Our study aims to investigate the role of the homing/receptor, pair mucosal addressin cell adhesion molecule-1 (MAdCAM-1)/β7-Integri...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2017.02.001

    authors: Drescher HK,Schippers A,Clahsen T,Sahin H,Noels H,Hornef M,Wagner N,Trautwein C,Streetz KL,Kroy DC

    更新日期:2017-06-01 00:00:00

  • Hepatocellular carcinoma decreases the chance of successful hepatitis C virus therapy with direct-acting antivirals.

    abstract:BACKGROUND & AIMS:The approval of all-oral direct-acting antiviral (DAA) regimens for the treatment of hepatitis C virus (HCV) has led to the expansion of therapy to include patients with cirrhosis who have hepatocellular carcinoma (HCC). Data on the use of DAAs in HCV+ patients with HCC is limited. The aim of this stu...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2017.01.020

    authors: Prenner SB,VanWagner LB,Flamm SL,Salem R,Lewandowski RJ,Kulik L

    更新日期:2017-06-01 00:00:00

  • Prevalence of hepatitis C virus infection in patients with antiphospholipid syndrome.

    abstract:BACKGROUND/AIMS:The aim of this study was to determine the prevalence and clinical significance of hepatitis C virus (HCV) infection in patients with the antiphospholipid syndrome (APS). METHODS:A series of 88 consecutive patients (78 female and 10 male), with a mean age of 39 years (range 15-79), was prospectively st...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(99)80127-5

    authors: Muñoz-Rodríguez FJ,Tàssies D,Font J,Reverter JC,Cervera R,Sánchez-Tapias JM,Mazzara R,Ordinas A,Ingelmo M

    更新日期:1999-05-01 00:00:00

  • Effects of additional administration of colchicine in ursodeoxycholic acid-treated patients with primary biliary cirrhosis: a prospective randomized study.

    abstract:BACKGROUND/AIMS:Although ursodeoxycholic acid is effective for the treatment of primary biliary cirrhosis, some patients do not respond to this treatment. The objective of the present study was to investigate the effects of additional administration of colchicine in ursodeoxycholic acid-treated patients with primary bi...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0168-8278(96)80191-7

    authors: Ikeda T,Tozuka S,Noguchi O,Kobayashi F,Sakamoto S,Marumo F,Sato C

    更新日期:1996-01-01 00:00:00

  • The impact of intestinal microflora on serum bilirubin levels.

    abstract:BACKGROUND/AIMS:Intestinal microflora plays an important role in the pathogenesis of neonatal jaundice by inhibiting enterosystemic circulation of bilirubin. The present study aimed to investigate the influence of intestinal microflora on serum bilirubin levels in hyperbilirubinemic Gunn rats. METHODS:After a baseline...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2004.10.012

    authors: Vítek L,Zelenka J,Zadinová M,Malina J

    更新日期:2005-02-01 00:00:00

  • Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes.

    abstract:BACKGROUND & AIMS:Hepatitis B virus (HBV) and D virus (HDV) co-infections cause the most severe form of viral hepatitis. HDV induces an innate immune response, but it is unknown how the host cell senses HDV and if this defense affects HDV replication. We aim to characterize interferon (IFN) activation by HDV, identify ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2018.02.021

    authors: Zhang Z,Filzmayer C,Ni Y,Sültmann H,Mutz P,Hiet MS,Vondran FWR,Bartenschlager R,Urban S

    更新日期:2018-07-01 00:00:00

  • Clinical outcome and hemodynamic changes following HCV eradication with oral antiviral therapy in patients with clinically significant portal hypertension.

    abstract:BACKGROUND & AIMS:Clinically significant portal hypertension (CSPH), defined as a hepatic venous pressure gradient (HVPG) ≥10 mmHg, persists 24 weeks after sustained virological response (SVR) in up to 78% of patients with HCV-related cirrhosis treated with direct-acting antivirals. These patients remain at risk of dec...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.05.050

    authors: Lens S,Baiges A,Alvarado-Tapias E,LLop E,Martinez J,Fortea JI,Ibáñez-Samaniego L,Mariño Z,Rodríguez-Tajes S,Gallego A,Bañares R,Puente Á,Albillos A,Calleja JL,Torras X,Hernández-Gea V,Bosch J,Villanueva C,García-Pagán

