Plasma somatostatin response to an oral mixed test meal in cirrhotic patients.

Abstract:

:Ten patients with non-alcoholic cirrhosis and ten control subjects were studied in basal conditions and after ingestion of a standard mixed test meal. Plasma somatostatin, blood glucose, plasma insulin, C-peptide and glucagon were determined before and 15, 30, 45, 60, 90, 120 and 180 min after the start of the meal. Basal somatostatin levels in patients (31.9 +/- 1.8 ng/l) were significantly higher (p less than 0.01) than in controls (12.5 +/- 0.9 ng/l). The time-course of the somatostatin secretory response after the meal was similar in the two groups, but the increase, evaluated as incremental area above baseline, was significantly smaller (p less than 0.01) in cirrhotics (804 +/- 134 ng/l per min) than in controls (1482 +/- 149 ng/l per min). Data indicate that elevated basal plasma somatostatin concentrations in cirrhosis may be consequent to elevated gastrointestinal and/or pancreatic secretion, whereas the blunted somatostatin response to the mixed test meal may derive from the hyperinsulinemia which occurs in the postprandial period.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Barreca T,Franceschini R,Cataldi A,Rolandi E

doi

10.1016/0168-8278(91)90906-r

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

40-4

issue

1

eissn

0168-8278

issn

1600-0641

pii

0168-8278(91)90906-R

journal_volume

12

pub_type

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