A patient with novel ABCB11 gene mutations with phenotypic transition between BRIC2 and PFIC2.

abstract：:Secondary biliary cirrhosis in the rat is an attractive model since unlike other models it does not rely on exogenous toxic compounds to induce cirrhosis. However, because little is known about the microcirculatory abnormalities of this model, this study investigated hemodynamics in rats with predefined functional imp...

journal_title：Journal of hepatology

authors： Ohara N,Schaffner T,Reichen J

更新日期：1993-02-01 00:00:00

abstract：:Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and microRNAs. They can originate from both healthy and stressed cells, and provide a snapshot of the cell of origin in physiological and pathological circumstances. Various processes that may give rise to the release of extracellular...

journal_title：Journal of hepatology

authors： Thietart S,Rautou PE

更新日期：2020-12-01 00:00:00

abstract：:The development of portal hypertension is a common consequence of chronic liver diseases leading to the formation of esophageal and gastric varices responsible for variceal bleeding, associated with a high mortality rate, as well as other severe complications such as portosystemic encephalopathy and sepsis. Measuremen...

journal_title：Journal of hepatology

authors： Castera L,Pinzani M,Bosch J

更新日期：2012-03-01 00:00:00

abstract：:In an attempt to evaluate the prevalence, kinetics and impact of HCV infection in renal transplantation, we analyzed 140 kidney recipients according to the histopathological status of the liver. Thirty-three HBsAg-negative patients had chronic active hepatitis, 73 HBsAg-negative patients had a normal liver, 21 HBsAg-n...

journal_title：Journal of hepatology

authors： Pol S,Legendre C,Saltiel C,Carnot F,Bréchot C,Berthelot P,Mattlinger B,Kreis H

更新日期：1992-05-01 00:00:00

abstract：:alpha-Interferon therapy normalizes aminotransferase levels in approximately 50% of the patients with chronic hepatitis C, but post-therapy relapses are common and predictive factors of sustained response remain largely unknown. We retrospectively assessed several parameters as predictors of sustained remission after ...

journal_title：Journal of hepatology

authors： Camps J,García-Granero M,Riezu-Boj JI,Larrea E,de Alava E,Civeira MP,Castilla A,Prieto J

更新日期：1994-07-01 00:00:00

abstract：:The present study was conducted to evaluate if the increased rate of apoptosis previously reported in the liver of ethanol-treated rats was accompanied by increased cell renewal. A quantitative analysis of apoptosis was performed in rats fed an ethanol-containing liquid diet for 5 weeks. S-phase cells were demonstrate...

journal_title：Journal of hepatology

authors： Baroni GS,Marucci L,Benedetti A,Mancini R,Jezequel AM,Orlandi F

更新日期：1994-04-01 00:00:00

abstract：:Thirty-five consecutive patients with primary biliary cirrhosis were examined using liver biopsy, laboratory tests and ultrasonography of the hepato-duodenal ligament to investigate the possible correlation between enlarged lymph nodes in the hepato-duodenal ligament and biochemical activity, histologic activity or st...

journal_title：Journal of hepatology

authors： Lyttkens K,Prytz H,Forsberg L,Hederström E,Hägerstrand I

更新日期：1992-05-01 00:00:00

abstract：:The heart and liver are organs that are closely related in both health and disease. Patients who undergo liver transplantation may suffer from heart disease that is: (a) related to the original cause of the liver disease such as hemochromatosis, (b) related to the liver disease itself, or (c) related to other associat...

journal_title：Journal of hepatology

authors： Ripoll C,Yotti R,Bermejo J,Bañares R

更新日期：2011-04-01 00:00:00

abstract：:This study evaluates systemic and splanchnic haemodynamics and the effect of propranolol in 15 patients with presinusoidal portal hypertension (portal vein obstruction, n = 11; schistosomiasis, n = 4). These patients exhibited a hyperkinetic circulatory syndrome characterized by high cardiac index (4.4 +/- 1.61.min-1....

journal_title：Journal of hepatology

authors： Braillon A,Moreau R,Hadengue A,Roulot D,Sayegh R,Lebrec D

更新日期：1989-11-01 00:00:00

abstract：:As growth hormone possesses anabolic properties that are active on protein metabolism, and thus of potential benefit to patients with chronic liver disease, we determined the metabolic effects of recombinant human growth hormone on insulin-like growth factor-I (IGF-I) its specific binding proteins, and liver function....

