WITHDRAWN: Null genotypes of GSTM1 and GSTT1 both associated with increased hepatocellular carcinoma risk in Asians: new evidence.


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J Hepatol


Journal of hepatology


Xi B,Zeng T




Has Abstract


2011-02-22 00:00:00








  • HBV replication, pathobiology and therapy: Unanswered questions.

    abstract::This volume explores these and other issues of relevance to our understanding of the HBV life cycle and clinical management of chronic HBV infections. The ultimate goals of these studies is not just to obtain a more precise understanding of the HBV life cycle, but to also acquire an understanding that will lead to mor...

    journal_title:Journal of hepatology

    pub_type: 社论


    authors: Seeger C,Mason WS

    更新日期:2016-04-01 00:00:00

  • Hepatocellular proliferation in patients with chronic hepatitis C and persistently normal or abnormal aminotransferase levels.

    abstract:BACKGROUND/AIMS:Some patients chronically infected with the hepatitis C virus (HCV) have persistently normal alanine aminotransferase (ALT) levels while progressive liver damage is observed histologically. In the present study, we compared the rate of proliferation, apoptosis, and necrosis in liver biopsy specimens of ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kronenberger B,Rüster B,Lee JH,Sarrazin C,Roth WK,Herrmann G,Zeuzem S

    更新日期:2000-10-01 00:00:00

  • Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat.

    abstract:BACKGROUND/AIMS:Hepatic stellate cells (HSCs) are known to play a role in hepatic regeneration. We investigated hepatocyte/HSC interaction and HSC activation at various times after 70% partial hepatectomy (PHx) in the rat. METHODS:The hepatic microcirculation was studied using intravital fluorescence microscopy (IVFM)...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Mabuchi A,Mullaney I,Sheard PW,Hessian PA,Mallard BL,Tawadrous MN,Zimmermann A,Senoo H,Wheatley AM

    更新日期:2004-06-01 00:00:00

  • Applicability of adult-to-adult living donor liver transplantation.

    abstract:BACKGROUND/AIMS:The applicability of adult-to-adult living donor liver transplantation has not been established yet. We report the first data in a European center of the process leading to this procedure from the first moment the patients were informed about it. METHODS:In phase 1 of the process, 121 adult patients en...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Rimola A,Llovet JM,Navasa M,Bruix J,Londoño MC,Fuster J,García-Valdecasas JC

    更新日期:2005-07-01 00:00:00

  • An ultrasound scoring system for the diagnosis of liver disease in cystic fibrosis.

    abstract::Advances in the management of the pulmonary complications of cystic fibrosis may result in an increasing prevalence of patients with chronic liver disease which may, therefore, become more important in the long-term management of cystic fibrosis patients. However, no simple and reliable test is available for the diagn...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章


    authors: Williams SG,Evanson JE,Barrett N,Hodson ME,Boultbee JE,Westaby D

    更新日期:1995-05-01 00:00:00

  • Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver.

    abstract:BACKGROUND/AIMS:Gadolinium chloride inactivates Kupffer cells and alleviates alcohol-induced liver lesions. We investigated the mechanism of gadolinium chloride protection after oral ethanol feeding. METHODS:Rats were maintained ethanol-intoxicated for 6 weeks by feeding ethanol in a low-carbohydrate/high-fat liquid d...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Järveläinen HA,Fang C,Ingelman-Sundberg M,Lukkari TA,Sippel H,Lindros KO

    更新日期:2000-06-01 00:00:00

  • The delay of rearterialization after initial portal reperfusion in living donor liver transplantation significantly determines the development of microvascular graft dysfunction.

    abstract:BACKGROUND/AIMS:Graft reperfusion in liver transplantation is usually performed by initial portal reperfusion (IPR) and delayed rearterialization. Its influence on graft microcirculation is unknown. This study aimed to assess sinusoidal perfusion in dependence to this reperfusion technique during human living-donor liv...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Puhl G,Schaser KD,Pust D,Köhler K,Vollmar B,Menger MD,Neuhaus P,Settmacher U

    更新日期:2004-08-01 00:00:00

  • Macrophages from rat livers with micronodular and macronodular cirrhosis differ with respect to mediator release and DNA-synthesis.

