96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B.

abstract：BACKGROUND/AIMS:Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate ...

journal_title：Journal of hepatology

authors： Werner M,Almer S,Prytz H,Lindgren S,Wallerstedt S,Björnsson E,Bergquist A,Sandberg-Gertzén H,Hultcrantz R,Sangfelt P,Weiland O,Danielsson A

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND/AIMS:To examine the extent and mechanisms of apoptosis in cholestatic liver injury and to explore the role of the transcription factor nuclear factor-kappa B in protection against bile acid-induced apoptosis. METHODS:Cholestatic liver injury was induced by bile duct ligation in Wistar rats. Furthermore, pri...

journal_title：Journal of hepatology

authors： Schoemaker MH,Gommans WM,Conde de la Rosa L,Homan M,Klok P,Trautwein C,van Goor H,Poelstra K,Haisma HJ,Jansen PL,Moshage H

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic liver disease is characterized by fibrosis that may progress to cirrhosis. Nucleotide oligomerization domain 2 (Nod2), a member of the Nod-like receptor (NLR) family of intracellular immune receptors, plays an important role in the defense against bacterial infection through binding to the lig...

journal_title：Journal of hepatology

authors： Wang L,Hartmann P,Haimerl M,Bathena SP,Sjöwall C,Almer S,Alnouti Y,Hofmann AF,Schnabl B

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND/AIMS AND METHODS:The etiology of intrahepatic cholestasis of pregnancy (JCP) is unknown. We have performed comprehensive chromatographic and mass spectrometric analyses of progesterone metabolites and bile acids in serum and urine of six patients in order to characterize changes that might be of importance f...

journal_title：Journal of hepatology

authors： Meng LJ,Reyes H,Palma J,Hernandez I,Ribalta J,Sjövall J

更新日期：1997-08-01 00:00:00

abstract：:An uncontrolled pilot study of adenine arabinoside monophosphate intramuscularly (ARA-AMP) for 5 days at 10 mg/kg/day and 23 days at 5 mg/kg/day in divided doses, was conducted in 15 consecutive patients known to be HBeAg-positive for a minimum of 12 months. Two patients were lost to follow-up (1 having developed an h...

journal_title：Journal of hepatology

authors： Alexander GJ,Fagan EA,Rolando N,Guarner P,Callender ME,Eddleston AL,Williams R

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:The MAGE, GAGE and BAGE genes encode tumor antigens recognized by autologous cytotoxic T lymphocytes. The aim of this study was to evaluate the possibility of using these genes as molecular markers and as the targets of specific immunotherapy for human hepatocellular carcinoma (HCC). METHODS:The expres...

journal_title：Journal of hepatology

authors： Kobayashi Y,Higashi T,Nouso K,Nakatsukasa H,Ishizaki M,Kaneyoshi T,Toshikuni N,Kariyama K,Nakayama E,Tsuji T

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND & AIMS:Therapy of chronic hepatitis B with HBV-polymerase inhibitors, in particular tenofovir or adefovir, may affect renal function. To assess renal function more accurately in the normal range, we used the recently validated, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate ...

journal_title：Journal of hepatology

authors： Mauss S,Berger F,Filmann N,Hueppe D,Henke J,Hegener P,Athmann C,Schmutz G,Herrmann E

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND/AIMS:Intrahepatic cholestasis of pregnancy is characterized by pruritus and increased levels of serum bile acids, and is often associated with premature delivery, fetal distress, and perinatal mortality. The aims of the present study were: (i) to better define the serum bile acid profile in intrahepatic chol...

journal_title：Journal of hepatology

authors： Brites D,Rodrigues CM,Oliveira N,Cardoso M,Graça LM

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:The association between polyarteritis nodosa and viral hepatitis B infection is well established and still remains a therapeutic challenge. Famciclovir--a new nucleoside analog--has a broad spectrum of antiviral activity against herpes viruses and the human hepatitis B virus. CASE REPORT:A 56-year-old man w...

journal_title：Journal of hepatology

authors： Kruger M,Böker KH,Zeidler H,Manns MP

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND & AIMS:High oxidative stress plays a major role in increasing hepatic vascular resistance in cirrhosis, by facilitating liver fibrosis and by increasing hepatic vascular tone. This study is aimed at investigating whether the use of the novel isoform of recombinant human manganese superoxide dismutase (rMnSOD...

journal_title：Journal of hepatology

authors： Guillaume M,Rodriguez-Vilarrupla A,Gracia-Sancho J,Rosado E,Mancini A,Bosch J,Garcia-Pagán JC

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND/AIMS:In 2002, the first reported outbreak of hepatitis A virus (HAV) infection involving mostly intravenous drug users (IDU) occurred in Italy. We attempted a thorough evaluation of the outbreak, including epidemiological, clinical and virological analyses. METHODS:We conducted an epidemiological investigat...

