Subclinical impairment of brain function in chronic hepatitis C infection.

Abstract:

BACKGROUND/AIMS:Central nervous system abnormalities such as fatigue and depression occur more frequently in chronic hepatitis C virus (HCV) infection than in many other causes of chronic liver disease. The finding that fatigue is unrelated to activity of hepatitis or mode of infection could indicate an independent effect of HCV on brain function. This study tested the hypothesis of a subclinical cognitive dysfunction in HCV-infected patients. METHODS:One-hundred untreated HCV-RNA positive biopsy-proven patients were investigated by P300 event-related potentials, a sensitive electrophysiologic test of cognitive processing. Health-related quality of life and fatigue were assessed using the SF-36 questionnaire and the Fatigue Impact Scale, respectively. RESULTS:Cognitive brain function was subclinically impaired in the cohort of HCV-infected patients as indicated by significantly prolonged P300 latencies (P=0.01 for comparison to matched healthy subjects) and reduced P300 amplitudes (P<0.001, respectively). Seventeen of the 100 HCV-infected patients had P300 latencies outside the age-adjusted normal range. Abnormal P300 characteristics were not related to the degree of histologic or biochemical activity of hepatitis, severity of fatigue or mental health impairment. CONCLUSIONS:This study demonstrates that patients with HCV infection showed a slight but significant neurocognitive impairment, possibly indicating a further extrahepatic manifestation of chronic hepatitis C.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Kramer L,Bauer E,Funk G,Hofer H,Jessner W,Steindl-Munda P,Wrba F,Madl C,Gangl A,Ferenci P

doi

10.1016/s0168-8278(02)00172-1

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

349-54

issue

3

eissn

0168-8278

issn

1600-0641

pii

S0168827802001721

journal_volume

37

pub_type

杂志文章
  • Effects of HIV superinfection on HBV replication in a chronic HBsAg carrier with liver disease.

    abstract::A case of HIV superinfection observed in an HBsAg/HBeAg-positive male homosexual with chronic persistent hepatitis is described. Soon after the appearance of clinical and serological features of acute HIV infection, a rapid fall to a normal value of ALT was noted with simultaneous recrudescence of HBV replication last...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(88)80478-1

    authors: Pastore G,Santantonio T,Monno L,Milella M,Luchena N,Angarano G

    更新日期:1988-10-01 00:00:00

  • Plasma volume expansion by albumin in cirrhosis. Relation to blood volume distribution, arterial compliance and severity of disease.

    abstract:BACKGROUND/AIMS:The aim of the study was to investigate the effect of a standard albumin load on blood volume distribution, arterial compliance, and the renin-angiotensin-aldosterone system in patients with different degrees of cirrhosis. METHODS:31 patients with cirrhosis (Child classes A/B/C=8/14/9) received an intr...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(03)00160-0

    authors: Brinch K,Møller S,Bendtsen F,Becker U,Henriksen JH

    更新日期:2003-07-01 00:00:00

  • Bone disease in patients with primary sclerosing cholangitis: prevalence, severity and prediction of progression.

    abstract:BACKGROUND/AIMS:Osteopenia is a common complication in some chronic cholestatic liver diseases. Our aims were to determine the prevalence and severity of bone disease in patients with primary sclerosing cholangitis; and identify risk factors to predict the presence and progression of osteopenia. METHODS:Eighty-one pat...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0168-8278(98)80253-5

    authors: Angulo P,Therneau TM,Jorgensen A,DeSotel CK,Egan KS,Dickson ER,Hay JE,Lindor KD

    更新日期:1998-11-01 00:00:00

  • Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations.

    abstract:BACKGROUND/AIMS:To study the outcome and the virologic profiles of severe hepatitis exacerbations due to YMDD mutants in lamivudine-treated patients. METHODS:Eighteen lamivudine-treated patients with severe hepatitis exacerbations due to YMDD mutants were recruited. Laboratory and clinical parameters were monitored. V...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(03)00388-x

    authors: Yuen MF,Kato T,Mizokami M,Chan AO,Yuen JC,Yuan HJ,Wong DK,Sum SM,Ng IO,Fan ST,Lai CL