    更新日期:2020-12-01 00:00:00

  • Mitochondrial abnormalities in non-alcoholic steatohepatitis.

    abstract:BACKGROUND/AIMS:We assessed mitochondrial morphology by electron microscopy and the prevalence of a mitochondrial gene deletion in patients with non-alcoholic steatohepatitis (NASH), alcohol-related liver disease and non-fatty liver diseases. Respiratory chain function using a cytoplasmic hybrid (cybrid) assay was furt...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(99)80033-6

    authors: Caldwell SH,Swerdlow RH,Khan EM,Iezzoni JC,Hespenheide EE,Parks JK,Parker WD Jr

    更新日期:1999-09-01 00:00:00

  • Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat.

    abstract:BACKGROUND/AIMS:The aim of this study was to investigate whether both matrix metalloproteinase-2 (MMP-2) and membrane type 1 MMP (MT1-MMP) participate in the spontaneous resolution of liver fibrosis. METHODS:Transcription of both genes was examined by reverse transcription-polymerase chain reaction (RT-PCR) and in sit...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(01)00177-5

    authors: Watanabe T,Niioka M,Ishikawa A,Hozawa S,Arai M,Maruyama K,Okada A,Okazaki I

    更新日期:2001-10-01 00:00:00

  • The orphan nuclear receptor COUP-TFII coordinates hypoxia-independent proangiogenic responses in hepatic stellate cells.

    abstract:BACKGROUND & AIMS:Hepatic stellate cell (HSC) transdifferentiation into collagen-producing myofibroblasts is a key event in hepatic fibrogenesis, but the transcriptional network that controls the acquisition of the activated phenotype is still poorly understood. In this study, we explored whether the nuclear receptor c...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2016.11.003

    authors: Ceni E,Mello T,Polvani S,Vasseur-Cognet M,Tarocchi M,Tempesti S,Cavalieri D,Beltrame L,Marroncini G,Pinzani M,Milani S,Galli A

    更新日期:2017-04-01 00:00:00

  • The option of HBIG-free prophylaxis against recurrent HBV.

    abstract::Since the early 1990's, hepatitis B immune globulin (HBIG) has been central to the prevention of hepatitis B virus (HBV) recurrence after liver transplantation. When used in combination with oral nucleos(t)ide analogues, HBIG prevents reinfection with HBV in ⩾90% of transplant recipients. While HBIG is highly efficaci...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jhep.2011.08.026

    authors: Fox AN,Terrault NA

    更新日期:2012-05-01 00:00:00

  • Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development.

    abstract:BACKGROUND & AIMS:To determine whether amino acid mutations in the core region of hepatitis C virus (HCV) genotype 1 are associated with response to interferon (IFN) therapy and development of hepatocellular carcinoma (HCC). METHODS:We followed up 361 patients (median duration, 121 months), and IFN monotherapy was adm...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2009.10.001

    authors: Nakamoto S,Imazeki F,Fukai K,Fujiwara K,Arai M,Kanda T,Yonemitsu Y,Yokosuka O

    更新日期:2010-01-01 00:00:00

  • Activation of dendritic cells by local ablation of hepatocellular carcinoma.

    abstract:BACKGROUND/AIMS:Local ablation methods are an effective treatment for hepatocellular carcinoma (HCC). The rate of recurrence or development of intra-hepatic metastases may be lowered by antitumoral immune responses. Since HCCs are in general only weakly immunogenic, cell injury induced by local tumor ablation (PEI/RFTA...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2005.04.016

    authors: Ali MY,Grimm CF,Ritter M,Mohr L,Allgaier HP,Weth R,Bocher WO,Endrulat K,Blum HE,Geissler M

    更新日期:2005-11-01 00:00:00

  • Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents.

    abstract:BACKGROUND & AIMS:Recent research has suggested that dietary fructose intake may increase serum uric acid (UA) concentrations. Both UA concentration and fructose consumption maybe also increase in NAFLD. It is not known whether dietary fructose consumption and UA concentration are independently associated with non-alco...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2016.12.025

    authors: Mosca A,Nobili V,De Vito R,Crudele A,Scorletti E,Villani A,Alisi A,Byrne CD

