Early increase in plasma parathyroid hormone levels following liver transplantation.

abstract：:The aim of the present investigation was to study the number and acinar distribution of apoptotic bodies in normal liver as an approach to a better understanding of cell kinetics in the hepatic parenchyma. The material included 20 normal human needle liver biopsies and 20 normal male Sprague-Dawley rats. For each live...

journal_title：Journal of hepatology

authors： Benedetti A,Jézéquel AM,Orlandi F

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Retrorsine, a naturally occurring pyrrolizidine alkaloid, impairs liver regeneration after partial hepatectomy by mechanisms that are still unclear. AIM:The aim of the study was to clarify the influence of retrorsine on cell cycle progression in the regenerating liver lobes of rats after portal branch ligat...

journal_title：Journal of hepatology

authors： Picard C,Lambotte L,Starkel P,Sempoux C,Saliez A,Van Den Berge V,de Saeger C,Horsmans Y

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND/AIMS:Bacillus Calmette Guerin (BCG) infection causes hepatic injury following granuloma formation and secretion of cytokines which render mice highly sensitive to endotoxin-mediated hepatotoxicity. This work investigates the role of inducible nitric oxide synthase (iNOS) in liver damage induced by BCG and en...

journal_title：Journal of hepatology

authors： Guler R,Olleros ML,Vesin D,Parapanov R,Vesin C,Kantengwa S,Rubbia-Brandt L,Mensi N,Angelillo-Scherrer A,Martinez-Soria E,Tacchini-Cottier F,Garcia I

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND/AIMS:Pegylated interferon plus ribavirin can cause dose-limiting anemia. Taribavirin, a ribavirin prodrug, has shown a lower incidence of anemia. We sought to determine the efficacy and safety of taribavirin vs. ribavirin combined with pegylated interferon in patients with chronic hepatitis C (CHC). METHODS...

journal_title：Journal of hepatology

authors： Gish RG,Arora S,Rajender Reddy K,Nelson DR,O'Brien C,Xu Y,Murphy B

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was launched in 1984. Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20 years after the launch of the vaccination program....

journal_title：Journal of hepatology

authors： Ni YH,Chang MH,Wu JF,Hsu HY,Chen HL,Chen DS

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND & AIMS:Animal models and human case series of acute liver failure (ALF) suggest moderate hypothermia (MH) to have protective effects against cerebral oedema (CO) development and intracranial hypertension (ICH). However, the optimum temperature for patient management is unknown. In a prospective randomized co...

journal_title：Journal of hepatology

authors： Bernal W,Murphy N,Brown S,Whitehouse T,Bjerring PN,Hauerberg J,Frederiksen HJ,Auzinger G,Wendon J,Larsen FS

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND/AIMS:Not all alcoholics develop liver disease (ALD). Thus, excessive ethanol consumption is necessary, but not sufficient, to induce alcoholic steatohepatitis (ASH) and ALD. Since endotoxemia is present in patients with ALD, it has been proposed that gut-derived, circulating endotoxin is the necessary co-fac...

journal_title：Journal of hepatology

authors： Keshavarzian A,Farhadi A,Forsyth CB,Rangan J,Jakate S,Shaikh M,Banan A,Fields JZ

更新日期：2009-03-01 00:00:00

abstract：:It has been postulated that one of the mechanisms of hypotension associated with cirrhosis is an attenuated responsiveness to catecholamines despite the increased activity of the sympathetic nervous system and the elevated plasma concentrations of the sympathetic neurotransmitter, norepinephrine. This abnormality was ...

journal_title：Journal of hepatology

authors： Bomzon A,Binah O,Blendis LM

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND & AIMS:Transcatheter arterial chemoembolization with lipiodol (TACE) is widely performed in patients with hepatocellular carcinoma (HCC) unsuitable for curative treatment. It has recently been recommended for patients with 2 or 3 tumors >3 cm or ≥4 tumors in a treatment algorithm proposed by Japanese guideli...

journal_title：Journal of hepatology

authors： Takayasu K,Arii S,Kudo M,Ichida T,Matsui O,Izumi N,Matsuyama Y,Sakamoto M,Nakashima O,Ku Y,Kokudo N,Makuuchi M

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate demographic characteristics, liver histology and virological features of hepatitis C virus (HCV) carriers with normal alanine transaminase (ALT) levels. METHODS:A nationwide prospective study was started in 1997. Four Italian centres have participated in this study. RESULTS:Eight hundred a...

journal_title：Journal of hepatology

authors： Puoti C,Castellacci R,Montagnese F,Zaltron S,Stornaiuolo G,Bergami N,Bellis L,Precone DF,Corvisieri P,Puoti M,Minola E,Gaeta GB

