当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Accumulation of hydroxyethyl starch (HES) in the liver of patients with renal failure and portal hypertension.

Accumulation of hydroxyethyl starch (HES) in the liver of patients with renal failure and portal hypertension.

Abstract：

:Hydroxyethyl starch (HES) has gained wide clinical acceptance as a colloidal plasma substitute. We were able to study the liver biopsies of two patients with renal failure who developed ascites after repeated infusions of HES. All types of liver cells displayed massive accumulation of HES with the morphologic resemblance to a storage disease. These changes could be distinguished clearly from the lesions of a hereditary disorder by light and electron microscopy. Although it is difficult to establish a causative role for HES in the development of ascites on the bases of morphological changes alone, one should be cautious about giving HES to patients with renal failure until exact data from further experimental studies are available.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Dienes HP,Gerharz CD,Wagner R,Weber M,John HD

doi

10.1016/s0168-8278(86)80030-7

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

223-7

issue

2

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(86)80030-7

journal_volume

3

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Hematopoietic stem cell transplantation from non-replicative hepatitis B virus carriers is safe.

    abstract：BACKGROUND/AIMS:Hepatitis B virus can cause serious problems in individuals undergoing organ transplantation. The aim of this study was to evaluate the hepatic events among HBs-Ag positive recipients and HBs-Ag negative recipients who received products from hepatitis B virus carriers. METHODS:A total of 151 patients r...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80214-1

    authors： Ustün C,Idilman R,Gürman G,Ozcan M,Akyol G,Akan H,Ilhan O,Beksaç M,Uysal A,Konuk N,Karayalçin S,Poyraz A,Van Thiel D,Koç H

    更新日期：1999-08-01 00:00:00

  • Normal pharmacologically-induced, but decreased regenerative liver growth in interleukin-6-deficient (IL-6(-/-)) mice.

    abstract：BACKGROUND/AIMS:In the absence of liver damage, rapid liver growth can be induced pharmacologically by so-called primary liver growth promoters. The importance of the acute-phase cytokines interleukin-6 and tumor necrosis factor-alpha for the actions of these compounds is not clear. This study aimed to investigate the ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80130-0

    authors： Wallenius V,Wallenius K,Jansson JO

    更新日期：2000-12-01 00:00:00

  • Plasma somatostatin response to an oral mixed test meal in cirrhotic patients.

    abstract：:Ten patients with non-alcoholic cirrhosis and ten control subjects were studied in basal conditions and after ingestion of a standard mixed test meal. Plasma somatostatin, blood glucose, plasma insulin, C-peptide and glucagon were determined before and 15, 30, 45, 60, 90, 120 and 180 min after the start of the meal. B...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90906-r

    authors： Barreca T,Franceschini R,Cataldi A,Rolandi E

    更新日期：1991-01-01 00:00:00

  • Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease.

    abstract：BACKGROUND & AIMS:In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting protein kinase (RIPK) 1. Herein, we assessed the potential for RIPK1 and its downstream effector mixed lineage kinase domain-like protein (MLK...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.11.008

    authors： Majdi A,Aoudjehane L,Ratziu V,Islam T,Afonso MB,Conti F,Mestiri T,Lagouge M,Foufelle F,Ballenghien F,Ledent T,Moldes M,Cadoret A,Fouassier L,Delaunay JL,Aït-Slimane T,Courtois G,Fève B,Scatton O,Prip-Buus C,Rodrig

    更新日期：2020-04-01 00:00:00

  • Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: effects on protein-L-isoaspartyl methyltransferase activity.

    abstract：BACKGROUND/AIMS:Protein-L-isoaspartyl methyltransferase (PIMT) is a methyltransferase that plays a crucial role in the repair of damaged proteins. In this study, we investigated whether ethanol exposure causes an accumulation of modified proteins bearing atypical isoaspartyl residues that may be related to impaired PIM...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2007.01.026

    authors： Kharbanda KK,Mailliard ME,Baldwin CR,Sorrell MF,Tuma DJ

    更新日期：2007-06-01 00:00:00

  • Hepatitis C virus genotype and RNA titer in the progression of type C chronic liver disease.

    abstract：:Hepatitis C virus genotype and the amounts of circulating HCV RNA are the most important factors in determining the efficacy of interferon therapy for chronic hepatitis C. To clarify the correlation of these two factors to the progression of liver disease, we classified 148 Japanese patients with type C chronic liver ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80330-7

    authors： Mita E,Hayashi N,Kanazawa Y,Hagiwara H,Ueda K,Kasahara A,Fusamoto H,Kamada T

