WITHDRAWN: Null genotypes of GSTM1 and GSTT1 both associated with increased hepatocellular carcinoma risk in Asians: new evidence.

abstract：BACKGROUND/AIMS:To compare carotid intima-media thickness (IMT) - an index of early atherosclerosis - among patients with non-alcoholic steatohepatitis (NASH), patients with chronic hepatitis B (HBV) or C (HCV) and control subjects. METHODS:We studied 60 consecutive patients with biopsy-proven NASH, 60 patients with H...

journal_title：Journal of hepatology

authors： Targher G,Bertolini L,Padovani R,Rodella S,Arcaro G,Day C

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND/AIMS:To review our experience of thrombolytic therapy in patients with acute Budd Chiari syndrome (BCS). METHODS:Records of 10 patients with BCS, treated by thrombolysis over a 12-year period were retrospectively analysed for demographics, clinical presentation/duration, primary disease, thrombolytic regime...

journal_title：Journal of hepatology

authors： Sharma S,Texeira A,Texeira P,Elias E,Wilde J,Olliff SP

更新日期：2004-01-01 00:00:00

abstract：:Pulmonary concerns in liver transplant candidates have intraoperative and outcome implications. Evolving MELD exception policies address transplant priority for problems such as hepatopulmonary syndrome, portopulmonary hypertension, and hemorrhagic hereditary telangiectasia. Other pulmonary issues such as refractory h...

journal_title：Journal of hepatology

authors： Krowka MJ,Wiesner RH,Heimbach JK

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study was to determine the prevalence and clinical significance of hepatitis C virus (HCV) infection in patients with the antiphospholipid syndrome (APS). METHODS:A series of 88 consecutive patients (78 female and 10 male), with a mean age of 39 years (range 15-79), was prospectively st...

journal_title：Journal of hepatology

authors： Muñoz-Rodríguez FJ,Tàssies D,Font J,Reverter JC,Cervera R,Sánchez-Tapias JM,Mazzara R,Ordinas A,Ingelmo M

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND & AIMS:Emricasan, an oral pan-caspase inhibitor, decreased portal pressure in experimental cirrhosis and in an open-label study in patients with cirrhosis and severe portal hypertension, defined as a hepatic venous pressure gradient (HVPG) ≥12 mmHg. We aimed to confirm these results in a placebo-controlled s...

journal_title：Journal of hepatology

authors： Garcia-Tsao G,Bosch J,Kayali Z,Harrison SA,Abdelmalek MF,Lawitz E,Satapathy SK,Ghabril M,Shiffman ML,Younes ZH,Thuluvath PJ,Berzigotti A,Albillos A,Robinson JM,Hagerty DT,Chan JL,Sanyal AJ,IDN-6556-14 Investigators(‡).

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND & AIMS:Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease usually requiring life-long immunosuppression. The mechanisms for disease initiation and chronicity are largely unknown. A contribution of deficient regulatory T cells (Tregs) in the blood was controversially discussed recently. So far i...

journal_title：Journal of hepatology

authors： Taubert R,Hardtke-Wolenski M,Noyan F,Wilms A,Baumann AK,Schlue J,Olek S,Falk CS,Manns MP,Jaeckel E

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND/AIMS:Most hepatocellular carcinomas are still discovered at an advanced stage and are left untreated as large hepatocellular carcinomas are contraindications to liver transplantation and percutaneous ethanol injection and are usually considered as poor indications for liver resection. The aim of this study w...

journal_title：Journal of hepatology

authors： Régimbeau JM,Farges O,Shen BY,Sauvanet A,Belghiti J

更新日期：1999-12-01 00:00:00

abstract：:In the human fetal liver, CYP3A7 is expressed as early as the 13th week of gestation. This continues to the perinatal period when it is sharply repressed prior to birth. Concomitantly, the expression of CYP3A4, not detectable in the fetus, sharply increases in the perinatal period to remain elevated throughout adultho...

journal_title：Journal of hepatology

authors： Ourlin JC,Jounaïdi Y,Maurel P,Vilarem MJ

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIMS:Gadolinium chloride inactivates Kupffer cells and alleviates alcohol-induced liver lesions. We investigated the mechanism of gadolinium chloride protection after oral ethanol feeding. METHODS:Rats were maintained ethanol-intoxicated for 6 weeks by feeding ethanol in a low-carbohydrate/high-fat liquid d...

journal_title：Journal of hepatology

authors： Järveläinen HA,Fang C,Ingelman-Sundberg M,Lukkari TA,Sippel H,Lindros KO

更新日期：2000-06-01 00:00:00

abstract：:Recently reports have indicated that both cimetidine and ranitidine delay cell proliferation in rats following 70% partial hepatectomy and result in an increased mortality following this procedure. The present study was designed to determine whether three H2 blocking agents (cimetidine, ranitidine, famotidine) and a n...