    更新日期:2003-11-01 00:00:00

  • Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis.

    abstract:BACKGROUND & AIMS:Autophagy plays a crucial role in hepatic homeostasis and its deregulation has been associated with chronic liver disease. However, the effect of autophagy on the release of fibrogenic extracellular vesicles (EVs) by platelet-derived growth factor (PDGF)-stimulated hepatic stellate cells (HSCs) remain...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.04.044

    authors: Gao J,Wei B,de Assuncao TM,Liu Z,Hu X,Ibrahim S,Cooper SA,Cao S,Shah VH,Kostallari E

    更新日期:2020-11-01 00:00:00

  • Treatment of chronic hepatitis B with interferon alpha-2b and interleukin-2.

    abstract::A total of 37 patients with histologically confirmed chronic viral hepatitis B and presence of HBV-DNA and HBsAg in the serum were treated in a randomized, prospectively controlled multicenter trial either with recombinant IFN alpha-2b alone or a combination of IFN alpha-2b and recombinant IL-2. Twenty-two patients fr...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0168-8278(05)80424-6

    authors: Bruch HR,Korn A,Klein H,Markus R,Malmus K,Baumgarten R,Müller R

    更新日期:1993-01-01 00:00:00

  • Effects of ursodeoxycholic acid after 4 to 12 years of therapy in early and late stages of primary biliary cirrhosis.

    abstract::Twenty-two patients with primary biliary cirrhosis were treated with ursodeoxycholic acid, 10 mg/kg per day. Fourteen patients with stages I/II were treated for 4-12 years (mean 7.5), and eight patients with stages III/IV for 5-12 years (mean 6.5). Twelve of 13 patients with early stages became asymptomatic. Aminotran...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0168-8278(94)80111-8

    authors: Leuschner U,Güldütuna S,Imhof M,Hübner K,Benjaminov A,Leuschner M

    更新日期:1994-10-01 00:00:00

  • Impact of immunoprophylaxis and patient selection on outcome of transplantation for HBsAg-positive liver recipients.

    abstract::We have studied the roles of immunoprophylaxis, patient selection policy and coexistent hepatitis D virus infection in the outcome of 56 HBsAg-positive elective liver transplant recipients. Twenty-nine unselected patients not treated with immunoprophylaxis formed group 1 and were compared to a recent consecutive serie...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0168-8278(05)80396-4

    authors: Devlin J,Smith HM,O'Grady JG,Portmann B,Tan KC,Williams R

    更新日期:1994-08-01 00:00:00

  • Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats.

    abstract:BACKGROUND/AIMS:To assess the effect of lactoferrin on oxidative liver damage and its mechanism, we used Long-Evans Cinnamon (LEC) rats that spontaneously develop fulminant-like hepatitis and lethal hepatic failure. METHODS:Four-week-old female LEC rats were divided into the untreated and treated groups. The latter wa...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2007.11.013

    authors: Tsubota A,Yoshikawa T,Nariai K,Mitsunaga M,Yumoto Y,Fukushima K,Hoshina S,Fujise K

    更新日期:2008-03-01 00:00:00

  • Portal vein thrombosis as complication of romiplostim treatment in a cirrhotic patient with hepatitis C-associated immune thrombocytopenic purpura.

    abstract:BACKGROUND & AIMS:Thrombopoietin receptor agonists are a new class of compounds licenced for the treatment of immune thrombocytopenic purpura. They are currently being studied for patients with thrombopenia in advanced liver disease or under therapy for hepatitis C. There are indications that the risk for development o...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2011.01.020

    authors: Dultz G,Kronenberger B,Azizi A,Mihm U,Vogl TJ,Sarrazin U,Sarrazin C,Zeuzem S,Hofmann WP

    更新日期:2011-07-01 00:00:00

  • Evidence for selection of hepatitis B mutants after liver transplantation through peripheral blood mononuclear cell infection.

