Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation.

abstract：BACKGROUND/AIMS:Venous hyporesponsiveness in portal hypertension has been reported previously by us. The present study was undertaken to investigate possible changes of phosphoinositide signal transduction pathway in the portal veins from portal hypertensive rats METHODS:Portal hypertension was induced by partial port...

journal_title：Journal of hepatology

authors： Huang YT,Chang SP,Lin HC,Yang MC,Hong CY

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatocellular carcinoma is one of the most malignant tumors in the world. Although a wide range of therapeutic options is available, the efficacy of these methods and the prognosis of hepatocellular carcinoma are still very poor. The nucleoside analogs 2-chlorodeoxyadenosine (Cladribine, 2-CdA) and 2',...

journal_title：Journal of hepatology

authors： Graziadei I,Kelly T,Schirmer M,Geisen FH,Vogel W,Konwalinka G

更新日期：1998-03-01 00:00:00

abstract：:Evidence is accumulating that there are changes in the expression of antigens on biliary epithelium in early primary biliary cirrhosis and graft rejection. If any of the biliary diseases including rejection are associated with specific alterations in biliary glycoprotein structure, lectin histochemistry could be usefu...

journal_title：Journal of hepatology

authors： Rhodes JM,Hubscher S,Black R,Elias E,Savage A

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND & AIMS:Autophagy plays a crucial role in hepatic homeostasis and its deregulation has been associated with chronic liver disease. However, the effect of autophagy on the release of fibrogenic extracellular vesicles (EVs) by platelet-derived growth factor (PDGF)-stimulated hepatic stellate cells (HSCs) remain...

journal_title：Journal of hepatology

authors： Gao J,Wei B,de Assuncao TM,Liu Z,Hu X,Ibrahim S,Cooper SA,Cao S,Shah VH,Kostallari E

更新日期：2020-11-01 00:00:00

abstract：AIM:In order to study the short-term effect of moderate and severe reduction of liver function by acetaminophen poisoning of different severity on gene expression for liver-specific functions, rats were given 3.75 and 7.5 g per kg body weight acetaminophen intragastrically. The lower dose is associated with low mortali...

journal_title：Journal of hepatology

authors： Tygstrup N,Jensen SA,Krog B,Dalhoff K

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND & AIM:Following acetaminophen (APAP) overdose, acute liver injury (ALI) can occur in patients that present too late for N-acetylcysteine treatment, potentially leading to acute liver failure, systemic inflammation, and death. Macrophages influence the progression and resolution of ALI due to their innate imm...

journal_title：Journal of hepatology

authors： Starkey Lewis P,Campana L,Aleksieva N,Cartwright JA,Mackinnon A,O'Duibhir E,Kendall T,Vermeren M,Thomson A,Gadd V,Dwyer B,Aird R,Man TY,Rossi AG,Forrester L,Park BK,Forbes SJ

更新日期：2020-08-01 00:00:00

abstract：:Since interferons are reported to inhibit collagen synthesis in vivo and in vitro, they are possible anti-fibrogenic drugs. However, little is known about the effect of interferons on connective tissue metabolism in liver disease. To investigate the effect, serum concentrations of the aminoterminal domain of procollag...

journal_title：Journal of hepatology

authors： Hayasaka A,Kohen H,Yoshikawa N,Iida S,Ohto M

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND & AIMS:Herpes simplex virus hepatitis is a rare, but severe disease, thus far only documented by case reports and short series. The present study was based on the SRTR registry, and included all listed patients for liver transplantation from 1985 to 2009 with a diagnosis of HSV hepatitis. METHODS:We assesse...

journal_title：Journal of hepatology

authors： Moldovan B,Mentha G,Majno P,Berney T,Morard I,Giostra E,Wildhaber BE,Van Delden C,Morel P,Toso C

更新日期：2011-12-01 00:00:00

abstract：:Two patients presented with neonatal cholestasis and acholic stools as first manifestations of McCune-Albright syndrome. Both went through an extensive evaluation including an exploratory laparotomy with peroperative cholangiography which ruled out biliary atresia. One patient presented from the fourth month of life w...

journal_title：Journal of hepatology

authors： Silva ES,Lumbroso S,Medina M,Gillerot Y,Sultan C,Sokal EM

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the study was to investigate the effect of a standard albumin load on blood volume distribution, arterial compliance, and the renin-angiotensin-aldosterone system in patients with different degrees of cirrhosis. METHODS:31 patients with cirrhosis (Child classes A/B/C=8/14/9) received an intr...

journal_title：Journal of hepatology

authors： Brinch K,Møller S,Bendtsen F,Becker U,Henriksen JH

更新日期：2003-07-01 00:00:00

abstract：:The implications of hepatitis B virus (HBV) reinfection after liver transplantation were studied in 29 patients followed for 1.7-15 years. Of 20 patients with HBV infection alone, nine were HBeAg and HBV DNA seronegative and 11 had evidence of HBV replication as measured by HBeAg or HBV DNA seropositivity. Nine patien...

