当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Prevalence of GBV-C and hepatitis G virus variants in patients with fulminant hepatic failure in Japan.

Prevalence of GBV-C and hepatitis G virus variants in patients with fulminant hepatic failure in Japan.

Abstract：

BACKGROUND/AIMS:Whether GB virus C and hepatitis G virus participate in fulminant hepatic failure is controversial. We studied the prevalence of the viral RNA in 48 patients. There were possible routes of infection, including blood transfusion, in 22 patients (group 1), and no risk factors in the other 26 (group 2). METHODS:We assayed serum viral RNA with reverse transcription and nested polymerase chain reactions. Serum was obtained at admission, and after transfusion in group 2. RESULTS:Five (10%) serum samples from group 1 at admission had viral RNA of the 5'-untranslated region, and three of these samples had viral RNA of the NS3/helicase region. All five patients had transfusions before sampling. Two (4%) samples from group 2 were positive by both tests only after transfusion. Of two patients, one with non-A-E fulminant hepatic failure survived. Her serum alanine aminotransferase did not increase further after transfusion, but did stay above the reference range during follow-up. The other patient, with infection with hepatitis B virus detected at admission, died. After transfusion, his alanine aminotransferase did not increase further. Partial nucleotide sequences of GB virus C and hepatitis G virus from three fulminant hepatic failure patients and five control patients with chronic hepatitis C were compared with published sequences. A viral variant causing fulminant hepatitis, suggested elsewhere, was not found, nor was all of a characteristic pattern of six mutations found elsewhere. CONCLUSIONS:GB virus C and hepatitis G virus may cause hepatitis, but probably not severe hepatitis such as fulminant hepatic failure.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Tanaka M,Nishiguchi S,Tanaka T,Enomoto M,Fukuda K,Takeda T,Nakajima S,Shiomi S,Kuroki T,Monna T,Yano Y,Otani S

doi

10.1016/s0168-8278(97)80138-9

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

966-72

issue

6

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(97)80138-9

journal_volume

27

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Quality of life and cognitive function in hepatitis C at different stages of liver disease.

    abstract：BACKGROUND/AIMS:Hepatitis C has been associated with a decrease in quality of life and with neurological abnormalities. The aim of our study was to investigate the relationship between quality of life and cognitive function. METHODS:Quality of life, clinical variables and neuropsychological function were evaluated in ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00189-2

    authors： Córdoba J,Flavià M,Jacas C,Sauleda S,Esteban JI,Vargas V,Esteban R,Guardia J

    更新日期：2003-08-01 00:00:00

  • Chronic kidney disease and associated mortality after liver transplantation--a time-dependent analysis using measured glomerular filtration rate.

    abstract：BACKGROUND & AIMS:The accuracy of creatinine-based estimated GFR (eGFR) in assessing the prevalence of chronic kidney disease (CKD) and associated mortality after liver transplantation (LTx) is unknown. Using measured GFR (mGFR) by iothalamate clearance, we determined the prevalence of the entire spectrum of renal dysf...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.03.034

    authors： Allen AM,Kim WR,Therneau TM,Larson JJ,Heimbach JK,Rule AD

    更新日期：2014-08-01 00:00:00

  • Hepatic but not brain iron is rapidly chelated by deferasirox in aceruloplasminemia due to a novel gene mutation.

    abstract：BACKGROUND & AIMS:Aceruloplasminemia is a rare autosomal recessive neurodegenerative disease associated with brain and liver iron accumulation which typically presents with movement disorders, retinal degeneration, and diabetes mellitus. Ceruloplasmin is a multi-copper ferroxidase that is secreted into plasma and facil...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.04.039

    authors： Finkenstedt A,Wolf E,Höfner E,Gasser BI,Bösch S,Bakry R,Creus M,Kremser C,Schocke M,Theurl M,Moser P,Schranz M,Bonn G,Poewe W,Vogel W,Janecke AR,Zoller H

    更新日期：2010-12-01 00:00:00

  • Mutations in DCDC2 (doublecortin domain containing protein 2) in neonatal sclerosing cholangitis.