journal_title：Journal of hepatology

authors： Spada E,Genovese D,Tosti ME,Mariano A,Cuccuini M,Proietti L,Giuli CD,Lavagna A,Crapa GE,Morace G,Taffon S,Mele A,Rezza G,Rapicetta M

更新日期：2005-12-01 00:00:00

abstract：:Linoleic and alpha-linolenic acids are the fatty acids designated as "essential" since they are not synthesized by mammalian cells and must be provided in the diet. The recent dietary shift towards the consumption of n-6 (omega-6) at the expense of n-3 (omega-3) polyunsaturated fatty acids (PUFAs) is thought to be a p...

journal_title：Journal of hepatology

authors： El-Badry AM,Graf R,Clavien PA

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND/AIMS:The roles of T cells, natural killer T cells (NKT) and macrophages in autoimmune hepatitis have been well documented. However, the roles of natural killer (NK) cells in liver injury remain obscure. Here we examined the effect of Polyinosinic: polycytidylic acid (PolyI:C)-activated NK cells on liver inju...

journal_title：Journal of hepatology

authors： Dong Z,Wei H,Sun R,Hu Z,Gao B,Tian Z

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND/AIMS:Despite anti-HBs immunoglobulin therapy, hepatitis B virus (HBV) infection recurs in a high proportion of patients transplanted for HBsAg positive and serum HBV DNA negative chronic liver disease. The contribution of HBV genetic variability to disease recurrence has not been yet thoroughly addressed. We...

journal_title：Journal of hepatology

authors： Brind A,Jiang J,Samuel D,Gigou M,Feray C,Bréchot C,Kremsdorf D

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND & AIMS:There is little information regarding the extent to which difficult to cure patients with advanced liver fibrosis, due to hepatitis C virus genotype-1 (HCV-1) can successfully and safely be treated with triple therapy with telaprevir (TVR), pegylated interferon alpha (P) and ribavirin (R). In the TVR ...

journal_title：Journal of hepatology

authors： Colombo M,Strasser S,Moreno C,Abrao Ferreira P,Urbanek P,Fernández I,Abdurakmonov D,Streinu-Cercel A,Verheyen A,Iraqi W,DeMasi R,Hill A,Lonjon-Domanec I,Wedemeyer H

更新日期：2014-11-01 00:00:00

abstract：:Rats were malnourished for 12 months with a highly inadequate fat-rich, calorie-sufficient but otherwise poly-deficient liquid diet composed of mashed potatoes with mayonnaise, comparable with the nutritional intake of many chronic alcoholics. When alcohol was incorporated into this diet, administered as whisky in dri...

journal_title：Journal of hepatology

authors： Bosma A,Seifert WF,van Thiel-de Ruiter GC,van Leeuwen RE,Blauw B,Roholl P,Knook DL,Brouwer A

更新日期：1994-09-01 00:00:00

abstract：:Recent progress in basic research has enhanced our understanding of the molecular mechanisms of normal bile secretion and their alterations in cholestasis. Genetic transporter variants contribute to an entire spectrum of cholestatic liver diseases and can cause hereditary cholestatic syndromes or determine susceptibil...

journal_title：Journal of hepatology

authors： Wagner M,Zollner G,Trauner M

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study was to determine the prevalence and clinical significance of hepatitis C virus (HCV) infection in patients with the antiphospholipid syndrome (APS). METHODS:A series of 88 consecutive patients (78 female and 10 male), with a mean age of 39 years (range 15-79), was prospectively st...

journal_title：Journal of hepatology

authors： Muñoz-Rodríguez FJ,Tàssies D,Font J,Reverter JC,Cervera R,Sánchez-Tapias JM,Mazzara R,Ordinas A,Ingelmo M

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND & AIMS:Although the growth suppressing Hippo pathway has been implicated in hepatocellular carcinoma (HCC) pathogenesis, it is unknown at which stage of hepatocarcinogenesis its dysregulation occurs. We investigated in rat and human preneoplastic lesions whether overexpression of the transcriptional co-activ...

journal_title：Journal of hepatology

authors： Perra A,Kowalik MA,Ghiso E,Ledda-Columbano GM,Di Tommaso L,Angioni MM,Raschioni C,Testore E,Roncalli M,Giordano S,Columbano A

更新日期：2014-11-01 00:00:00

abstract：:Reactivation of Hedgehog (Hh), a morphogenic signaling pathway that controls progenitor cell fate and tissue construction during embryogenesis occurs during many types of liver injury in adult. The net effects of activating the Hedgehog pathway include expansion of liver progenitor populations to promote liver regener...

journal_title：Journal of hepatology

authors： Omenetti A,Choi S,Michelotti G,Diehl AM

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND & AIMS:Toll-like receptor 4 (TLR4) plays an essential role in mediating organ injury in acute liver failure (ALF) and acute-on-chronic liver failure (ACLF). Herein, we assess whether inhibiting TLR4 signaling can ameliorate liver failure and serve as a potential treatment. METHODS:Circulating TLR4 ligands a...

