Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats.


BACKGROUND/AIMS:To assess the effect of lactoferrin on oxidative liver damage and its mechanism, we used Long-Evans Cinnamon (LEC) rats that spontaneously develop fulminant-like hepatitis and lethal hepatic failure. METHODS:Four-week-old female LEC rats were divided into the untreated and treated groups. The latter was fed bovine lactoferrin at 2% mixed with conventional diet. RESULTS:The cumulative survival rates were 75.0% vs. 100% at 14 weeks, 37.5% vs. 91.7% at 15 weeks, and 12.5% vs. 91.7% at 16 weeks, respectively, for untreated and treated rats (P=0.0008). The 8-OHdG levels in liver mitochondrial DNA and malondialdehyde in plasma and liver tissues were significantly lower in treated than untreated rats (P<0.001, =0.017 and 0.034, respectively). Mitochondrial DNA mutations were more common in untreated rats. OGG1 mRNA and protein expression levels were significantly lower in untreated than treated rats (P=0.003 and 0.007, respectively). Hypermethylation of the second CpG island located upstream of OGG1 gene was observed in untreated rats. CONCLUSIONS:Our findings indicated that lactoferrin inhibits oxidative liver damage in LEC rats. Lactoferrin could be potentially useful for the treatment of oxidative stress-induced liver diseases.


J Hepatol


Journal of hepatology


Tsubota A,Yoshikawa T,Nariai K,Mitsunaga M,Yumoto Y,Fukushima K,Hoshina S,Fujise K




Has Abstract


2008-03-01 00:00:00














  • Delta infection in the Naples area. Epidemiologic and clinical significance.

    abstract::To define the epidemiologic and clinical significance of delta infection in the Naples area, we sought anti-delta antibodies in all cases of HBV-associated liver diseases, hospitalized in our department during 1983 (234 acute hepatitis, 9 of which fulminant; 51 chronic hepatitis; 32 cirrhosis; 19 hepatocarcinomas) and...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Amoroso P,Giorgio A,Fico P,Lettieri G,de Stefano G,Scala V,Pesce G,Pierri P,Pempinello R,Finelli L

    更新日期:1986-01-01 00:00:00

  • Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial.

    abstract:BACKGROUND/AIMS:Silymarin has protective effects in different experimental conditions, but its efficacy in human liver cirrhosis has not been completely established. Therefore, this study was carried out to determine the effect of silymarin in alcoholics with liver cirrhosis with respect to survival and clinical and la...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Parés A,Planas R,Torres M,Caballería J,Viver JM,Acero D,Panés J,Rigau J,Santos J,Rodés J

    更新日期:1998-04-01 00:00:00

  • Evidence of two major genotypes of hepatitis C virus in France and close relatedness of the predominant one with the prototype virus.

    abstract::Hepatitis C virus (HCV) cDNA sequence in the nonstructural region NS3 was amplified from the serum of 66% French non-A, non-B hepatitis patients by the nested polymerase chain reaction. A 407 base-pair sequence was determined from four such cases, which revealed the presence of two different virus genotypes F1 (three ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Li JS,Tong SP,Vitvitski L,Lepot D,Trépo C

    更新日期:1991-01-01 00:00:00

  • Noradrenalin vs terlipressin in patients with hepatorenal syndrome: a prospective, randomized, unblinded, pilot study.

    abstract:BACKGROUND/AIMS:Treatment of hepatorenal syndrome (HRS) is based on vasoconstrictors. Terlipressin is the one with the soundest evidence. Noradrenalin has been suggested as an effective alternative. The current study was aimed at assessing the efficacy and safety of noradrenalin vs terlipressin in patients with HRS. M...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,随机对照试验


    authors: Alessandria C,Ottobrelli A,Debernardi-Venon W,Todros L,Cerenzia MT,Martini S,Balzola F,Morgando A,Rizzetto M,Marzano A

    更新日期:2007-10-01 00:00:00

  • Quantification of HBV core antibodies may help predict HBV reactivation in patients with lymphoma and resolved HBV infection.

    abstract:BACKGROUND & AIMS:Absence or low anti-HBV surface antibody (anti-HBs) is associated with an increased risk of HBV reactivation in patients with lymphoma and resolved HBV infection receiving rituximab-containing chemotherapy. Quantification of anti-HBV core antibody (anti-HBc) is a new marker associated with the natural...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Yang HC,Tsou HH,Pei SN,Chang CS,Chen JH,Yao M,Lin SJ,Lin J,Yuan Q,Xia N,Liu TW,Chen PJ,Cheng AL,Hsu C,Taiwan Cooperative Oncology Group.

