当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Cyclooxygenase-1 inhibition corrects endothelial dysfunction in cirrhotic rat livers.

Cyclooxygenase-1 inhibition corrects endothelial dysfunction in cirrhotic rat livers.

Abstract：

BACKGROUND/AIMS:Cirrhotic livers exhibit endothelial dysfunction that contributes to the increased hepatic vascular resistance. The present study evaluates the role of cyclooxygenase (COX)-derived prostanoids, implicated in the pathogenesis of endothelial dysfunction in other settings, in the pathogenesis of endothelial dysfunction in cirrhotic livers. METHODS:Endothelial dysfunction was evaluated by performing concentration-effect curves to acetylcholine after precontracting the liver with methoxamine in groups of control and CCl(4)-cirrhotic rat livers preincubated either with vehicle, indomethacin, the COX-1 selective inhibitor, SC-560, the COX-2 selective inhibitor, SC-236, the thromboxane A(2) receptor antagonist, SQ 29,548 or the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine. Thromboxane A(2) (TXA(2)) production was determined in samples of the perfusate. RESULTS:Cirrhotic livers exhibited endothelial dysfunction, as shown by the significantly lower relaxation to acetylcholine than control livers, that was totally corrected by indomethacin. COX-1 inhibition and TXA(2) blockade, but not COX-2 inhibition, also corrected endothelial dysfunction. Acetylcholine significantly increased TXA(2) production in cirrhotic but not in control livers. Indomethacin and COX-1 inhibition, but not COX-2 or NO inhibition, prevented the increased production of TXA(2). CONCLUSIONS:An increased production of TXA(2) is involved in the pathogenesis of endothelial dysfunction in cirrhotic rat livers. This is mainly mediated by COX-1, but not by COX-2.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Graupera M,García-Pagán JC,Parés M,Abraldes JG,Roselló J,Bosch J,Rodés J

doi

10.1016/s0168-8278(03)00347-7

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

515-21

issue

4

eissn

0168-8278

issn

1600-0641

pii

S0168827803003477

journal_volume

39

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome.

    abstract：BACKGROUND/AIMS:We conducted an analysis of chromosomal numerical aberrations and their clinical significance in hepatocellular carcinoma. METHODS:We analyzed 87 hepatocellular carcinomas by array-based comparative genomic hybridization with an array containing 800 bacterial artificial chromosome clones. RESULTS:Freq...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.05.033

    authors： Katoh H,Shibata T,Kokubu A,Ojima H,Loukopoulos P,Kanai Y,Kosuge T,Fukayama M,Kondo T,Sakamoto M,Hosoda F,Ohki M,Imoto I,Inazawa J,Hirohashi S

    更新日期：2005-11-01 00:00:00

  • Hsp72 protects against liver injury via attenuation of hepatocellular death, oxidative stress, and JNK signaling.

    abstract：BACKGROUND & AIMS:Heat shock protein (Hsp) 72 is a molecular chaperone that has broad cytoprotective functions and is upregulated in response to stress. To determine its hepatic functions, we studied its expression in human liver disorders and its biological significance in newly generated transgenic animals. METHODS:...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2018.01.003

    authors： Levada K,Guldiken N,Zhang X,Vella G,Mo FR,James LP,Haybaeck J,Kessler SM,Kiemer AK,Ott T,Hartmann D,Hüser N,Ziol M,Trautwein C,Strnad P

    更新日期：2018-05-01 00:00:00

  • Differential effect of ARA-AMP on serum DNA polymerase activity and serum HBV-DNA in chronic hepatitis B virus infection. A possible reason for lack of efficacy.

    abstract：:An uncontrolled pilot study of adenine arabinoside monophosphate intramuscularly (ARA-AMP) for 5 days at 10 mg/kg/day and 23 days at 5 mg/kg/day in divided doses, was conducted in 15 consecutive patients known to be HBeAg-positive for a minimum of 12 months. Two patients were lost to follow-up (1 having developed an h...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80104-0

    authors： Alexander GJ,Fagan EA,Rolando N,Guarner P,Callender ME,Eddleston AL,Williams R

