当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Prevalence of hepatitis C virus infection in patients with antiphospholipid syndrome.

Prevalence of hepatitis C virus infection in patients with antiphospholipid syndrome.

Abstract：

BACKGROUND/AIMS:The aim of this study was to determine the prevalence and clinical significance of hepatitis C virus (HCV) infection in patients with the antiphospholipid syndrome (APS). METHODS:A series of 88 consecutive patients (78 female and 10 male), with a mean age of 39 years (range 15-79), was prospectively studied. All patients had been diagnosed with APS: 54 (61%) primary APS and 34 (39%) APS associated with systemic lupus erythematosus. A group of 200 apparently healthly blood donors was included in the study. Anti-HCV antibodies were investigated in the serum of all patients using a third-generation ELISA and confirmed by recombinant immunoblot assay. RNA-HCV was investigated in anti-HCV positive samples by polymerase chain reaction. Anticardiolipin, anti-beta2-glycoprotein I and antiprothrombin antibodies were evaluated by ELISA. Lupus anticoagulant was studied by coagulometric assays. RESULTS:Only 2 (2.2%) patients showed positivity for anti-HCV antibodies, but none of them had clinical or biochemical signs of liver disease. Furthermore, RNA-HCV was not detected in serum of any of these patients. Lupus anticoagulant was positive in 57% of patients. Anticardiolipin antibodies were positive in 60% of patients, anti-beta2-glycoprotein I antibodies in 43% of patients, and antiprothrombin antibodies in 56% of patients. The prevalence of anti-HCV in blood donors was 1%. CONCLUSIONS:The prevalence of anti-HCV in patients with APS is low and similar to that in healthy people in our area. HCV infection does not seem to be involved in the etiopathogenesis of this syndrome.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Muñoz-Rodríguez FJ,Tàssies D,Font J,Reverter JC,Cervera R,Sánchez-Tapias JM,Mazzara R,Ordinas A,Ingelmo M

doi

10.1016/s0168-8278(99)80127-5

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

770-3

issue

5

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(99)80127-5

journal_volume

30

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Use of the methacetin breath test to classify the risk of cirrhotic complications and mortality in patients evaluated/listed for liver transplantation.

    abstract：BACKGROUND & AIMS:The MELD score predicts short-term mortality in patients with cirrhosis; however, some patients with low scores develop complications and die unexpectedly. Consequently, we evaluated the diagnostic accuracy of the methacetin breath test (MBT), an assay of liver metabolic function, and the MELD score, ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.07.021

    authors： Stravitz RT,Reuben A,Mizrahi M,Lalazar G,Brown K,Gordon SC,Ilan Y,Sanyal A

    更新日期：2015-12-01 00:00:00

  • Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells.

    abstract：BACKGROUND/AIMS:The precise mechanism of formation and significance of Mallory bodies (MBs) are poorly understood. The endoplasmic reticulum (ER) is the organelle responsible for proper folding and elimination of unfolded proteins. Therefore, failure of this function increases defective proteins in the cell. METHODS:W...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2007.01.039

    authors： Hanada S,Harada M,Kumemura H,Bishr Omary M,Koga H,Kawaguchi T,Taniguchi E,Yoshida T,Hisamoto T,Yanagimoto C,Maeyama M,Ueno T,Sata M

    更新日期：2007-07-01 00:00:00

  • Problems in the management of chronic hepatitis B with interferon: experience in a randomized, multicentre study.

    abstract：:In a multicentre trial, 82 patients known to be hepatitis B e antigen and hepatitis B virus DNA positive for at least 1 year, with elevated serum alanine aminotransferase levels and chronic liver lesions on biopsy, were randomized to receive either recombinant interferon alfa-2a at a dose of 4.5 million units thrice w...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/0168-8278(90)90179-u

    authors： Realdi G,Fattovich G,Pastore G,Caredda F,Noventa F,Santantonio T,Moroni M,Criscuolo D,Maladorno D,Rugge M

    更新日期：1990-01-01 00:00:00

  • The ubiquitously expressed MURR1 protein is absent in canine copper toxicosis.