journal_title：Journal of hepatology

authors： O'Grady JG,Smith HM,Davies SE,Daniels HM,Donaldson PT,Tan KC,Portmann B,Alexander GJ,Williams R

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIM:Since patients with high viral load and HCV subtype 1b are known to respond poorly to interferon (IFN) therapy, the viral dynamics of HCV RNA after initiation of interferon therapy were examined in the present study with respect to two different administration regimens, once vs. twice a day. METHODS:Twe...

journal_title：Journal of hepatology

authors： Shiratori Y,Perelson AS,Weinberger L,Imazeki F,Yokosuka O,Nakata R,Ihori M,Hirota K,Ono N,Kuroda H,Motojima T,Nishigaki M,Omata M

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND/AIMS:Liver allograft is known to protect simultaneously transplanted organs from acute rejection. We have reported that only 6% of combined liver-kidney recipients, versus 32.5% of kidney recipients, develop kidney graft acute rejection. Release of soluble human leukocyte antigen (HLA) molecules by the liver...

journal_title：Journal of hepatology

authors： Créput C,Durrbach A,Menier C,Guettier C,Samuel D,Dausset J,Charpentier B,Carosella ED,Rouas-Freiss N

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND/AIMS:The efficacy and safety of rifaximin in comparison with lactitol in the treatment of acute hepatic encephalopathy was assessed in a prospective randomized, double-blind, double-dummy, controlled trial. METHODS:A total of 103 patients with grade I-III acute hepatic encephalopathy were randomized to rece...

journal_title：Journal of hepatology

authors： Mas A,Rodés J,Sunyer L,Rodrigo L,Planas R,Vargas V,Castells L,Rodríguez-Martínez D,Fernández-Rodríguez C,Coll I,Pardo A,Spanish Association for the Study of the Liver Hepatic Encephalopathy Cooperative Group.

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIMS:Most hepatocellular carcinomas are still discovered at an advanced stage and are left untreated as large hepatocellular carcinomas are contraindications to liver transplantation and percutaneous ethanol injection and are usually considered as poor indications for liver resection. The aim of this study w...

journal_title：Journal of hepatology

authors： Régimbeau JM,Farges O,Shen BY,Sauvanet A,Belghiti J

更新日期：1999-12-01 00:00:00

abstract：:The clinical relevance of a new antimitochondrial antibody, anti-M9, reacting with an outer membrane-associated antigen on liver mitochondria is described. Sera from 22 anti-M2-negative patients with histologically proven primary biliary cirrhosis (PBC) who had been followed for 5-15 years were tested for anti-M9 in t...

journal_title：Journal of hepatology

authors： Klein R,Klöppel G,Fischer R,Fintelmann V,Müting D,Berg PA

更新日期：1988-06-01 00:00:00

abstract：:Activities of superoxide dismutase, catalase and glutathione peroxidase were measured in liver biopsy specimens from patients with various liver diseases, including six with chronic persistent hepatitis, nine with chronic active hepatitis, nine with non-alcoholic cirrhosis, eight with alcoholic cirrhosis and eight wit...

journal_title：Journal of hepatology

authors： Togashi H,Shinzawa H,Wakabayashi H,Nakamura T,Yamada N,Takahashi T,Ishikawa M

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND/AIMS:Von Willebrand factor (vWf) is found in high levels in plasma of patients with acute and chronic liver disease. The role of vWf in liver injury and repair is unknown. We studied the effect of liver mass and remodeling on plasma and tissue vWf after partial hepatectomy. METHODS:Rats were sacrificed post...

journal_title：Journal of hepatology

authors： Baruch Y,Neubauer K,Shenkar L,Sabo E,Ritzel A,Wilfling T,Ramadori G

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND/AIMS:The organic anion transporting polypeptides (OATPs) mediate the uptake of numerous amphipathic compounds into hepatocytes. Our aim was to study the expression and regulation of OATP8 (OATP1B3, SLC21A8/SLCO1B3) and OATP-C (OATP1B1, SLC21A6/SLCO1B1) in hepatocellular carcinomas (HCC). METHODS:RNA and pro...

journal_title：Journal of hepatology

authors： Vavricka SR,Jung D,Fried M,Grützner U,Meier PJ,Kullak-Ublick GA

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND/AIMS:To assess the efficacy and safety of naltrexone for the short and long term treatment of pruritus of cholestasis. METHODS:Twenty patients with pruritus and cholestasis were included. A baseline pruritus score was obtained over 1 week. Patients were then randomized to receive 50 mg/day of naltrexone or ...

