当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: a randomized phase II trial for safety and optimal dosage.

Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: a randomized phase II trial for safety and optimal dosage.

Abstract：

BACKGROUND/AIMS:Hepatocellular carcinoma recurrence after curative treatment adversely influences clinical outcome. It is important to explore adjuvant therapies. This phase II/stage 1 multi-center, randomized trial investigated the safety, optimal dosage and preliminary efficacy of PI-88, a novel heparanase inhibitor, in the setting of post-operative recurrence of HCC according to a Simon's 2-stage design. METHODS:Three groups were included: one untreated arm (Group A) and two PI-88 arms (Group B: 160 mg/day; Group C: 250 mg/day). Treatment groups received PI-88 over nine 4-week treatment cycles, followed by a 12-week treatment-free period. Safety and optimal dosage were assessed. RESULTS:Overall, 172 patients were randomized and 168 were included in the intention-to-treat (ITT) population. Treatment-related adverse effects included cytopenia, injection site hemorrhage, PT prolongation, etc. Four serious adverse events were possibly related to PI-88 treatment. One (1.8%) group B patients and six (10.5%) group C had hepatotoxicity-related withdrawals. Among the ITT population, 29 patients (50%) in Group A, 35 (63%) in Group B, and 22 (41%) in Group C remained recurrence-free at completion. Calculated T(1) value suggested 160 mg/day treatment satisfied the criteria for the next stage of the trial. CONCLUSIONS:PI-88 at 160 mg/day is optimal and safe, and shows preliminary efficacy as an adjunct therapy for post-operative HCC.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Liu CJ,Lee PH,Lin DY,Wu CC,Jeng LB,Lin PW,Mok KT,Lee WC,Yeh HZ,Ho MC,Yang SS,Lee CC,Yu MC,Hu RH,Peng CY,Lai KL,Chang SS,Chen PJ

doi

10.1016/j.jhep.2008.12.023

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

958-68

issue

5

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(09)00056-7

journal_volume

50

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Subclinical impairment of brain function in chronic hepatitis C infection.

    abstract：BACKGROUND/AIMS:Central nervous system abnormalities such as fatigue and depression occur more frequently in chronic hepatitis C virus (HCV) infection than in many other causes of chronic liver disease. The finding that fatigue is unrelated to activity of hepatitis or mode of infection could indicate an independent eff...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(02)00172-1

    authors： Kramer L,Bauer E,Funk G,Hofer H,Jessner W,Steindl-Munda P,Wrba F,Madl C,Gangl A,Ferenci P

    更新日期：2002-09-01 00:00:00

  • Effect of intravenous albumin on systemic and hepatic hemodynamics and vasoactive neurohormonal systems in patients with cirrhosis and spontaneous bacterial peritonitis.

    abstract：BACKGROUND/AIMS:Albumin administration prevents renal failure and improves survival in spontaneous bacterial peritonitis. This study characterizes the mechanisms of action of albumin in this condition. METHODS:Systemic and splanchnic hemodynamics, plasma renin activity and plasma concentration of interleukin-6, serum ...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jhep.2004.05.009

    authors： Fernández J,Navasa M,Garcia-Pagan JC,G-Abraldes J,Jiménez W,Bosch J,Arroyo V

    更新日期：2004-09-01 00:00:00

  • Portal hemodynamics in chronic portal-systemic encephalopathy. Angiographic study in seven cases.

    abstract：:A portal hemodynamic study was made in 7 consecutive patients with chronic portal-systemic encephalopathy by percutaneous transhepatic catheterization of the portal vein and injecting contrast medium into the superior mesenteric vein or by superior mesenteric arterial portography in comparison with patients without en...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(85)80745-5

    authors： Takashi M,Igarashi M,Hino S,Takayasu K,Goto N,Musha H,Ohnishi K,Okuda K

    更新日期：1985-01-01 00:00:00

  • Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency.

