Mechanisms of HBV-related hepatocarcinogenesis.

abstract：BACKGROUND & AIMS:Transcatheter arterial chemoembolization with lipiodol (TACE) is widely performed in patients with hepatocellular carcinoma (HCC) unsuitable for curative treatment. It has recently been recommended for patients with 2 or 3 tumors >3 cm or ≥4 tumors in a treatment algorithm proposed by Japanese guideli...

journal_title：Journal of hepatology

authors： Takayasu K,Arii S,Kudo M,Ichida T,Matsui O,Izumi N,Matsuyama Y,Sakamoto M,Nakashima O,Ku Y,Kokudo N,Makuuchi M

更新日期：2012-04-01 00:00:00

abstract：:This review will highlight some of the important recent trends in liver transplantation. When possible, we will compare and contrast these trends across various regions of the world, in an effort to improve global consensus and better recognition of emerging data. ...

journal_title：Journal of hepatology

authors： Burra P,Freeman R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND & AIMS:Little is known about the frequency, phenotype and function of HBV-specific B cells during chronic infection. Here we study HBcAg and HBsAg-specific B cells in different clinical phases of a chronic HBV infection. METHODS:We included 118 treatment naïve and 34 nucleos(t)ide analogue-treated patients ...

journal_title：Journal of hepatology

authors： Vanwolleghem T,Groothuismink ZMA,Kreefft K,Hung M,Novikov N,Boonstra A

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND & AIMS:We previously showed that Reptin is overexpressed in hepatocellular carcinoma (HCC), and that in vitro depletion of Reptin with siRNAs led to HCC cell growth arrest and apoptosis. Here, we asked whether in vivo targeting of Reptin in established tumours had a therapeutic effect. METHODS:We used lenti...

journal_title：Journal of hepatology

authors： Ménard L,Taras D,Grigoletto A,Haurie V,Nicou A,Dugot-Senant N,Costet P,Rousseau B,Rosenbaum J

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND & AIMS:In developed countries, hepatitis E is usually associated with travelling to endemic areas, but a growing number of sporadic cases are also seen in patients with no travel history. The aim of this study was to assess the impact and the molecular epidemiology of hepatitis E in Italy. METHODS:Between J...

journal_title：Journal of hepatology

authors： Romanò L,Paladini S,Tagliacarne C,Canuti M,Bianchi S,Zanetti AR

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cirrhotic patients chronically treated with beta-blockers who achieve a decrease of hepatic venous pressure gradient (HVPG) > or =20% from baseline or to < or =12 mmHg have a marked reduction of first bleeding or re-bleeding. However, two HVPG measurements are needed to evaluate response. This study was...

journal_title：Journal of hepatology

authors： La Mura V,Abraldes JG,Raffa S,Retto O,Berzigotti A,García-Pagán JC,Bosch J

更新日期：2009-08-01 00:00:00

abstract：:The presence of hepatitis B virus DNA (HBV-DNA) in the peripheral blood mononuclear cells (PBMC) of 29 anti-HIV symptomless carriers (eleven HBeAg positive, eleven anti-HBe positive and seven HBsAg negative) and of 40 anti-human immunodeficiency virus (HIV)-negative patients (15 HBeAg positive, 15 anti-HBe positive an...

journal_title：Journal of hepatology

authors： Bartolomé FJ,Moraleda G,Castillo I,Martinez MG,Porres JC,Carreño V

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND/AIMS:The liver is the main source of circulating insulin-like growth factor binding proteins. In man, the cellular origin of insulin-like growth factor binding proteins has remained obscure. METHODS:Human hepatocytes isolated from surgical specimens were purified and cultured using a collagen gel immobiliza...

journal_title：Journal of hepatology

authors： Scharf JG,Schmidt-Sandte W,Pahernik SA,Koebe HG,Hartmann H

更新日期：1995-10-01 00:00:00

abstract：:Progressive familial intrahepatic cholestasis 2 is an autosomal-recessive disorder caused by mutations in the ABCB11 gene, which encodes the bile salt export pump (BSEP). Recurrence of BSEP deficiency after liver transplantation is caused by the development of anti-BSEP antibodies. Antibody-induced BSEP deficiency is ...

journal_title：Journal of hepatology

authors： Brinkert F,Pukite I,Krebs-Schmitt D,Briem-Richter A,Stindt J,Häussinger D,Keitel V,Müller I,Grabhorn E

更新日期：2018-10-01 00:00:00

abstract：:Ciprofloxacin, a fluorinated quinolone, is a powerful antibiotic widely used for its broad spectrum of activity in ambulatory and long-term care setting. Until now, ciprofloxacin administration has been associated with a few cases of acute, sometimes cholestatic jaundice or fulminant hepatic failure believed mainly re...

