Abstract:
:Hepatitis C virus (HCV) infection is associated with tremendous morbidity and mortality due to liver complications. HCV infection is also associated with many extrahepatic manifestations including cardiovascular diseases, glucose metabolism impairment, cryoglobulinemia vasculitis, B cell non-Hodgkin lymphoma and chronic kidney disease (CKD). Many studies have shown a strong association between HCV and CKD, by reporting (i) an increased prevalence of HCV infection in patients on haemodialysis, (ii) an increased incidence of CKD and proteinuria in HCV-infected patients, and (iii) the development of membranoproliferative glomerulonephritis secondary to HCV-induced cryoglobulinemia vasculitis. HCV seropositivity is found to be associated with an increased relative risk for all-cause and cardiovascular mortality in the dialysis population. HCV seropositivity is linked to lower patient and graft survival after kidney transplantation. Such poor HCV-associated prognosis should have encouraged clinicians to treat HCV in CKD patients. However, due to frequent side effects and the poor efficacy of interferon-based treatments, very few HCV dialysis patients have received HCV medications until now. The emergence of new direct acting, interferon-free antiviral treatment, leading to HCV cure in most cases with a satisfactory safety profile, will shortly modify the management of HCV infection in CKD patients. In patients with a glomerular filtration rate (GFR) >30ml/min, the choice of DAA is not restricted. In those with a GFR <30 and >15ml/min, only paritaprevir/ritonavir/ombitasvir/dasabuvir or a grazoprevir plus elbasvir regimen are approved. In patients with end stage renal disease (GFR <15ml/min or dialysis), current data only allows for the use of a grazoprevir plus elbasvir combination. No doubt these data will be modified in the future with the advent of new studies including larger cohorts of HCV patients with renal impairment.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Cacoub P,Desbois AC,Isnard-Bagnis C,Rocatello D,Ferri Cdoi
10.1016/j.jhep.2016.06.011subject
Has Abstractpub_date
2016-10-01 00:00:00pages
S82-S94issue
1 Suppleissn
0168-8278issn
1600-0641pii
S0168-8278(16)30273-2journal_volume
65pub_type
杂志文章,评审abstract::This study set out to examine the relative effectiveness and tolerability of 12- versus 24-week courses of thrice weekly intramuscular lymphoblastoid interferon in the treatment of hepatitis B 'e' antigen (HBeAg)-positive chronic hepatitis B virus (HBV) infection, and to identify pretreatment factors predicting the ou...
journal_title:Journal of hepatology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-08-01 00:00:00
abstract::A technique is described for the isolation and culture of Kupffer cells (Kc) from needle and surgical liver biopsies of humans and rats. The isolation procedure is based on puncture perfusion of the specimen with collagenase and pronase, and subsequent gradient centrifugation. The ultrastructure of the cultured cells ...
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doi:10.1016/s0168-8278(88)80505-1
更新日期:1988-08-01 00:00:00
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更新日期:2013-12-01 00:00:00
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更新日期:2012-02-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,随机对照试验
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更新日期:2007-10-01 00:00:00
abstract:BACKGROUND & AIMS:Innate sensing of viral infection activates a global defense response including type I interferon (IFN) and IFN-stimulated genes (ISGs) expression. We previously reported that HCV NS3/4A protease, an essential protein in viral polyprotein processing, can abrogate antiviral signaling pathways and effec...
journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2011.07.017
更新日期:2012-01-01 00:00:00
abstract::Two groups of patients with HBV DNA-positive chronic active hepatitis B, from 20 French hospitals, separated according to HBe status, were prospectively subjected to a comparative analysis of various epidemiological, clinical, biochemical, serologic and histologic features. There were 61 patients with anti-HBe and 215...
journal_title:Journal of hepatology
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doi:10.1016/s0168-8278(05)80352-6
更新日期:1994-05-01 00:00:00
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更新日期:2014-07-01 00:00:00
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更新日期:1997-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0168-8278(90)90276-w
更新日期:1990-07-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
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更新日期:2009-10-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-03-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2016.04.025
更新日期:2016-08-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2019.02.011
更新日期:2019-07-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2003.11.024
更新日期:2004-03-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(87)80005-3
更新日期:1987-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jhep.2009.02.027
更新日期:2009-07-01 00:00:00
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journal_title:Journal of hepatology
pub_type:
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更新日期:2005-02-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of hepatology
pub_type: 临床试验,杂志文章
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abstract::In situ hybridization with oligonucleotide probes has been used to localise hepatitis A virus RNA genomic sequences in formalin-fixed and routinely processed human liver biopsies from three patients. Using radiolabelled Sulphur-35 antisense probes, viral genomic sequences were found in all three cases, but signal inte...
journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:1994-03-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:1997-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:1997-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-02-01 00:00:00
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更新日期:2010-10-01 00:00:00