Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.

abstract：BACKGROUND/AIMS:After liver transplantation for autoimmune hepatitis, the long-term results and the incidence of recurrence of primary disease are unknown. METHODS:In this retrospective study we reviewed the clinical course of 25 patients transplanted for autoimmune hepatitis and followed for a mean of 5.3 years (2-8....

journal_title：Journal of hepatology

authors： Ratziu V,Samuel D,Sebagh M,Farges O,Saliba F,Ichai P,Farahmand H,Gigou M,Féray C,Reynès M,Bismuth H

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis C has been associated with a decrease in quality of life and with neurological abnormalities. The aim of our study was to investigate the relationship between quality of life and cognitive function. METHODS:Quality of life, clinical variables and neuropsychological function were evaluated in ...

journal_title：Journal of hepatology

authors： Córdoba J,Flavià M,Jacas C,Sauleda S,Esteban JI,Vargas V,Esteban R,Guardia J

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND/AIMS:Albumin administration prevents renal failure and improves survival in spontaneous bacterial peritonitis. This study characterizes the mechanisms of action of albumin in this condition. METHODS:Systemic and splanchnic hemodynamics, plasma renin activity and plasma concentration of interleukin-6, serum ...

journal_title：Journal of hepatology

authors： Fernández J,Navasa M,Garcia-Pagan JC,G-Abraldes J,Jiménez W,Bosch J,Arroyo V

更新日期：2004-09-01 00:00:00

abstract：:We report a case of chronic active hepatitis caused by benzarone, a benzofuran derivative used in Europe for the treatment of peripheral venous disorders. Jaundice and serum alanine aminotransferase activity increased while drug administration was continued, but promptly decreased when it was eventually interrupted. L...

journal_title：Journal of hepatology

authors： Babany G,Larrey D,Pessayre D,Degott C,Rueff B,Benhamou JP

更新日期：1987-12-01 00:00:00

abstract：:Secondary biliary cirrhosis in the rat is an attractive model since unlike other models it does not rely on exogenous toxic compounds to induce cirrhosis. However, because little is known about the microcirculatory abnormalities of this model, this study investigated hemodynamics in rats with predefined functional imp...

journal_title：Journal of hepatology

authors： Ohara N,Schaffner T,Reichen J

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with cirrhosis and refractory ascites the role of beta-blockers in the development of paracentesis-induced circulatory dysfunction (PICD) is unknown. The aim of this study was to investigate the incidence of PICD before and after discontinuation of beta-blockers in patients with cirrhosis ...

journal_title：Journal of hepatology

authors： Sersté T,Francoz C,Durand F,Rautou PE,Melot C,Valla D,Moreau R,Lebrec D

更新日期：2011-10-01 00:00:00

abstract：:The aim of the present investigation was to study the number and acinar distribution of apoptotic bodies in normal liver as an approach to a better understanding of cell kinetics in the hepatic parenchyma. The material included 20 normal human needle liver biopsies and 20 normal male Sprague-Dawley rats. For each live...

journal_title：Journal of hepatology

authors： Benedetti A,Jézéquel AM,Orlandi F

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND & AIMS:High oxidative stress plays a major role in increasing hepatic vascular resistance in cirrhosis, by facilitating liver fibrosis and by increasing hepatic vascular tone. This study is aimed at investigating whether the use of the novel isoform of recombinant human manganese superoxide dismutase (rMnSOD...

journal_title：Journal of hepatology

authors： Guillaume M,Rodriguez-Vilarrupla A,Gracia-Sancho J,Rosado E,Mancini A,Bosch J,Garcia-Pagán JC

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND & AIMS:The pathomechanisms underlying non-alcoholic fatty liver disease (NAFLD) and the involved molecular regulators are incompletely explored. The nuclear factor-kappa B (NF-κB)-cofactor gene B cell leukemia-3 (Bcl-3) plays a critical role in altering the transcriptional capacity of NF-κB - a key inducer o...

journal_title：Journal of hepatology

authors： Gehrke N,Wörns MA,Huber Y,Hess M,Straub BK,Hövelmeyer N,Waisman A,Kim YO,Schuppan D,Galle PR,Schattenberg JM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to sequence the precore region of HBV isolated from serum and tumorous and non-tumorous liver tissue from patients with hepatocellular carcinoma to identify mutations that might play a role in malignant transformation. METHODS:HBV DNA was extracted from 62 sera, 14 tumorous and...

journal_title：Journal of hepatology

authors： Kramvis A,Kew MC,Bukofzer S

更新日期：1998-01-01 00:00:00

abstract：:Maturity onset diabetes of the young type 3 (MODY3) and hepatocellular adenomas (HCAs) are associated with mutations in the HNF1A gene. HNF1A codes for the transcription factor HNF1α, which interacts with DNA as a homodimer or a heterodimer with HNF1β, to regulate multiple cellular functions including glucidic metabol...