    abstract：BACKGROUND & AIMS:Neonatal sclerosing cholangitis (NSC) is a severe neonatal-onset cholangiopathy commonly leading to liver transplantation (LT) for end-stage liver disease in childhood. Liver biopsy findings histopathologically resemble those in biliary atresia (BA); however, in NSC extrahepatic bile ducts are patent,...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2016.07.017

    authors： Grammatikopoulos T,Sambrotta M,Strautnieks S,Foskett P,Knisely AS,Wagner B,Deheragoda M,Starling C,Mieli-Vergani G,Smith J,University of Washington Center for Mendelian Genomics.,Bull L,Thompson RJ

    更新日期：2016-12-01 00:00:00

  • Treatment with non-selective beta blockers is associated with reduced severity of systemic inflammation and improved survival of patients with acute-on-chronic liver failure.

    abstract：BACKGROUND & AIMS:Non-selective beta blockers (NSBBs) have been shown to have deleterious outcomes in patients with refractory ascites, alcoholic hepatitis and spontaneous bacterial peritonitis leading many physicians to stop the drug in these cases. Acute-on-chronic liver failure (ACLF) is characterized by systemic in...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.10.018

    authors： Mookerjee RP,Pavesi M,Thomsen KL,Mehta G,Macnaughtan J,Bendtsen F,Coenraad M,Sperl J,Gines P,Moreau R,Arroyo V,Jalan R,CANONIC Study Investigators of the EASL-CLIF Consortium.

    更新日期：2016-03-01 00:00:00

  • Prevention of alcoholic fatty liver and mitochondrial dysfunction in the rat by long-chain polyunsaturated fatty acids.

    abstract：BACKGROUND/AIMS:We reported that reduced dietary intake of polyunsaturated fatty acids (PUFA) such as arachidonic (AA,20:4n6,omega-6) and docosahexaenoic (DHA,22:6n3,omega-3) acids led to alcohol-induced fatty liver and fibrosis. This study was aimed at studying the mechanisms by which a DHA/AA-supplemented diet preven...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.04.023

    authors： Song BJ,Moon KH,Olsson NU,Salem N Jr

    更新日期：2008-08-01 00:00:00

  • The prognostic role of hepatic venous pressure gradient in cirrhotic patients undergoing elective extrahepatic surgery.

    abstract：BACKGROUND & AIMS:Surgery in cirrhosis is associated with a high morbidity and mortality. Retrospectively reported prognostic factors include emergency procedures, liver function (MELD/Child-Pugh scores) and portal hypertension (assessed by indirect markers). This study assessed the prognostic role of hepatic venous pr...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jhep.2019.07.007

    authors： Reverter E,Cirera I,Albillos A,Debernardi-Venon W,Abraldes JG,Llop E,Flores A,Martínez-Palli G,Blasi A,Martínez J,Turon F,García-Valdecasas JC,Berzigotti A,de Lacy AM,Fuster J,Hernández-Gea V,Bosch J,García-Pagán JC

    更新日期：2019-11-01 00:00:00

  • Alterations of leptin during IFN-alpha therapy in patients with chronic viral hepatitis.

    abstract：BACKGROUND/AIMS:Leptin has a particular profibrogenic role in the liver. We investigated whether IFN-alpha influences leptin production in patients with chronic hepatitis B (CHB) and C (CHC). Leptin was determined in serial samples from 63 CHB and 42 CHC IFN-alpha treated patients. Furthermore, we evaluated whether lep...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.01.025

    authors： Zografos TA,Rigopoulou EI,Liaskos C,Togousidis E,Zachou K,Gatselis N,Germenis A,Dalekos GN

    更新日期：2006-05-01 00:00:00

  • Prevalence of elevated ALT values, HBsAg, and anti-HCV in the primary care setting and evaluation of guideline defined hepatitis risk scenarios.

    abstract：BACKGROUND & AIMS:Prevalence data for hepatitis B and C and an evaluation of a guideline based screening in the primary care setting are not yet available. We therefore implemented a hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) screening and developed guideline based screening strategies. METHO...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.01.011

    authors： Wolffram I,Petroff D,Bätz O,Jedrysiak K,Kramer J,Tenckhoff H,Berg T,Wiegand J,German Check-Up 35+ Study Group.