    abstract：BACKGROUND/AIMS:Copper toxicosis (CT) in Bedlington terriers is an autosomal recessive disorder characterized by massive lysosomal copper accumulation in livers of affected dogs, and a defect in the biliary excretion of this metal. We propose that MURR1, the gene defective in canine CT, has a role in the regulation of ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00380-5

    authors： Klomp AE,van de Sluis B,Klomp LW,Wijmenga C

    更新日期：2003-11-01 00:00:00

  • Complete removal of the tumor-bearing portal territory decreases local tumor recurrence and improves disease-specific survival of patients with hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:Anatomic resection (AR) of the tumor-bearing portal territory has been reported to be associated with a decreased recurrence of hepatocellular carcinoma (HCC). However, because of the heterogeneity of the study populations, its oncologic advantage remains controversial. The objective of the present st...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.10.015

    authors： Shindoh J,Makuuchi M,Matsuyama Y,Mise Y,Arita J,Sakamoto Y,Hasegawa K,Kokudo N

    更新日期：2016-03-01 00:00:00

  • p53 haploinsufficiency and increased mTOR signalling define a subset of aggressive hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:p53 mutations occur frequently in human HCC. Activation of the mammalian target of rapamycin (mTOR) pathway is also associated with HCC. However, it is still unknown whether these changes together initiate HCC and can be targeted as a potential therapeutic strategy. METHODS:We generated mouse models ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.07.036

    authors： Luo YD,Fang L,Yu HQ,Zhang J,Lin XT,Liu XY,Wu D,Li GX,Huang D,Zhang YJ,Chen S,Jiang Y,Shuai L,He Y,Zhang LD,Bie P,Xie CM

    更新日期：2021-01-01 00:00:00

  • Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts.

    abstract：BACKGROUND/AIM:Chronic rejection is an important cause of graft loss following liver transplantation. A number of risk factors for chronic rejection have been identified previously, albeit inconsistently. These include cytomegalovirus infection detected by a number of different techniques, including immunohistochemical...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80294-3

    authors： Evans PC,Coleman N,Wreghitt TG,Wight DG,Alexander GJ

    更新日期：1999-11-01 00:00:00

  • Terbinafine-associated hepatic injury.

    abstract：:We describe two cases of terbinafine-associated hepatic injury, in which a mixed cholestatic-hepatocellular type of hepatitis was present. In both cases extrahepatic cholestasis and viral hepatitis were excluded and involvement of other drugs was unlikely. In the first patient all abnormalities have disappeared, but i...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(94)80146-0

    authors： van 't Wout JW,Herrmann WA,de Vries RA,Stricker BH

    更新日期：1994-07-01 00:00:00

  • Hepatitis C virus infection and autoimmune thrombocytopenic purpura.

    abstract：BACKGROUND/AIMS:Chronic hepatitis C virus infections are often associated with extra-hepatic immunological manifestations, including various autoimmune disorders. The aims of this study were: (i) to determine the prevalence of hepatitis C virus markers in patients with autoimmune thrombocytopenic purpura, and (ii) to d...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80027-1

    authors： Pawlotsky JM,Bouvier M,Fromont P,Deforges L,Duval J,Dhumeaux D,Bierling P

    更新日期：1995-12-01 00:00:00

  • Visceral adiposity index is not a predictor of liver histology in patients with non-alcoholic fatty liver disease.

    abstract：BACKGROUND & AIMS:Visceral adiposity is associated with hepatic steatosis, inflammation, and fibrosis in non-alcoholic fatty liver disease (NAFLD). The visceral adiposity index (VAI), a novel marker of visceral fat distribution and dysfunction, has been correlated with histology in hepatitis C. We assessed the ability ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.03.013

    authors： Vongsuvanh R,George J,McLeod D,van der Poorten D

    更新日期：2012-08-01 00:00:00

  • Tauroursodeoxycholate prevents taurolithocholate-induced cholestasis and toxicity in rat liver.

