Kupffer cells from CCl4-induced fibrotic livers stimulate proliferation of fat-storing cells.

abstract：BACKGROUND & AIMS:Macrophages (Mϕ) represent a major component of tumor tissues and play an important role in both tumor progression and therapeutic response. Although tumor Mϕ are generally considered to be derived from circulating monocytes, emerging evidence indicates that tissue Mϕ pools can be maintained by self-r...

journal_title：Journal of hepatology

authors： Wang J,Wang Y,Chu Y,Li Z,Yu X,Huang Z,Xu J,Zheng L

更新日期：2020-10-31 00:00:00

abstract：BACKGROUND/AIMS:In these studies, we tested the hypothesis that increased lipid intake would exacerbate the severity of nutritional steatohepatitis. METHODS:C57Bl/6J mice were fed methionine-and-choline deficient (MCD) diets containing 20% (high) or 5% (low) fat by weight for 3 weeks and compared to lipid-matched cont...

journal_title：Journal of hepatology

authors： Larter CZ,Yeh MM,Williams J,Bell-Anderson KS,Farrell GC

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND/AIMS:Graft reperfusion in liver transplantation is usually performed by initial portal reperfusion (IPR) and delayed rearterialization. Its influence on graft microcirculation is unknown. This study aimed to assess sinusoidal perfusion in dependence to this reperfusion technique during human living-donor liv...

journal_title：Journal of hepatology

authors： Puhl G,Schaser KD,Pust D,Köhler K,Vollmar B,Menger MD,Neuhaus P,Settmacher U

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND/AIMS:To analyze the kinetics of the hepatitis C virus and the patterns of resistance to interferon alpha, we assessed HCV RNA levels early during retreatment with high-dose interferon in patients who did not respond to standard treatment. METHODS:Eleven non-responders to previous therapy with 3-6 MU interfe...

journal_title：Journal of hepatology

authors： Bekkering FC,Brouwer JT,Leroux-Roels G,Van Vlierberghe H,Elewaut A,Schalm SW

更新日期：1998-06-01 00:00:00

abstract：:alpha-Interferon therapy normalizes aminotransferase levels in approximately 50% of the patients with chronic hepatitis C, but post-therapy relapses are common and predictive factors of sustained response remain largely unknown. We retrospectively assessed several parameters as predictors of sustained remission after ...

journal_title：Journal of hepatology

authors： Camps J,García-Granero M,Riezu-Boj JI,Larrea E,de Alava E,Civeira MP,Castilla A,Prieto J

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate demographic characteristics, liver histology and virological features of hepatitis C virus (HCV) carriers with normal alanine transaminase (ALT) levels. METHODS:A nationwide prospective study was started in 1997. Four Italian centres have participated in this study. RESULTS:Eight hundred a...

journal_title：Journal of hepatology

authors： Puoti C,Castellacci R,Montagnese F,Zaltron S,Stornaiuolo G,Bergami N,Bellis L,Precone DF,Corvisieri P,Puoti M,Minola E,Gaeta GB

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND & AIMS:Alcoholic hepatitis is an acute life- and health-threatening disease that may be increasingly frequent. However, accurate and representative data on time trends in its incidence and prognosis are not available. This study aims to provide nationwide population-based estimates of alcoholic hepatitis inc...

journal_title：Journal of hepatology

authors： Sandahl TD,Jepsen P,Thomsen KL,Vilstrup H

更新日期：2011-04-01 00:00:00

abstract：:The possible aggravation of liver injury by impaired cellular antioxidant function was investigated. A vitamin E-deficient diet (0.5 mg/kg alpha-tocopherol; control 100 mg/kg) significantly reduced rat liver alpha-tocopherol concentrations after 4 weeks (1.8 +/- 1.7 micrograms/g; control 34.4 +/- 2.4 micrograms/g, p <...

journal_title：Journal of hepatology

authors： Barrow L,Patel HR,Tanner MS

更新日期：1992-11-01 00:00:00

abstract：:Data derived from population, case-control, and cohort studies conducted in several Euro-Mediterranean and African countries disclose impressive similarities in the age and modes of hepatitis B virus (HBV) transmission and in the prevalence, duration, and outcome of the four phases of the natural history of chronic in...

journal_title：Journal of hepatology

authors： Hadziyannis SJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND/AIMS:Whether GB virus C and hepatitis G virus participate in fulminant hepatic failure is controversial. We studied the prevalence of the viral RNA in 48 patients. There were possible routes of infection, including blood transfusion, in 22 patients (group 1), and no risk factors in the other 26 (group 2). M...

journal_title：Journal of hepatology

authors： Tanaka M,Nishiguchi S,Tanaka T,Enomoto M,Fukuda K,Takeda T,Nakajima S,Shiomi S,Kuroki T,Monna T,Yano Y,Otani S