journal_title：Journal of hepatology

authors： Terg R,Coronel E,Sordá J,Muñoz AE,Findor J

更新日期：2002-12-01 00:00:00

abstract：:In this paper, we studied the usefulness of polymerase chain reaction (PCR) in HDV-RNA detection. Using serial dilutions of serum samples of known concentrations of HDV-RNA, PCR was 10,000-times more sensitive than slot-blot hybridization. PCR was used for the detection of HDV-RNA in 33 serum samples negative to HDV-R...

journal_title：Journal of hepatology

authors： Madejón A,Castillo I,Bartolomé J,Melero M,Campillo ML,Porres JC,Moreno A,Carreño V

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic stellate cell (HSC) transdifferentiation into collagen-producing myofibroblasts is a key event in hepatic fibrogenesis, but the transcriptional network that controls the acquisition of the activated phenotype is still poorly understood. In this study, we explored whether the nuclear receptor c...

journal_title：Journal of hepatology

authors： Ceni E,Mello T,Polvani S,Vasseur-Cognet M,Tarocchi M,Tempesti S,Cavalieri D,Beltrame L,Marroncini G,Pinzani M,Milani S,Galli A

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND/AIMS:Septins are ubiquitous and multifunctional scaffold proteins involved in cytoskeletal organization, exocytosis and other cellular processes. We disclose the quiescent hepatic stellate cells (HSCs)-specific expression of a septin subunit Sept4 in the liver, and explore the significance of the septin syst...

journal_title：Journal of hepatology

authors： Iwaisako K,Hatano E,Taura K,Nakajima A,Tada M,Seo S,Tamaki N,Sato F,Ikai I,Uemoto S,Kinoshita M

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND/AIMS:This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). METHODS:Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. RESULTS:All patie...

journal_title：Journal of hepatology

authors： Broomé U,Glaumann H,Lindstöm E,Lööf L,Almer S,Prytz H,Sandberg-Gertzén H,Lindgren S,Fork FT,Järnerot G,Olsson R

更新日期：2002-05-01 00:00:00

abstract：:Intracellular ion homeostasis in liver cell is accomplished through the concerted action of ion pumps, carriers and channels. Description of these elements includes the Na+/K+-ATPase, Na+/H+- and Cl-/ HCO3(-)-exchange and Na+-HCO-3(-)- and Na(+)-K(+)-2 Cl(-)-cotransport as well as K+-, Cl(-)-, Na+ and nonselective cat...

journal_title：Journal of hepatology

authors： Graf J,Häussinger D

更新日期：1996-01-01 00:00:00

abstract：:The First European Consensus Conference on the Treatment of Chronic Hepatitis B and C in HIV Co-infected Patients aimed to produce recommendations that could be applied across Europe. However, some important differences exist around Europe, in terms of access to treatment and tests for monitoring. This short survey of...

journal_title：Journal of hepatology

authors： Salmon D,Robain M,Rockstroh JK,Benhamou Y

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND & AIMS:ER stress promotes liver fat accumulation and induction of inflammatory cytokines, which contribute to the development of steatohepatitis. Unresolved ER stress upregulates the pro-apoptotic CHOP. IL-1α is localized to the nucleus in apoptotic cells, but is released when these cells become necrotic and...

journal_title：Journal of hepatology

authors： Kandel-Kfir M,Almog T,Shaish A,Shlomai G,Anafi L,Avivi C,Barshack I,Grosskopf I,Harats D,Kamari Y

更新日期：2015-10-01 00:00:00

abstract：:We report a case of chronic active hepatitis caused by benzarone, a benzofuran derivative used in Europe for the treatment of peripheral venous disorders. Jaundice and serum alanine aminotransferase activity increased while drug administration was continued, but promptly decreased when it was eventually interrupted. L...

journal_title：Journal of hepatology

authors： Babany G,Larrey D,Pessayre D,Degott C,Rueff B,Benhamou JP

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND/AIMS:Leptin has a particular profibrogenic role in the liver. We investigated whether IFN-alpha influences leptin production in patients with chronic hepatitis B (CHB) and C (CHC). Leptin was determined in serial samples from 63 CHB and 42 CHC IFN-alpha treated patients. Furthermore, we evaluated whether lep...

journal_title：Journal of hepatology

authors： Zografos TA,Rigopoulou EI,Liaskos C,Togousidis E,Zachou K,Gatselis N,Germenis A,Dalekos GN

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND & AIMS:Histopathology is the gold standard in the diagnosis of liver diseases but may be complicated by sampling error and bleeding. Confocal laser endomicroscopy (CLE) is a novel imaging modality providing in vivo histology. Previous studies using CLE for liver microscopy suffered from limited imaging depth...

journal_title：Journal of hepatology

authors： Goetz M,Deris I,Vieth M,Murr E,Hoffman A,Delaney P,Galle PR,Neurath MF,Kiesslich R

更新日期：2010-07-01 00:00:00