    更新日期:2017-05-01 00:00:00

  • Sympathetic nervous activity in cirrhosis. A survey of plasma catecholamine studies.

    abstract::This review summarizes recent progress in the knowledge of catecholamines in cirrhosis. Compensated patients have normal plasma concentration of noradrenaline. Highly elevated plasma noradrenaline concentration in decompensated patients indicates that the sympathetic nervous system is enhanced in this condition. This ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0168-8278(85)80068-4

    authors: Henriksen JH,Ring-Larsen H,Christensen NJ

    更新日期:1985-01-01 00:00:00

  • The delay of rearterialization after initial portal reperfusion in living donor liver transplantation significantly determines the development of microvascular graft dysfunction.

    abstract:BACKGROUND/AIMS:Graft reperfusion in liver transplantation is usually performed by initial portal reperfusion (IPR) and delayed rearterialization. Its influence on graft microcirculation is unknown. This study aimed to assess sinusoidal perfusion in dependence to this reperfusion technique during human living-donor liv...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2004.04.017

    authors: Puhl G,Schaser KD,Pust D,Köhler K,Vollmar B,Menger MD,Neuhaus P,Settmacher U

    更新日期:2004-08-01 00:00:00

  • Non-invasive diagnosis of hepatocellular carcinoma ≤ 2 cm in cirrhosis. Diagnostic accuracy assessing fat, capsule and signal intensity at dynamic MRI.

    abstract:BACKGROUND & AIMS:To prospectively assess the diagnostic accuracy of the incorporation of additional magnetic resonance imaging (MRI) parameters in those based on contrast enhancement pattern for the diagnosis of solitary nodules between 5 and 20mm, detected during surveillance in patients with cirrhosis. METHODS:Betw...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2012.01.004

    authors: Rimola J,Forner A,Tremosini S,Reig M,Vilana R,Bianchi L,Rodríguez-Lope C,Solé M,Ayuso C,Bruix J

    更新日期:2012-06-01 00:00:00

  • Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection.

    abstract:BACKGROUND/AIMS:Alamifovir is a purine nucleotide analogue prodrug that shows potent activity against wild type and lamivudine resistant hepatitis B virus in preclinical studies. The aim of this study was to assess the safety and potential antiviral effects of alamifovir in humans. METHODS:A randomised, placebo contro...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.jhep.2004.07.028

    authors: Soon DK,Lowe SL,Teng CH,Yeo KP,McGill J,Wise SD

    更新日期:2004-11-01 00:00:00

  • Clinical significance of worsening portal hypertension during long-term medical treatment in patients with cirrhosis who had been classified as early good-responders on haemodynamic criteria.

    abstract:BACKGROUND & AIMS:It is established that cirrhotic patients who respond to beta-blockers by lowering their hepatic venous pressure gradient (HVPG) to < or =12 mmHg or by > or =20% of the baseline values are protected from bleeding. However, it is not known whether the effect remains unchanged over the treatment period....

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2009.10.014

    authors: Merkel C,Bolognesi M,Berzigotti A,Amodio P,Cavasin L,Casarotto IM,Zoli M,Gatta A

    更新日期:2010-01-01 00:00:00

  • Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease.

    abstract:BACKGROUND/AIMS:No information is yet available about the influence of alcohol abuse on the translocation of larger molecules (Mr>1200) through the intestinal mucosa in man. The present study aimed to determine the intestinal permeability to macromolecules in patients with chronic alcohol abuse and mild to more advance...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(00)80242-1

    authors: Parlesak A,Schäfer C,Schütz T,Bode JC,Bode C

    更新日期:2000-05-01 00:00:00

  • Treatment of acute hepatic porphyria with hematin.

    abstract::The efficacy of hematin has been evaluated in eight patients with acute intermittent porphyria: six with acute attacks and two with chronic subacute symptoms. Hematin suppressed the chemical signs of porphyria in all patients and the symptoms in those with acute attacks. The clinical response to hematin occurred unifo...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(88)80456-2

    authors: Bissell DM

    更新日期:1988-02-01 00:00:00