Birth cohort-specific disparities in hepatocellular carcinoma stage at diagnosis, treatment, and long-term survival.


BACKGROUND & AIMS:Individuals born between 1945 and 1965 account for nearly 75% of hepatitis C virus (HCV) infections in the United States. As this cohort ages, progressive HCV-related liver disease leading to cirrhosis and hepatocellular carcinoma (HCC) will place a significant burden on the healthcare system. We aim to evaluate birth cohort-specific disparities in HCC stage at diagnosis, treatment rates, and overall survival with a focus on the 1945-1965 birth cohort. METHODS:A population-based retrospective cohort study of adult patients with HCC identified in the Surveillance, Epidemiology, and End Results 2003-2011 registry evaluated birth cohort-specific disparities in the prevalence and outcomes of HCC, including multivariate logistic regression models to evaluate disparities in HCC stage at diagnosis and HCC treatment received. Birth cohort-specific survival was evaluated with Kaplan-Meier methods and multivariate Cox proportional hazard models. RESULTS:The proportion of HCC represented by the 1945-1965 cohort increased by 64% from 2003-2011, and accounted for 57.4% of all HCC in 2011. Compared to patients born after 1965, the 1945-1965 cohort were more likely to have HCC within Milan criteria (OR, 3.66; 95% CI, 3.13-4.28; p<0.001). However, among patients with HCC within Milan criteria, the 1945-1965 cohort had no difference in receipt of surgical treatment, but had higher overall long-term survival (HR, 0.82; 95% CI, 0.69-0.97; p<0.03). CONCLUSIONS:The 1945-1965 birth cohort accounts for the majority of HCC in the United States. Despite earlier HCC stage at diagnosis, no difference in receipt of surgical treatment was observed, but higher overall survival was achieved.


J Hepatol


Journal of hepatology


Yan M,Ha J,Aguilar M,Bhuket T,Liu B,Gish RG,Cheung R,Wong RJ




Has Abstract


2016-02-01 00:00:00














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    更新日期:2012-04-01 00:00:00

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    abstract:BACKGROUND/AIMS:The factors which predict the long-term outcome in patients with hepatocellular carcinoma who are treated with percutaneous laser ablation (PLA) are not well established. METHODS:We prospectively analyzed treatment and survival parameters of 148 cirrhotic patients with nonsurgical hepatocellular carcin...

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    pub_type: 杂志文章


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  • Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depth.

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    authors: Acuña M,González-Hódar L,Amigo L,Castro J,Morales MG,Cancino GI,Groen AK,Young J,Miquel JF,Zanlungo S

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    abstract:BACKGROUND/AIMS:To examine the T-cell repertoire which is involved in the immunopathogenesis of chronic hepatitis, we analyzed the T-cell receptor Vbeta gene usage in liver-infiltrating lymphocytes by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical technique. METHODS:Complementary DNA ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


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    更新日期:1997-03-01 00:00:00

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    abstract:BACKGROUND/AIMS:In this study, a detailed morphometrical analysis of the hepatic microvasculature in the different zones of hepatic parenchyma was performed in normal and cirrhotic rat liver (CCl4-induced). The aims were to detect, in CCl4-induced cirrhosis, the real presence of the "capillarization" of hepatic sinusoi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


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    更新日期:2000-10-01 00:00:00

  • Therapeutic management of hepatitis and HIV infection in co-infected patients: results of a survey performed before the 2005 Consensus Conference.

    abstract::The First European Consensus Conference on the Treatment of Chronic Hepatitis B and C in HIV Co-infected Patients aimed to produce recommendations that could be applied across Europe. However, some important differences exist around Europe, in terms of access to treatment and tests for monitoring. This short survey of...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,多中心研究


    authors: Salmon D,Robain M,Rockstroh JK,Benhamou Y

    更新日期:2006-01-01 00:00:00

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    abstract:BACKGROUND & AIMS:Liver macrophages can be involved in both pathogen clearance and/or pathogenesis. To get further insight on their role during chronic hepatitis B virus (HBV) infections, our aim was to phenotypically and functionally characterize in vivo and ex vivo the interplay between HBV, primary human liver macro...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Faure-Dupuy S,Delphin M,Aillot L,Dimier L,Lebossé F,Fresquet J,Parent R,Matter MS,Rivoire M,Bendriss-Vermare N,Salvetti A,Heide D,Flores L,Klumpp K,Lam A,Zoulim F,Heikenwälder M,Durantel D,Lucifora J

    更新日期:2019-12-01 00:00:00

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


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    更新日期:2000-04-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2002-07-01 00:00:00

  • Mouse hepatocytes and LSEC proteome reveal novel mechanisms of ischemia/reperfusion damage and protection by A2aR stimulation.

    abstract:BACKGROUND & AIMS:Ischemia-reperfusion (IR) of liver results in hepatocytes (HP) and sinusoidal endothelial cells (LSEC) irreversible damage. Ischemic preconditioning protects IR damage upon adenosine A2a receptor (A2aR) stimulation. Understanding the phenotypic changes that underlie hepatocellular damage and protectio...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


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    更新日期:2015-03-01 00:00:00