Subclinical impairment of brain function in chronic hepatitis C infection.


BACKGROUND/AIMS:Central nervous system abnormalities such as fatigue and depression occur more frequently in chronic hepatitis C virus (HCV) infection than in many other causes of chronic liver disease. The finding that fatigue is unrelated to activity of hepatitis or mode of infection could indicate an independent effect of HCV on brain function. This study tested the hypothesis of a subclinical cognitive dysfunction in HCV-infected patients. METHODS:One-hundred untreated HCV-RNA positive biopsy-proven patients were investigated by P300 event-related potentials, a sensitive electrophysiologic test of cognitive processing. Health-related quality of life and fatigue were assessed using the SF-36 questionnaire and the Fatigue Impact Scale, respectively. RESULTS:Cognitive brain function was subclinically impaired in the cohort of HCV-infected patients as indicated by significantly prolonged P300 latencies (P=0.01 for comparison to matched healthy subjects) and reduced P300 amplitudes (P<0.001, respectively). Seventeen of the 100 HCV-infected patients had P300 latencies outside the age-adjusted normal range. Abnormal P300 characteristics were not related to the degree of histologic or biochemical activity of hepatitis, severity of fatigue or mental health impairment. CONCLUSIONS:This study demonstrates that patients with HCV infection showed a slight but significant neurocognitive impairment, possibly indicating a further extrahepatic manifestation of chronic hepatitis C.


J Hepatol


Journal of hepatology


Kramer L,Bauer E,Funk G,Hofer H,Jessner W,Steindl-Munda P,Wrba F,Madl C,Gangl A,Ferenci P




Has Abstract


2002-09-01 00:00:00














  • Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride.

    abstract:BACKGROUND/AIMS:Liver fibrosis is a dynamic state between matrix production and degradation. Since our report in 1974, many studies have examined collagenase and liver fibrosis, but not the identification of cells responsible for collagenase production in vivo. The aim of this study was to investigate the gene expressi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Watanabe T,Niioka M,Hozawa S,Kameyama K,Hayashi T,Arai M,Ishikawa A,Maruyama K,Okazaki I

    更新日期:2000-08-01 00:00:00

  • Gastro-oesophageal reflux and alcoholic cirrhosis. A reappraisal.

    abstract::The oesophageal pH was recorded for 3 h after a test-meal in 27 healthy control subjects (group I), 40 patients with alcoholic cirrhosis (group II), and 22 patients with a normal liver and symptoms of gastro-oesophageal reflux (control refluxers). Gastro-oesophageal reflux was observed in 10 of the cirrhotic patients....

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Arsene D,Bruley des Varannes S,Galmiche JP,Denis P,Chayvialle JA,Hellot MF,Ducrotte P,Colin R

    更新日期:1987-04-01 00:00:00

  • Molecular virology of the hepatitis C virus.

    abstract::Infection with the hepatitis C virus (HCV) is the major cause of nonA-nonB hepatitis worldwide. Although this virus cannot be cultivated in vitro, several of its key features have been elucidated in the past few years. The viral genome is a positive-sense, single-stranded, 9.6 kb long RNA molecule. The viral genome is...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: De Francesco R

    更新日期:1999-01-01 00:00:00

  • Aquaretic agents: a new potential treatment of dilutional hyponatremia in cirrhosis.

    abstract::An impairment in the renal capacity to excrete water is a common finding in patients with cirrhosis and ascites. In some patients this abnormality is minor since it is only detectable by measuring urine volume or free water clearance after a water load and is not associated with changes in plasma osmolality and serum ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Ginès P,Jiménez W

    更新日期:1996-04-01 00:00:00

  • Prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic disease.

    abstract:BACKGROUND/AIMS:The aims were to study: 1) the prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic liver disease, 2) viral and host immunogenetic factors that may predispose to diabetes, and 3) liver transplantation outcome in patients with or without d...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Zein NN,Abdulkarim AS,Wiesner RH,Egan KS,Persing DH

    更新日期:2000-02-01 00:00:00

  • Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids.

    abstract:BACKGROUND & AIMS:It is widely recognized that in the early stages of liver regeneration after partial hepatectomy, the hepatocytes accumulate a significant amount of lipids. The functional meaning of this transient steatosis and its effect on hepatocellular proliferation are not well defined. In addition, the basic me...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Pauta M,Rotllan N,Vales F,Fernandez-Hernando A,Allen RM,Ford DA,Marí M,Jiménez W,Baldán A,Morales-Ruiz M,Fernández-Hernando C