journal_title：Journal of hepatology

authors： Francavilla A,Panella C,Polimeno L,Di Leo A,Makowka L,Barone M,Amoruso A,Ingrosso M,Starzl TE

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND & AIMS:Liver macrophages can be involved in both pathogen clearance and/or pathogenesis. To get further insight on their role during chronic hepatitis B virus (HBV) infections, our aim was to phenotypically and functionally characterize in vivo and ex vivo the interplay between HBV, primary human liver macro...

journal_title：Journal of hepatology

authors： Faure-Dupuy S,Delphin M,Aillot L,Dimier L,Lebossé F,Fresquet J,Parent R,Matter MS,Rivoire M,Bendriss-Vermare N,Salvetti A,Heide D,Flores L,Klumpp K,Lam A,Zoulim F,Heikenwälder M,Durantel D,Lucifora J

更新日期：2019-12-01 00:00:00

abstract：:Hepatitis B virus (HBV) remains a major risk of transfusion-transmitted infection due to the pre-seroconversion window period (WP), infection with immunovariant viruses, and with occult carriage of HBV infection (OBI). Reduction of HBV residual risk depends upon developing more sensitive HBV surface antigen (HBsAg) te...

journal_title：Journal of hepatology

authors： Candotti D,Allain JP

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis B virus (HBV) disease is caused by both necroinflammation and active viral replication. The role of ALT levels as a predictor of liver injury has recently been questioned. The aim of the study was to determine whether normal ALT is associated with liver injury in a cohort of HBV patien...

journal_title：Journal of hepatology

authors： Lai M,Hyatt BJ,Nasser I,Curry M,Afdhal NH

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic stellate cells (HSCs) have a role in liver fibrosis. Guanine nucleotide-binding α-subunit 12 (Gα12) converges signals from G-protein-coupled receptors whose ligand levels are elevated in the environment during liver fibrosis; however, information is lacking on the effect of Gα12 on HSC trans-d...

journal_title：Journal of hepatology

authors： Kim KM,Han CY,Kim JY,Cho SS,Kim YS,Koo JH,Lee JM,Lim SC,Kang KW,Kim JS,Hwang SJ,Ki SH,Kim SG

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition and the most common liver disease worldwide, affecting more than one-third of the population. So far there have been no reports on mendelian inheritance in families with NAFLD. METHODS:We performed whole-exome or targeted next-ge...

journal_title：Journal of hepatology

authors： Youssefian L,Vahidnezhad H,Saeidian AH,Pajouhanfar S,Sotoudeh S,Mansouri P,Amirkashani D,Zeinali S,Levine MA,Peris K,Colombo R,Uitto J

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND/AIMS:We developed a bioartificial liver (BAL) based on a direct hemoperfusion typed nonwoven fabric bioreactor containing porcine hepatocytes. In this study, the efficacy of our BAL was evaluated with a pig fulminant hepatic failure (FHF) model. METHODS:FHF was induced with intravenous administration of D-g...

journal_title：Journal of hepatology

authors： Li LJ,Du WB,Zhang YM,Li J,Pan XP,Chen JJ,Cao HC,Chen Y,Chen YM

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND/METHODS:The cause of fulminant hepatitis is still not fully understood. We studied 23 patients with fulminant hepatitis, using polymerase chain reaction to detect hepatitis virus genomes. Tests for HBsAg and IgM anti-HAV and IgM anti-HBc were performed in all patients. Serum samples were stored at -70 degree...

journal_title：Journal of hepatology

authors： Inokuchi K,Nakata K,Hamasaki K,Daikoku M,Nakao K,Kato Y,Yatsuhashi H,Koga M,Yano M,Nagataki S

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND/AIMS:The relationship between HCV RNA levels and the severity of HCV-related liver disease has been addressed in a few studies, which has led to conflicting results. To clarify this point, we studied serum HCV RNA levels in patients with HCV liver disease at various stages, using a second-generation branched...

journal_title：Journal of hepatology

authors： Duvoux C,Pawlotsky JM,Bastie A,Cherqui D,Soussy CJ,Dhumeaux D

更新日期：1999-10-01 00:00:00

abstract：:Drug induced hepatotoxicity has been reported infrequently with sulfonylureas. For glimepiride, a second-generation sulfonylurea there is no report of hepatotoxicity in English literature. A patient with non-insulin-dependent diabetes mellitus who developed cholestatic liver injury soon after initiation of glimepiride...

journal_title：Journal of hepatology

authors： Chounta A,Zouridakis S,Ellinas C,Tsiodras S,Zoumpouli C,Kopanakis S,Giamarellou H

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND/AIM:Liver cirrhosis is accompanied by a fall in whole-body protein turnover and alterations of the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis. However, the influence of liver cirrhosis on the GH/IGF-1 axis in the perioperative period, and the contribution of the GH/IGF-1 axis alteration in...