    abstract:BACKGROUND/AIMS:Liver macrophages play an essential role in necro-inflammatory liver damage which leads to fibrosis and cirrhosis. The aim of the present study was to compare the mediator release and the DNA synthesis of macrophages at an early and at a later stage of liver cirrhosis induced by thioacetamide. METHODS:...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Vogl S,Junker U,Vogelsang H,Dargel R

    更新日期:1997-05-01 00:00:00

  • Safety and efficacy of in vitro fertilisation in patients with chronic liver disease and liver transplantation recipients.

    abstract:BACKGROUND:Chronic liver disease and liver transplantation (LT) can delay both timing and ability of women to conceive. With increased awareness and availability of in vitro fertilisation (IVF), the need for accurate counselling is paramount. To date, minimal data exists to inform outcomes of IVF in patients with chron...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Rahim MN,Theocharidou E,Yen Lau KG,Ahmed R,Marattukalam F,Long L,Cannon MD,Heneghan MA

    更新日期:2021-01-15 00:00:00

  • Assessment of hepatitis B virus DNA levels in chronic HBsAg carriers with or without hepatitis delta virus superinfection.

    abstract::In order to document the incidence of hepatitis delta virus (HDV) replication markers and their relationship to HBV replication, 91 HBsAg chronic carriers were studied. Of these, 51 were anti-HD-positive (19 HBeAg-positive and 32 anti-HBe-positive). Liver HDAg was found in 75% of anti-HD-positive patients. Of the 19 p...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Bas C,Bartolomé J,La Banda F,Porres JC,Quiroga JA,Mora I,Carreño V

    更新日期:1988-04-01 00:00:00

  • An outbreak of hepatitis A virus infection with a high case-fatality rate among injecting drug users.

    abstract:BACKGROUND/AIMS:In 2002, the first reported outbreak of hepatitis A virus (HAV) infection involving mostly intravenous drug users (IDU) occurred in Italy. We attempted a thorough evaluation of the outbreak, including epidemiological, clinical and virological analyses. METHODS:We conducted an epidemiological investigat...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Spada E,Genovese D,Tosti ME,Mariano A,Cuccuini M,Proietti L,Giuli CD,Lavagna A,Crapa GE,Morace G,Taffon S,Mele A,Rezza G,Rapicetta M

    更新日期:2005-12-01 00:00:00

  • Hepatic but not brain iron is rapidly chelated by deferasirox in aceruloplasminemia due to a novel gene mutation.

    abstract:BACKGROUND & AIMS:Aceruloplasminemia is a rare autosomal recessive neurodegenerative disease associated with brain and liver iron accumulation which typically presents with movement disorders, retinal degeneration, and diabetes mellitus. Ceruloplasmin is a multi-copper ferroxidase that is secreted into plasma and facil...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Finkenstedt A,Wolf E,Höfner E,Gasser BI,Bösch S,Bakry R,Creus M,Kremser C,Schocke M,Theurl M,Moser P,Schranz M,Bonn G,Poewe W,Vogel W,Janecke AR,Zoller H

    更新日期:2010-12-01 00:00:00

  • Anticoagulation in chronic liver disease.

    abstract::In this Grand Round presentation, the case of a man with decompensated liver disease is described. He subsequently developed a fatal pulmonary embolism, which may not have occurred if he had been prescribed prophylactic anticoagulation to prevent venous thromboembolic disease. The burden of thrombotic disease in those...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Dhar A,Mullish BH,Thursz MR

    更新日期:2017-06-01 00:00:00

  • NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly.

    abstract:BACKGROUND & AIMS:Hepatomegaly can be triggered by insulin and insulin-unrelated etiologies. Insulin acts via AKT, but how other challenges cause hepatomegaly is unknown. METHODS:Since many hepatomegaly-inducing toxicants and stressors activate NRF2, we examined the effect of NRF2 activation on liver size and metaboli...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: He F,Antonucci L,Yamachika S,Zhang Z,Taniguchi K,Umemura A,Hatzivassiliou G,Roose-Girma M,Reina-Campos M,Duran A,Diaz-Meco MT,Moscat J,Sun B,Karin M

    更新日期:2020-06-01 00:00:00

  • Protein C in patients with alcoholic cirrhosis and other liver diseases.

    abstract::The coagulation inhibitor protein C was measured in 151 patients with various liver diseases. The protein C level was significantly decreased in patients with alcoholic cirrhosis (n = 73) compared to patients with steatosis (n = 24) (40 +/- 2%) vs. 88 +/- 4%, mean S.E., p less than 0.001). It was also decreased in cas...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Bell H,Odegaard OR,Andersson T,Raknerud N