    更新日期：2015-06-01 00:00:00

  • Anticoagulation in chronic liver disease.

    abstract：:In this Grand Round presentation, the case of a man with decompensated liver disease is described. He subsequently developed a fatal pulmonary embolism, which may not have occurred if he had been prescribed prophylactic anticoagulation to prevent venous thromboembolic disease. The burden of thrombotic disease in those...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2017.01.006

    authors： Dhar A,Mullish BH,Thursz MR

    更新日期：2017-06-01 00:00:00

  • Bone disease in patients with primary sclerosing cholangitis: prevalence, severity and prediction of progression.

    abstract：BACKGROUND/AIMS:Osteopenia is a common complication in some chronic cholestatic liver diseases. Our aims were to determine the prevalence and severity of bone disease in patients with primary sclerosing cholangitis; and identify risk factors to predict the presence and progression of osteopenia. METHODS:Eighty-one pat...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(98)80253-5

    authors： Angulo P,Therneau TM,Jorgensen A,DeSotel CK,Egan KS,Dickson ER,Hay JE,Lindor KD

    更新日期：1998-11-01 00:00:00

  • Natural history of chronic hepatitis B virus-related liver disease and its relationship to serum markers of viral replication.

    abstract：:Our understanding of the process whereby replicating Hepatitis B virus is eradicated has been substantially modified by the development of highly sensitive assays of viral replication, such as the detection of HBV-DNA in serum. The implications of these developments on our therapeutic approach in terms of both timing ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80094-0

    authors： Williams R,Alexander GJ

    更新日期：1986-01-01 00:00:00

  • Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.

    abstract：BACKGROUND & AIMS:Several lipid synthesis pathways play important roles in the development and progression of hepatocellular carcinoma (HCC), although the precise molecular mechanisms remain to be elucidated. Here, we show the relationship between HCC progression and alteration of phospholipid composition regulated by ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.02.030

    authors： Morita Y,Sakaguchi T,Ikegami K,Goto-Inoue N,Hayasaka T,Hang VT,Tanaka H,Harada T,Shibasaki Y,Suzuki A,Fukumoto K,Inaba K,Murakami M,Setou M,Konno H

    更新日期：2013-08-01 00:00:00

  • Hepatocyte proliferative activity in human liver cirrhosis.

    abstract：BACKGROUND/AIMS:The objective of this study was to validate, with an independent prospective cohort of patients, our previous data indicating that the proliferating cell nuclear antigen-labeling index (PCNA-LI) reflects the liver functional reserve in human cirrhosis and might have prognostic significance for patient s...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80106-8

    authors： Delhaye M,Louis H,Degraef C,Le Moine O,Devière J,Peny MO,Adler M,Galand P

    更新日期：1999-03-01 00:00:00

  • Oncostatin M stimulates tissue inhibitor of metalloproteinase-1 via a MEK-sensitive mechanism in human myofibroblasts.

    abstract：BACKGROUND/AIMS:We previously showed that in cultured human myofibroblasts (hMFBs), Oncostatin M (OSM)-stimulated collagen accumulation is associated with increased tissue inhibitor of metalloproteinase (TIMP)1 message. However, the mechanism is unknown. METHODS:hMFBs were isolated by outgrowth from cirrhotic liver ex...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00265-3

    authors： Sohara N,Trojanowska M,Reuben A

    更新日期：2002-02-01 00:00:00

  • Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat.

    abstract：BACKGROUND/AIMS:The aim of this study was to investigate whether both matrix metalloproteinase-2 (MMP-2) and membrane type 1 MMP (MT1-MMP) participate in the spontaneous resolution of liver fibrosis. METHODS:Transcription of both genes was examined by reverse transcription-polymerase chain reaction (RT-PCR) and in sit...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00177-5

    authors： Watanabe T,Niioka M,Ishikawa A,Hozawa S,Arai M,Maruyama K,Okada A,Okazaki I

    更新日期：2001-10-01 00:00:00

  • Acute exacerbation and reactivation of chronic hepatitis C virus infection in cancer patients.

