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Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant.

Abstract：

:A patient with evidence of chronic infection with hepatitis B virus (seropositive for hepatitis B surface antigen, and with antibody to hepatitis B e antigen) underwent renal transplantation, which subsequently failed. The patient developed abnormal liver function tests and 8 months after the removal of the transplanted kidney, hepatitis B virus DNA was detected in the serum in the absence of hepatitis B e antigen. Liver biopsy revealed the presence of fibrosing cholestatic hepatitis. Sequence analysis of the serum hepatitis B virus DNA showed the presence of the pre-core mutant. This case shows that fibrosing cholestatic hepatitis can occur outside the setting of liver transplantation, and coincided with the development of the pre-core mutant of hepatitis B virus.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Booth JC,Goldin RD,Brown JL,Karayiannis P,Thomas HC

doi

10.1016/0168-8278(95)80116-2

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

500-3

issue

4

eissn

0168-8278

issn

1600-0641

pii

0168-8278(95)80116-2

journal_volume

22

pub_type

杂志文章

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