    abstract：:Ursodeoxycholate has been advocated for the treatment of cholestatic liver diseases. The coinfusion of tauroursodeoxycholate with taurolithocholate in the perfused rat liver completely prevented the decrease of bile flow and the increase of oxygen uptake found with taurolithocholate only. Bile flow and bile salt secre...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(90)90133-c

    authors： Schölmerich J,Baumgartner U,Miyai K,Gerok W

    更新日期：1990-05-01 00:00:00

  • Role of the liver-enriched transcription factors C/EBP alpha and DBP in the expression of human CYP3A4 and CYP3A7.

    abstract：:In the human fetal liver, CYP3A7 is expressed as early as the 13th week of gestation. This continues to the perinatal period when it is sharply repressed prior to birth. Concomitantly, the expression of CYP3A4, not detectable in the fetus, sharply increases in the perinatal period to remain elevated throughout adultho...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80497-7

    authors： Ourlin JC,Jounaïdi Y,Maurel P,Vilarem MJ

    更新日期：1997-01-01 00:00:00

  • Kupffer cell number is normal, but their lysozyme content is reduced in alcoholic liver disease.

    abstract：:A quantitative immunohistochemical study of Kupffer cells in liver biopsies from alcoholics was carried out. Two markers were compared, lysozyme and an antimacrophage monoclonal antibody EMB/11. The results showed that there is no significant reduction in Kupffer cell numbers in acute and chronic alcoholic liver disea...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(89)90005-6

    authors： Kelly PM,Heryet AR,McGee JO

    更新日期：1989-03-01 00:00:00

  • Vinyl chloride and the liver.

    abstract：:Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver, and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. However, the data on which this conclusion is based is incomplete. There is inadequate ascertainme...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2009.09.012

    authors： Sherman M

    更新日期：2009-12-01 00:00:00

  • THF gamma 2 stimulates cytokine release by peripheral blood mononuclear cells of patients with chronic hepatitis B virus infection.

    abstract：:A recent study indicated that thymic hormones have antiviral effects in human hepatitis B virus infection and woodchuck hepatitis virus infection. These hormones are known to exert immunomodulatory effects on lymphocyte maturation and function; because these are abnormal in patients with chronic hepatitis B virus infe...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(94)80010-3

    authors： Daniels HM,O'Toole A,Hussein MJ,Corridori S,Alexander GJ,Williams R

    更新日期：1994-03-01 00:00:00

  • Hepatic and skeletal muscle glycogen metabolism in rats with short-term cholestasis.

    abstract：BACKGROUND/AIMS:To study the effect of short-term cholestasis on glycogen metabolism. METHODS:Rats were bile duct ligated (BDL) for 4 or 8 days and compared to sham-operated control rats pair-fed to BDL (pair-fed CON) or fed ad libitum (ad libitum-fed CON). RESULTS:Four days after surgery, the hepatic glycogen conten...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00287-2

    authors： Lang C,Schäfer M,Varga L,Zimmermann A,Krähenbühl S,Krähenbühl L

    更新日期：2002-01-01 00:00:00

  • Remodelling of calcium signalling during liver regeneration in the rat.

    abstract：BACKGROUND/AIMS:During liver regeneration, a network of cytokines and growth factors interact with hepatocytes, helping to restore the liver mass and functions after partial tissue loss. Agonists that trigger Ca2+ signals in the liver contribute to this process, although little is known about calcium signalling during ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.08.014

    authors： Nicou A,Serrière V,Hilly M,Prigent S,Combettes L,Guillon G,Tordjmann T

    更新日期：2007-02-01 00:00:00

  • YAP activation is an early event and a potential therapeutic target in liver cancer development.

    abstract：BACKGROUND & AIMS:Although the growth suppressing Hippo pathway has been implicated in hepatocellular carcinoma (HCC) pathogenesis, it is unknown at which stage of hepatocarcinogenesis its dysregulation occurs. We investigated in rat and human preneoplastic lesions whether overexpression of the transcriptional co-activ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.06.033

    authors： Perra A,Kowalik MA,Ghiso E,Ledda-Columbano GM,Di Tommaso L,Angioni MM,Raschioni C,Testore E,Roncalli M,Giordano S,Columbano A