journal_title：Journal of hepatology

authors： Engelmann C,Sheikh M,Sharma S,Kondo T,Loeffler-Wirth H,Zheng YB,Novelli S,Hall A,Kerbert AJC,Macnaughtan J,Mookerjee R,Habtesion A,Davies N,Ali T,Gupta S,Andreola F,Jalan R

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND/AIMS:Currently the diagnosis and severity of hepatic steatosis can be established accurately only by liver biopsy. Previous small studies found that steatosis measured by magnetic resonance spectroscopy (MRS) and imaging (MRI) correlated with histological assessment of liver triglyceride content. However, th...

journal_title：Journal of hepatology

authors： McPherson S,Jonsson JR,Cowin GJ,O'Rourke P,Clouston AD,Volp A,Horsfall L,Jothimani D,Fawcett J,Galloway GJ,Benson M,Powell EE

更新日期：2009-08-01 00:00:00

abstract：:This review summarizes recent progress in the knowledge of catecholamines in cirrhosis. Compensated patients have normal plasma concentration of noradrenaline. Highly elevated plasma noradrenaline concentration in decompensated patients indicates that the sympathetic nervous system is enhanced in this condition. This ...

journal_title：Journal of hepatology

authors： Henriksen JH,Ring-Larsen H,Christensen NJ

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND/AIMS:We previously showed that in cultured human myofibroblasts (hMFBs), Oncostatin M (OSM)-stimulated collagen accumulation is associated with increased tissue inhibitor of metalloproteinase (TIMP)1 message. However, the mechanism is unknown. METHODS:hMFBs were isolated by outgrowth from cirrhotic liver ex...

journal_title：Journal of hepatology

authors： Sohara N,Trojanowska M,Reuben A

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND/AIMS:Familial hypobetalipoproteinemia (FHBL) is a co-dominant disorder characterized by reduced plasma levels of low-density lipoproteins. It can be caused by mutations in the gene encoding apolipoprotein B-100 (apo B), leading to the formation of truncated apo Bs which have a reduced capacity to export lipi...

journal_title：Journal of hepatology

authors： Tarugi P,Lonardo A,Ballarini G,Erspamer L,Tondelli E,Bertolini S,Calandra S

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND & AIMS:The gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) often depicts non-hypervascular hypointense hepatic nodules during the hepatobiliary phase in patients with hepatocellular carcinoma (HCC). It is unclear whether the presence of thes...

journal_title：Journal of hepatology

authors： Toyoda H,Kumada T,Tada T,Niinomi T,Ito T,Sone Y,Kaneoka Y,Maeda A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND & AIMS:The pathomechanisms underlying non-alcoholic fatty liver disease (NAFLD) and the involved molecular regulators are incompletely explored. The nuclear factor-kappa B (NF-κB)-cofactor gene B cell leukemia-3 (Bcl-3) plays a critical role in altering the transcriptional capacity of NF-κB - a key inducer o...

journal_title：Journal of hepatology

authors： Gehrke N,Wörns MA,Huber Y,Hess M,Straub BK,Hövelmeyer N,Waisman A,Kim YO,Schuppan D,Galle PR,Schattenberg JM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND/AIMS:Orthotopic liver transplantation has been shown to improve survival in fulminant hepatic failure. However, after orthotopic liver transplantation life-long immunosuppression is necessary and graft complications may occur. METHODS:We employed heterotopic auxiliary liver transplantation in a 26-year-old ...

journal_title：Journal of hepatology

authors： van Hoek B,Ringers J,Kroes AC,van Krieken JH,van Schelven WD,Masclee AA,van Krikken-Hogenberk LG,Haak HR,Lamers CB,Terpstra OT

更新日期：1995-08-01 00:00:00

abstract：:Twelve cirrhotic patients and six controls were fed an eucaloric high carbohydrate (CHO) diet for 3 days. Fasting serum triglyceride (TG), non-esterified fatty acids (NEFA), glucose, insulin and glycerol were estimated daily. On the 3rd day of the study we measured NEFA, glucose, insulin, and fructose every 45 min fro...

journal_title：Journal of hepatology

authors： Avgerinos A,Harry D,Bousboulas S,Theodossiadou E,Komesidou V,Pallikari A,Raptis S,McIntyre N

更新日期：1992-01-01 00:00:00

abstract：:In this Grand Round presentation, the case of a man with decompensated liver disease is described. He subsequently developed a fatal pulmonary embolism, which may not have occurred if he had been prescribed prophylactic anticoagulation to prevent venous thromboembolic disease. The burden of thrombotic disease in those...

journal_title：Journal of hepatology

authors： Dhar A,Mullish BH,Thursz MR

更新日期：2017-06-01 00:00:00