journal_title：Journal of hepatology

authors： Bataille L,Rahier J,Geubel A

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND & AIMS:High-carbohydrate diets contribute to the development of liver stress and fatty liver disease. While saturated fatty acids are known to induce liver stress, the role of monounsaturated fatty acids (MUFA), synthesized by the stearoyl-CoA desaturase (SCD) family of enzymes, in regulation of liver functi...

journal_title：Journal of hepatology

authors： Liu X,Burhans MS,Flowers MT,Ntambi JM

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND & AIMS:Accurate evaluation of renal function in patients with liver cirrhosis is critical for clinical management. However, there are still discrepancies between the measured glomerular filtration rate (mGFR) and creatinine-based estimated GFR (eGFR). In this study, we compared the performance of 2 common eG...

journal_title：Journal of hepatology

authors： Yoo JJ,Kim SG,Kim YS,Lee B,Lee MH,Jeong SW,Jang JY,Lee SH,Kim HS,Kim YD,Cheon GJ

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic undifferentiated (embryonal) sarcoma (HUS) is an exceptional hepatic malignant tumor in adults. Genetic studies were never reported in adult cases. METHODS:In this study concerning three cases of HUS occurring in adult, we studied the three classical ways of carcinogenesis i.e. the TP53 (p53), ...

journal_title：Journal of hepatology

authors： Lepreux S,Rebouissou S,Le Bail B,Saric J,Balabaud C,Bloch B,Martin-Négrier ML,Zucman-Rossi J,Bioulac-Sage P

更新日期：2005-03-01 00:00:00

abstract：:Intravascular coagulation is involved in the development of certain types of liver injury, including that induced by dimethylnitrosamine. Nitric oxide inhibits platelet aggregation and adhesion; however, its role in protecting against intravascular coagulation has not been clarified. We therefore investigated the effe...

journal_title：Journal of hepatology

authors： Nagase S,Isobe H,Ayukawa K,Sakai H,Nawata H

更新日期：1995-11-01 00:00:00

abstract：:This article summarizes the current state of antiviral therapy of hepatitis B with special attention given to areas that remain controversial or poorly defined. Strict adherence to liver association practice guidelines may result in missed opportunities to treat patients with significant underlying liver disease. In p...

journal_title：Journal of hepatology

authors： Zoulim F,Perrillo R

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study evaluates the agreement between reported use of interventions for patients with liver diseases and research evidence in Cochrane systematic reviews. METHODS:In July 2002, the Cochrane Hepato-Biliary Group had completed 28 systematic reviews on 36 interventions that were available in Denmark....

journal_title：Journal of hepatology

authors： Kürstein P,Gluud LL,Willemann M,Olsen KR,Kjellberg J,Sogaard J,Gluud C

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND/AIMS:Terlipressin is a long-acting vasopressin analogue that has been proved useful in the treatment of variceal haemorrhage. This study investigates the time profile of the haemodynamic effects of terlipressin on portal hypertension as well as the efficacy in decreasing portal-pressure and collateral blood ...

journal_title：Journal of hepatology

authors： Escorsell A,Bandi JC,Moitinho E,Feu F,García-Pagan JC,Bosch J,Rodés J

更新日期：1997-03-01 00:00:00

abstract：:Liver diseases affect millions of people worldwide. In most developed countries, the incidence of viral hepatitis is waning as a result of modern advances in disease prevention, diagnosis, and therapies. Expanded programmes for systematic immunisation against hepatitis B virus have also significantly brought down the ...

journal_title：Journal of hepatology

authors： Xiao J,Wang F,Wong NK,He J,Zhang R,Sun R,Xu Y,Liu Y,Li W,Koike K,He W,You H,Miao Y,Liu X,Meng M,Gao B,Wang H,Li C

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:Data from clinical trials suggest a potential role for on-treatment monitoring of serum HBsAg titres during interferon-alpha (pegIFN) therapy in predicting virological responses. However, baseline HBsAg titres during the natural history of chronic hepatitis B (CHB) have not been well-characterized. We...

journal_title：Journal of hepatology

authors： Nguyen T,Thompson AJ,Bowden S,Croagh C,Bell S,Desmond PV,Levy M,Locarnini SA

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocyte-like cells, differentiated from different stem cell sources, are considered to have a range of possible therapeutic applications, including drug discovery, metabolic disease modelling, and cell transplantation. However, little is known about how stem cells differentiate into mature and func...

journal_title：Journal of hepatology

authors： Chen KT,Pernelle K,Tsai YH,Wu YH,Hsieh JY,Liao KH,Guguen-Guillouzo C,Wang HW