journal_title：Journal of hepatology

authors： Møller S,Becker U,Grønbaek M,Juul A,Winkler K,Skakkebaek NE

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND & AIMS:Histopathology is the gold standard in the diagnosis of liver diseases but may be complicated by sampling error and bleeding. Confocal laser endomicroscopy (CLE) is a novel imaging modality providing in vivo histology. Previous studies using CLE for liver microscopy suffered from limited imaging depth...

journal_title：Journal of hepatology

authors： Goetz M,Deris I,Vieth M,Murr E,Hoffman A,Delaney P,Galle PR,Neurath MF,Kiesslich R

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND/AIMS:Extrahepatic biliary atresia (EHBA) and chronic progressive intra-hepatic cholestasis (Byler's disease) are two distinct disorders of unknown etiology in the neonate, characterized by profound cholestasis. The aim of the present study was to investigate the inflammatory reaction in liver tissue from pat...

journal_title：Journal of hepatology

authors： Broomé U,Nemeth A,Hultcrantz R,Scheynius A

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND & AIMS:The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote hepatosteatosis, but the possible role of vitamin D receptor (VDR) in NAFLD has not been investigated. METHOD...

journal_title：Journal of hepatology

authors： Bozic M,Guzmán C,Benet M,Sánchez-Campos S,García-Monzón C,Gari E,Gatius S,Valdivielso JM,Jover R

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study was to determine the prevalence and clinical significance of hepatitis C virus (HCV) infection in patients with the antiphospholipid syndrome (APS). METHODS:A series of 88 consecutive patients (78 female and 10 male), with a mean age of 39 years (range 15-79), was prospectively st...

journal_title：Journal of hepatology

authors： Muñoz-Rodríguez FJ,Tàssies D,Font J,Reverter JC,Cervera R,Sánchez-Tapias JM,Mazzara R,Ordinas A,Ingelmo M

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND/AIMS:Multidrug resistance-associated protein 3 (MRP3) is a carrier-type transport protein belonging to the ABC transporters. It is expressed in normal tissues, and enhanced expression in many cancers has been reported. In this study, we investigated the usefulness of MRP3 as a target antigen in immunotherapy...

journal_title：Journal of hepatology

authors： Mizukoshi E,Honda M,Arai K,Yamashita T,Nakamoto Y,Kaneko S

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND/AIMS:Suspensions of isolated hepatocytes are a valuable tool to study liver functions. For optimal use of the isolated hepatocytes, methods are needed to preserve the hepatocytes while maintaining their viability, metabolic and transport functions. Until now, little has been known about the maintenance of th...

journal_title：Journal of hepatology

authors： Olinga P,Merema M,Slooff MJ,Meijer DK,Groothuis GM

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND/AIMS:Repetitive indomethacin administration induces down-regulation of hepatic cytochrome P450 (CYP) enzymes. We tested the hypothesis that an increase in intestinal permeability by indomethacin-induced intestinal injury leads to entry of bacterial endotoxin and reaching into liver via the portal vein, resul...

journal_title：Journal of hepatology

authors： Masubuchi Y,Horie T

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND/AIMS:We previously showed that in cultured human myofibroblasts (hMFBs), Oncostatin M (OSM)-stimulated collagen accumulation is associated with increased tissue inhibitor of metalloproteinase (TIMP)1 message. However, the mechanism is unknown. METHODS:hMFBs were isolated by outgrowth from cirrhotic liver ex...

journal_title：Journal of hepatology

authors： Sohara N,Trojanowska M,Reuben A

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND/AIMS:The pathogenesis of post-transplantation bone loss is poorly understood, although glucocorticoid therapy is believed to play an important role. In the present study we have measured plasma parathyroid hormone concentrations in the first few months after orthotopic liver transplantation, in order to exam...

journal_title：Journal of hepatology

authors： Compston JE,Greer S,Skingle SJ,Stirling DM,Price C,Friend PJ,Alexander G

更新日期：1996-11-01 00:00:00

abstract：:A recent study indicated that thymic hormones have antiviral effects in human hepatitis B virus infection and woodchuck hepatitis virus infection. These hormones are known to exert immunomodulatory effects on lymphocyte maturation and function; because these are abnormal in patients with chronic hepatitis B virus infe...

journal_title：Journal of hepatology

authors： Daniels HM,O'Toole A,Hussein MJ,Corridori S,Alexander GJ,Williams R

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND/AIMS:During liver regeneration, a network of cytokines and growth factors interact with hepatocytes, helping to restore the liver mass and functions after partial tissue loss. Agonists that trigger Ca2+ signals in the liver contribute to this process, although little is known about calcium signalling during ...