    更新日期:2018-08-01 00:00:00

  • Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.

    abstract:BACKGROUND/AIMS:Non-alcoholic fatty liver disease (NAFLD) pathogenesis remains unknown. Due to the emerging role of free cholesterol (FC) in NAFLD, our aim was to examine the correlation between FC accumulation in patients with NAFLD and the expression of enzymes that regulate cholesterol homeostasis. METHODS:Filipin ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Caballero F,Fernández A,De Lacy AM,Fernández-Checa JC,Caballería J,García-Ruiz C

    更新日期:2009-04-01 00:00:00

  • Activation of dendritic cells by local ablation of hepatocellular carcinoma.

    abstract:BACKGROUND/AIMS:Local ablation methods are an effective treatment for hepatocellular carcinoma (HCC). The rate of recurrence or development of intra-hepatic metastases may be lowered by antitumoral immune responses. Since HCCs are in general only weakly immunogenic, cell injury induced by local tumor ablation (PEI/RFTA...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Ali MY,Grimm CF,Ritter M,Mohr L,Allgaier HP,Weth R,Bocher WO,Endrulat K,Blum HE,Geissler M

    更新日期:2005-11-01 00:00:00

  • Management and treatment of chronic hepatitis B virus infection in HIV positive and negative patients: the EPIB 2008 study.

    abstract:BACKGROUND & AIMS:To compare the management and the virological and serological efficacy of treatments for chronic hepatitis B (CHB) in HIV positive and negative patients. METHODS:Two hundred and forty-six HIV positive and 205 HIV negative consecutive patients with past or present CHB, seen in October 2008 in particip...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,多中心研究


    authors: Piroth L,Pol S,Lacombe K,Miailhes P,Rami A,Rey D,Loustau-Ratti V,Morlat P,Goderel I,Sene D,Rosenthal E,Carrat F,Cacoub P,GERMIVIC Study Group.

    更新日期:2010-12-01 00:00:00

  • Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver.

    abstract:BACKGROUND/AIMS:Gadolinium chloride inactivates Kupffer cells and alleviates alcohol-induced liver lesions. We investigated the mechanism of gadolinium chloride protection after oral ethanol feeding. METHODS:Rats were maintained ethanol-intoxicated for 6 weeks by feeding ethanol in a low-carbohydrate/high-fat liquid d...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Järveläinen HA,Fang C,Ingelman-Sundberg M,Lukkari TA,Sippel H,Lindros KO

    更新日期:2000-06-01 00:00:00

  • Management of hepatitis C: current and future perspectives.

    abstract::Chronic hepatitis C is now a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma. In March 1997, the National Institutes of Health sponsored a Consensus Development Conference entitled "Management of Hepatitis C". The final statement from the Consensus Panel set forth clear, evidence-based gui...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Hoofnagle JH

    更新日期:1999-01-01 00:00:00

  • CD4+ CXCR5+ T cells in chronic HCV infection produce less IL-21, yet are efficient at supporting B cell responses.

    abstract:BACKGROUND & AIMS:During chronic HCV infection, T cell dependent virus-specific antibodies are produced. However, the role of B-T cell interaction in chronic HCV is largely unknown. CD4(+)CXCR5(+) T follicular helper (TFH)-cells activate B cells and are important for clearance of various chronic viral infections. We in...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Spaan M,Kreefft K,de Graav GN,Brouwer WP,de Knegt RJ,ten Kate FJ,Baan CC,Vanwolleghem T,Janssen HL,Boonstra A

    更新日期:2015-02-01 00:00:00

  • Understanding liver immunology using intravital microscopy.

    abstract::The liver has come a long way since it was considered only a metabolic organ attached to the gastrointestinal tract. The simultaneous ascension of immunology and intravital microscopy evidenced the liver as a central axis in the immune system, controlling immune responses to local and systemic agents as well as diseas...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Marques PE,Oliveira AG,Chang L,Paula-Neto HA,Menezes GB

    更新日期:2015-09-01 00:00:00

  • Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.

    abstract:BACKGROUND & AIMS:Hallmarks of non-alcoholic fatty liver disease (NAFLD) are increased triglyceride accumulation within hepatocytes. The prevalence of NAFLD increases steadily with increasing thyrotropin (TSH) levels. However, the underlying mechanisms are largely unknown. Here, we focused on exploring the effect and m...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Yan F,Wang Q,Lu M,Chen W,Song Y,Jing F,Guan Y,Wang L,Lin Y,Bo T,Zhang J,Wang T,Xin W,Yu C,Guan Q,Zhou X,Gao L,Xu C,Zhao J

    更新日期:2014-12-01 00:00:00

  • Sustained virological response with telaprevir in 1,078 patients with advanced hepatitis C: the international telaprevir access program.