    更新日期：1994-09-01 00:00:00

  • The impact of waiting list alpha-fetoprotein changes on the outcome of liver transplant for hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:Liver transplantation is a recognized treatment for selected patients with hepatocellular carcinoma (HCC), but transplant criteria still need to be refined, especially in the case of more advanced or downstaged tumors. METHODS:The present study investigated alpha-fetoprotein (AFP) as a predictor of o...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.12.040

    authors： Merani S,Majno P,Kneteman NM,Berney T,Morel P,Mentha G,Toso C

    更新日期：2011-10-01 00:00:00

  • Complete nucleotide sequence and viral envelope protein expression of a hepatitis B virus DNA derived from a hepatitis B surface antigen-seronegative patient.

    abstract：:An HBV strain isolated from a patient lacking conventional serological markers of HBV infection was characterized. The complete nucleotide sequence was determined following PCR amplification. Only 22 nucleotide substitutions were found relative to the reported sequence of the ayw subtype. Five of these point mutations...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80252-1

    authors： Kremsdorf D,Garreau F,Duclos H,Thiers V,Schellekens H,Petit MA,Bréchot C

    更新日期：1993-06-01 00:00:00

  • Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant.

    abstract：:A patient with evidence of chronic infection with hepatitis B virus (seropositive for hepatitis B surface antigen, and with antibody to hepatitis B e antigen) underwent renal transplantation, which subsequently failed. The patient developed abnormal liver function tests and 8 months after the removal of the transplant...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80116-2

    authors： Booth JC,Goldin RD,Brown JL,Karayiannis P,Thomas HC

    更新日期：1995-04-01 00:00:00

  • MELD score is better than Child-Pugh score in predicting 3-month survival of patients undergoing transjugular intrahepatic portosystemic shunt.

    abstract：BACKGROUND/AIMS:Patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) are at risk of early death due to end-stage liver failure. The aim of this study was to compare model of end-stage liver disease (MELD) and Child-Pugh scores as predictors of survival after TIPS. METHODS:We studied 140 cirrhotic p...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00309-9

    authors： Salerno F,Merli M,Cazzaniga M,Valeriano V,Rossi P,Lovaria A,Meregaglia D,Nicolini A,Lubatti L,Riggio O

    更新日期：2002-04-01 00:00:00

  • A specific immune response to purified HA antigen (HAAg) demonstrated by leukocyte migration inhibition in patients recovering from viral hepatitis A.

    abstract：:The mechanism responsible for liver cell necrosis in patients with hepatitis A is not known. Since the type of hepatic lesions and the clinical presentation of acute hepatitis B are similar and are probably related to the cell-mediated immune response to a viral antigen located in the liver cell, it is possible that a...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80082-4

    authors： Fasel-Folley J,Overby LR,Frei PC

    更新日期：1986-01-01 00:00:00

  • Detection of HDV-RNA by PCR in serum of patients with chronic HDV infection.

    abstract：:In this paper, we studied the usefulness of polymerase chain reaction (PCR) in HDV-RNA detection. Using serial dilutions of serum samples of known concentrations of HDV-RNA, PCR was 10,000-times more sensitive than slot-blot hybridization. PCR was used for the detection of HDV-RNA in 33 serum samples negative to HDV-R...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(90)90225-g

    authors： Madejón A,Castillo I,Bartolomé J,Melero M,Campillo ML,Porres JC,Moreno A,Carreño V

    更新日期：1990-11-01 00:00:00

  • Overexpression of the two nucleotide excision repair genes ERCC1 and XPC in human hepatocellular carcinoma.

    abstract：BACKGROUND/AIMS:Little is known about the nucleotide excision repair (NER) pathway in the resistance of human hepatocellular carcinoma (HCC) to chemotherapeutics. We investigated expression of several NER genes in human HCC and matching non-tumor tissue (NT) and in normal liver. METHODS:Expression of CSA, CSB, XPC, hH...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.02.020

    authors： Fautrel A,Andrieux L,Musso O,Boudjema K,Guillouzo A,Langouët S

    更新日期：2005-08-01 00:00:00

  • Behavior and significance of autoantibodies in type 1 autoimmune hepatitis.

    abstract：BACKGROUND/AIM:Smooth muscle antibodies and antinuclear antibodies characterize type 1 autoimmune hepatitis. Our aim was to correlate the appearance and disappearance of these autoantibodies with clinical and histological events. METHODS:One hundred and seven patients were evaluated successively over 128+/-9 months. A...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80096-8

    authors： Czaja AJ

    更新日期：1999-03-01 00:00:00

  • Interleukin-1α deficiency attenuates endoplasmic reticulum stress-induced liver damage and CHOP expression in mice.

