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Evaluation of amantadine in chronic hepatitis C: a meta-analysis.

Abstract：

BACKGROUND/AIMS:The benefit of amantadine combination therapy, either with interferon (IFN) alone (double therapy) or with ribavirin and IFN (triple therapy) is unknown. METHODS:We analyzed the effect of amantadine on the end-of-treatment virological response and the sustained response using meta-analysis of 31 randomized controlled trials. RESULTS:Overall analysis revealed a significant effect of amantadine. Triple therapy was the best regimen for improving the sustained response (mean difference: 8.4%, 95% CI: 2.4-13.8%, P=0.002). In subgroup analysis, amantadine did not have a significant effect upon naive patients or relapsers. In non-responders, combination therapy with amantadine was associated with a significant effect on the sustained response (mean difference: 8.3%, 95% CI: 1.9-14.6%, P=0.01). In sensitivity analysis, double therapy did not improve virological responses. Conversely, triple therapy tended to improve the end-of-treatment virological response and was associated with a significant effect upon the sustained response (mean difference: 12.7%, 95% CI: 3.8-21.6%, P=0.005). CONCLUSIONS:Combination therapy with amantadine is of no effect upon naive patients or relapsers. In non-responders, triple therapy with amantadine improved the sustained response. New randomized controlled trials are required to confirm this meta-analysis.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Deltenre P,Henrion J,Canva V,Dharancy S,Texier F,Louvet A,De Maeght S,Paris JC,Mathurin P

doi

10.1016/j.jhep.2004.05.019

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

462-73

issue

3

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(04)00307-1

journal_volume

41

pub_type

杂志文章,meta分析

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