    更新日期:2013-10-01 00:00:00

  • Menopausal age and sex hormones in postmenopausal women with alcoholic and non-alcoholic liver disease.

    abstract::In order to evaluate age at menopause and serum sex hormone profiles in postmenopausal women with stable chronic liver disease, six non-cirrhotic alcoholics, 13 with alcoholic cirrhosis, eight with non-alcoholic cirrhosis, and 46 healthy controls were studied. In all three groups, patients were significantly (p less t...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Becker U,Gluud C,Farholt S,Bennett P,Micic S,Svenstrup B,Hardt F

    更新日期:1991-07-01 00:00:00

  • Twenty-one percent partial hepatectomy. In vivo rat model for the study of liver regeneration.

    abstract::We describe a new model of submaximal stimulation of liver regeneration in the rat. Removal of the right lateral lobes in the rat produced a 21% hepatectomy. The measurement accuracy of the incorporation rate of [14C]thymidine into DNA 24 h after 21% hepatectomy (n = 32) was less than that after the standard 34% hepat...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Baruch Y,Frith LO,Kirsch RE

    更新日期:1991-05-01 00:00:00

  • Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts.

    abstract:BACKGROUND/AIM:Chronic rejection is an important cause of graft loss following liver transplantation. A number of risk factors for chronic rejection have been identified previously, albeit inconsistently. These include cytomegalovirus infection detected by a number of different techniques, including immunohistochemical...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Evans PC,Coleman N,Wreghitt TG,Wight DG,Alexander GJ

    更新日期:1999-11-01 00:00:00

  • Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells.

    abstract:BACKGROUND & AIMS:Sepsis is an acute systemic inflammatory response to infection associated with high patient mortality (28-40%). We hypothesized that interleukin (IL)-30, a novel cytokine protecting mice against liver injury resulting from inflammation, would generate a protective effect against systemic inflammation ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Yan J,Mitra A,Hu J,Cutrera JJ,Xia X,Doetschman T,Gagea M,Mishra L,Li S

    更新日期:2016-05-01 00:00:00

  • Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients.

    abstract:BACKGROUND/AIMS:A 4977-base pair deletion has been detected in the hepatic mitochondrial DNA of alcoholic patients with microvesicular steatosis, a lesion ascribed to impaired mitochondrial beta-oxidation. However, only a single deletion had been looked for in this previous study, and it could not be determined whether...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Mansouri A,Fromenty B,Berson A,Robin MA,Grimbert S,Beaugrand M,Erlinger S,Pessayre D

    更新日期:1997-07-01 00:00:00

  • Norfloxacin primary prophylaxis of bacterial infections in cirrhotic patients with ascites: a double-blind randomized trial.

    abstract:BACKGROUND/AIMS:Norfloxacin is useful to prevent infections in hospitalized cirrhotic patients with low ascitic fluid protein concentrations. It is also effective in preventing the recurrence of spontaneous bacterial peritonitis. The aim of our study was to determine the efficacy of norfloxacin in the primary prophylax...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Grangé JD,Roulot D,Pelletier G,Pariente EA,Denis J,Ink O,Blanc P,Richardet JP,Vinel JP,Delisle F,Fischer D,Flahault A,Amiot X

    更新日期:1998-09-01 00:00:00

  • Effect of somatostatin on oesophageal variceal pressure assessed by direct measurement.

    abstract::The effect of a single bolus of somatostatin on oesophageal variceal pressure has been studied in 7 patients with cirrhosis and 5 patients with non-cirrhotic portal hypertension using a non-invasive variceal pressure gauge. Both groups of patients demonstrated similar reductions in variceal pressure with all subjects ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Clements D,Rhodes JM,Elias E

    更新日期:1986-01-01 00:00:00

  • Reducing environment protects sinusoidal lymphocytes isolated from normal human liver from apoptosis.

    abstract:BACKGROUND/AIMS:We previously reported that the populations of lymphocytes and the expression of activated antigens in human sinusoidal mononuclear cells were different from those in peripheral blood mononuclear cells. Attempts to culture these cells for further study failed because they died rapidly under standard cul...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kinoshita K,Kanai M,Awane M,Furuke K,Shirakata Y,Gomi T,Nakamura Y,Ikai I,Yamauchi A,Inamoto T,Ohmori K,Yamaoka Y

    更新日期:1997-01-01 00:00:00

  • Transdermal oestrogen therapy protects postmenopausal liver transplant women from osteoporosis. A 2-year follow-up study.