journal_title：Journal of hepatology

authors： Willson JS,Godwin TD,Wiggins GA,Guilford PJ,McCall JL

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND/AIMS:Interferon therapy has been shown to have beneficial effects in chronic hepatitis C, but the optimal duration of treatment has not been clearly defined. The aims of this study were: (a) to perform a detailed histological comparison of the effects of a 6-month and a 12-month treatment using the Knodell s...

journal_title：Journal of hepatology

authors： Ziol M,Nhieu JT,Roudot-Thoraval F,Métreau JM,Deugnier Y,Dhumeaux D,Zafrani ES

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND/AIMS:Rats with long-term cholestasis have reduced ketosis of unknown origin. METHODS:Fatty acid metabolism was studied in starved rats with biliary obstruction for 4 weeks (bile duct ligated rats = BDL rats), and 3, 7, 14, 28 and 84 days after reversal of biliary obstruction by Roux-en-Y anastomosis (RY rat...

journal_title：Journal of hepatology

authors： Lang C,Berardi S,Schäfer M,Serra D,Hegardt FG,Krähenbühl L,Krähenbühl S

更新日期：2002-11-01 00:00:00

abstract：:In this study plasma free fatty acids and adipose tissue fatty acid composition in 10 cirrhotic patients, 5 patients with non-cirrhotic chronic liver disease and in 5 controls have been investigated. Fatty acid composition of adipose tissue in cirrhotic patients demonstrated a significant increase of 16:1 and a decrea...

journal_title：Journal of hepatology

authors： Merli M,Iapichino S,Bolognese A,Bruni A,Cantafora A,Riggio O,Capocaccia L

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote hepatosteatosis, but the possible role of vitamin D receptor (VDR) in NAFLD has not been investigated. METHOD...

journal_title：Journal of hepatology

authors： Bozic M,Guzmán C,Benet M,Sánchez-Campos S,García-Monzón C,Gari E,Gatius S,Valdivielso JM,Jover R

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND & AIMS:Blocking intestinal bile acid (BA) absorption by inhibiting or inactivating the apical sodium-dependent BA transporter (Asbt) classically induces hepatic BA synthesis. In contrast, blocking intestinal BA absorption by inactivating the basolateral BA transporter, organic solute transporter alpha-beta (...

journal_title：Journal of hepatology

authors： Lan T,Rao A,Haywood J,Kock ND,Dawson PA

更新日期：2012-08-01 00:00:00

abstract：:Interleukin-6 has a variety of biological effects, mainly on the immune system. The regulation of this signal at both the site of production and the site of action is necessary to maintain the organism's homeostasis. In the microenvironment of the hepatic sinusoids, Kupffer cells as resident macrophages are the most p...

journal_title：Journal of hepatology

authors： Hoffmann R,Henninger HP,Schulze-Specking A,Decker K

更新日期：1994-10-01 00:00:00

abstract：:Hepatitis viruses are major threats to human health. During the last decade, highly diverse viruses related to human hepatitis viruses were found in animals other than primates. Herein, we describe both surprising conservation and striking differences of the unique biological properties and infection patterns of human...

journal_title：Journal of hepatology

authors： Rasche A,Sander AL,Corman VM,Drexler JF

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND/AIMS:To assess the effect of lactoferrin on oxidative liver damage and its mechanism, we used Long-Evans Cinnamon (LEC) rats that spontaneously develop fulminant-like hepatitis and lethal hepatic failure. METHODS:Four-week-old female LEC rats were divided into the untreated and treated groups. The latter wa...

journal_title：Journal of hepatology

authors： Tsubota A,Yoshikawa T,Nariai K,Mitsunaga M,Yumoto Y,Fukushima K,Hoshina S,Fujise K

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND/AIMS:Oxidative DNA damage, identifiable in the formation of 8-hydroxydeoxyguanosine (8-OHdG), is relevant in the mutagenesis/carcinogenesis process. The aim of this study was to assess 8-OHdG levels in patients with hepatitis C virus (HCV) infection in relation to extent of liver damage and HCV genotype. ME...

journal_title：Journal of hepatology

authors： Cardin R,Saccoccio G,Masutti F,Bellentani S,Farinati F,Tiribelli C

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Little is known about EBV-associated intrahepatic cholangiocarcinoma (EBVaICC) due to its rarity. We aimed to comprehensively investigate the clinicopathology, tumor immune microenvironment (TIME) and genomic landscape of this entity in southern China. METHODS:We evaluated 303 ICCs using in situ hy...