更新日期：1997-12-01 00:00:00

abstract：:Hepatic fibrosis represents an important stage in the progression of chronic liver disease to cirrhosis. In the present paper we have investigated whether capsaicin-sensitive neuropeptide-containing sensory neurons may participate in the development of liver fibrosis. The expression of hepatic fibrosis induced by comm...

journal_title：Journal of hepatology

authors： Casini A,Lippe IT,Evangelista S,Geppetti P,Santicioli P,Urso C,Paglierani M,Maggi CA,Surrenti C

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic hepatitis C virus (HCV)-infected patients with cirrhosis are a high-priority population for treatment. To help inform the benefit-risk profile of the all-oral direct-acting antiviral (DAA) combination regimen of ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir (OBV/PTV/r±DSV)...

journal_title：Journal of hepatology

authors： Poordad F,Nelson DR,Feld JJ,Fried MW,Wedemeyer H,Larsen L,Cohen DE,Cohen E,Mobashery N,Tatsch F,Foster GR

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND & AIMS:The pool of HCV genotype 1 patients likely to be cured by peg-interferon and ribavirin remains to be quantified. METHODS:In 1045 patients treated with peg-interferon and ribavirin, two therapeutic strategies were confronted: the first one evaluated only baseline variables associated with sustained vi...

journal_title：Journal of hepatology

authors： Andriulli A,Di Marco V,Margaglione M,Ippolito AM,Fattovich G,Smedile A,Valvano MR,Calvaruso V,Gioffreda D,Milella M,Morisco F,Felder M,Brancaccio G,Fasano M,Gatti P,Tundo P,Barone M,Cozzolongo R,Angelico M,D'Andrea

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Norfloxacin is useful to prevent infections in hospitalized cirrhotic patients with low ascitic fluid protein concentrations. It is also effective in preventing the recurrence of spontaneous bacterial peritonitis. The aim of our study was to determine the efficacy of norfloxacin in the primary prophylax...

journal_title：Journal of hepatology

authors： Grangé JD,Roulot D,Pelletier G,Pariente EA,Denis J,Ink O,Blanc P,Richardet JP,Vinel JP,Delisle F,Fischer D,Flahault A,Amiot X

更新日期：1998-09-01 00:00:00

abstract：:The purpose of the present study was to determine the effects of chronic portal diversion on antioxidant levels in the rat liver. Male Sprague-Dawley rats (n = 32) were used for these studies. An end-to-side portacaval anastomosis was constructed in 17 of the rats. Sham-operated rats (n = 15) served as controls. Two w...

journal_title：Journal of hepatology

authors： Benoit JN,Grisham MB,Mesh CL,Korthuis RJ,Granger DN

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND & AIMS:Living donor liver transplantation (LDLT) provides a timely alternative to deceased donor liver transplantation (DDLT) for patients with hepatitis C virus-related (HCV-related) diseases in the circumstances of severe organ dearth. However, the patient and graft outcomes, and recurrence of HCV after LD...

journal_title：Journal of hepatology

authors： Hu A,Liang W,Zheng Z,Guo Z,He X

更新日期：2012-12-01 00:00:00

abstract：:Histological fibrosis stage is one of the most important prognostic factors in compensated and decompensated alcohol-related liver disease (ALD). Morphological assessment of fibrosis is useful for patient stratification, enabling individualised management, and for evaluation of treatment effects in clinical studies. I...

journal_title：Journal of hepatology

authors： Lackner C,Tiniakos D

更新日期：2019-02-01 00:00:00

abstract：:Three patients with Budd-Chiari syndrome in association with the 'lupus' anticoagulant are described. This anticoagulant was looked for in our patients with an otherwise idiopathic hepatic venous thrombosis because of the presence of a pronounced thrombocytopenia, a prolonged activated partial thromboplastin time or a...

journal_title：Journal of hepatology

authors： Van Steenbergen W,Beyls J,Vermylen J,Fevery J,Marchal G,Desmet V,De Groote J

更新日期：1986-01-01 00:00:00

abstract：:The liver contributes to immune surveillance against pathogens entering via the gut and is itself influenced by alterations in mucosal immune responses and the microbiome. Mucosal immunity is also implicated in autoimmune liver diseases that associate with inflammatory bowel disease (IBD), and in steatohepatitis where...

journal_title：Journal of hepatology

authors： Trivedi PJ,Adams DH

更新日期：2016-05-01 00:00:00

abstract：:Uridine 5'-diphosphate-glucose dolichyl-phosphate glucosyltransferase and bile acid glucosyltransferase were quantitatively determined in subcellular fractions obtained by differential centrifugation of human liver homogenate. Both enzymes were exclusively enriched in the microsomal fraction with a recovery of total e...

