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Hedgehog signaling in the liver.

Abstract：

:Reactivation of Hedgehog (Hh), a morphogenic signaling pathway that controls progenitor cell fate and tissue construction during embryogenesis occurs during many types of liver injury in adult. The net effects of activating the Hedgehog pathway include expansion of liver progenitor populations to promote liver regeneration, but also hepatic accumulation of inflammatory cells, liver fibrogenesis, and vascular remodeling. All of these latter responses are known to be involved in the pathogenesis of cirrhosis. In addition, Hh signaling may play a role in primary liver cancers, such as cholangiocarcinoma and hepatocellular carcinoma. Study of Hedgehog signaling in liver cells is in its infancy. Additional research in this area is justified given growing experimental and clinical data supporting a role for the pathway in regulating outcomes of liver injury.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Omenetti A,Choi S,Michelotti G,Diehl AM

doi

10.1016/j.jhep.2010.10.003

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

366-73

issue

2

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(10)00897-4

journal_volume

54

pub_type

杂志文章,评审

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