    abstract:BACKGROUND/AIMS:Despite anti-HBs immunoglobulin therapy, hepatitis B virus (HBV) infection recurs in a high proportion of patients transplanted for HBsAg positive and serum HBV DNA negative chronic liver disease. The contribution of HBV genetic variability to disease recurrence has not been yet thoroughly addressed. We...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(97)80035-9

    authors: Brind A,Jiang J,Samuel D,Gigou M,Feray C,Bréchot C,Kremsdorf D

    更新日期:1997-02-01 00:00:00

  • Clinical effects of viral relapse after interferon plus ribavirin in patients co-infected with human immunodeficiency virus and hepatitis C virus.

    abstract:BACKGROUND & AIMS:Sustained viral response (SVR) after therapy with interferon-ribavirin (IF-RB) reduces liver-related (LR) complications and mortality in HIV/HCV-co-infected patients. Here, we assess the impact of end-of-treatment response with subsequent relapse (REL) on LR events (LR death, liver decompensation, hep...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2013.01.042

    authors: Berenguer J,Alvarez-Pellicer J,Carrero A,Von Wichmann MA,López-Aldeguer J,Mallolas J,Galindo MJ,Van Den Eynde E,Téllez MJ,Quereda C,Tural C,Sanz J,Barros C,Santos I,Pulido F,Guardiola JM,Ortega E,Rubio R,Jusdado JJ,

    更新日期:2013-06-01 00:00:00

  • Vinyl chloride and the liver.

    abstract::Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver, and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. However, the data on which this conclusion is based is incomplete. There is inadequate ascertainme...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jhep.2009.09.012

    authors: Sherman M

    更新日期:2009-12-01 00:00:00

  • Decorin and actin expression and distribution in patients with chronic hepatitis C following interferon-alfa-2b treatment.

    abstract:BACKGROUND/AIMS:Chronic hepatitis C can lead to cirrhosis and hepatocellular carcinoma. Interferon-alfa therapy may prevent the progression of the disease. The expressions of decorin and alfa-smooth muscle cell actin of the extracellular matrix play a central role in liver fibrosis. We set out to assess the expressions...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(00)80104-x

    authors: Jármay K,Gallai M,Karácsony G,Ozsvár Z,Schaff Z,Lonovics J,Kovalszky I

    更新日期:2000-06-01 00:00:00

  • A new life for bile acids.

    abstract::TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- and loss-of-function studies invivo, we show here that TGR5 sign...

    journal_title:Journal of hepatology

    pub_type: 评论,杂志文章

    doi:10.1016/j.jhep.2010.02.003

    authors: Jansen PL

    更新日期:2010-06-01 00:00:00

  • Hepatitis B: reflections on the current approach to antiviral therapy.

    abstract::This article summarizes the current state of antiviral therapy of hepatitis B with special attention given to areas that remain controversial or poorly defined. Strict adherence to liver association practice guidelines may result in missed opportunities to treat patients with significant underlying liver disease. In p...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jhep.2008.01.011

    authors: Zoulim F,Perrillo R

    更新日期:2008-01-01 00:00:00

  • Kupffer cells from CCl4-induced fibrotic livers stimulate proliferation of fat-storing cells.

    abstract::The interaction between fat-storing cells (FSCs) and Kupffer cells (KCs) in vitro has been studied in an attempt to clarify certain aspects of the pathogenesis of fibrotic process in the liver. FSCs and KCs were isolated from the livers of rats either treated with CCl4 for 6 weeks, or with vitamin A for 6 weeks or fro...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(86)80481-0

    authors: Shiratori Y,Geerts A,Ichida T,Kawase T,Wisse E

    更新日期:1986-01-01 00:00:00

  • Cyclin D1 is up-regulated in hepatocytes in vivo following cell-cycle block induced by retrorsine.