journal_title：Journal of hepatology

authors： Gartung C,Matern S,Matern H

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study assesses the safety, pharmacokinetics and efficacy of transarterial chemoembolization using drug eluting beads (DEB), an embolizing device that slowly releases chemotherapy to decrease systemic toxicity. METHODS:Twenty-seven Child-Pugh A cirrhotics (76% male, 59% HCV) with untreated large/mu...

journal_title：Journal of hepatology

authors： Varela M,Real MI,Burrel M,Forner A,Sala M,Brunet M,Ayuso C,Castells L,Montañá X,Llovet JM,Bruix J

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis C can lead to cirrhosis and hepatocellular carcinoma. Interferon-alfa therapy may prevent the progression of the disease. The expressions of decorin and alfa-smooth muscle cell actin of the extracellular matrix play a central role in liver fibrosis. We set out to assess the expressions...

journal_title：Journal of hepatology

authors： Jármay K,Gallai M,Karácsony G,Ozsvár Z,Schaff Z,Lonovics J,Kovalszky I

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND/AIMS:Venous hyporesponsiveness in portal hypertension has been reported previously by us. The present study was undertaken to investigate possible changes of phosphoinositide signal transduction pathway in the portal veins from portal hypertensive rats METHODS:Portal hypertension was induced by partial port...

journal_title：Journal of hepatology

authors： Huang YT,Chang SP,Lin HC,Yang MC,Hong CY

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND & AIMS:Cerebral oxidative stress plays an important role in the pathogenesis of hepatic encephalopathy (HE), but the underlying mechanisms are incompletely understood. Herein, we analyzed a role of heme oxygenase (HO)1, iron and NADPH oxidase 4 (Nox4) for the induction of oxidative stress and senescence in H...

journal_title：Journal of hepatology

authors： Görg B,Karababa A,Schütz E,Paluschinski M,Schrimpf A,Shafigullina A,Castoldi M,Bidmon HJ,Häussinger D

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIMS:The independent role of soft drink consumption in non-alcoholic fatty liver disease (NAFLD) patients remains unclear. We aimed to assess the association between consumption of soft drinks and fatty liver in patients with or without metabolic syndrome. METHODS:We recruited 31 patients (age: 43+/-12 year...

journal_title：Journal of hepatology

authors： Abid A,Taha O,Nseir W,Farah R,Grosovski M,Assy N

更新日期：2009-11-01 00:00:00

abstract：:A diagnostic test has been developed to detect hepatitis B virus (HBV) DNA in human sera. This test involves a dot-blot technique in which non-radioactive nucleic acid labelled with 2-acetylaminofluorene (AAF) is used as probe. Two series of human sera from 228 blood donors and 113 HBsAg chronic carriers were tested b...

journal_title：Journal of hepatology

authors： Larzul D,Thiers V,Courouce AM,Bréchot C,Guesdon JL

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis C virus infections are often associated with extra-hepatic immunological manifestations, including various autoimmune disorders. The aims of this study were: (i) to determine the prevalence of hepatitis C virus markers in patients with autoimmune thrombocytopenic purpura, and (ii) to d...

journal_title：Journal of hepatology

authors： Pawlotsky JM,Bouvier M,Fromont P,Deforges L,Duval J,Dhumeaux D,Bierling P

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND/AIMS:Reactive oxygen species, proinflammatory cytokines, glutathione depletion and nitric oxide have all been implicated in the pathogenesis of fulminant hepatic failure. The aim of the present study was to examine the respective roles of these factors in the pathogenesis of thioacetamide-induced fulminant h...

journal_title：Journal of hepatology

authors： Bruck R,Aeed H,Shirin H,Matas Z,Zaidel L,Avni Y,Halpern Z

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND/AIMS:Severe alcoholic hepatitis occurs mainly in patients with cirrhosis, and has a high death rate. Corticosteroid therapy has been particularly advocated as reducing mortality in patients with severe histologic lesions. However, identification of these patients is difficult, requiring transvenous liver bio...

journal_title：Journal of hepatology

authors： Castera L,Hartmann DJ,Chapel F,Guettier C,Mall F,Lons T,Richardet JP,Grimbert S,Morassi O,Beaugrand M,Trinchet JC

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND & AIMS:The pathomechanisms underlying non-alcoholic fatty liver disease (NAFLD) and the involved molecular regulators are incompletely explored. The nuclear factor-kappa B (NF-κB)-cofactor gene B cell leukemia-3 (Bcl-3) plays a critical role in altering the transcriptional capacity of NF-κB - a key inducer o...

journal_title：Journal of hepatology

authors： Gehrke N,Wörns MA,Huber Y,Hess M,Straub BK,Hövelmeyer N,Waisman A,Kim YO,Schuppan D,Galle PR,Schattenberg JM

更新日期：2016-12-01 00:00:00