Treatment of autoimmune and extrahepatic manifestations of hepatitis C virus infection.

abstract：:The natural history of HBV is known to be complicated by HIV-co-infection. In contrast, the effect of HBV on the outcome of patients infected with HIV-1 is controversial. Some cohort studies from the pre-HAART era described a more rapid progression to AIDS in patients carrying antibodies to the core-antigen or having ...

journal_title：Journal of hepatology

authors： Rockstroh JK

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:No information is yet available about the influence of alcohol abuse on the translocation of larger molecules (Mr>1200) through the intestinal mucosa in man. The present study aimed to determine the intestinal permeability to macromolecules in patients with chronic alcohol abuse and mild to more advance...

journal_title：Journal of hepatology

authors： Parlesak A,Schäfer C,Schütz T,Bode JC,Bode C

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND/AIMS:During liver regeneration, a network of cytokines and growth factors interact with hepatocytes, helping to restore the liver mass and functions after partial tissue loss. Agonists that trigger Ca2+ signals in the liver contribute to this process, although little is known about calcium signalling during ...

journal_title：Journal of hepatology

authors： Nicou A,Serrière V,Hilly M,Prigent S,Combettes L,Guillon G,Tordjmann T

更新日期：2007-02-01 00:00:00

abstract：:In this Grand Round presentation, the case of a man with decompensated liver disease is described. He subsequently developed a fatal pulmonary embolism, which may not have occurred if he had been prescribed prophylactic anticoagulation to prevent venous thromboembolic disease. The burden of thrombotic disease in those...

journal_title：Journal of hepatology

authors： Dhar A,Mullish BH,Thursz MR

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND & AIMS:Recent research has suggested that dietary fructose intake may increase serum uric acid (UA) concentrations. Both UA concentration and fructose consumption maybe also increase in NAFLD. It is not known whether dietary fructose consumption and UA concentration are independently associated with non-alco...

journal_title：Journal of hepatology

authors： Mosca A,Nobili V,De Vito R,Crudele A,Scorletti E,Villani A,Alisi A,Byrne CD

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND/AIMS:The primary cause of Familial Amyloidotic Polyneuropathy is a variant transthyretin gene on chromosome 18. Progressive polyneuropathy followed by fatal cardiac and renal failure commonly manifest during middle age. Within 10 years after onset of clinical symptoms, affected individuals usually die due to...

journal_title：Journal of hepatology

authors： Schmidt HH,Nashan B,Pröpsting MJ,Nakazato M,Flemming P,Kubicka S,Böker K,Pichlmayr R,Manns MP

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. However, their origin is still unknown. We tested the hypothesis that bone marrow (BM) contributes to the population of HSCs. METHODS:Chimeric mice transplanted with donor BM from collagen alpha1(I)-GFP+ reporter mice were subjected...

journal_title：Journal of hepatology

authors： Kisseleva T,Uchinami H,Feirt N,Quintana-Bustamante O,Segovia JC,Schwabe RF,Brenner DA

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND & AIMS:We used longitudinal data from the ANRS CO13 HEPAVIH cohort study of HIV-HCV co-infected individuals to investigate whether polyphenol rich food intake through coffee and/or daily chocolate consumption could play a role in reducing liver enzymes levels. METHODS:Longitudinal data collection included s...

journal_title：Journal of hepatology

authors： Carrieri MP,Lions C,Sogni P,Winnock M,Roux P,Mora M,Bonnard P,Salmon D,Dabis F,Spire B,ANRS CO13 HEPAVIH Study Group.

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND & AIMS:Data on the natural history of chronic hepatitis C virus (HCV) genotype 6 is lacking. METHODS:We compared the natural history of 138 HCV genotype 1 patients (median age: 50) with 78 HCV genotype 6 patients (median age: 46.5). Baseline demographic data including gender, route of transmission, liver bi...

journal_title：Journal of hepatology

authors： Seto WK,Lai CL,Fung J,Hung I,Yuen J,Young J,Wong DK,Yuen MF

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis B virus (HBV) disease is caused by both necroinflammation and active viral replication. The role of ALT levels as a predictor of liver injury has recently been questioned. The aim of the study was to determine whether normal ALT is associated with liver injury in a cohort of HBV patien...

journal_title：Journal of hepatology

authors： Lai M,Hyatt BJ,Nasser I,Curry M,Afdhal NH

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND/AIMS:The aim was to study the reproducibility of magnetic resonance velocity mapping, when measuring portal vein and superior mesenteric artery blood flow, under fasting and post-prandial conditions. Magnetic resonance flow measurements for the portal vein were compared with echo-Doppler measurements in the ...