journal_title：Journal of hepatology

authors： Nicou A,Serrière V,Hilly M,Prigent S,Combettes L,Guillon G,Tordjmann T

更新日期：2007-02-01 00:00:00

abstract：:Two patients presented with neonatal cholestasis and acholic stools as first manifestations of McCune-Albright syndrome. Both went through an extensive evaluation including an exploratory laparotomy with peroperative cholangiography which ruled out biliary atresia. One patient presented from the fourth month of life w...

journal_title：Journal of hepatology

authors： Silva ES,Lumbroso S,Medina M,Gillerot Y,Sultan C,Sokal EM

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIMS:The mechanism of action of recombinant interferon-alpha (rIFN alpha) treatment in chronic hepatitis C is not fully understood, and may include modulation of the immune system as well as a direct antiviral effect. We have therefore evaluated the plasma concentrations of pro- and anti-inflammatory cytokin...

journal_title：Journal of hepatology

authors： Naveau S,Emilie D,Borotto E,Portier A,Lazizi Y,Giraud V,Grangeot-Keros L,Capron F,Galanaud P,Chaput JC

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND/AIMS:Patients infected with hepatitis C virus (HCV) genotype 2 or 3 usually respond better to interferon (IFN) treatment than those infected with genotype 1. In this study, we investigated whether the non-structural 5A protein (NS5A) of HCV genotypes 1 and 2 (1b-NS5A and 2a-NS5A, respectively) exerted differ...

journal_title：Journal of hepatology

authors： Tsai YH,Kuang WF,Lu TY,Kao JH,Lai MY,Liu CJ,Chen PJ,Hwang LH

更新日期：2008-12-01 00:00:00

abstract：:The relationship of the endoscopic aspect of esophageal varices, portal quantitative Doppler ultrasound parameters and clinical and biochemical findings was assessed in 149 patients with cirrhosis stratified according to the presence of esophageal varices (n = 115) and the absence of previous bleeding (n = 96). In thi...

journal_title：Journal of hepatology

authors： Siringo S,Bolondi L,Gaiani S,Sofia S,Di Febo G,Zironi G,Rigamonti A,Miglioli M,Cavalli G,Barbara L

更新日期：1994-01-01 00:00:00

abstract：AIM/METHODS:To elucidate the metabolic effect of interferon alpha, the following tests were performed on 14 patients with chronic active hepatitis C before and after interferon therapy (6 million units/day for 2 weeks): (1) oral glucose tolerance tests to measure insulin secretion; (2) euglycemic hyperinsulinemic clamp...

journal_title：Journal of hepatology

authors： Imano E,Kanda T,Ishigami Y,Kubota M,Ikeda M,Matsuhisa M,Kawamori R,Yamasaki Y

更新日期：1998-02-01 00:00:00

abstract：:This article has been withdrawn at the request of the authors and with approval of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Journal of hepatology

authors： Xi B,Zeng T

更新日期：2011-02-22 00:00:00

abstract：:Hepatitis C virus has been recognized as a major cause of non-A, non-B viral hepatitis. Although serologic tests have been commercialized, no specific histological or immuno-histochemical markers for hepatitis C virus infection are available for routine use. In an effort to detect hepatitis C virus antigen in liver ti...

journal_title：Journal of hepatology

authors： Yap SH,Willems M,Van den Oord J,Habets W,Middeldorp JM,Hellings JA,Nevens F,Moshage H,Desmet V,Fevery J

更新日期：1994-02-01 00:00:00

abstract：:Worldwide, the increasingly dominant model of laboratory testing is the centralised laboratory, in which automation of analytical processes increases, enabling the analysis of large numbers of samples at a relatively low cost. However, this trend does not fulfil the requirements for care of patients with chronic hepat...

journal_title：Journal of hepatology

authors： Chevaliez S,Pawlotsky JM

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND & AIM:Chronic liver diseases are characterized by expansion of the small immature cholangiocytes - a mechanism named ductular reaction (DR) - which have the capacity to differentiate into hepatocytes. We investigated the kinetics of this differentiation, as well as analyzing several important features of the...

journal_title：Journal of hepatology

authors： Manco R,Clerbaux LA,Verhulst S,Bou Nader M,Sempoux C,Ambroise J,Bearzatto B,Gala JL,Horsmans Y,van Grunsven L,Desdouets C,Leclercq I

更新日期：2019-06-01 00:00:00