当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development.

Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development.

Abstract：

BACKGROUND & AIMS:To determine whether amino acid mutations in the core region of hepatitis C virus (HCV) genotype 1 are associated with response to interferon (IFN) therapy and development of hepatocellular carcinoma (HCC). METHODS:We followed up 361 patients (median duration, 121 months), and IFN monotherapy was administered to 275 (76%) [sustained virological response (SVR) rate, 26.5%]. Using pretreatment sera, mutations at core residues 70 and 91 were analyzed [double wild (DW)-type amino acid pattern: arginine, residue 70; leucine, residue 91]. RESULTS:A low aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio and low HCV load were independently associated with SVR, but core mutations were not. During follow-up, 12 of 81 (14.8%) patients with the DW-type pattern and 52 of 216 (24.1%) patients with non-DW-type pattern developed HCC (p=0.06, Breslow-Gehan-Wilcoxon test). Multivariate analysis with the Cox proportional-hazards model revealed the following independent risk factors for HCC: male gender [p<0.0001; risk ratio (RR), 3.97], older age (p<0.05; RR, 2.08), advanced fibrosis (p<0.0001; RR, 5.75), absence of SVR (p<0.01; RR, 10.0), high AST level (p<0.01; RR, 2.08), high AST/ALT ratio (p<0.01; RR, 2.21), and non-DW-type pattern (p<0.05; RR, 1.96). In patients with F0-F2 fibrosis at entry, non-DW-type was likely to lead to cirrhosis (p=0.051). CONCLUSIONS:In HCV genotype 1 patients, HCC risk could be predicted by studying core mutations, response to IFN, and host factors like age, gender, and liver fibrosis.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Nakamoto S,Imazeki F,Fukai K,Fujiwara K,Arai M,Kanda T,Yonemitsu Y,Yokosuka O

doi

10.1016/j.jhep.2009.10.001

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

72-8

issue

1

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(09)00647-3

journal_volume

52

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • An ultrasound scoring system for the diagnosis of liver disease in cystic fibrosis.

    abstract：:Advances in the management of the pulmonary complications of cystic fibrosis may result in an increasing prevalence of patients with chronic liver disease which may, therefore, become more important in the long-term management of cystic fibrosis patients. However, no simple and reliable test is available for the diagn...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0168-8278(95)80444-7

    authors： Williams SG,Evanson JE,Barrett N,Hodson ME,Boultbee JE,Westaby D

    更新日期：1995-05-01 00:00:00

  • Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate.

    abstract：:Drug hepatotoxicity is partially determined by genetic factors involved in drug metabolism, which may involve the debrisoquine oxidation polymorphism mediated by cytochrome (CYP) 2D6. The purpose of this study was to assess the relationship between drug hepatotoxicity and another genetic polymorphism of drug oxidation...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80620-8

    authors： Horsmans Y,Lannes D,Pessayre D,Larrey D

    更新日期：1994-12-01 00:00:00

  • Influence of 48 hours of cold storage in University of Wisconsin organ preservation solution on metabolic capacity of rat hepatocytes.

    abstract：BACKGROUND/AIMS:Suspensions of isolated hepatocytes are a valuable tool to study liver functions. For optimal use of the isolated hepatocytes, methods are needed to preserve the hepatocytes while maintaining their viability, metabolic and transport functions. Until now, little has been known about the maintenance of th...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80091-8

    authors： Olinga P,Merema M,Slooff MJ,Meijer DK,Groothuis GM

    更新日期：1997-10-01 00:00:00

  • Release of lysosomal enzymes is not correlated with superoxide and prostaglandin production by stimulated rat Kupffer cells in primary culture.

    abstract：:A substantial production of prostaglandin E2 (PGE2) was induced in primary cultures of rat Kupffer cells by zymosan, calcium ionophore A23187, phorbol ester and arachidonic acid, whereas contact with latex particles, glucan or immunocomplexes led to a minor PGE2 release only. Superoxide generation, on the other hand, ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(88)80028-x

    authors： Dieter P,Schulze-Specking A,Decker K

    更新日期：1988-04-01 00:00:00

  • Choosing the best endpoint.