journal_title：Journal of hepatology

authors： Lycklama à Nijeholt GJ,Burggraaf K,Wasser MN,Schultze Kool LJ,Schoemaker RC,Cohen AF,de Roos A

更新日期：1997-02-01 00:00:00

abstract：:Pulmonary concerns in liver transplant candidates have intraoperative and outcome implications. Evolving MELD exception policies address transplant priority for problems such as hepatopulmonary syndrome, portopulmonary hypertension, and hemorrhagic hereditary telangiectasia. Other pulmonary issues such as refractory h...

journal_title：Journal of hepatology

authors： Krowka MJ,Wiesner RH,Heimbach JK

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND/AIMS:Suspensions of isolated hepatocytes are a valuable tool to study liver functions. For optimal use of the isolated hepatocytes, methods are needed to preserve the hepatocytes while maintaining their viability, metabolic and transport functions. Until now, little has been known about the maintenance of th...

journal_title：Journal of hepatology

authors： Olinga P,Merema M,Slooff MJ,Meijer DK,Groothuis GM

更新日期：1997-10-01 00:00:00

abstract：:The Hepatitis Delta Virus (HDV), a defective ribonucleic acid virus dependent on the Hepatitis B Virus (HBV) is a cause of severe liver disease that often leads to cirrhosis and death. Since the HDV finds in the HBV infection a biological niche in which to thrive indefinitely, the major victims of its infection are th...

journal_title：Journal of hepatology

authors： Rizzetto M,Rosina F,Saracco G,Bellando PC,Actis GC,Bonino F,Smedile A,Trinchero P,Sansalvadore F,Pintus C

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of stages from simple steatosis to non-alcoholic steatohepatitis (NASH). However, disease pathogenesis remains largely unknown. microRNA (miRNA or miR) expression has recently been reported to be altered in human NASH, and modulated by urs...

journal_title：Journal of hepatology

authors： Castro RE,Ferreira DM,Afonso MB,Borralho PM,Machado MV,Cortez-Pinto H,Rodrigues CM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND & AIMS:Cholangiocarcinoma (CCA) carries a very poor prognosis due to a typically late clinical presentation and a poor response to current therapeutics. While these tumors commonly express PD-1 and PD-L1, the response to immune checkpoint inhibitors (ICI) is poor. Stimulating antigen-presenting cells includi...

journal_title：Journal of hepatology

authors： Diggs LP,Ruf B,Ma C,Heinrich B,Cui L,Zhang Q,McVey JC,Wabitsch S,Heinrich S,Rosato U,Lai W,Subramanyam V,Longerich T,Loosen SH,Luedde T,Neumann UP,Desar S,Kleiner D,Gores G,Wang XW,Greten TF

更新日期：2020-12-01 00:00:00

abstract：:The EASL Monothematic Conference on Translational Research in Viral Hepatitis brought together a group of leading scientists and clinicians working on both, basic and clinical aspects of viral hepatitis, thereby building bridges from bench to bedside. This report recapitulates the presentations and discussions at the ...

journal_title：Journal of hepatology

authors： Boettler T,Moradpour D,Thimme R,Zoulim F

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND/AIMS:A distinct subgroup of angiotensin II type 1 receptor (AT1R) blockers (ARBs) have been reported to suppress the development of hepatic steatosis. These effects were generally explained by selective peroxisome proliferator-activated receptor (PPAR) gamma modulating properties of ARBs, independent of thei...

journal_title：Journal of hepatology

authors： Nabeshima Y,Tazuma S,Kanno K,Hyogo H,Chayama K

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND/AIMS:This study assesses the safety, pharmacokinetics and efficacy of transarterial chemoembolization using drug eluting beads (DEB), an embolizing device that slowly releases chemotherapy to decrease systemic toxicity. METHODS:Twenty-seven Child-Pugh A cirrhotics (76% male, 59% HCV) with untreated large/mu...

journal_title：Journal of hepatology

authors： Varela M,Real MI,Burrel M,Forner A,Sala M,Brunet M,Ayuso C,Castells L,Montañá X,Llovet JM,Bruix J

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND & AIMS:Liver macrophages can be involved in both pathogen clearance and/or pathogenesis. To get further insight on their role during chronic hepatitis B virus (HBV) infections, our aim was to phenotypically and functionally characterize in vivo and ex vivo the interplay between HBV, primary human liver macro...

journal_title：Journal of hepatology

authors： Faure-Dupuy S,Delphin M,Aillot L,Dimier L,Lebossé F,Fresquet J,Parent R,Matter MS,Rivoire M,Bendriss-Vermare N,Salvetti A,Heide D,Flores L,Klumpp K,Lam A,Zoulim F,Heikenwälder M,Durantel D,Lucifora J