    abstract：BACKGROUND & AIMS:Data on acute exacerbation and reactivation of chronic hepatitis C virus (HCV) infection following chemotherapy are very limited. We sought to characterize the episodes of acute exacerbation and viral reactivation of HCV infection in cancer patients. METHODS:The medical records of HCV-infected patien...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.07.031

    authors： Mahale P,Kontoyiannis DP,Chemaly RF,Jiang Y,Hwang JP,Davila M,Torres HA

    更新日期：2012-12-01 00:00:00

  • Preferential distribution of apoptotic bodies in acinar zone 3 of normal human and rat liver.

    abstract：:The aim of the present investigation was to study the number and acinar distribution of apoptotic bodies in normal liver as an approach to a better understanding of cell kinetics in the hepatic parenchyma. The material included 20 normal human needle liver biopsies and 20 normal male Sprague-Dawley rats. For each live...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(88)80004-7

    authors： Benedetti A,Jézéquel AM,Orlandi F

    更新日期：1988-12-01 00:00:00

  • Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility.

    abstract：BACKGROUND/AIMS:Hepatic stellate cells (HSCs) are perisinusoidal pericytes which have receptors for vasoactive factors, such as endothelin-1, which can regulate cell contractility in an autocrine manner. It is unknown whether human HSCs have receptors for and are able to synthesize the vasodilator peptide adrenomedulli...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)00016-7

    authors： Görbig MN,Ginès P,Bataller R,Nicolás JM,Garcia-Ramallo E,Cejudo P,Sancho-Bru P,Jiménez W,Arroyo V,Rodés J

    更新日期：2001-02-01 00:00:00

  • Epidemiology of hepatitis C virus infection in an area of Southern Italy.

    abstract：BACKGROUND/AIMS:Hepatitis C virus (HCV) has been recognized as a major cause of liver disease, but little is known about its diffusion at population level. To estimate the prevalence and incidence of HCV infection and to explore potential risk factors at population level, an epidemiologic study was carried out. METHOD...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80276-0

    authors： Osella AR,Misciagna G,Leone A,Di Leo A,Fiore G

    更新日期：1997-07-01 00:00:00

  • Targeted vaccination programme successful in reducing acute hepatitis B in men having sex with men in Amsterdam, the Netherlands.

    abstract：BACKGROUND & AIMS:In the Netherlands, transmission of hepatitis B virus occurs mainly within behavioural high-risk groups, such as in men who have sex with men. Therefore, a vaccination programme has targeted these high-risk groups. This study evaluates the impact of the vaccination programme targeting Amsterdam's larg...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.08.002

    authors： van Rijckevorsel G,Whelan J,Kretzschmar M,Siedenburg E,Sonder G,Geskus R,Coutinho R,van den Hoek A

    更新日期：2013-12-01 00:00:00

  • Effect of terlipressin on in vitro vascular hyporeactivity of portal hypertensive rats.

    abstract：BACKGROUND/AIMS:Isolated vessels of portal hypertensive rats exhibit decreased responsiveness to vasoconstrictors. The vasopressin analogue terlipressin is used in the treatment of portal hypertension since it is known to reduce portal pressure, an effect that is thought to arise from splanchnic vasoconstriction via st...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80271-6

    authors： Heinemann A,Stauber RE

    更新日期：1996-06-01 00:00:00

  • Caspase-dependent apoptosis in fulminant hepatic failure induced by herpes simplex virus in mice.

    abstract：BACKGROUND/AIMS:Herpes simplex virus (HSV) is known to induce fulminant hepatic failure. The aim of this study is to clarify the molecular basis of liver injury in HSV-induced hepatitis. METHODS:Immunocompetent mice were inoculated with HSV or ultraviolet-inactivated HSV (UV-HSV) intravenously. Extent of liver injury ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00385-4

    authors： Hashimoto K,Minagawa H,Yanagi Y

    更新日期：2003-11-01 00:00:00

  • β7-Integrin and MAdCAM-1 play opposing roles during the development of non-alcoholic steatohepatitis.