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND/AIMS:Lamivudine is an antiviral drug that is used to treat hepatitis B virus (HBV) infection. Long-term therapy does not completely suppress viral replication, and resistant mutants emerge. Resistance is mediated by changes in the tyrosine-methionine-apartate-aspartate (YMDD) motif in the catalytic site of t...

journal_title：Journal of hepatology

authors： Punia P,Cane P,Teo CG,Saunders N

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND/AIMS:The underlying mechanisms of steatosis, the first stage of non-alcoholic fatty liver disease (NAFLD) that is characterized by the accumulation of lipids in hepatocytes, remain unclear. Our study aimed to investigate the hypothesis that cigarette smoke is known to change circulating lipid profiles and th...

journal_title：Journal of hepatology

authors： Yuan H,Shyy JY,Martins-Green M

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND/AIMS:The mechanism by which many cytochrome P450 (CYP) isozymes decrease during liver regeneration is unclear. Peptides and growth factors are thought to be involved. Putrescine, the first polyamine synthesised by ornithine decarboxylase, peaks early following partial hepatectomy and is known to play an esse...

journal_title：Journal of hepatology

authors： Favre C,Monti JA,Scapini C,Pellegrino J,Carnovale CE,Carrillo MC

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND & AIMS:Treating HCV infection reduces overall mortality and reduces the risk of multiple extrahepatic complications. Whether the reduction in mortality is primarily due to a reduction in liver-related causes or extrahepatic complications is unknown. METHODS:We identified HCV-positive individuals treated for...

journal_title：Journal of hepatology

authors： Butt AA,Yan P,Shaikh OS,Lo Re V 3rd,Abou-Samra AB,Sherman KE

更新日期：2020-08-01 00:00:00

abstract：:The Hepatitis Delta Virus (HDV), a defective ribonucleic acid virus dependent on the Hepatitis B Virus (HBV) is a cause of severe liver disease that often leads to cirrhosis and death. Since the HDV finds in the HBV infection a biological niche in which to thrive indefinitely, the major victims of its infection are th...

journal_title：Journal of hepatology

authors： Rizzetto M,Rosina F,Saracco G,Bellando PC,Actis GC,Bonino F,Smedile A,Trinchero P,Sansalvadore F,Pintus C

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Recently, a novel DNA virus was isolated from the serum of a patient with post-transfusion non-A-G hepatitis and named TT virus. The aim of this study was to determine the prevalence and clinical characteristics of TT virus infection in patients with sporadic acute hepatitis of unknown etiology. METHOD...

journal_title：Journal of hepatology

authors： Parquet MC,Yatsuhashi H,Koga M,Inoue O,Matsumoto T,Hamada R,Igarashi A,Yano M

更新日期：1999-12-01 00:00:00

abstract：:Surveillance of patients at risk of developing hepatocellular carcinoma (HCC) is based on ultrasound (US) examinations performed at either 6 or 12 month intervals. Early detection of HCC in patients with cirrhosis is a challenging issue, since the different entities that are involved in the multi-step process of hepat...

journal_title：Journal of hepatology

authors： Lencioni R,Piscaglia F,Bolondi L

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND & AIMS:Acetaminophen (APAP)-induced liver injury is the most frequent cause of acute liver failure in the US and many other countries. Metabolism of APAP results in formation of APAP protein adducts (APAP-AD) in hepatocytes and triggers mitochondrial dysfunction and necrosis. However, the mechanisms for how ...

journal_title：Journal of hepatology

authors： Ni HM,McGill MR,Chao X,Du K,Williams JA,Xie Y,Jaeschke H,Ding WX

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND & AIMS:Diabetes occurring as a direct consequence of loss of liver function is usually characterized by non-diabetic fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) levels and should regress after orthotopic liver transplantation (OLT). This observational, longitudinal study investigated the relatio...

journal_title：Journal of hepatology

authors： Grancini V,Trombetta M,Lunati ME,Boselli ML,Gatti S,Donato MF,Palmieri E,Resi V,Pugliese G,Bonadonna RC,Orsi E

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis C has been associated with a decrease in quality of life and with neurological abnormalities. The aim of our study was to investigate the relationship between quality of life and cognitive function. METHODS:Quality of life, clinical variables and neuropsychological function were evaluated in ...

journal_title：Journal of hepatology

authors： Córdoba J,Flavià M,Jacas C,Sauleda S,Esteban JI,Vargas V,Esteban R,Guardia J

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND & AIMS:The approval of all-oral direct-acting antiviral (DAA) regimens for the treatment of hepatitis C virus (HCV) has led to the expansion of therapy to include patients with cirrhosis who have hepatocellular carcinoma (HCC). Data on the use of DAAs in HCV+ patients with HCC is limited. The aim of this stu...

