Abstract：
BACKGROUND/AIMS:Extrahepatic biliary atresia (EHBA) and chronic progressive intra-hepatic cholestasis (Byler's disease) are two distinct disorders of unknown etiology in the neonate, characterized by profound cholestasis. The aim of the present study was to investigate the inflammatory reaction in liver tissue from patients with EHBA and Byler's disease. METHODS:The expression of HLA-DR and ICAM-1 and the number of CD4+, CD8+ and gamma/delta+ T-cells were investigated with immunoperoxidase technique on cryostat sections of liver tissue from patients with EHBA (n=11), Byler's disease (n=7) and (healthy controls (n=5). RESULTS:Only mild inflammation was seen, mainly with CD4+ cells, predominantly in the portal tracts in EHBA and throughout the lobuli in Byler's disease. Neither ICAM-1 nor HLA-DR was present on the bile duct cells or hepatocytes in the control patients. The bile duct cells in all EHBA patients expressed both ICAM-1 and HLA-DR. HLA-DR was expressed on the hepatocytes in five EHBA patients, but ICAM-1 was only found on the hepatocytes in two EHBA patients. In Byler's disease the bile duct cells did not express ICAM-1 or HLA-DR, but the hepatocytes from all Byler patients expressed both ICAM-1 and HLA-DR. CONCLUSIONS:Although neither EHBA nor Byler's disease is characterized by intense inflammatory cell infiltration, an aberrant expression of ICAM-1 and HLA-DR was found in the liver in both patients with EHBA and patients with Byler's disease. The expression of HLA-DR and ICAM-1, was clearly distinct between the two disorders, indicating that it is not merely an unspecific event secondary to cholestasis.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Broomé U,Nemeth A,Hultcrantz R,Scheynius Adoi
10.1016/s0168-8278(97)80253-xsubject
Has Abstractpub_date
1997-04-01 00:00:00pages
857-62issue
4eissn
0168-8278issn
1600-0641pii
S0168-8278(97)80253-Xjournal_volume
26pub_type
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abstract：BACKGROUND/AIMS:Interleukin-12 (IL-12), a cytokine with antitumor activity, was examined for the suppressive effect on hepatocellular carcinoma (HCC) in mouse model, and its mechanism of antitumor activity was analyzed. METHODS:Mice implanted with MIH-2 HCC cells were treated with recombinant mouse IL-12 (500 ng/mouse...
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pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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abstract：:Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality. Prospective data to define ...
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更新日期：2005-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jhep.2012.02.016
更新日期：2012-07-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 杂志文章,评审
doi：10.1016/j.jhep.2009.05.020
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND & AIMS:Hepatitis C virus antiviral treatment is effective for individual patients but few active injecting drug users are treated. We considered the utility of antiviral treatment for primary prevention of hepatitis C. METHODS:A hepatitis C transmission model among injecting drug users was developed, incorp...
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pub_type： 杂志文章
doi：10.1016/j.jhep.2010.08.029
更新日期：2011-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0168-8278(91)90036-b
更新日期：1991-01-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2014.10.011
更新日期：2015-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0168-8278(96)80072-9
更新日期：1996-08-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2004-05-01 00:00:00
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更新日期：1994-04-01 00:00:00
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更新日期：2012-05-01 00:00:00
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pub_type： 临床试验,杂志文章
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1998-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-01-01 00:00:00
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doi：10.1016/j.jhep.2009.01.018
更新日期：2009-06-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1994-10-01 00:00:00
abstract：:The epidemiology of HDV infection in Italy was assessed in a retrospective study involving 1556 HBsAg chronic carriers on their first presentation at one of the 35 Liver Units in 1987. Total anti-HD was detected in 23.4% of HBsAg carriers and was significantly more frequent in southern than in northern Italy (26.6% vs...
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更新日期：1992-05-01 00:00:00