    abstract:BACKGROUND & AIMS:There is little information regarding the extent to which difficult to cure patients with advanced liver fibrosis, due to hepatitis C virus genotype-1 (HCV-1) can successfully and safely be treated with triple therapy with telaprevir (TVR), pegylated interferon alpha (P) and ribavirin (R). In the TVR ...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Colombo M,Strasser S,Moreno C,Abrao Ferreira P,Urbanek P,Fernández I,Abdurakmonov D,Streinu-Cercel A,Verheyen A,Iraqi W,DeMasi R,Hill A,Lonjon-Domanec I,Wedemeyer H

    更新日期:2014-11-01 00:00:00

  • Hypotension in experimental cirrhosis. Is loss of vascular responsiveness to norepinephrine the cause of hypotension in chronic bile-duct-ligated dogs?

    abstract::It has been postulated that one of the mechanisms of hypotension associated with cirrhosis is an attenuated responsiveness to catecholamines despite the increased activity of the sympathetic nervous system and the elevated plasma concentrations of the sympathetic neurotransmitter, norepinephrine. This abnormality was ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Bomzon A,Binah O,Blendis LM

    更新日期:1993-01-01 00:00:00

  • CD40-mediated immune cell activation enhances response to anti-PD1 in murine intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND & AIMS:Cholangiocarcinoma (CCA) carries a very poor prognosis due to a typically late clinical presentation and a poor response to current therapeutics. While these tumors commonly express PD-1 and PD-L1, the response to immune checkpoint inhibitors (ICI) is poor. Stimulating antigen-presenting cells includi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Diggs LP,Ruf B,Ma C,Heinrich B,Cui L,Zhang Q,McVey JC,Wabitsch S,Heinrich S,Rosato U,Lai W,Subramanyam V,Longerich T,Loosen SH,Luedde T,Neumann UP,Desar S,Kleiner D,Gores G,Wang XW,Greten TF

    更新日期:2020-12-01 00:00:00

  • Ion transport in hepatocytes: mechanisms and correlations to cell volume, hormone actions and metabolism.

    abstract::Intracellular ion homeostasis in liver cell is accomplished through the concerted action of ion pumps, carriers and channels. Description of these elements includes the Na+/K+-ATPase, Na+/H+- and Cl-/ HCO3(-)-exchange and Na+-HCO-3(-)- and Na(+)-K(+)-2 Cl(-)-cotransport as well as K+-, Cl(-)-, Na+ and nonselective cat...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Graf J,Häussinger D

    更新日期:1996-01-01 00:00:00

  • Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome.

    abstract:BACKGROUND/AIMS:The independent role of soft drink consumption in non-alcoholic fatty liver disease (NAFLD) patients remains unclear. We aimed to assess the association between consumption of soft drinks and fatty liver in patients with or without metabolic syndrome. METHODS:We recruited 31 patients (age: 43+/-12 year...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Abid A,Taha O,Nseir W,Farah R,Grosovski M,Assy N

    更新日期:2009-11-01 00:00:00

  • The impact of waiting list alpha-fetoprotein changes on the outcome of liver transplant for hepatocellular carcinoma.

    abstract:BACKGROUND & AIMS:Liver transplantation is a recognized treatment for selected patients with hepatocellular carcinoma (HCC), but transplant criteria still need to be refined, especially in the case of more advanced or downstaged tumors. METHODS:The present study investigated alpha-fetoprotein (AFP) as a predictor of o...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Merani S,Majno P,Kneteman NM,Berney T,Morel P,Mentha G,Toso C

    更新日期:2011-10-01 00:00:00

  • miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease.

    abstract:BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of stages from simple steatosis to non-alcoholic steatohepatitis (NASH). However, disease pathogenesis remains largely unknown. microRNA (miRNA or miR) expression has recently been reported to be altered in human NASH, and modulated by urs...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Castro RE,Ferreira DM,Afonso MB,Borralho PM,Machado MV,Cortez-Pinto H,Rodrigues CM

    更新日期:2013-01-01 00:00:00

  • A randomized controlled trial of recombinant interferon alpha-2b in the treatment of Chinese patients with acute post-transfusion hepatitis C.

    abstract::To evaluate the efficacy of recombinant interferon alpha-2b in the treatment of patients with acute post-transfusion hepatitis C, a randomized controlled trial was conducted in 33 acute post-transfusion hepatitis C patients; 16 patients received 3 million units of subcutaneously injected recombinant interferon alpha-2...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hwang SJ,Lee SD,Chan CY,Lu RH,Lo KJ

    更新日期:1994-11-01 00:00:00

  • Bacterial meningitis in cirrhosis: review of 16 cases.