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Platelet cytosolic calcium is necessary for normal platelet function, and may reflect intracellular signalling in vascular smooth muscle cells. METHODS:The cytosolic calcium of platelets from patients with cirrhosis and control subjects was measured in contact with plasma from either source, using FURA 2AM....

journal_title：Journal of hepatology

authors： Forrest EH,Dillon JF,Campbell TJ,Newsome PN,Hayes PC

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND/AIMS:Patients with cholestatic liver disease have 'low-turnover' osteoporosis. Since we reported that bile-duct ligated (BDL) rats develop bone disease with low bone formation and mass, we examined whether their reduced bone mass results in skeletal fragility, and whether the reduction in osteoprogenitor cel...

journal_title：Journal of hepatology

authors： Weinreb M,Pollak RD,Ackerman Z

更新日期：2004-03-01 00:00:00

abstract：:We report a novel method to assess bile secretory pressure using a Statham pressure transducer. The studies were performed in vivo in male Sprague-Dawley rats under pentobarbital anesthesia. Maximal secretory pressure averaged 21.8 +/- 1.1 (S.D.) cmH2O. The bile accumulated after 10 min of obstruction was 7.7 +/- 2.8 ...

journal_title：Journal of hepatology

authors： Cotting J,Reichen J

更新日期：1989-01-01 00:00:00

abstract：:Secondary biliary cirrhosis in the rat is an attractive model since unlike other models it does not rely on exogenous toxic compounds to induce cirrhosis. However, because little is known about the microcirculatory abnormalities of this model, this study investigated hemodynamics in rats with predefined functional imp...

journal_title：Journal of hepatology

authors： Ohara N,Schaffner T,Reichen J

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND/AIMS:Osteopenia is a common complication in some chronic cholestatic liver diseases. Our aims were to determine the prevalence and severity of bone disease in patients with primary sclerosing cholangitis; and identify risk factors to predict the presence and progression of osteopenia. METHODS:Eighty-one pat...

journal_title：Journal of hepatology

authors： Angulo P,Therneau TM,Jorgensen A,DeSotel CK,Egan KS,Dickson ER,Hay JE,Lindor KD

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis C virus infections are often associated with extra-hepatic immunological manifestations, including various autoimmune disorders. The aims of this study were: (i) to determine the prevalence of hepatitis C virus markers in patients with autoimmune thrombocytopenic purpura, and (ii) to d...

journal_title：Journal of hepatology

authors： Pawlotsky JM,Bouvier M,Fromont P,Deforges L,Duval J,Dhumeaux D,Bierling P

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND/AIMS:ATP stimulation of purinergic P2 receptors (P2YR and P2XR) regulates several hepatic functions. Here we report the involvement of ATP-mediated signals in enhancing hepatocyte tolerance to lethal stress. METHODS:The protection given by purinergic agonists was investigated in rat hepatocytes exposed to h...

journal_title：Journal of hepatology

authors： Carini R,Alchera E,De Cesaris MG,Splendore R,Piranda D,Baldanzi G,Albano E

更新日期：2006-08-01 00:00:00

abstract：:Activities of superoxide dismutase, catalase and glutathione peroxidase were measured in liver biopsy specimens from patients with various liver diseases, including six with chronic persistent hepatitis, nine with chronic active hepatitis, nine with non-alcoholic cirrhosis, eight with alcoholic cirrhosis and eight wit...

journal_title：Journal of hepatology

authors： Togashi H,Shinzawa H,Wakabayashi H,Nakamura T,Yamada N,Takahashi T,Ishikawa M

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND/AIMS:The objective of this study was to validate, with an independent prospective cohort of patients, our previous data indicating that the proliferating cell nuclear antigen-labeling index (PCNA-LI) reflects the liver functional reserve in human cirrhosis and might have prognostic significance for patient s...

journal_title：Journal of hepatology

authors： Delhaye M,Louis H,Degraef C,Le Moine O,Devière J,Peny MO,Adler M,Galand P

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND & AIMS:Non-selective beta blockers (NSBBs) have been shown to have deleterious outcomes in patients with refractory ascites, alcoholic hepatitis and spontaneous bacterial peritonitis leading many physicians to stop the drug in these cases. Acute-on-chronic liver failure (ACLF) is characterized by systemic in...

journal_title：Journal of hepatology

authors： Mookerjee RP,Pavesi M,Thomsen KL,Mehta G,Macnaughtan J,Bendtsen F,Coenraad M,Sperl J,Gines P,Moreau R,Arroyo V,Jalan R,CANONIC Study Investigators of the EASL-CLIF Consortium.

更新日期：2016-03-01 00:00:00