    abstract:BACKGROUND/AIMS:Hormone replacement therapy (HRT) prevents osteoporosis in postmenopausal women by inhibiting bone resorption, but the benefits of oestrogen therapy in liver transplant patients have not been studied. METHODS:The effect of transdermal HRT was studied in 33 postmenopausal liver transplant women. The mai...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章


    authors: Isoniemi H,Appelberg J,Nilsson CG,Mäkelä P,Risteli J,Höckerstedt K

    更新日期:2001-02-01 00:00:00

  • Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis.

    abstract:BACKGROUND & AIMS:Weak hepatitis C virus (HCV) specific immunity in peripheral blood has been shown to be partially controlled by regulatory T cells (Treg). However, little is known about Treg present in livers of HCV-infected patients, their association with clinical parameters, and immunopathology resulting in diseas...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Claassen MA,de Knegt RJ,Tilanus HW,Janssen HL,Boonstra A

    更新日期:2010-03-01 00:00:00

  • Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients.

    abstract:BACKGROUND/AIMS:The electroencephalogram (EEG) is frequently altered in cirrhotic patients. We, therefore, performed a study to ascertain the features and the prognosis of cirrhotic patients without current overt hepatic encephalopathy (OHE) who have EEG alterations. METHODS:A series of 296 consecutive cirrhotic patie...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Amodio P,Del Piccolo F,Pettenò E,Mapelli D,Angeli P,Iemmolo R,Muraca M,Musto C,Gerunda G,Rizzo C,Merkel C,Gatta A

    更新日期:2001-07-01 00:00:00

  • Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat.

    abstract:BACKGROUND/AIMS:Hepatic stellate cells (HSCs) are known to play a role in hepatic regeneration. We investigated hepatocyte/HSC interaction and HSC activation at various times after 70% partial hepatectomy (PHx) in the rat. METHODS:The hepatic microcirculation was studied using intravital fluorescence microscopy (IVFM)...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Mabuchi A,Mullaney I,Sheard PW,Hessian PA,Mallard BL,Tawadrous MN,Zimmermann A,Senoo H,Wheatley AM

    更新日期:2004-06-01 00:00:00

  • Lymphoblastoid interferon therapy of chronic HBV infection. A comparison of 12 vs. 24 weeks of thrice weekly treatment.

    abstract::This study set out to examine the relative effectiveness and tolerability of 12- versus 24-week courses of thrice weekly intramuscular lymphoblastoid interferon in the treatment of hepatitis B 'e' antigen (HBeAg)-positive chronic hepatitis B virus (HBV) infection, and to identify pretreatment factors predicting the ou...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Scully LJ,Shein R,Karayiannis P,McDonald JA,Thomas HC

    更新日期:1987-08-01 00:00:00

  • Increasing hepatic arteriole wall thickness and decreased luminal diameter occur with increasing age in normal livers.

    abstract:BACKGROUND & AIMS:There is no data to suggest that the size of bile ducts, portal venules, and hepatic arterioles varies according to age in the normal human liver. We sought to examine whether hepatic arteriolar size, wall thickness, and luminal diameter change with increasing age. METHODS:Histologically normal liver...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Fiel MI,Deniz K,Elmali F,Schiano TD

    更新日期:2011-09-01 00:00:00

  • A randomized controlled trial of recombinant interferon alpha-2b in the treatment of Chinese patients with acute post-transfusion hepatitis C.

    abstract::To evaluate the efficacy of recombinant interferon alpha-2b in the treatment of patients with acute post-transfusion hepatitis C, a randomized controlled trial was conducted in 33 acute post-transfusion hepatitis C patients; 16 patients received 3 million units of subcutaneously injected recombinant interferon alpha-2...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hwang SJ,Lee SD,Chan CY,Lu RH,Lo KJ

    更新日期:1994-11-01 00:00:00

  • Lactitol versus lactulose in the treatment of chronic hepatic encephalopathy. A double-blind, randomised, cross-over study.

    abstract::Lactitol is a disaccharide analogue of lactulose which is available as a pure crystalline powder. The efficacy of lactitol in the treatment of chronic hepatic encephalopathy was assessed in 9 cirrhotic patients in a randomised, double-blind, cross-over comparison with lactulose. The sugars were dispensed in solutions,...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Morgan MY,Hawley KE,Stambuk D

    更新日期:1987-04-01 00:00:00

  • Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping.