    abstract:BACKGROUND/AIMS:We reported massive liver repopulation by transplanted hepatocytes in rats given retrorsine (RS), a pyrrolizidine alkaloid which blocks proliferation of resident cells. In these studies, molecular alterations induced by RS on hepatocyte cell cycle were investigated. METHODS:Animals were treated accordi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2005.03.029

    authors: Pitzalis S,Doratiotto S,Greco M,Montisci S,Pasciu D,Porcu G,Pani P,Laconi S,Laconi E

    更新日期:2005-09-01 00:00:00

  • Hepatitis C virus core protein exerts an inhibitory effect on suppressor of cytokine signaling (SOCS)-1 gene expression.

    abstract:BACKGROUND/AIMS:Suppressor of cytokine signaling (SOCS)-1, a negative feedback regulator of cytokine signaling pathway, also has a tumor suppressor activity, the silencing of its gene by hypermethylation is suggested to contribute to hepatocarcinogenesis. We studied the effect of the core protein of hepatitis C virus (...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2005.03.028

    authors: Miyoshi H,Fujie H,Shintani Y,Tsutsumi T,Shinzawa S,Makuuchi M,Kokudo N,Matsuura Y,Suzuki T,Miyamura T,Moriya K,Koike K

    更新日期:2005-11-01 00:00:00

  • Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat.

    abstract:BACKGROUND/AIMS:Hepatic stellate cells (HSCs) are known to play a role in hepatic regeneration. We investigated hepatocyte/HSC interaction and HSC activation at various times after 70% partial hepatectomy (PHx) in the rat. METHODS:The hepatic microcirculation was studied using intravital fluorescence microscopy (IVFM)...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2004.02.005

    authors: Mabuchi A,Mullaney I,Sheard PW,Hessian PA,Mallard BL,Tawadrous MN,Zimmermann A,Senoo H,Wheatley AM

    更新日期:2004-06-01 00:00:00

  • Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.

    abstract:BACKGROUND & AIMS:Hepatitis C virus (HCV) evades humoral immunity and establishes chronic infections. Virus particles circulate in complex with lipoproteins facilitating antibody escape. Apolipoprotein E (ApoE) is essential for intracellular HCV assembly and for HCV cell entry. We aimed to explore if ApoE released from...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2017.04.010

    authors: Bankwitz D,Doepke M,Hueging K,Weller R,Bruening J,Behrendt P,Lee JY,Vondran FWR,Manns MP,Bartenschlager R,Pietschmann T

    更新日期:2017-09-01 00:00:00

  • Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: A pilot study.

    abstract:BACKGROUND & AIMS:To evaluate the hypothesis that increasing T cell frequency and activity may provide durable control of hepatitis B virus (HBV), we administered nivolumab, a programmed death receptor 1 (PD-1) inhibitor, with or without GS-4774, an HBV therapeutic vaccine, in virally suppressed patients with HBV e ant...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.06.028

    authors: Gane E,Verdon DJ,Brooks AE,Gaggar A,Nguyen AH,Subramanian GM,Schwabe C,Dunbar PR

    更新日期:2019-11-01 00:00:00

  • Extracellular vesicles as biomarkers in liver diseases: A clinician's point of view.

    abstract::Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and microRNAs. They can originate from both healthy and stressed cells, and provide a snapshot of the cell of origin in physiological and pathological circumstances. Various processes that may give rise to the release of extracellular...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jhep.2020.07.014

    authors: Thietart S,Rautou PE

    更新日期:2020-12-01 00:00:00

  • Prolonged QTc interval and its relationship to autonomic cardiovascular reflexes in patients with cirrhosis.

    abstract:BACKGROUND/AIMS:We have previously shown that an abnormality in cardiac autonomic reflexes (AN) is an independent predictor of mortality in patients with chronic liver disease. Aim of this study was to determine whether there was an association between prolonged QTc interval and cardiac AN. METHODS:Cardiac AN and QTc ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(01)00217-3

    authors: Puthumana L,Chaudhry V,Thuluvath PJ

    更新日期:2001-12-01 00:00:00

  • A multidisciplinary support programme increases the efficiency of pegylated interferon alfa-2a and ribavirin in hepatitis C.