    abstract：BACKGROUND & AIMS:Lysosomal acid lipase deficiency is an autosomal recessive enzyme deficiency resulting in lysosomal accumulation of cholesteryl esters and triglycerides. LAL-CL04, an ongoing extension study, investigates the long-term effects of sebelipase alfa, a recombinant human lysosomal acid lipase. METHODS:Seb...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.jhep.2014.06.022

    authors： Valayannopoulos V,Malinova V,Honzík T,Balwani M,Breen C,Deegan PB,Enns GM,Jones SA,Kane JP,Stock EO,Tripuraneni R,Eckert S,Schneider E,Hamilton G,Middleton MS,Sirlin C,Kessler B,Bourdon C,Boyadjiev SA,Sharma R,Twe

    更新日期：2014-11-01 00:00:00

  • Expression of multidrug resistance-associated protein 3 and cytotoxic T cell responses in patients with hepatocellular carcinoma.

    abstract：BACKGROUND/AIMS:Multidrug resistance-associated protein 3 (MRP3) is a carrier-type transport protein belonging to the ABC transporters. It is expressed in normal tissues, and enhanced expression in many cancers has been reported. In this study, we investigated the usefulness of MRP3 as a target antigen in immunotherapy...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.05.012

    authors： Mizukoshi E,Honda M,Arai K,Yamashita T,Nakamoto Y,Kaneko S

    更新日期：2008-12-01 00:00:00

  • Hepatitis C virus infection and chronic kidney disease: Time for reappraisal.

    abstract：:Hepatitis C virus (HCV) infection is associated with tremendous morbidity and mortality due to liver complications. HCV infection is also associated with many extrahepatic manifestations including cardiovascular diseases, glucose metabolism impairment, cryoglobulinemia vasculitis, B cell non-Hodgkin lymphoma and chron...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2016.06.011

    authors： Cacoub P,Desbois AC,Isnard-Bagnis C,Rocatello D,Ferri C

    更新日期：2016-10-01 00:00:00

  • Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis.

    abstract：BACKGROUND & AIMS:Low levels of toll-like receptor 3 (TLR3) in patients with hepatocellular carcinoma (HCC) are associated with poor prognosis, primarily owing to the loss of inflammatory signaling and subsequent lack of immune cell recruitment to the liver. Herein, we explore the role of TLR3-triggered apoptosis in HC...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.05.031

    authors： Bonnin M,Fares N,Testoni B,Estornes Y,Weber K,Vanbervliet B,Lefrançois L,Garcia A,Kfoury A,Pez F,Coste I,Saintigny P,Viari A,Lang K,Guey B,Hervieu V,Bancel B,Bartoch B,Durantel D,Renno T,Merle P,Lebecque S

    更新日期：2019-10-01 00:00:00

  • The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.

    abstract：BACKGROUND/AIMS:The organic anion transporting polypeptides (OATPs) mediate the uptake of numerous amphipathic compounds into hepatocytes. Our aim was to study the expression and regulation of OATP8 (OATP1B3, SLC21A8/SLCO1B3) and OATP-C (OATP1B1, SLC21A6/SLCO1B1) in hepatocellular carcinomas (HCC). METHODS:RNA and pro...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2003.10.008

    authors： Vavricka SR,Jung D,Fried M,Grützner U,Meier PJ,Kullak-Ublick GA

    更新日期：2004-02-01 00:00:00

  • Woodchuck hepatitis virus-induced carcinoma as a relevant natural model for therapy of human hepatoma.

    abstract：BACKGROUND:Eastern American woodchuck (Marmota monax), naturally infected with woodchuck hepatitis virus, a virus similar to human hepatitis B virus, develops liver cancer with a high prevalence. AIMS:The aim of this work was to assess Marmota monax as a model of human hepatocellular carcinoma, especially to assess ne...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80468-0

    authors： Gouillat C,Manganas D,Zoulim F,Vitrey D,Saguier G,Guillaud M,Ain JF,Duque-Campos R,Jamard C,Praves M,Trepo C

    更新日期：1997-06-01 00:00:00

  • Hepatitis C virus infection and autoimmune thrombocytopenic purpura.

    abstract：BACKGROUND/AIMS:Chronic hepatitis C virus infections are often associated with extra-hepatic immunological manifestations, including various autoimmune disorders. The aims of this study were: (i) to determine the prevalence of hepatitis C virus markers in patients with autoimmune thrombocytopenic purpura, and (ii) to d...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80027-1

    authors： Pawlotsky JM,Bouvier M,Fromont P,Deforges L,Duval J,Dhumeaux D,Bierling P