    abstract:BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and obesity are epidemiologically correlated with each other but the causal inter-relationships between them remain incompletely understood. We aimed to explore the causal relationships between the 3 diseases. METHODS:Using both UK Biob...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Liu Z,Zhang Y,Graham S,Wang X,Cai D,Huang M,Pique-Regi R,Dong XC,Chen YE,Willer C,Liu W

    更新日期:2020-08-01 00:00:00

  • Hepatic oxidant and antioxidant systems in portacaval-shunted rats.

    abstract::The purpose of the present study was to determine the effects of chronic portal diversion on antioxidant levels in the rat liver. Male Sprague-Dawley rats (n = 32) were used for these studies. An end-to-side portacaval anastomosis was constructed in 17 of the rats. Sham-operated rats (n = 15) served as controls. Two w...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Benoit JN,Grisham MB,Mesh CL,Korthuis RJ,Granger DN

    更新日期:1992-03-01 00:00:00

  • Detection of antibodies against pre-S1 proteins in sera of patients with hepatitis B virus (HBV) infection.

    abstract::Pre-S1 (large S) proteins are components of the envelope of HBV. The presence of pre-S1 proteins is correlated with viral replication. To test sera of patients with HBV infection for the presence of antibodies against pre-S1 proteins (anti-pre-S1), an E. coli extract containing a pre-S fusion protein covering the grea...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Theilmann L,Klinkert MQ,Gmelin K,Kommerell B,Pfaff E

    更新日期:1987-02-01 00:00:00

  • Prevalence of hepatitis C virus infection in patients with antiphospholipid syndrome.

    abstract:BACKGROUND/AIMS:The aim of this study was to determine the prevalence and clinical significance of hepatitis C virus (HCV) infection in patients with the antiphospholipid syndrome (APS). METHODS:A series of 88 consecutive patients (78 female and 10 male), with a mean age of 39 years (range 15-79), was prospectively st...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Muñoz-Rodríguez FJ,Tàssies D,Font J,Reverter JC,Cervera R,Sánchez-Tapias JM,Mazzara R,Ordinas A,Ingelmo M

    更新日期:1999-05-01 00:00:00

  • Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis.

    abstract:BACKGROUND & AIMS:Mannose-binding lectin (MBL) is a serum lectin synthesized by the liver and involved in innate host defense. MBL deficiency increases the risk of various infectious diseases mostly in immune-deficient conditions. Bacterial infections are a significant cause of morbidity and mortality in liver cirrhosi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Altorjay I,Vitalis Z,Tornai I,Palatka K,Kacska S,Farkas G,Udvardy M,Harsfalvi J,Dinya T,Orosz P,Lombay B Jr,Par G,Par A,Csak T,Osztovits J,Szalay F,Csepregi A,Lakatos PL,Papp M

    更新日期:2010-09-01 00:00:00

  • Efficacy and safety of oral naltrexone treatment for pruritus of cholestasis, a crossover, double blind, placebo-controlled study.

    abstract:BACKGROUND/AIMS:To assess the efficacy and safety of naltrexone for the short and long term treatment of pruritus of cholestasis. METHODS:Twenty patients with pruritus and cholestasis were included. A baseline pruritus score was obtained over 1 week. Patients were then randomized to receive 50 mg/day of naltrexone or ...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Terg R,Coronel E,Sordá J,Muñoz AE,Findor J

    更新日期:2002-12-01 00:00:00

  • Bone disease in patients with primary sclerosing cholangitis: prevalence, severity and prediction of progression.

    abstract:BACKGROUND/AIMS:Osteopenia is a common complication in some chronic cholestatic liver diseases. Our aims were to determine the prevalence and severity of bone disease in patients with primary sclerosing cholangitis; and identify risk factors to predict the presence and progression of osteopenia. METHODS:Eighty-one pat...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Angulo P,Therneau TM,Jorgensen A,DeSotel CK,Egan KS,Dickson ER,Hay JE,Lindor KD

    更新日期:1998-11-01 00:00:00

  • Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depth.

    abstract:BACKGROUND & AIMS:Histopathology is the gold standard in the diagnosis of liver diseases but may be complicated by sampling error and bleeding. Confocal laser endomicroscopy (CLE) is a novel imaging modality providing in vivo histology. Previous studies using CLE for liver microscopy suffered from limited imaging depth...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Goetz M,Deris I,Vieth M,Murr E,Hoffman A,Delaney P,Galle PR,Neurath MF,Kiesslich R

    更新日期:2010-07-01 00:00:00