Abstract:
BACKGROUND:The expression and the distribution of fibrillin-1 and elastin were studied in normal and pathological human liver samples. METHODS:As controls, histologically normal/subnormal liver samples (n = 24) were used. Pathological samples corresponded to seven cirrhosis and eight hepatocellular carcinomas (HCC) developed on cirrhotic (four) or noncirrhotic (four) liver. RESULTS:In normal liver, fibrillin-1 and elastin co-localized in vessel walls and portal tract connective tissue. Fibrillin-1 alone was detected along sinusoids and in portal spaces at the interface with the limiting hepatocytic plates and close to the basement membrane of bile ducts. By transmission electron microscopy, typical bundles of microfibrils were detected both in Disse space and in portal zones. Cirrhotic nodules were usually rich in fibrillin-1 along sinusoids; fibrillin-1 and elastin were co-localized in fibrotic septa surrounding nodules. In HCC, fibrillin-1 was present between tumoral hepatocytes; stromal reaction around the tumors contained both fibrillin-1 and elastin. CONCLUSIONS:Fibrillin-1 was associated with elastin in portal mesenchyme and vessel walls of normal liver, in fibrotic septa around cirrhotic nodules and stromal reaction around HCC, but was expressed alone in the perisinusoidal space. The functional roles for fibrillin-1 in non-elastic tissues, such as the liver, remain to be elucidated.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Dubuisson L,Lepreux S,Bioulac-Sage P,Balabaud C,Costa AM,Rosenbaum J,Desmoulière Adoi
10.1016/s0168-8278(00)00048-9subject
Has Abstractpub_date
2001-04-01 00:00:00pages
514-22issue
4eissn
0168-8278issn
1600-0641pii
S0168827800000489journal_volume
34pub_type
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journal_title:Journal of hepatology
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(05)80270-3
更新日期:1993-07-01 00:00:00
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journal_title:Journal of hepatology
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Journal of hepatology
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更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0168-8278(00)80163-4
更新日期:2000-07-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 社论
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0168-8278(91)90032-7
更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-05-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2004.02.009
更新日期:2004-06-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2012.12.024
更新日期:2013-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0168-8278(95)80222-3
更新日期:1995-06-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-06-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:1988-12-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2005.09.013
更新日期:2006-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2017.02.024
更新日期:2017-08-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(01)00243-4
更新日期:2002-02-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 临床试验,杂志文章
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更新日期:1996-02-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2004.11.041
更新日期:2005-04-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2017.04.010
更新日期:2017-09-01 00:00:00
abstract::To study experimentally the protective effect of post-exposure prophylaxis against hepatitis B (HB), a special preparation of hepatitis B immune globulin (HBIG) was injected intravenously (i.v.) into three chimpanzees simultaneously with, or at different time intervals after, intravenous injection of a titred inoculum...
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pub_type: 杂志文章
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更新日期:1989-09-01 00:00:00