    abstract:BACKGROUND & AIMS:Adherence to antiviral treatment is important to achieve sustained virological response (SVR) in chronic hepatitis C (CHC). We evaluated the efficiency of a multidisciplinary support programme (MSP), based on published HIV treatment experience, to increase patient adherence and the efficacy of pegylat...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2013.06.019

    authors: Carrión JA,Gonzalez-Colominas E,García-Retortillo M,Cañete N,Cirera I,Coll S,Giménez MD,Márquez C,Martin-Escudero V,Castellví P,Navinés R,Castaño JR,Galeras JA,Salas E,Bory F,Martín-Santos R,Solà R

    更新日期:2013-11-01 00:00:00

  • Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial.

    abstract:BACKGROUND/AIMS:The efficacy and safety of rifaximin in comparison with lactitol in the treatment of acute hepatic encephalopathy was assessed in a prospective randomized, double-blind, double-dummy, controlled trial. METHODS:A total of 103 patients with grade I-III acute hepatic encephalopathy were randomized to rece...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0168-8278(02)00350-1

    authors: Mas A,Rodés J,Sunyer L,Rodrigo L,Planas R,Vargas V,Castells L,Rodríguez-Martínez D,Fernández-Rodríguez C,Coll I,Pardo A,Spanish Association for the Study of the Liver Hepatic Encephalopathy Cooperative Group.

    更新日期:2003-01-01 00:00:00

  • Transgenic overexpression of Niemann-Pick C2 protein promotes cholesterol gallstone formation in mice.

    abstract:BACKGROUND & AIMS:Niemann-Pick C2 (NPC2) is a lysosomal protein involved in the egress of low-density lipoprotein-derived cholesterol from lysosomes to other intracellular compartments. NPC2 has been detected in several tissues and is also secreted from the liver into bile. We have previously shown that NPC2-deficient ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2015.10.002

    authors: Acuña M,González-Hódar L,Amigo L,Castro J,Morales MG,Cancino GI,Groen AK,Young J,Miquel JF,Zanlungo S

    更新日期:2016-02-01 00:00:00

  • Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients.

    abstract:BACKGROUND/AIMS:The electroencephalogram (EEG) is frequently altered in cirrhotic patients. We, therefore, performed a study to ascertain the features and the prognosis of cirrhotic patients without current overt hepatic encephalopathy (OHE) who have EEG alterations. METHODS:A series of 296 consecutive cirrhotic patie...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(01)00129-5

    authors: Amodio P,Del Piccolo F,Pettenò E,Mapelli D,Angeli P,Iemmolo R,Muraca M,Musto C,Gerunda G,Rizzo C,Merkel C,Gatta A

    更新日期:2001-07-01 00:00:00

  • Sympathetic nervous activity in cirrhosis. A survey of plasma catecholamine studies.

    abstract::This review summarizes recent progress in the knowledge of catecholamines in cirrhosis. Compensated patients have normal plasma concentration of noradrenaline. Highly elevated plasma noradrenaline concentration in decompensated patients indicates that the sympathetic nervous system is enhanced in this condition. This ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0168-8278(85)80068-4

    authors: Henriksen JH,Ring-Larsen H,Christensen NJ

    更新日期:1985-01-01 00:00:00

  • Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines.

    abstract:BACKGROUND & AIMS:Transcatheter arterial chemoembolization with lipiodol (TACE) is widely performed in patients with hepatocellular carcinoma (HCC) unsuitable for curative treatment. It has recently been recommended for patients with 2 or 3 tumors >3 cm or ≥4 tumors in a treatment algorithm proposed by Japanese guideli...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2011.10.021

    authors: Takayasu K,Arii S,Kudo M,Ichida T,Matsui O,Izumi N,Matsuyama Y,Sakamoto M,Nakashima O,Ku Y,Kokudo N,Makuuchi M

    更新日期:2012-04-01 00:00:00