    更新日期：1986-01-01 00:00:00

  • Elevation of the serum bilirubin diconjugate fraction provides an early marker for cholestasis in the rat.

    abstract：AIMS/METHODS:During cholestasis, components normally excreted into bile, e.g. bilirubin, accumulate in liver cells and biliary passages. In order to assess the conjugation of bilirubin retained in the hepatocyte during cholestasis, we analyzed the pattern of bilirubin pigments in rat serum and bile, using reversed phas...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80330-3

    authors： Mesa VA,De Vos R,Fevery J

    更新日期：1997-11-01 00:00:00

  • The hydroxyl radical scavengers dimethylsulfoxide and dimethylthiourea protect rats against thioacetamide-induced fulminant hepatic failure.

    abstract：BACKGROUND/AIMS:Reactive oxygen species, proinflammatory cytokines, glutathione depletion and nitric oxide have all been implicated in the pathogenesis of fulminant hepatic failure. The aim of the present study was to examine the respective roles of these factors in the pathogenesis of thioacetamide-induced fulminant h...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80160-3

    authors： Bruck R,Aeed H,Shirin H,Matas Z,Zaidel L,Avni Y,Halpern Z

    更新日期：1999-07-01 00:00:00

  • The role of thiazolidinediones in non-alcoholic steatohepatitis - a systematic review and meta analysis.

    abstract：BACKGROUND & AIMS:Non alcoholic steatohepatitis (NASH) has no approved pharmacological therapy. Insulin sensitisers such as thiazolidinediones ameliorate insulin resistance and are a potential therapeutic option. We performed a systematic review and meta-analysis of the effect of thiazolidinediones on histological and ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jhep.2011.03.016

    authors： Mahady SE,Webster AC,Walker S,Sanyal A,George J

    更新日期：2011-12-01 00:00:00

  • Inhibition of nitric oxide production increases dimethylnitrosamine-induced liver injury in rats.

    abstract：:Intravascular coagulation is involved in the development of certain types of liver injury, including that induced by dimethylnitrosamine. Nitric oxide inhibits platelet aggregation and adhesion; however, its role in protecting against intravascular coagulation has not been clarified. We therefore investigated the effe...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80068-9

    authors： Nagase S,Isobe H,Ayukawa K,Sakai H,Nawata H

    更新日期：1995-11-01 00:00:00

  • Hepatitis B virus infection in lymphatic tissues in inactive hepatitis B carriers.

    abstract：BACKGROUND/AIMS:Hepatitis B virus (HBV) infection in extrahepatic tissues is controversial. To clarify whether episomal HBV can infect nonhepatic tissues, we investigated the molecular forms of HBV in the lymphatic cells of inactive HBV carriers who lacked viremia, thus avoiding contamination with HBV genomes originati...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.01.016

    authors： Umeda M,Marusawa H,Seno H,Katsurada A,Nabeshima M,Egawa H,Uemoto S,Inomata Y,Tanaka K,Chiba T

    更新日期：2005-06-01 00:00:00

  • Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores.

    abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) risk stratification in individuals with dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk scores (PRS) that can be evaluated in the clinic to gain insight into t...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.11.024

    authors： Bianco C,Jamialahmadi O,Pelusi S,Baselli G,Dongiovanni P,Zanoni I,Santoro L,Maier S,Liguori A,Meroni M,Borroni V,D'Ambrosio R,Spagnuolo R,Alisi A,Federico A,Bugianesi E,Petta S,Miele L,Vespasiani-Gentilucci U,Anstee

    更新日期：2020-11-25 00:00:00

  • Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population.

    abstract：:Abnormalities of carbohydrate metabolism, including hyperinsulinaemia and insulin resistance, are well recognised complications of cirrhosis. While diabetes mellitus can be explained in many instances on the basis of coincident pancreatic disease, in most the characteristic glucose intolerance of cirrhosis is not read...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80631-2

    authors： Allison ME,Wreghitt T,Palmer CR,Alexander GJ

    更新日期：1994-12-01 00:00:00

  • Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).