    abstract：BACKGROUND & AIMS:ER stress promotes liver fat accumulation and induction of inflammatory cytokines, which contribute to the development of steatohepatitis. Unresolved ER stress upregulates the pro-apoptotic CHOP. IL-1α is localized to the nucleus in apoptotic cells, but is released when these cells become necrotic and...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.05.012

    authors： Kandel-Kfir M,Almog T,Shaish A,Shlomai G,Anafi L,Avivi C,Barshack I,Grosskopf I,Harats D,Kamari Y

    更新日期：2015-10-01 00:00:00

  • Endpoints and design of clinical trials in patients with decompensated cirrhosis: Position paper of the LiverHope Consortium.

    abstract：:Management of decompensated cirrhosis is currently geared towards the treatment of complications once they occur. To date there is no established disease-modifying therapy aimed at halting progression of the disease and preventing the development of complications in patients with decompensated cirrhosis. The design of...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.08.009

    authors： Solà E,Pose E,Campion D,Piano S,Roux O,Simon-Talero M,Uschner F,de Wit K,Zaccherini G,Alessandria C,Beuers U,Caraceni P,Francoz C,Mookerjee RP,Trebicka J,Vargas V,Serra M,Torres F,Montagnese S,Krag A,Hernaez R,K

    更新日期：2021-01-01 00:00:00

  • Transjugular intrahepatic portosystemic stent-shunt (TIPSS) occlusion and the role of biliary venous fistulae.

    abstract：BACKGROUND/AIM:The aim of this study was to assess the pathology and pathogenic mechanisms involved in the occlusion of transjugular intrahepatic portosystemic stent-shunts. METHODS:Thirty-four patients with transjugular intrahepatic portosystemic stent-shunt who had at least two portographic assessments of shunt func...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0168-8278(96)80026-2

    authors： Jalan R,Harrison DJ,Redhead DN,Hayes PC

    更新日期：1996-02-01 00:00:00

  • Evaluation of a bioartificial liver based on a nonwoven fabric bioreactor with porcine hepatocytes in pigs.

    abstract：BACKGROUND/AIMS:We developed a bioartificial liver (BAL) based on a direct hemoperfusion typed nonwoven fabric bioreactor containing porcine hepatocytes. In this study, the efficacy of our BAL was evaluated with a pig fulminant hepatic failure (FHF) model. METHODS:FHF was induced with intravenous administration of D-g...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.08.006

    authors： Li LJ,Du WB,Zhang YM,Li J,Pan XP,Chen JJ,Cao HC,Chen Y,Chen YM

    更新日期：2006-02-01 00:00:00

  • Functional activity of isolated pig hepatocytes attached to different extracellular matrix substrates. Implication for application of pig hepatocytes in a bioartificial liver.

    abstract：:For the manufacture of a bioartificial liver for human application, large amounts of viable and active hepatocytes are needed. Pig hepatocytes are considered to be the best alternative to scarce human hepatocytes. In vitro hepatocyte functions have so far been tested under different circumstances, mainly with rat hepa...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80333-5

    authors： te Velde AA,Ladiges NC,Flendrig LM,Chamuleau RA

    更新日期：1995-08-01 00:00:00

  • Quantitation of hepatitis B lamivudine resistant mutants by real-time amplification refractory mutation system PCR.

    abstract：BACKGROUND/AIMS:Lamivudine is an antiviral drug that is used to treat hepatitis B virus (HBV) infection. Long-term therapy does not completely suppress viral replication, and resistant mutants emerge. Resistance is mediated by changes in the tyrosine-methionine-apartate-aspartate (YMDD) motif in the catalytic site of t...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.02.009

    authors： Punia P,Cane P,Teo CG,Saunders N

    更新日期：2004-06-01 00:00:00

  • Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients.

    abstract：BACKGROUND & AIMS:Innate sensing of viral infection activates a global defense response including type I interferon (IFN) and IFN-stimulated genes (ISGs) expression. We previously reported that HCV NS3/4A protease, an essential protein in viral polyprotein processing, can abrogate antiviral signaling pathways and effec...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2011.07.017

    authors： Jouan L,Chatel-Chaix L,Melançon P,Rodrigue-Gervais IG,Raymond VA,Selliah S,Bilodeau M,Grandvaux N,Lamarre D

    更新日期：2012-01-01 00:00:00

  • Tauroursodeoxycholate prevents taurolithocholate-induced cholestasis and toxicity in rat liver.

    abstract：:Ursodeoxycholate has been advocated for the treatment of cholestatic liver diseases. The coinfusion of tauroursodeoxycholate with taurolithocholate in the perfused rat liver completely prevented the decrease of bile flow and the increase of oxygen uptake found with taurolithocholate only. Bile flow and bile salt secre...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(90)90133-c

    authors： Schölmerich J,Baumgartner U,Miyai K,Gerok W

    更新日期：1990-05-01 00:00:00

  • Phase 2 study of the combination of merimepodib with peginterferon-alpha2b, and ribavirin in nonresponders to previous therapy for chronic hepatitis C.