journal_title：Journal of hepatology

authors： Prenner SB,VanWagner LB,Flamm SL,Salem R,Lewandowski RJ,Kulik L

更新日期：2017-06-01 00:00:00

abstract：:Intracellular ion homeostasis in liver cell is accomplished through the concerted action of ion pumps, carriers and channels. Description of these elements includes the Na+/K+-ATPase, Na+/H+- and Cl-/ HCO3(-)-exchange and Na+-HCO-3(-)- and Na(+)-K(+)-2 Cl(-)-cotransport as well as K+-, Cl(-)-, Na+ and nonselective cat...

journal_title：Journal of hepatology

authors： Graf J,Häussinger D

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIMS:The oral administration of the major transplant immunosuppressants cyclosporine A and tacrolimus leads to unpredictable drug levels requiring drug monitoring. Hepatic and extrahepatic metabolism of cyclosporine A and tacrolimus by cytochrome P450 proteins has been analyzed but metabolism and inactivatio...

journal_title：Journal of hepatology

authors： Strassburg CP,Barut A,Obermayer-Straub P,Li Q,Nguyen N,Tukey RH,Manns MP

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND & AIMS:The MELD score predicts short-term mortality in patients with cirrhosis; however, some patients with low scores develop complications and die unexpectedly. Consequently, we evaluated the diagnostic accuracy of the methacetin breath test (MBT), an assay of liver metabolic function, and the MELD score, ...

journal_title：Journal of hepatology

authors： Stravitz RT,Reuben A,Mizrahi M,Lalazar G,Brown K,Gordon SC,Ilan Y,Sanyal A

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Fatty acid translocase CD36 (CD36) is a membrane protein with multiple immuno-metabolic functions. Palmitoylation has been suggested to regulate the distribution and functions of CD36, but little is known about its significance in non-alcoholic steatohepatitis (NASH). METHODS:Human liver tissue sam...

journal_title：Journal of hepatology

authors： Zhao L,Zhang C,Luo X,Wang P,Zhou W,Zhong S,Xie Y,Jiang Y,Yang P,Tang R,Pan Q,Hall AR,Luong TV,Fan J,Varghese Z,Moorhead JF,Pinzani M,Chen Y,Ruan XZ

更新日期：2018-09-01 00:00:00

abstract：:Ten patients with non-alcoholic cirrhosis and ten control subjects were studied in basal conditions and after ingestion of a standard mixed test meal. Plasma somatostatin, blood glucose, plasma insulin, C-peptide and glucagon were determined before and 15, 30, 45, 60, 90, 120 and 180 min after the start of the meal. B...

journal_title：Journal of hepatology

authors： Barreca T,Franceschini R,Cataldi A,Rolandi E

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cirrhotic patients chronically treated with beta-blockers who achieve a decrease of hepatic venous pressure gradient (HVPG) > or =20% from baseline or to < or =12 mmHg have a marked reduction of first bleeding or re-bleeding. However, two HVPG measurements are needed to evaluate response. This study was...

journal_title：Journal of hepatology

authors： La Mura V,Abraldes JG,Raffa S,Retto O,Berzigotti A,García-Pagán JC,Bosch J

更新日期：2009-08-01 00:00:00

abstract：:Twelve cirrhotic patients and six controls were fed an eucaloric high carbohydrate (CHO) diet for 3 days. Fasting serum triglyceride (TG), non-esterified fatty acids (NEFA), glucose, insulin and glycerol were estimated daily. On the 3rd day of the study we measured NEFA, glucose, insulin, and fructose every 45 min fro...

journal_title：Journal of hepatology

authors： Avgerinos A,Harry D,Bousboulas S,Theodossiadou E,Komesidou V,Pallikari A,Raptis S,McIntyre N

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study evaluates the agreement between reported use of interventions for patients with liver diseases and research evidence in Cochrane systematic reviews. METHODS:In July 2002, the Cochrane Hepato-Biliary Group had completed 28 systematic reviews on 36 interventions that were available in Denmark....

journal_title：Journal of hepatology

authors： Kürstein P,Gluud LL,Willemann M,Olsen KR,Kjellberg J,Sogaard J,Gluud C

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND & AIMS:Anatomic resection (AR) of the tumor-bearing portal territory has been reported to be associated with a decreased recurrence of hepatocellular carcinoma (HCC). However, because of the heterogeneity of the study populations, its oncologic advantage remains controversial. The objective of the present st...

journal_title：Journal of hepatology

authors： Shindoh J,Makuuchi M,Matsuyama Y,Mise Y,Arita J,Sakamoto Y,Hasegawa K,Kokudo N

更新日期：2016-03-01 00:00:00