    abstract：:Design and endpoints of clinical trials in hepatocellular carcinoma. Llovet JM, Di Bisceglie AM, Bruix J, Kramer BS, Lencioni R, Zhu AX, Sherman M, Schwartz M, Lotze M, Talwalkar J, Gores GJ; for the Panel of Experts in HCC-Design Clinical Trials. The design of clinical trials in hepatocellular carcinoma (HCC) is comp...

    journal_title：Journal of hepatology

    pub_type： 评论,杂志文章

    doi：10.1016/j.jhep.2008.07.012

    authors： Christensen E

    更新日期：2008-10-01 00:00:00

  • HBV replication, pathobiology and therapy: Unanswered questions.

    abstract：:This volume explores these and other issues of relevance to our understanding of the HBV life cycle and clinical management of chronic HBV infections. The ultimate goals of these studies is not just to obtain a more precise understanding of the HBV life cycle, but to also acquire an understanding that will lead to mor...

    journal_title：Journal of hepatology

    pub_type： 社论

    doi：10.1016/j.jhep.2016.01.006

    authors： Seeger C,Mason WS

    更新日期：2016-04-01 00:00:00

  • Increasing hepatic arteriole wall thickness and decreased luminal diameter occur with increasing age in normal livers.

    abstract：BACKGROUND & AIMS:There is no data to suggest that the size of bile ducts, portal venules, and hepatic arterioles varies according to age in the normal human liver. We sought to examine whether hepatic arteriolar size, wall thickness, and luminal diameter change with increasing age. METHODS:Histologically normal liver...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.12.018

    authors： Fiel MI,Deniz K,Elmali F,Schiano TD

    更新日期：2011-09-01 00:00:00

  • Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.

    abstract：BACKGROUND/AIMS:Non-alcoholic fatty liver disease (NAFLD) pathogenesis remains unknown. Due to the emerging role of free cholesterol (FC) in NAFLD, our aim was to examine the correlation between FC accumulation in patients with NAFLD and the expression of enzymes that regulate cholesterol homeostasis. METHODS:Filipin ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.12.016

    authors： Caballero F,Fernández A,De Lacy AM,Fernández-Checa JC,Caballería J,García-Ruiz C

    更新日期：2009-04-01 00:00:00

  • The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin.

    abstract：BACKGROUND/AIMS:Selective cyclooxygenase (COX)-2 inhibitors do not adversely affect renal function in experimental cirrhosis. In the current study, we investigated the molecular mechanisms underlying the effects of the selective COX-2 inhibitor, celecoxib, and assessed the influence of albumin on its actions. METHODS:...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.09.011

    authors： López-Parra M,Clària J,Titos E,Planagumà A,Párrizas M,Masferrer JL,Jiménez W,Arroyo V,Rivera F,Rodés J

    更新日期：2005-01-01 00:00:00

  • Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats.

    abstract：BACKGROUND & AIMS:High oxidative stress plays a major role in increasing hepatic vascular resistance in cirrhosis, by facilitating liver fibrosis and by increasing hepatic vascular tone. This study is aimed at investigating whether the use of the novel isoform of recombinant human manganese superoxide dismutase (rMnSOD...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.09.010

    authors： Guillaume M,Rodriguez-Vilarrupla A,Gracia-Sancho J,Rosado E,Mancini A,Bosch J,Garcia-Pagán JC

    更新日期：2013-02-01 00:00:00

  • Toxicity of low dose azathioprine and 6-mercaptopurine in rat hepatocytes. Roles of xanthine oxidase and mitochondrial injury.