    abstract：BACKGROUND & AIMS:FibroTest™ (FT) and Transient Elastography (TE) have been validated as non-invasive markers of METAVIR fibrosis stages from F0 to F4 using biopsy, and as prognostic markers of liver related mortality in patients with chronic hepatitis C. The aim was to extend the validation of FT and TE as markers of ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.11.016

    authors： Poynard T,Vergniol J,Ngo Y,Foucher J,Munteanu M,Merrouche W,Colombo M,Thibault V,Schiff E,Brass CA,Albrecht JK,Rudler M,Deckmyn O,Lebray P,Thabut D,Ratziu V,de Ledinghen V,FibroFrance Study Group.,Epic3 Study Group.,

    更新日期：2014-04-01 00:00:00

  • Expression of liver-specific functions in rat hepatocytes following sublethal and lethal acetaminophen poisoning.

    abstract：AIM:In order to study the short-term effect of moderate and severe reduction of liver function by acetaminophen poisoning of different severity on gene expression for liver-specific functions, rats were given 3.75 and 7.5 g per kg body weight acetaminophen intragastrically. The lower dose is associated with low mortali...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80072-9

    authors： Tygstrup N,Jensen SA,Krog B,Dalhoff K

    更新日期：1996-08-01 00:00:00

  • Safety of the 2D/3D direct-acting antiviral regimen in HCV-induced Child-Pugh A cirrhosis - A pooled analysis.

    abstract：BACKGROUND & AIMS:Chronic hepatitis C virus (HCV)-infected patients with cirrhosis are a high-priority population for treatment. To help inform the benefit-risk profile of the all-oral direct-acting antiviral (DAA) combination regimen of ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir (OBV/PTV/r±DSV)...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2017.06.011

    authors： Poordad F,Nelson DR,Feld JJ,Fried MW,Wedemeyer H,Larsen L,Cohen DE,Cohen E,Mobashery N,Tatsch F,Foster GR

    更新日期：2017-10-01 00:00:00

  • Cellular immune response to hepatitis B virus antigens. An overview.

    abstract：:It has been suggested that the cellular immune response to HBV antigens is responsible for hepatocellular injury in acute and chronic hepatitis B. However, definitive immunological studies have so far been hampered by the lack of appropriate model systems to study HBV antigen-specific T cells. The availability of high...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-8278(88)80503-8

    authors： Ferrari C,Penna A,DegliAntoni A,Fiaccadori F

    更新日期：1988-08-01 00:00:00

  • Hepatitis B virus and human immunodeficiency virus drugs in pregnancy: findings from the Antiretroviral Pregnancy Registry.

    abstract：BACKGROUND & AIMS:Fetal safety of antiviral therapies is important given the long-term treatment of women with chronic hepatitis B (CHB) infection who may become pregnant. We analyzed neonatal safety data from the Antiretroviral Pregnancy Registry (APR), the largest safety database in pregnancy for antivirals used for ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.06.031

    authors： Brown RS Jr,Verna EC,Pereira MR,Tilson HH,Aguilar C,Leu CS,Buti M,Fagan EA

    更新日期：2012-11-01 00:00:00

  • Hepatocellular carcinoma decreases the chance of successful hepatitis C virus therapy with direct-acting antivirals.

    abstract：BACKGROUND & AIMS:The approval of all-oral direct-acting antiviral (DAA) regimens for the treatment of hepatitis C virus (HCV) has led to the expansion of therapy to include patients with cirrhosis who have hepatocellular carcinoma (HCC). Data on the use of DAAs in HCV+ patients with HCC is limited. The aim of this stu...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.01.020

    authors： Prenner SB,VanWagner LB,Flamm SL,Salem R,Lewandowski RJ,Kulik L

    更新日期：2017-06-01 00:00:00

  • Hematopoietic stem cell transplantation from non-replicative hepatitis B virus carriers is safe.

    abstract：BACKGROUND/AIMS:Hepatitis B virus can cause serious problems in individuals undergoing organ transplantation. The aim of this study was to evaluate the hepatic events among HBs-Ag positive recipients and HBs-Ag negative recipients who received products from hepatitis B virus carriers. METHODS:A total of 151 patients r...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80214-1

    authors： Ustün C,Idilman R,Gürman G,Ozcan M,Akyol G,Akan H,Ilhan O,Beksaç M,Uysal A,Konuk N,Karayalçin S,Poyraz A,Van Thiel D,Koç H

