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Tumour suppressors in liver carcinogenesis.

Abstract：

:The circuitous cell signalling pathways of hepatocytes comprise several factors that operate to downgrade or even interrupt the transmission of a given signal. These down-regulating influences are essential to keep cell proliferation and cell survival in check and if impaired, can alter a delicate balance in favour of cell proliferation. Each signalling pathway that has been implicated in carcinogenesis is influenced by both oncogenic factors that promote tumour growth when activated as well as tumour suppressor proteins that have to be impaired to favour tumour growth. This summary of the Tumour Suppressors in Liver Carcinogenesis Symposium held at the 2007 EASL Annual Meeting discusses four pathways with pre-eminent tumour suppressor activity, each involved in hepatocarcinogenesis: p53, mTOR, beta-catenin and hedgehog.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Dufour JF,Huber O,Kozma SC,Lu X,Toftgård R

doi

10.1016/j.jhep.2007.09.003

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

860-7

issue

6

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(07)00513-2

journal_volume

47

pub_type

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