    更新日期：2014-11-01 00:00:00

  • A histopathological study of the effects of 6-month versus 12-month interferon alpha-2b therapy in chronic hepatitis C.

    abstract：BACKGROUND/AIMS:Interferon therapy has been shown to have beneficial effects in chronic hepatitis C, but the optimal duration of treatment has not been clearly defined. The aims of this study were: (a) to perform a detailed histological comparison of the effects of a 6-month and a 12-month treatment using the Knodell s...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(96)80286-8

    authors： Ziol M,Nhieu JT,Roudot-Thoraval F,Métreau JM,Deugnier Y,Dhumeaux D,Zafrani ES

    更新日期：1996-12-01 00:00:00

  • Expression and cellular localization of fibrillin-1 in normal and pathological human liver.

    abstract：BACKGROUND:The expression and the distribution of fibrillin-1 and elastin were studied in normal and pathological human liver samples. METHODS:As controls, histologically normal/subnormal liver samples (n = 24) were used. Pathological samples corresponded to seven cirrhosis and eight hepatocellular carcinomas (HCC) de...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)00048-9

    authors： Dubuisson L,Lepreux S,Bioulac-Sage P,Balabaud C,Costa AM,Rosenbaum J,Desmoulière A

    更新日期：2001-04-01 00:00:00

  • Prevalence of GBV-C and hepatitis G virus variants in patients with fulminant hepatic failure in Japan.

    abstract：BACKGROUND/AIMS:Whether GB virus C and hepatitis G virus participate in fulminant hepatic failure is controversial. We studied the prevalence of the viral RNA in 48 patients. There were possible routes of infection, including blood transfusion, in 22 patients (group 1), and no risk factors in the other 26 (group 2). M...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80138-9

    authors： Tanaka M,Nishiguchi S,Tanaka T,Enomoto M,Fukuda K,Takeda T,Nakajima S,Shiomi S,Kuroki T,Monna T,Yano Y,Otani S

    更新日期：1997-12-01 00:00:00

  • Interleukin-1 receptor antagonist plasma concentration is specifically increased by alpha-2A-interferon treatment.

    abstract：BACKGROUND/AIMS:The mechanism of action of recombinant interferon-alpha (rIFN alpha) treatment in chronic hepatitis C is not fully understood, and may include modulation of the immune system as well as a direct antiviral effect. We have therefore evaluated the plasma concentrations of pro- and anti-inflammatory cytokin...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80171-7

    authors： Naveau S,Emilie D,Borotto E,Portier A,Lazizi Y,Giraud V,Grangeot-Keros L,Capron F,Galanaud P,Chaput JC

    更新日期：1997-08-01 00:00:00

  • Targeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease.

    abstract：BACKGROUND & AIMS:The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is affected by epigenetic factors as well as by genetic variation. METHODS:We performed targeted-bisulfite sequencing to determine the levels of DNA methylation of 4 CpG islands (CpG99, CpG71, CpG26, and CpG101) in the regulatory regions o...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.02.049

    authors： Kitamoto T,Kitamoto A,Ogawa Y,Honda Y,Imajo K,Saito S,Yoneda M,Nakamura T,Nakajima A,Hotta K

    更新日期：2015-08-01 00:00:00

  • Identification of naïve HCV-1 patients with chronic hepatitis who may benefit from dual therapy with peg-interferon and ribavirin.

    abstract：BACKGROUND & AIMS:The pool of HCV genotype 1 patients likely to be cured by peg-interferon and ribavirin remains to be quantified. METHODS:In 1045 patients treated with peg-interferon and ribavirin, two therapeutic strategies were confronted: the first one evaluated only baseline variables associated with sustained vi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.07.040

    authors： Andriulli A,Di Marco V,Margaglione M,Ippolito AM,Fattovich G,Smedile A,Valvano MR,Calvaruso V,Gioffreda D,Milella M,Morisco F,Felder M,Brancaccio G,Fasano M,Gatti P,Tundo P,Barone M,Cozzolongo R,Angelico M,D'Andrea