    更新日期：1999-08-01 00:00:00

  • Cost-effectiveness of semi-annual surveillance for hepatocellular carcinoma in cirrhotic patients of the Italian Liver Cancer population.

    abstract：BACKGROUND & AIMS:It was recently shown that semi-annual surveillance for hepatocellular carcinoma (HCC) in cirrhotic patients provides a prognostic advantage over the annual program; however, its cost-effectiveness (CE) in the general cirrhotic population still needs to be defined. METHODS:A Markov model was built to...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jhep.2011.11.022

    authors： Cucchetti A,Trevisani F,Cescon M,Ercolani G,Farinati F,Poggio PD,Rapaccini G,Nolfo MAD,Benvegnù L,Zoli M,Borzio F,Giannini EG,Caturelli E,Chiaramonte M,Pinna AD,Italian Liver Cancer (ITA.LI.CA) Group.

    更新日期：2012-05-01 00:00:00

  • Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C.

    abstract：BACKGROUND & AIMS:The mechanisms of treatment resistance to interferon (IFN) and ribavirin (Rib) combination therapy for hepatitis C virus (HCV) infection are not known. This study aims to gain insight into these mechanisms by exploring hepatic gene expression before and during treatment. METHODS:Liver biopsy was perf...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.04.036

    authors： Honda M,Nakamura M,Tateno M,Sakai A,Shimakami T,Shirasaki T,Yamashita T,Arai K,Yamashita T,Sakai Y,Kaneko S

    更新日期：2010-11-01 00:00:00

  • Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

    abstract：BACKGROUND & AIMS:Liver sinusoidal endothelial cells (LSECs) are prominent liver-resident antigen (cross-)presenting cells. LSEC cross-priming of naïve CD8 T cells does not require CD4 T cell help in contrast to priming by dendritic cells (DC) but leads to the formation of memory T cells that is preceded by transient G...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2016.12.015

    authors： Wittlich M,Dudek M,Böttcher JP,Schanz O,Hegenbarth S,Bopp T,Schmitt E,Kurts C,Garbers C,Rose John S,Knolle PA,Wohlleber D

    更新日期：2017-05-01 00:00:00

  • 96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B.

    abstract：BACKGROUND/AIMS:In order to prevent the occurrence of drug-resistant mutants associated with treatment for chronic hepatitis B virus (HBV) infection, combination therapy is being developed. To determine the efficacy of adefovir dipivoxil (ADV) plus emtricitabine (FTC) combination therapy in chronic HBV infection. METH...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jhep.2007.10.013

    authors： Hui CK,Zhang HY,Bowden S,Locarnini S,Luk JM,Leung KW,Yueng YH,Wong A,Rousseau F,Yuen KY,Naoumov NN,Lau GK

    更新日期：2008-05-01 00:00:00

  • Choosing the best endpoint.

    abstract：:Design and endpoints of clinical trials in hepatocellular carcinoma. Llovet JM, Di Bisceglie AM, Bruix J, Kramer BS, Lencioni R, Zhu AX, Sherman M, Schwartz M, Lotze M, Talwalkar J, Gores GJ; for the Panel of Experts in HCC-Design Clinical Trials. The design of clinical trials in hepatocellular carcinoma (HCC) is comp...

    journal_title：Journal of hepatology

    pub_type： 评论,杂志文章

    doi：10.1016/j.jhep.2008.07.012

    authors： Christensen E

    更新日期：2008-10-01 00:00:00

  • Alternatively activated macrophages promote resolution of necrosis following acute liver injury.