    abstract：BACKGROUND/AIMS:To study effects of pharmacologic concentrations of azathioprine and 6-mercaptopurine (6-MP) on rat hepatocytes. METHODS:Hepatocytes cultured on matrigel were incubated with azathioprine or 6-MP; effects of putative protective agents were studied. Viability (LDH leakage), reduced (GSH) and oxidized glu...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2003.11.024

    authors： Tapner MJ,Jones BE,Wu WM,Farrell GC

    更新日期：2004-03-01 00:00:00

  • Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation.

    abstract：BACKGROUND & AIMS:Although there is increasing interest in its use, definitive evidence demonstrating a benefit for postmortem normothermic regional perfusion (NRP) in controlled donation after circulatory death (cDCD) liver transplantation is lacking. The aim of this study was to compare results of cDCD liver transpla...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2018.12.013

    authors： Hessheimer AJ,Coll E,Torres F,Ruíz P,Gastaca M,Rivas JI,Gómez M,Sánchez B,Santoyo J,Ramírez P,Parrilla P,Marín LM,Gómez-Bravo MÁ,García-Valdecasas JC,López-Monclús J,Boscá A,López-Andújar R,Fundora-Suárez J,Villar J,

    更新日期：2019-04-01 00:00:00

  • Expression of liver-specific functions in rat hepatocytes following sublethal and lethal acetaminophen poisoning.

    abstract：AIM:In order to study the short-term effect of moderate and severe reduction of liver function by acetaminophen poisoning of different severity on gene expression for liver-specific functions, rats were given 3.75 and 7.5 g per kg body weight acetaminophen intragastrically. The lower dose is associated with low mortali...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80072-9

    authors： Tygstrup N,Jensen SA,Krog B,Dalhoff K

    更新日期：1996-08-01 00:00:00

  • Isolation, characterization and biological significance of hepatitis B virus mutants from serum of a patient with immunologically negative HBV infection.

    abstract：BACKGROUND/AIM:A low-titered hepatitis B virus infection without immunological markers was identified in a prospective study in the serum of a kidney transplant recipient by PCR. The aim of this study was to analyze HBV genomes and their biological significance. METHODS:The genome was amplified in two overlapping frag...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80313-x

    authors： Schories M,Peters T,Rasenack J

    更新日期：2000-11-01 00:00:00

  • Schistosomiasis mansoni and viral B hepatitis in woodchucks.

    abstract：BACKGROUND/AIMS:An interaction between human schistosomiasis and viral hepatitis B has often been suggested, but never established. The experimental investigation has been hampered by the lack of a suitable model. Only woodchucks are susceptible to both Schistosoma mansoni and a B-like hepatitis virus (WHV) infections....

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)00068-4

    authors： Andrade ZA,Berthillon P,Paraná R,Grimaud JA,Trépo C

    更新日期：2001-01-01 00:00:00

  • Evaluation of amantadine in chronic hepatitis C: a meta-analysis.

    abstract：BACKGROUND/AIMS:The benefit of amantadine combination therapy, either with interferon (IFN) alone (double therapy) or with ribavirin and IFN (triple therapy) is unknown. METHODS:We analyzed the effect of amantadine on the end-of-treatment virological response and the sustained response using meta-analysis of 31 random...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jhep.2004.05.019

    authors： Deltenre P,Henrion J,Canva V,Dharancy S,Texier F,Louvet A,De Maeght S,Paris JC,Mathurin P

    更新日期：2004-09-01 00:00:00

  • Tumour suppressors in liver carcinogenesis.

    abstract：:The circuitous cell signalling pathways of hepatocytes comprise several factors that operate to downgrade or even interrupt the transmission of a given signal. These down-regulating influences are essential to keep cell proliferation and cell survival in check and if impaired, can alter a delicate balance in favour of...

    journal_title：Journal of hepatology

    pub_type：

    doi：10.1016/j.jhep.2007.09.003

    authors： Dufour JF,Huber O,Kozma SC,Lu X,Toftgård R

    更新日期：2007-12-01 00:00:00

  • Improvement of prognostic power of the Child-Pugh classification of liver cirrhosis by hyaluronan.

    abstract：BACKGROUND/AIMS:Modifications of the Child-Pugh classification of liver cirrhosis by incorporation of hyaluronan were tested to improve the prognostic power for long term evaluation of liver cirrhosis in 126 patients observed over a period of 10 years. METHODS:Serum concentrations of HA were determined at study entry....