    更新日期:1992-03-01 00:00:00

  • Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins.

    abstract:BACKGROUND/AIMS:Bacillus Calmette Guerin (BCG) infection causes hepatic injury following granuloma formation and secretion of cytokines which render mice highly sensitive to endotoxin-mediated hepatotoxicity. This work investigates the role of inducible nitric oxide synthase (iNOS) in liver damage induced by BCG and en...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Guler R,Olleros ML,Vesin D,Parapanov R,Vesin C,Kantengwa S,Rubbia-Brandt L,Mensi N,Angelillo-Scherrer A,Martinez-Soria E,Tacchini-Cottier F,Garcia I

    更新日期:2004-11-01 00:00:00

  • Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection.

    abstract:BACKGROUND/AIMS:Alamifovir is a purine nucleotide analogue prodrug that shows potent activity against wild type and lamivudine resistant hepatitis B virus in preclinical studies. The aim of this study was to assess the safety and potential antiviral effects of alamifovir in humans. METHODS:A randomised, placebo contro...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Soon DK,Lowe SL,Teng CH,Yeo KP,McGill J,Wise SD

    更新日期:2004-11-01 00:00:00

  • Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection.

    abstract:BACKGROUND & AIMS:Liver macrophages can be involved in both pathogen clearance and/or pathogenesis. To get further insight on their role during chronic hepatitis B virus (HBV) infections, our aim was to phenotypically and functionally characterize in vivo and ex vivo the interplay between HBV, primary human liver macro...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Faure-Dupuy S,Delphin M,Aillot L,Dimier L,Lebossé F,Fresquet J,Parent R,Matter MS,Rivoire M,Bendriss-Vermare N,Salvetti A,Heide D,Flores L,Klumpp K,Lam A,Zoulim F,Heikenwälder M,Durantel D,Lucifora J

    更新日期:2019-12-01 00:00:00

  • Pattern of HCV antibodies with special reference to NS5A reactivity in HCV-infected patients: relation to viral genotype, cryoglobulinemia and response to interferon.

    abstract:BACKGROUND/AIMS:We aimed to compare the anti-hepatitis C virus reactivity in confirmatory assays (RIBA 3.0 Ortho Diagnostic and INNO-LIA HCV Ab III Innogenetics) among patients infected with different hepatitis C virus genotypes, with or without cryoglobulinemia, and in patients treated with interferon. METHODS:One hu...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章


    authors: Frangeul L,Cresta P,Perrin M,Duverlie G,Khorsi H,Musset L,Opolon P,Huraux JM,Lunel F

    更新日期:1998-04-01 00:00:00

  • Neurally-mediated vasodilatation in normal and portal hypertensive rats: role of nitric oxide and calcitonin gene-related peptide.

    abstract:BACKGROUND/AIMS:Portal hypertension is associated with systemic vasodilatation and vascular hyporeactivity, and is reversed by inhibiting nitric oxide biosynthesis. Nitric oxide and calcitonin gene-related peptide are neurotransmitters of non-adrenergic non-cholinergic nerves. The role of nitric oxide and calcitonin ge...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Moll-Kaufmann C,Sumanovski LT,Sieber CC

    更新日期:1998-06-01 00:00:00

  • Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis.

    abstract:BACKGROUND & AIM:Virus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon (IFN-I) on myeloid cells, including liver-resident Kupffer cells (KC), is only partially understood. Herein, we dissected the impact of locally induced IFN-I responses...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Borst K,Frenz T,Spanier J,Tegtmeyer PK,Chhatbar C,Skerra J,Ghita L,Namineni S,Lienenklaus S,Köster M,Heikenwaelder M,Sutter G,Kalinke U

    更新日期:2018-04-01 00:00:00

  • The hydroxyl radical scavengers dimethylsulfoxide and dimethylthiourea protect rats against thioacetamide-induced fulminant hepatic failure.

    abstract:BACKGROUND/AIMS:Reactive oxygen species, proinflammatory cytokines, glutathione depletion and nitric oxide have all been implicated in the pathogenesis of fulminant hepatic failure. The aim of the present study was to examine the respective roles of these factors in the pathogenesis of thioacetamide-induced fulminant h...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Bruck R,Aeed H,Shirin H,Matas Z,Zaidel L,Avni Y,Halpern Z