    更新日期：1995-12-01 00:00:00

  • The epidemiology of hepatitis delta infection in Italy. Promoting Group.

    abstract：:The epidemiology of HDV infection in Italy was assessed in a retrospective study involving 1556 HBsAg chronic carriers on their first presentation at one of the 35 Liver Units in 1987. Total anti-HD was detected in 23.4% of HBsAg carriers and was significantly more frequent in southern than in northern Italy (26.6% vs...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(92)90038-q

    authors： Sagnelli E,Stroffolini T,Ascione A,Bonino F,Chiaramonte M,Colombo M,Craxi A,Giusti G,Manghisi OG,Pastore G

    更新日期：1992-05-01 00:00:00

  • Hepatic lipid profiling in chronic hepatitis C: an in vitro and in vivo proton magnetic resonance spectroscopy study.

    abstract：BACKGROUND & AIMS:Hepatic steatosis is an important factor in pathogenesis, progression and response to treatment in hepatitis C. We aimed to investigate differences in hepatic lipid composition in liver biopsies from patients with chronic hepatitis C using proton magnetic resonance spectroscopy ((1)H MRS) and to trans...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.10.006

    authors： Cobbold JF,Patel JH,Goldin RD,North BV,Crossey MM,Fitzpatrick J,Wylezinska M,Thomas HC,Cox IJ,Taylor-Robinson SD

    更新日期：2010-01-01 00:00:00

  • Efficacy and tolerability of an IFN-free regimen with DCV/ASV for elderly patients infected with HCV genotype 1B.

    abstract：BACKGROUND & AIMS:Anti-hepatitis C virus (HCV) therapy by interferon (IFN)-free regimen with oral direct-acting antiviral drugs are tolerable in aged patients, with fewer adverse effects than IFN-based therapies. We investigated the efficacy and tolerability of an IFN-free anti-HCV therapy in extremely aged patients, a...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.jhep.2016.11.012

    authors： Toyoda H,Kumada T,Tada T,Shimada N,Takaguchi K,Senoh T,Tsuji K,Tachi Y,Hiraoka A,Ishikawa T,Shima T,Okanoue T

    更新日期：2017-03-01 00:00:00

  • Inositol phosphate responses in portal veins from portal hypertensive rats: receptor- and nonreceptor-mediated responses.

    abstract：BACKGROUND/AIMS:Venous hyporesponsiveness in portal hypertension has been reported previously by us. The present study was undertaken to investigate possible changes of phosphoinositide signal transduction pathway in the portal veins from portal hypertensive rats METHODS:Portal hypertension was induced by partial port...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80055-4

    authors： Huang YT,Chang SP,Lin HC,Yang MC,Hong CY

    更新日期：1997-02-01 00:00:00

  • Synthesis of insulin-like growth factor binding proteins and of the acid-labile subunit of the insulin-like growth factor ternary binding protein complex in primary cultures of human hepatocytes.

    abstract：BACKGROUND/AIMS:The liver is the main source of circulating insulin-like growth factor binding proteins. In man, the cellular origin of insulin-like growth factor binding proteins has remained obscure. METHODS:Human hepatocytes isolated from surgical specimens were purified and cultured using a collagen gel immobiliza...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80201-0

    authors： Scharf JG,Schmidt-Sandte W,Pahernik SA,Koebe HG,Hartmann H

    更新日期：1995-10-01 00:00:00

  • Effects of propranolol and sucralfate on ethanol-induced gastric mucosal damage in chronic portal hypertensive rats.

    abstract：:In a rat model of chronic portal hypertension we studied ethanol-induced gastric mucosal damage and the effects of pretreatment by propranolol and sucralfate. Susceptibility to ethanol was increased in chronic portal hypertensive rats compared with sham-operated rats (55 +/- 8% vs. 25 +/- 4%). Both acute pretreatment ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(87)80568-8

    authors： Geoffroy P,Duchateau A,Thiéfin G,Zeitoun P

    更新日期：1987-10-01 00:00:00

  • Effect of therapeutic paracentesis on plasma volume and transvascular escape rate of albumin in patients with cirrhosis.