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00431-8

    authors： Körner T,Kropf J,Kosche B,Kristahl H,Jaspersen D,Gressner AM

    更新日期：2003-12-01 00:00:00

  • Evidence against a role for endotoxin in the hyperdynamic circulation of rats with prehepatic portal hypertension.

    abstract：BACKGROUND/AIMS:Excessive formation of nitric oxide may mediate the generalized vasorelaxation and hyporesponsiveness to vasoconstrictors observed in portal hypertensive states. Endotoxin, released from the bowel and detoxified by the liver, could stimulate inducible nitric oxide synthase directly or indirectly via the...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80266-9

    authors： Chu CJ,Lee FY,Wang SS,Chang FY,Lin HC,Lu RH,Wu SL,Chan CC,Tai CC,Lai IN,Lee SD

    更新日期：1999-06-01 00:00:00

  • The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection.

    abstract：BACKGROUND/AIMS:The chemokine receptor CX3CR1 and its specific ligand fractalkine (CX3CL1) are known to modulate inflammatory and fibroproliferative diseases. Here we investigate the role of CX3CR1/fractalkine in HCV-induced liver fibrosis. METHODS:A genotype analysis of CX3CR1 variants was performed in 211 HCV-infect...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2007.09.008

    authors： Wasmuth HE,Zaldivar MM,Berres ML,Werth A,Scholten D,Hillebrandt S,Tacke F,Schmitz P,Dahl E,Wiederholt T,Hellerbrand C,Berg T,Weiskirchen R,Trautwein C,Lammert F

    更新日期：2008-02-01 00:00:00

  • Early increase in plasma parathyroid hormone levels following liver transplantation.

    abstract：BACKGROUND/AIMS:The pathogenesis of post-transplantation bone loss is poorly understood, although glucocorticoid therapy is believed to play an important role. In the present study we have measured plasma parathyroid hormone concentrations in the first few months after orthotopic liver transplantation, in order to exam...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80243-1

    authors： Compston JE,Greer S,Skingle SJ,Stirling DM,Price C,Friend PJ,Alexander G

    更新日期：1996-11-01 00:00:00

  • Lectin histochemistry of the liver in biliary disease, following transplantation and in cholangiocarcinoma.

    abstract：:Evidence is accumulating that there are changes in the expression of antigens on biliary epithelium in early primary biliary cirrhosis and graft rejection. If any of the biliary diseases including rejection are associated with specific alterations in biliary glycoprotein structure, lectin histochemistry could be usefu...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(88)80043-6

    authors： Rhodes JM,Hubscher S,Black R,Elias E,Savage A

    更新日期：1988-06-01 00:00:00

  • β7-Integrin and MAdCAM-1 play opposing roles during the development of non-alcoholic steatohepatitis.

    abstract：BACKGROUND & AIMS:Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease in Western countries. It is unclear how infiltrating leukocytes affect NASH-development. Our study aims to investigate the role of the homing/receptor, pair mucosal addressin cell adhesion molecule-1 (MAdCAM-1)/β7-Integri...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.02.001

    authors： Drescher HK,Schippers A,Clahsen T,Sahin H,Noels H,Hornef M,Wagner N,Trautwein C,Streetz KL,Kroy DC

    更新日期：2017-06-01 00:00:00

  • Genomics and HCV infection: progression of fibrosis and treatment response.