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND/AIMS:Suppressor of cytokine signaling (SOCS)-1, a negative feedback regulator of cytokine signaling pathway, also has a tumor suppressor activity, the silencing of its gene by hypermethylation is suggested to contribute to hepatocarcinogenesis. We studied the effect of the core protein of hepatitis C virus (...

journal_title：Journal of hepatology

authors： Miyoshi H,Fujie H,Shintani Y,Tsutsumi T,Shinzawa S,Makuuchi M,Kokudo N,Matsuura Y,Suzuki T,Miyamura T,Moriya K,Koike K

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIMS:Silymarin has protective effects in different experimental conditions, but its efficacy in human liver cirrhosis has not been completely established. Therefore, this study was carried out to determine the effect of silymarin in alcoholics with liver cirrhosis with respect to survival and clinical and la...

journal_title：Journal of hepatology

authors： Parés A,Planas R,Torres M,Caballería J,Viver JM,Acero D,Panés J,Rigau J,Santos J,Rodés J

更新日期：1998-04-01 00:00:00

abstract：:Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality. Prospective data to define ...

journal_title：Journal of hepatology

authors： Jalan R,Gines P,Olson JC,Mookerjee RP,Moreau R,Garcia-Tsao G,Arroyo V,Kamath PS

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND & AIMS:Recently, we have shown that micro-metastases, in the hypoxic transition zone surrounding lesions generated by radiofrequency ablation (RFA), display strongly accelerated outgrowth. CD95 is best known for its ability to induce apoptosis but can also promote tumorigenesis in apoptosis-resistant tumor c...

journal_title：Journal of hepatology

authors： Nijkamp MW,Hoogwater FJ,Steller EJ,Westendorp BF,van der Meulen TA,Leenders MW,Borel Rinkes IH,Kranenburg O

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND/AIMS:Evidence that the geno/subtype of hepatitis C virus (HCV) is predictive of the response to interferon-alpha therapy suggests that typing methods are clinically useful. In the present study, HCV isolates obtained from 74 patients with chronic hepatitis C were used to evaluate three genotyping and two ser...

journal_title：Journal of hepatology

authors： Lee JH,Roth WK,Zeuzem S

更新日期：1997-05-01 00:00:00

abstract：:Drug induced hepatotoxicity has been reported infrequently with sulfonylureas. For glimepiride, a second-generation sulfonylurea there is no report of hepatotoxicity in English literature. A patient with non-insulin-dependent diabetes mellitus who developed cholestatic liver injury soon after initiation of glimepiride...

journal_title：Journal of hepatology

authors： Chounta A,Zouridakis S,Ellinas C,Tsiodras S,Zoumpouli C,Kopanakis S,Giamarellou H

更新日期：2005-06-01 00:00:00

abstract：:There are three main types of interferon, now designated alpha, beta and gamma. Human interferons-alpha exist as many subtypes, probably more than 26. These are chemically quite closely related, but each has a unique chemical composition and biological properties. Preparations of interferon-alpha derived from stimulat...

journal_title：Journal of hepatology

authors： Finter NB

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:Steatohepatitis (SH) is associated with mitochondrial dysfunction and excessive production of superoxide, which can then be converted into H(2)O(2) by SOD2. Since mitochondrial GSH (mGSH) plays a critical role in H(2)O(2) reduction, we explored the interplay between superoxide, H(2)O(2), and mGSH in n...

journal_title：Journal of hepatology

authors： von Montfort C,Matias N,Fernandez A,Fucho R,Conde de la Rosa L,Martinez-Chantar ML,Mato JM,Machida K,Tsukamoto H,Murphy MP,Mansouri A,Kaplowitz N,Garcia-Ruiz C,Fernandez-Checa JC

更新日期：2012-10-01 00:00:00

abstract：:Hepatitis C virus genotype and the amounts of circulating HCV RNA are the most important factors in determining the efficacy of interferon therapy for chronic hepatitis C. To clarify the correlation of these two factors to the progression of liver disease, we classified 148 Japanese patients with type C chronic liver ...

journal_title：Journal of hepatology

authors： Mita E,Hayashi N,Kanazawa Y,Hagiwara H,Ueda K,Kasahara A,Fusamoto H,Kamada T

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND/AIMS:Catabolism is associated with decreased serum concentrations of insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-3 associated with elevated IGFBP-3 protease activity and increased concentrations of IGFBP-1 and -4. The effects of the acute phase mediators interleu...

journal_title：Journal of hepatology

authors： Lelbach A,Scharf JG,Ramadori G

更新日期：2001-11-01 00:00:00