    abstract：BACKGROUND/AIMS:While combination of peginterferon-alpha (PEG-IFN) and ribavirin (RBV) therapy is the current standard of care for chronic hepatitis C (CHC), only 44-51% of genotype-1 patients achieve a sustained virological response (SVR), and both agents produce treatment-limiting toxicities. In the hepatitis C virus...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jhep.2007.03.028

    authors： Marcellin P,Horsmans Y,Nevens F,Grange JD,Bronowicki JP,Vetter D,Purdy S,Garg V,Bengtsson L,McNair L,Alam J

    更新日期：2007-10-01 00:00:00

  • Mechanism of hepatic fatty acid uptake.

    abstract：:In recent years a new concept of the mechanism of hepatic fatty acid uptake has been described. It was shown that this major class of energy yielding substrates enters hepatocytes by a carrier-mediated uptake system. After the dissociation of the fatty acid-albumin complex at the sinusoidal liver cell plasma membrane,...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/0168-8278(89)90148-7

    authors： Stremmel W

    更新日期：1989-11-01 00:00:00

  • Early post-transplant survival: Interaction of MELD score and hospitalization status.

    abstract：BACKGROUND & AIMS:Urgency-based allocation that relies on the MELD score prioritizes patients at the highest risk of waitlist mortality. However, identifying patients at greatest risk for short-term post-transplant mortality is needed in order to optimize the potential gains in overall survival obtained through improve...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.03.034

    authors： Bittermann T,Makar G,Goldberg DS

    更新日期：2015-09-01 00:00:00

  • Selection for a pre-C stop codon mutation in a hepatitis B virus variant with a pre-C initiation codon mutation during interferon treatment.

    abstract：:Hepatitis B virus (HBV) variants with a stop codon, a mutated translation initiation codon or other mutations in the pre-C region which prevent e-antigen expression are highly prevalent in anti-HBe chronic carriers and can be positively selected from a mixed virus infection. Our laboratories recently described pre-C v...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90083-n

    authors： Santantonio T,Jung MC,Schneider R,Pastore G,Pape GR,Will H

    更新日期：1991-11-01 00:00:00

  • Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins.

    abstract：BACKGROUND/AIMS:Bacillus Calmette Guerin (BCG) infection causes hepatic injury following granuloma formation and secretion of cytokines which render mice highly sensitive to endotoxin-mediated hepatotoxicity. This work investigates the role of inducible nitric oxide synthase (iNOS) in liver damage induced by BCG and en...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.07.031

    authors： Guler R,Olleros ML,Vesin D,Parapanov R,Vesin C,Kantengwa S,Rubbia-Brandt L,Mensi N,Angelillo-Scherrer A,Martinez-Soria E,Tacchini-Cottier F,Garcia I

    更新日期：2004-11-01 00:00:00

  • Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered.

    abstract：BACKGROUND/AIMS:Currently the diagnosis and severity of hepatic steatosis can be established accurately only by liver biopsy. Previous small studies found that steatosis measured by magnetic resonance spectroscopy (MRS) and imaging (MRI) correlated with histological assessment of liver triglyceride content. However, th...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.04.012

    authors： McPherson S,Jonsson JR,Cowin GJ,O'Rourke P,Clouston AD,Volp A,Horsfall L,Jothimani D,Fawcett J,Galloway GJ,Benson M,Powell EE

    更新日期：2009-08-01 00:00:00

  • Influence of superimposed alcoholic hepatitis on the outcome of liver transplantation for end-stage alcoholic liver disease.

    abstract：BACKGROUND/AIMS:Alcoholic cirrhosis is a common indication for liver transplantation. The present study was aimed to assess the influence of superimposed alcoholic hepatitis on the outcome of liver transplantation in patients with alcoholic cirrhosis. METHODS:Survival rates of 68 patients transplanted for alcoholic ci...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(02)00047-8

    authors： Tomé S,Martinez-Rey C,González-Quintela A,Gude F,Brage A,Otero E,Abdulkader I,Forteza J,Bustamante M,Varo E

    更新日期：2002-06-01 00:00:00

  • Pharmacological thrombolysis in Budd Chiari syndrome: a single centre experience and review of the literature.

    abstract：BACKGROUND/AIMS:To review our experience of thrombolytic therapy in patients with acute Budd Chiari syndrome (BCS). METHODS:Records of 10 patients with BCS, treated by thrombolysis over a 12-year period were retrospectively analysed for demographics, clinical presentation/duration, primary disease, thrombolytic regime...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2003.09.028

    authors： Sharma S,Texeira A,Texeira P,Elias E,Wilde J,Olliff SP

    更新日期：2004-01-01 00:00:00