    abstract：BACKGROUND & AIM:Following acetaminophen (APAP) overdose, acute liver injury (ALI) can occur in patients that present too late for N-acetylcysteine treatment, potentially leading to acute liver failure, systemic inflammation, and death. Macrophages influence the progression and resolution of ALI due to their innate imm...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.02.031

    authors： Starkey Lewis P,Campana L,Aleksieva N,Cartwright JA,Mackinnon A,O'Duibhir E,Kendall T,Vermeren M,Thomson A,Gadd V,Dwyer B,Aird R,Man TY,Rossi AG,Forrester L,Park BK,Forbes SJ

    更新日期：2020-08-01 00:00:00

  • IL-6 pathway in the liver: From physiopathology to therapy.

    abstract：:Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple functions in the body. In the liver, IL-6 is an important inducer of the acute phase response and infection defense. IL-6 is furthermore crucial for hepatocyte homeostasis and is a potent hepatocyte mitogen. It is not only implicated...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2016.02.004

    authors： Schmidt-Arras D,Rose-John S

    更新日期：2016-06-01 00:00:00

  • Mechanism of hepatic fatty acid uptake.

    abstract：:In recent years a new concept of the mechanism of hepatic fatty acid uptake has been described. It was shown that this major class of energy yielding substrates enters hepatocytes by a carrier-mediated uptake system. After the dissociation of the fatty acid-albumin complex at the sinusoidal liver cell plasma membrane,...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/0168-8278(89)90148-7

    authors： Stremmel W

    更新日期：1989-11-01 00:00:00

  • Human serum albumin, systemic inflammation, and cirrhosis.

    abstract：:Human serum albumin (HSA) is one of the most frequent treatments in patients with decompensated cirrhosis. Prevention of paracentesis-induced circulatory dysfunction, prevention of type-1 HRS associated with bacterial infections, and treatment of type-1 hepatorenal syndrome are the main indications. In these indicatio...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2014.04.012

    authors： Arroyo V,García-Martinez R,Salvatella X

    更新日期：2014-08-01 00:00:00

  • Pulmonary contraindications, indications and MELD exceptions for liver transplantation: a contemporary view and look forward.

    abstract：:Pulmonary concerns in liver transplant candidates have intraoperative and outcome implications. Evolving MELD exception policies address transplant priority for problems such as hepatopulmonary syndrome, portopulmonary hypertension, and hemorrhagic hereditary telangiectasia. Other pulmonary issues such as refractory h...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2013.03.026

    authors： Krowka MJ,Wiesner RH,Heimbach JK

    更新日期：2013-08-01 00:00:00

  • Metabolic activity of microcarrier attached liver cells after intraperitoneal transplantation during severe liver insufficiency in the rat.

    abstract：:Short- and long-term effects of intraperitoneally transplanted microcarrier attached liver cells (MAL) have been studied in two experimental models of severe liver insufficiency in the rat: subtotal hepatectomy (HX) and acute liver ischemia. Intraperitoneal transplantation of MAL immediately after subtotal hepatectomy...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(89)90075-5

    authors： Bosman DK,de Haan JG,Smit J,Jorning GG,Maas MA,Chamuleau RA

    更新日期：1989-07-01 00:00:00

  • Expression of HLA antigens and T cell infiltrates in chronic viral hepatitis. A comparison of biopsy and fine-needle aspiration findings.

    abstract：:To evaluate the expression of hepatocyte HLA Class I and II antigens and the infiltration of CD8-positive lymphocytes in patients with chronic hepatitis, cells obtained by the technique of fine-needle aspiration were compared with those obtained by percutaneous liver biopsy. In general, correlation between cytological...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90937-7

    authors： Krawitt EL,Zannier A,Chossegros P,Gerard F,Chevallier M,Mutin M,Trepo C,Touraine JL

    更新日期：1991-03-01 00:00:00

  • Effect of HBV polymerase inhibitors on renal function in patients with chronic hepatitis B.

    abstract：BACKGROUND & AIMS:Therapy of chronic hepatitis B with HBV-polymerase inhibitors, in particular tenofovir or adefovir, may affect renal function. To assess renal function more accurately in the normal range, we used the recently validated, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2011.03.030

    authors： Mauss S,Berger F,Filmann N,Hueppe D,Henke J,Hegener P,Athmann C,Schmutz G,Herrmann E

    更新日期：2011-12-01 00:00:00