    abstract：:HCV infection is a global health problem that affects 170 million people worldwide. The severity of the disease varies from asymptomatic chronic infection to cirrhosis and hepatocellular carcinoma (HCC). Recently, the standard of care for genotype 1 patients has greatly improved with the addition of protease inhibitor...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2012.05.016

    authors： Estrabaud E,Vidaud M,Marcellin P,Asselah T

    更新日期：2012-11-01 00:00:00

  • Platelet basal cytosolic calcium: the influence of plasma factors in cirrhosis.

    abstract：BACKGROUND:Platelet cytosolic calcium is necessary for normal platelet function, and may reflect intracellular signalling in vascular smooth muscle cells. METHODS:The cytosolic calcium of platelets from patients with cirrhosis and control subjects was measured in contact with plasma from either source, using FURA 2AM....

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80117-6

    authors： Forrest EH,Dillon JF,Campbell TJ,Newsome PN,Hayes PC

    更新日期：1996-09-01 00:00:00

  • Gastro-oesophageal reflux and alcoholic cirrhosis. A reappraisal.

    abstract：:The oesophageal pH was recorded for 3 h after a test-meal in 27 healthy control subjects (group I), 40 patients with alcoholic cirrhosis (group II), and 22 patients with a normal liver and symptoms of gastro-oesophageal reflux (control refluxers). Gastro-oesophageal reflux was observed in 10 of the cirrhotic patients....

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(87)80088-0

    authors： Arsene D,Bruley des Varannes S,Galmiche JP,Denis P,Chayvialle JA,Hellot MF,Ducrotte P,Colin R

    更新日期：1987-04-01 00:00:00

  • Hepatic lipid profiling in chronic hepatitis C: an in vitro and in vivo proton magnetic resonance spectroscopy study.

    abstract：BACKGROUND & AIMS:Hepatic steatosis is an important factor in pathogenesis, progression and response to treatment in hepatitis C. We aimed to investigate differences in hepatic lipid composition in liver biopsies from patients with chronic hepatitis C using proton magnetic resonance spectroscopy ((1)H MRS) and to trans...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.10.006

    authors： Cobbold JF,Patel JH,Goldin RD,North BV,Crossey MM,Fitzpatrick J,Wylezinska M,Thomas HC,Cox IJ,Taylor-Robinson SD

    更新日期：2010-01-01 00:00:00

  • Effects of ursodeoxycholic acid after 4 to 12 years of therapy in early and late stages of primary biliary cirrhosis.

    abstract：:Twenty-two patients with primary biliary cirrhosis were treated with ursodeoxycholic acid, 10 mg/kg per day. Fourteen patients with stages I/II were treated for 4-12 years (mean 7.5), and eight patients with stages III/IV for 5-12 years (mean 6.5). Twelve of 13 patients with early stages became asymptomatic. Aminotran...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0168-8278(94)80111-8

    authors： Leuschner U,Güldütuna S,Imhof M,Hübner K,Benjaminov A,Leuschner M

    更新日期：1994-10-01 00:00:00

  • Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes.

    abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) and D virus (HDV) co-infections cause the most severe form of viral hepatitis. HDV induces an innate immune response, but it is unknown how the host cell senses HDV and if this defense affects HDV replication. We aim to characterize interferon (IFN) activation by HDV, identify ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2018.02.021

    authors： Zhang Z,Filzmayer C,Ni Y,Sültmann H,Mutz P,Hiet MS,Vondran FWR,Bartenschlager R,Urban S

    更新日期：2018-07-01 00:00:00

  • Treatment of autoimmune and extrahepatic manifestations of hepatitis C virus infection.

    abstract：:Hepatitis C virus (HCV) infects mononuclear cells and may be responsible, as are other viruses, for immunologic disorders. The immunologic abnormalities observed in HCV infections are usually non-specific (i.e. cryoglobulinemia, immune complex deposits, autoantibodies). The association with cryoglobulinemia is clear a...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-8278(99)80404-8

    authors： Lunel F,Cacoub P

    更新日期：1999-01-01 00:00:00