journal_title：Journal of hepatology

authors： Huang YH,Zhang CZ,Huang QS,Yeong J,Wang F,Yang X,He YF,Zhang XL,Zhang H,Chen SL,Zheng YL,Deng R,Lin CS,Yang MM,Li Y,Jiang C,Kin-Wah Lee T,Ma S,Zeng MS,Yun JP

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND/AIM:Since patients with high viral load and HCV subtype 1b are known to respond poorly to interferon (IFN) therapy, the viral dynamics of HCV RNA after initiation of interferon therapy were examined in the present study with respect to two different administration regimens, once vs. twice a day. METHODS:Twe...

journal_title：Journal of hepatology

authors： Shiratori Y,Perelson AS,Weinberger L,Imazeki F,Yokosuka O,Nakata R,Ihori M,Hirota K,Ono N,Kuroda H,Motojima T,Nishigaki M,Omata M

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis C virus (HCV) incidence among HIV-positive men who have sex with men (MSM) has increased since 2000, although there are regional differences. We aimed to 1) estimate trends in HCV incidence among HIV-positive MSM, 2) assess the association between incidence and geographical region, age and H...

journal_title：Journal of hepatology

authors： van Santen DK,van der Helm JJ,Del Amo J,Meyer L,D'Arminio Monforte A,Price M,Béguelin CA,Zangerle R,Sannes M,Porter K,Geskus RB,Prins M,CASCADE Collaboration in EuroCoord.

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND/AIMS:The x gene of hepatitis B virus encodes a transactivating factor of 154 amino acids, termed HBx, which stimulates transcription of multiple viral and cellular genes. The transactivating function is probably associated with a tumorigenic potential of HBx, since x gene sequences, encoding functional HBx, ...

journal_title：Journal of hepatology

authors： Renner M,Haniel A,Bürgelt E,Hofschneider PH,Koch W

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND & AIMS:Current techniques for predicting outcome and requirement for emergency liver transplantation (ELT) in acute liver failure (ALF) are imperfect, though The Kings College Criteria (KCC) are the most commonly applied tools for this purpose. Their performance in identification of patients with non-paracet...

journal_title：Journal of hepatology

authors： McPhail MJ,Wendon JA,Bernal W

更新日期：2010-09-01 00:00:00

abstract：:Twenty-two patients with primary biliary cirrhosis were treated with ursodeoxycholic acid, 10 mg/kg per day. Fourteen patients with stages I/II were treated for 4-12 years (mean 7.5), and eight patients with stages III/IV for 5-12 years (mean 6.5). Twelve of 13 patients with early stages became asymptomatic. Aminotran...

journal_title：Journal of hepatology

authors： Leuschner U,Güldütuna S,Imhof M,Hübner K,Benjaminov A,Leuschner M

更新日期：1994-10-01 00:00:00

abstract：:The etiologic agent responsible for epidemics of enterically-transmitted non-A, non-B hepatitis has been molecularly characterized as the hepatitis E virus (HEV). The cloning of a portion of the Burma strain of HEV (HEV(B); 'Old World' strain) has been described together with the isolation of a contiguous overlapping ...

journal_title：Journal of hepatology

authors： Reyes GR,Huang CC,Yarbough PO,Tam AW

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIMS:The objective of this study was to validate, with an independent prospective cohort of patients, our previous data indicating that the proliferating cell nuclear antigen-labeling index (PCNA-LI) reflects the liver functional reserve in human cirrhosis and might have prognostic significance for patient s...

journal_title：Journal of hepatology

authors： Delhaye M,Louis H,Degraef C,Le Moine O,Devière J,Peny MO,Adler M,Galand P

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND & AIMS:It was recently shown that semi-annual surveillance for hepatocellular carcinoma (HCC) in cirrhotic patients provides a prognostic advantage over the annual program; however, its cost-effectiveness (CE) in the general cirrhotic population still needs to be defined. METHODS:A Markov model was built to...

journal_title：Journal of hepatology

authors： Cucchetti A,Trevisani F,Cescon M,Ercolani G,Farinati F,Poggio PD,Rapaccini G,Nolfo MAD,Benvegnù L,Zoli M,Borzio F,Giannini EG,Caturelli E,Chiaramonte M,Pinna AD,Italian Liver Cancer (ITA.LI.CA) Group.

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND & AIMS:Virus-specific T cells capable of controlling HBV and eliminating hepatocellular carcinoma (HCC) expressing HBV antigens are deleted or dysfunctional in patients with chronic HBV or HBV-related HCC. The goal of this study was to determine if T cell receptor (TCR) gene transfer can reconstitute HBV-spe...

journal_title：Journal of hepatology

authors： Gehring AJ,Xue SA,Ho ZZ,Teoh D,Ruedl C,Chia A,Koh S,Lim SG,Maini MK,Stauss H,Bertoletti A

更新日期：2011-07-01 00:00:00