    更新日期：2014-01-01 00:00:00

  • Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats.

    abstract：BACKGROUND/AIMS:To assess the effect of lactoferrin on oxidative liver damage and its mechanism, we used Long-Evans Cinnamon (LEC) rats that spontaneously develop fulminant-like hepatitis and lethal hepatic failure. METHODS:Four-week-old female LEC rats were divided into the untreated and treated groups. The latter wa...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2007.11.013

    authors： Tsubota A,Yoshikawa T,Nariai K,Mitsunaga M,Yumoto Y,Fukushima K,Hoshina S,Fujise K

    更新日期：2008-03-01 00:00:00

  • Quantitative analysis of IgM anti-HBc in chronic hepatitis B patients using a new "gray-zone" for the evaluation of "borderline" values.

    abstract：BACKGROUND/METHODS:In order to define the clinical significance of borderline levels of IgM anti-HBc in chronic hepatitis B patients, we followed up 89 untreated hepatitis B patients (19 HBeAg pos and 70 anti-HBe pos) for 1 year, with monthly monitoring of IgM anti-HBc using a highly sensitive quantitative microparticl...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80233-9

    authors： Colloredo G,Bellati G,Leandro G,Colombatto P,Rho A,Bissoli F,Brunetto MR,Angeli G,Ideo G,Bonino F

    更新日期：1996-11-01 00:00:00

  • Pharmacological thrombolysis in Budd Chiari syndrome: a single centre experience and review of the literature.

    abstract：BACKGROUND/AIMS:To review our experience of thrombolytic therapy in patients with acute Budd Chiari syndrome (BCS). METHODS:Records of 10 patients with BCS, treated by thrombolysis over a 12-year period were retrospectively analysed for demographics, clinical presentation/duration, primary disease, thrombolytic regime...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2003.09.028

    authors： Sharma S,Texeira A,Texeira P,Elias E,Wilde J,Olliff SP

    更新日期：2004-01-01 00:00:00

  • Cholestatic liver injury after glimepiride therapy.

    abstract：:Drug induced hepatotoxicity has been reported infrequently with sulfonylureas. For glimepiride, a second-generation sulfonylurea there is no report of hepatotoxicity in English literature. A patient with non-insulin-dependent diabetes mellitus who developed cholestatic liver injury soon after initiation of glimepiride...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.02.011

    authors： Chounta A,Zouridakis S,Ellinas C,Tsiodras S,Zoumpouli C,Kopanakis S,Giamarellou H

    更新日期：2005-06-01 00:00:00

  • Hepatitis G virus infection in chronic hepatitis C: frequency, features and response to interferon therapy.

    abstract：BACKGROUND/AIMS:The pathogenic relevance of the hepatitis G virus (HGV) and its sensitivity to interferon are currently under investigation. This study aimed to investigate the prevalence of HGV infection in patients with chronic hepatitis C and to elucidate if HGV co-infection modifies the clinical course and the resp...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80243-7

    authors： Sáiz JC,Ampurdanés S,Olmedo E,López-Labrador FX,Forns X,Guilera M,Tassies D,Costa J,Sánchez-Tapias JM,Jiménez de Anta MT,Rodés J

    更新日期：1997-04-01 00:00:00

  • Evidence for Galalpha(1-3)Gal expression on primary porcine hepatocytes: implications for bioartificial liver systems.

    abstract：BACKGROUND/AIMS:To bridge acute liver failure (ALF) patients to orthotopic liver transplantation, several bioartificial liver (BAL) systems have been developed. The bio-component of most BAL systems consists mainly of porcine hepatocytes. Plasma or blood of ALF patients is perfused through the BAL thereby contacting po...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.11.041

    authors： van de Kerkhove MP,Germans MR,Deurholt T,Hoekstra R,Joziasse DH,van Wijk AC,van Gulik TM,Chamuleau RA,Roos A

    更新日期：2005-04-01 00:00:00