    abstract：BACKGROUND/AIMS:Circulatory abnormalities with activation of vasoconstrictor systems after large-volume paracentesis are generally considered secondary to an increased extravasation of fluid from the intravascular compartment to the extravascular space with subsequent reduction in plasma volume. To test this hypothesis...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80081-5

    authors： Saló J,Ginès A,Ginès P,Piera C,Jiménez W,Guevara M,Fernández-Esparrach G,Sort P,Bataller R,Arroyo V,Rodés J

    更新日期：1997-10-01 00:00:00

  • A histopathological study of the effects of 6-month versus 12-month interferon alpha-2b therapy in chronic hepatitis C.

    abstract：BACKGROUND/AIMS:Interferon therapy has been shown to have beneficial effects in chronic hepatitis C, but the optimal duration of treatment has not been clearly defined. The aims of this study were: (a) to perform a detailed histological comparison of the effects of a 6-month and a 12-month treatment using the Knodell s...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(96)80286-8

    authors： Ziol M,Nhieu JT,Roudot-Thoraval F,Métreau JM,Deugnier Y,Dhumeaux D,Zafrani ES

    更新日期：1996-12-01 00:00:00

  • Dendritic cell maturation in HCV infection: altered regulation of MHC class I antigen processing-presenting machinery.

    abstract：BACKGROUND & AIMS:Modulation of dendritic cell (DC) function has been theorized as one of the mechanisms used by hepatitis C virus (HCV) to evade the host immune response and cause persistent infection. METHODS:We used a range of cell and molecular biology techniques to study DC subsets from uninfected and HCV-infecte...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.04.007

    authors： Leone P,Di Tacchio M,Berardi S,Santantonio T,Fasano M,Ferrone S,Vacca A,Dammacco F,Racanelli V

    更新日期：2014-08-01 00:00:00

  • Glucagon increases hepatic efficacy for urea synthesis.

    abstract：:The effect of glucagon on the relation between urea synthesis and blood amino acid concentration was studied in seven healthy volunteers. Alanine was given as prime-continuous infusions and, after 1 hr for equilibration, the urea nitrogen synthesis rate was measured in two periods of about 2 hrs as urinary excretion c...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(90)90072-y

    authors： Vilstrup H,Hansen BA,Almdal TP

    更新日期：1990-01-01 00:00:00

  • Hepatitis B: reflections on the current approach to antiviral therapy.

    abstract：:This article summarizes the current state of antiviral therapy of hepatitis B with special attention given to areas that remain controversial or poorly defined. Strict adherence to liver association practice guidelines may result in missed opportunities to treat patients with significant underlying liver disease. In p...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2008.01.011

    authors： Zoulim F,Perrillo R

    更新日期：2008-01-01 00:00:00

  • The lessons from in vitro lithotripsy for the clinical treatment of gallstones.

    abstract：:Fifty-eight gallbladder stones were treated in vitro, using a Wolf Piezolith 2300 lithotripter, to discover whether complete fragmentation (i.e., no particles greater than 2 mm diameter) could be achieved by lithotripsy alone. In 16 stones this was accomplished with up to 6000 shocks being administered. The degree of ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(89)90082-2

    authors： Bird NC,Frost EA,Kanaris-Sotiriou R,Johnson AG

    更新日期：1989-07-01 00:00:00

  • Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN.

    abstract：BACKGROUND/AIMS:The impact of dietary fatty acids on the development of cancers is highly controversial. We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in hepatocytes. In this study, we investigated whether unsa...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.01.027

    authors： Vinciguerra M,Carrozzino F,Peyrou M,Carlone S,Montesano R,Benelli R,Foti M

    更新日期：2009-06-01 00:00:00

  • Platelet basal cytosolic calcium: the influence of plasma factors in cirrhosis.

    abstract：BACKGROUND:Platelet cytosolic calcium is necessary for normal platelet function, and may reflect intracellular signalling in vascular smooth muscle cells. METHODS:The cytosolic calcium of platelets from patients with cirrhosis and control subjects was measured in contact with plasma from either source, using FURA 2AM....