    abstract：BACKGROUND & AIMS:Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease in Western countries. It is unclear how infiltrating leukocytes affect NASH-development. Our study aims to investigate the role of the homing/receptor, pair mucosal addressin cell adhesion molecule-1 (MAdCAM-1)/β7-Integri...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.02.001

    authors： Drescher HK,Schippers A,Clahsen T,Sahin H,Noels H,Hornef M,Wagner N,Trautwein C,Streetz KL,Kroy DC

    更新日期：2017-06-01 00:00:00

  • Safety and efficacy of in vitro fertilisation in patients with chronic liver disease and liver transplantation recipients.

    abstract：BACKGROUND:Chronic liver disease and liver transplantation (LT) can delay both timing and ability of women to conceive. With increased awareness and availability of in vitro fertilisation (IVF), the need for accurate counselling is paramount. To date, minimal data exists to inform outcomes of IVF in patients with chron...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.12.022

    authors： Rahim MN,Theocharidou E,Yen Lau KG,Ahmed R,Marattukalam F,Long L,Cannon MD,Heneghan MA

    更新日期：2021-01-15 00:00:00

  • Efficacy and safety of oral naltrexone treatment for pruritus of cholestasis, a crossover, double blind, placebo-controlled study.

    abstract：BACKGROUND/AIMS:To assess the efficacy and safety of naltrexone for the short and long term treatment of pruritus of cholestasis. METHODS:Twenty patients with pruritus and cholestasis were included. A baseline pruritus score was obtained over 1 week. Patients were then randomized to receive 50 mg/day of naltrexone or ...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(02)00318-5

    authors： Terg R,Coronel E,Sordá J,Muñoz AE,Findor J

    更新日期：2002-12-01 00:00:00

  • Effects of propranolol and sucralfate on ethanol-induced gastric mucosal damage in chronic portal hypertensive rats.

    abstract：:In a rat model of chronic portal hypertension we studied ethanol-induced gastric mucosal damage and the effects of pretreatment by propranolol and sucralfate. Susceptibility to ethanol was increased in chronic portal hypertensive rats compared with sham-operated rats (55 +/- 8% vs. 25 +/- 4%). Both acute pretreatment ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(87)80568-8

    authors： Geoffroy P,Duchateau A,Thiéfin G,Zeitoun P

    更新日期：1987-10-01 00:00:00

  • Non-invasive diagnosis of hepatocellular carcinoma ≤ 2 cm in cirrhosis. Diagnostic accuracy assessing fat, capsule and signal intensity at dynamic MRI.

    abstract：BACKGROUND & AIMS:To prospectively assess the diagnostic accuracy of the incorporation of additional magnetic resonance imaging (MRI) parameters in those based on contrast enhancement pattern for the diagnosis of solitary nodules between 5 and 20mm, detected during surveillance in patients with cirrhosis. METHODS:Betw...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.01.004

    authors： Rimola J,Forner A,Tremosini S,Reig M,Vilana R,Bianchi L,Rodríguez-Lope C,Solé M,Ayuso C,Bruix J

    更新日期：2012-06-01 00:00:00

  • Relationship between hepatitis C virus subtypes and clinical features of liver disease seen in alcoholics.

    abstract：:The influence of hepatitis C virus and its subtypes on the clinical course of liver disease in alcoholics was assessed. Hepatitis C virus infection was confirmed by a reverse transcription and polymerase chain reaction method for the hepatitis C virus NS-5 region in the sera of alcoholics with various stages of histol...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80419-6

    authors： Yokoyama H,Ishii H,Moriya S,Nagata S,Watanabe T,Kamegaya K,Takahashi H,Maruyama K,Haber P,Tsuchiya M

    更新日期：1995-02-01 00:00:00

  • Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts.

    abstract：BACKGROUND/AIM:Chronic rejection is an important cause of graft loss following liver transplantation. A number of risk factors for chronic rejection have been identified previously, albeit inconsistently. These include cytomegalovirus infection detected by a number of different techniques, including immunohistochemical...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80294-3

    authors： Evans PC,Coleman N,Wreghitt TG,Wight DG,Alexander GJ

    更新日期：1999-11-01 00:00:00