    更新日期:1999-07-01 00:00:00

  • IL-6 pathway in the liver: From physiopathology to therapy.

    abstract::Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple functions in the body. In the liver, IL-6 is an important inducer of the acute phase response and infection defense. IL-6 is furthermore crucial for hepatocyte homeostasis and is a potent hepatocyte mitogen. It is not only implicated...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Schmidt-Arras D,Rose-John S

    更新日期:2016-06-01 00:00:00

  • Inhibition of nitric oxide production increases dimethylnitrosamine-induced liver injury in rats.

    abstract::Intravascular coagulation is involved in the development of certain types of liver injury, including that induced by dimethylnitrosamine. Nitric oxide inhibits platelet aggregation and adhesion; however, its role in protecting against intravascular coagulation has not been clarified. We therefore investigated the effe...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Nagase S,Isobe H,Ayukawa K,Sakai H,Nawata H

    更新日期:1995-11-01 00:00:00

  • Prognostic relevance of serum inhibitory factors (SIF) in protracted and persistent hepatitis B.

    abstract::In a follow-up study of 3 years' duration, serum inhibitory factors (SIF) were analysed in 23 patients with a protracted course of viral hepatitis B (PVH) and 12 patients with chronic persistent hepatitis (CPH). Four patients showed a progressive course, developing chronic active hepatitis, and one died of liver failu...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Brattig NW,Ortmans H,Wildhirt W,Klinge O,Berg PA

    更新日期:1987-04-01 00:00:00

  • MELD score is better than Child-Pugh score in predicting 3-month survival of patients undergoing transjugular intrahepatic portosystemic shunt.

    abstract:BACKGROUND/AIMS:Patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) are at risk of early death due to end-stage liver failure. The aim of this study was to compare model of end-stage liver disease (MELD) and Child-Pugh scores as predictors of survival after TIPS. METHODS:We studied 140 cirrhotic p...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Salerno F,Merli M,Cazzaniga M,Valeriano V,Rossi P,Lovaria A,Meregaglia D,Nicolini A,Lubatti L,Riggio O

    更新日期:2002-04-01 00:00:00

  • Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate.

    abstract::Drug hepatotoxicity is partially determined by genetic factors involved in drug metabolism, which may involve the debrisoquine oxidation polymorphism mediated by cytochrome (CYP) 2D6. The purpose of this study was to assess the relationship between drug hepatotoxicity and another genetic polymorphism of drug oxidation...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Horsmans Y,Lannes D,Pessayre D,Larrey D

    更新日期:1994-12-01 00:00:00

  • Involvement of natural killer cells in PolyI:C-induced liver injury.

    abstract:BACKGROUND/AIMS:The roles of T cells, natural killer T cells (NKT) and macrophages in autoimmune hepatitis have been well documented. However, the roles of natural killer (NK) cells in liver injury remain obscure. Here we examined the effect of Polyinosinic: polycytidylic acid (PolyI:C)-activated NK cells on liver inju...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Dong Z,Wei H,Sun R,Hu Z,Gao B,Tian Z

    更新日期:2004-12-01 00:00:00

  • Interleukin-1 receptor antagonist plasma concentration is specifically increased by alpha-2A-interferon treatment.

    abstract:BACKGROUND/AIMS:The mechanism of action of recombinant interferon-alpha (rIFN alpha) treatment in chronic hepatitis C is not fully understood, and may include modulation of the immune system as well as a direct antiviral effect. We have therefore evaluated the plasma concentrations of pro- and anti-inflammatory cytokin...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Naveau S,Emilie D,Borotto E,Portier A,Lazizi Y,Giraud V,Grangeot-Keros L,Capron F,Galanaud P,Chaput JC

    更新日期:1997-08-01 00:00:00

  • Elevated levels of serum carbohydrate deficient transferrin are not specific for alcohol abuse in patients with liver disease.

    abstract:BACKGROUND:Serum carbohydrate deficient transferrin is a marker of chronic alcohol consumption; it increases above normal in healthy individuals after a daily alcohol intake of more than 60 g/d for more than 2 weeks. The influence of liver disease itself on carbohydrate deficient transferrin levels has not been suffici...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Radosavljevic M,Temsch E,Hammer J,Pfeffel F,Mayer G,Renner F,Pidlich J,Muller C

    更新日期:1995-12-01 00:00:00