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80117-6

    authors： Forrest EH,Dillon JF,Campbell TJ,Newsome PN,Hayes PC

    更新日期：1996-09-01 00:00:00

  • Prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic disease.

    abstract：BACKGROUND/AIMS:The aims were to study: 1) the prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic liver disease, 2) viral and host immunogenetic factors that may predispose to diabetes, and 3) liver transplantation outcome in patients with or without d...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80065-3

    authors： Zein NN,Abdulkarim AS,Wiesner RH,Egan KS,Persing DH

    更新日期：2000-02-01 00:00:00

  • Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1.

    abstract：BACKGROUND & AIMS:Clinical evidence has indicated a close link between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, the underlying mechanism remains to be elucidated. This study aimed to explore a potential role of hepatocyte-derived extracellular vesicles (EVs) in endothelial in...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.09.014

    authors： Jiang F,Chen Q,Wang W,Ling Y,Yan Y,Xia P

    更新日期：2020-01-01 00:00:00

  • Different turnover rate of hepatitis C virus clearance by different treatment regimen using interferon-beta.

    abstract：BACKGROUND/AIM:Since patients with high viral load and HCV subtype 1b are known to respond poorly to interferon (IFN) therapy, the viral dynamics of HCV RNA after initiation of interferon therapy were examined in the present study with respect to two different administration regimens, once vs. twice a day. METHODS:Twe...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(00)80373-6

    authors： Shiratori Y,Perelson AS,Weinberger L,Imazeki F,Yokosuka O,Nakata R,Ihori M,Hirota K,Ono N,Kuroda H,Motojima T,Nishigaki M,Omata M

    更新日期：2000-08-01 00:00:00

  • Incidence of hepatocellular carcinoma in HIV/HBV-coinfected patients on tenofovir therapy: Relevance for screening strategies.

    abstract：BACKGROUND & AIMS:Robust data on hepatocellular carcinoma (HCC) incidence among HIV/hepatitis B virus (HBV)-coinfected individuals on antiretroviral therapy (ART) are needed to inform HCC screening strategies. We aimed to evaluate the incidence and risk factors of HCC among HIV/HBV-coinfected individuals on tenofovir d...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.03.032

    authors： Wandeler G,Mauron E,Atkinson A,Dufour JF,Kraus D,Reiss P,Peters L,Dabis F,Fehr J,Bernasconi E,van der Valk M,Smit C,Gjærde LK,Rockstroh J,Neau D,Bonnet F,Rauch A,Swiss HIV Cohort Study, Athena Observational Cohort Study

    更新日期：2019-08-01 00:00:00

  • Hepatocellular ballooning in NASH.

    abstract：BACKGROUND & AIMS:Hepatocellular ballooning is a key finding in nonalcoholic steatohepatitis (NASH). It is conventionally defined by hemotoxylin and eosin (H&E) staining showing enlarged cells with rarefied cytoplasm and recently by changes in the cytoskeleton. Fat droplets are emerging as important organelles in cell ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.04.031

    authors： Caldwell S,Ikura Y,Dias D,Isomoto K,Yabu A,Moskaluk C,Pramoonjago P,Simmons W,Scruggs H,Rosenbaum N,Wilkinson T,Toms P,Argo CK,Al-Osaimi AM,Redick JA

    更新日期：2010-10-01 00:00:00

  • Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:The presence of multifocal tumors, developed either from intrahepatic metastasis (IM) or multicentric occurrence (MO), is a distinct feature of hepatocellular carcinoma (HCC). Immunogenomic characterization of multifocal HCC is important for understanding immune escape in different lesions and develop...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.12.014

    authors： Dong LQ,Peng LH,Ma LJ,Liu DB,Zhang S,Luo SZ,Rao JH,Zhu HW,Yang SX,Xi SJ,Chen M,Xie FF,Li FQ,Li WH,Ye C,Lin LY,Wang YJ,Wang XY,Gao DM,Zhou H,Yang HM,Wang J,Zhu SD,Wang XD,Cao Y,Zhou J,Fan J,Wu K,Gao

    更新日期：2020-05-01 00:00:00