journal_title：Journal of hepatology

authors： Inaba T,Saito H,Inoue T,Han I,Furukawa S,Matsuda T,Ikeda S,Muto T

更新日期：1999-08-01 00:00:00

abstract：:Thirty-two patients with chronic hepatitis B were randomly assigned to two groups. Sixteen patients received 10 million units of alpha-interferon per square meter of body surface (MU/m2), three times weekly for 4 months. Sixteen patients were treated simultaneously with gamma-interferon at a dose of 2 MU/m2, and 10 MU...

journal_title：Journal of hepatology

authors： Carreño V,Moreno A,Galiana F,Bartolomé FJ

更新日期：1993-03-01 00:00:00

abstract：:Ten patients with non-alcoholic cirrhosis and ten control subjects were studied in basal conditions and after ingestion of a standard mixed test meal. Plasma somatostatin, blood glucose, plasma insulin, C-peptide and glucagon were determined before and 15, 30, 45, 60, 90, 120 and 180 min after the start of the meal. B...

journal_title：Journal of hepatology

authors： Barreca T,Franceschini R,Cataldi A,Rolandi E

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIMS:Extrahepatic biliary atresia (EHBA) and chronic progressive intra-hepatic cholestasis (Byler's disease) are two distinct disorders of unknown etiology in the neonate, characterized by profound cholestasis. The aim of the present study was to investigate the inflammatory reaction in liver tissue from pat...

journal_title：Journal of hepatology

authors： Broomé U,Nemeth A,Hultcrantz R,Scheynius A

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the present study was to compare MELD score, Child-Turcotte-Pugh (CTP) score, modified Maddrey's Discriminant Function (DF) score, and the related variables in predicting in-hospital mortality of patients with alcoholic hepatitis. METHODS:A retrospective chart review and statistical analyses...

journal_title：Journal of hepatology

authors： Srikureja W,Kyulo NL,Runyon BA,Hu KQ

更新日期：2005-05-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD has traditionally been considered a consequence of metabolic syndrome (MetS). However, the link between NAFLD and MetS components, especially typ...

journal_title：Journal of hepatology

authors： Lonardo A,Nascimbeni F,Mantovani A,Targher G

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND & AIMS:Recent studies have suggested that insulin resistance exerts a strong influence on chronic hepatitis C virus (HCV) infection. We analyzed pretreatment factors useful for predicting sustained virological response (SVR), especially interleukin (IL) 28B polymorphism and Homeostasis Model Assessment of In...

journal_title：Journal of hepatology

authors： Ogawa E,Furusyo N,Murata M,Ikezaki H,Ihara T,Hayashi T,Toyoda K,Taniai H,Okada K,Kainuma M,Hayashi J

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND/AIMS:Liver negative-strand hepatitis C virus (HCV) RNA is the most direct indicator of active viral replication but has only been examined in a few semiquantitative studies. METHODS:Positive- and negative-strand HCV RNA in the right (R) and left (L) liver lobes was quantified by rTth-based strand-specific r...

journal_title：Journal of hepatology

authors： Yuki N,Matsumoto S,Tadokoro K,Mochizuki K,Kato M,Yamaguchi T

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND & AIMS:Aceruloplasminemia is a rare autosomal recessive neurodegenerative disease associated with brain and liver iron accumulation which typically presents with movement disorders, retinal degeneration, and diabetes mellitus. Ceruloplasmin is a multi-copper ferroxidase that is secreted into plasma and facil...

journal_title：Journal of hepatology

authors： Finkenstedt A,Wolf E,Höfner E,Gasser BI,Bösch S,Bakry R,Creus M,Kremser C,Schocke M,Theurl M,Moser P,Schranz M,Bonn G,Poewe W,Vogel W,Janecke AR,Zoller H

更新日期：2010-12-01 00:00:00

abstract：:Advances in the management of the pulmonary complications of cystic fibrosis may result in an increasing prevalence of patients with chronic liver disease which may, therefore, become more important in the long-term management of cystic fibrosis patients. However, no simple and reliable test is available for the diagn...

journal_title：Journal of hepatology

authors： Williams SG,Evanson JE,Barrett N,Hodson ME,Boultbee JE,Westaby D

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND & AIMS:Adherence to antiviral treatment is important to achieve sustained virological response (SVR) in chronic hepatitis C (CHC). We evaluated the efficiency of a multidisciplinary support programme (MSP), based on published HIV treatment experience, to increase patient adherence and the efficacy of pegylat...

journal_title：Journal of hepatology

authors： Carrión JA,Gonzalez-Colominas E,García-Retortillo M,Cañete N,Cirera I,Coll S,Giménez MD,Márquez C,Martin-Escudero V,Castellví P,Navinés R,Castaño JR,Galeras JA,Salas E,Bory F,Martín-Santos R,Solà R

更新日期：2013-11-01 00:00:00