    abstract:BACKGROUND:Although bacterial infections are frequent in patients with liver cirrhosis, only isolated cases of bacterial meningitis have been reported. METHODS:We have reviewed a series of 16 cases of bacterial meningitis in patients with cirrhosis, diagnosed in a single hospital over a 30-year period. RESULTS:Thirte...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Pauwels A,Pinès E,Abboura M,Chiche I,Lévy VG

    更新日期:1997-11-01 00:00:00

  • A histopathological study of the effects of 6-month versus 12-month interferon alpha-2b therapy in chronic hepatitis C.

    abstract:BACKGROUND/AIMS:Interferon therapy has been shown to have beneficial effects in chronic hepatitis C, but the optimal duration of treatment has not been clearly defined. The aims of this study were: (a) to perform a detailed histological comparison of the effects of a 6-month and a 12-month treatment using the Knodell s...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ziol M,Nhieu JT,Roudot-Thoraval F,Métreau JM,Deugnier Y,Dhumeaux D,Zafrani ES

    更新日期:1996-12-01 00:00:00

  • Higher risk of renal disease in chronic hepatitis C patients: Antiviral therapy survival benefit in patients on hemodialysis.

    abstract:BACKGROUND & AIMS:Several studies have shown that chronic hepatitis C (CHC) infection has a negative impact on kidney function, as well as survival, in patients with chronic kidney disease (CKD) or on hemodialysis. The aim of this nationwide registry study was to describe renal disease in Swedish patients with CHC. ME...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Söderholm J,Millbourn C,Büsch K,Kövamees J,Schvarcz R,Lindahl K,Bruchfeld A

    更新日期:2018-05-01 00:00:00

  • Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations.

    abstract:BACKGROUND & AIMS:γδ T cells comprise a substantial proportion of tissue-associated lymphocytes. However, our current understanding of human γδ T cells is primarily based on peripheral blood subsets, while the immunobiology of tissue-associated subsets remains largely unclear. Therefore, we aimed to elucidate the T cel...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Hunter S,Willcox CR,Davey MS,Kasatskaya SA,Jeffery HC,Chudakov DM,Oo YH,Willcox BE

    更新日期:2018-09-01 00:00:00

  • Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia.

    abstract:BACKGROUND/AIMS:Because dietary modifications have prolonged the life expectancy of patients with glycogen storage disease type Ia (GSD Ia), the incidence of hepatocellular adenoma (HCA) to carcinoma (HCC) transformation is increasing. The objective of this retrospective study is to assess the safety and effectiveness ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Reddy SK,Kishnani PS,Sullivan JA,Koeberl DD,Desai DM,Skinner MA,Rice HE,Clary BM

    更新日期:2007-11-01 00:00:00

  • Mechanisms of HBV-induced hepatocellular carcinoma.

    abstract::Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early steps of clonal tumor expansion and induces both genomic instability and direct insertional mutagenesis of diverse cancer-related genes. Pro...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Levrero M,Zucman-Rossi J

    更新日期:2016-04-01 00:00:00

  • Hepatic and skeletal muscle glycogen metabolism in rats with short-term cholestasis.

    abstract:BACKGROUND/AIMS:To study the effect of short-term cholestasis on glycogen metabolism. METHODS:Rats were bile duct ligated (BDL) for 4 or 8 days and compared to sham-operated control rats pair-fed to BDL (pair-fed CON) or fed ad libitum (ad libitum-fed CON). RESULTS:Four days after surgery, the hepatic glycogen conten...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Lang C,Schäfer M,Varga L,Zimmermann A,Krähenbühl S,Krähenbühl L

    更新日期:2002-01-01 00:00:00

  • A multidisciplinary support programme increases the efficiency of pegylated interferon alfa-2a and ribavirin in hepatitis C.

    abstract:BACKGROUND & AIMS:Adherence to antiviral treatment is important to achieve sustained virological response (SVR) in chronic hepatitis C (CHC). We evaluated the efficiency of a multidisciplinary support programme (MSP), based on published HIV treatment experience, to increase patient adherence and the efficacy of pegylat...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Carrión JA,Gonzalez-Colominas E,García-Retortillo M,Cañete N,Cirera I,Coll S,Giménez MD,Márquez C,Martin-Escudero V,Castellví P,Navinés R,Castaño JR,Galeras JA,Salas E,Bory F,Martín-Santos R,Solà R

    更新日期:2013-11-01 00:00:00

  • Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC).

    abstract:BACKGROUND/AIMS:This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). METHODS:Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. RESULTS:All patie...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Broomé U,Glaumann H,Lindstöm E,Lööf L,Almer S,Prytz H,Sandberg-Gertzén H,Lindgren S,Fork FT,Järnerot G,Olsson R

    更新日期:2002-05-01 00:00:00