当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Prevention of alcoholic fatty liver and mitochondrial dysfunction in the rat by long-chain polyunsaturated fatty acids.

Prevention of alcoholic fatty liver and mitochondrial dysfunction in the rat by long-chain polyunsaturated fatty acids.

Abstract：

BACKGROUND/AIMS:We reported that reduced dietary intake of polyunsaturated fatty acids (PUFA) such as arachidonic (AA,20:4n6,omega-6) and docosahexaenoic (DHA,22:6n3,omega-3) acids led to alcohol-induced fatty liver and fibrosis. This study was aimed at studying the mechanisms by which a DHA/AA-supplemented diet prevents alcohol-induced fatty liver. METHODS:Male Long-Evans rats were fed an ethanol or control liquid-diet with or without DHA/AA for 9 weeks. Plasma transaminase levels, liver histology, oxidative/nitrosative stress markers, and activities of oxidatively-modified mitochondrial proteins were evaluated. RESULTS:Chronic alcohol administration increased the degree of fatty liver but fatty liver decreased significantly in rats fed the alcohol-DHA/AA-supplemented diet. Alcohol exposure increased oxidative/nitrosative stress with elevated levels of ethanol-inducible CYP2E1, nitric oxide synthase, nitrite and mitochondrial hydrogen peroxide. However, these increments were normalized in rats fed the alcohol-DHA/AA-supplemented diet. The number of oxidatively-modified mitochondrial proteins was markedly increased following alcohol exposure but significantly reduced in rats fed the alcohol-DHA/AA-supplemented diet. The suppressed activities of mitochondrial aldehyde dehydrogenase, ATP synthase, and 3-ketoacyl-CoA thiolase in ethanol-exposed rats were also recovered in animals fed the ethanol-DHA/AA-supplemented diet. CONCLUSIONS:Addition of DHA/AA prevents alcohol-induced fatty liver and mitochondrial dysfunction in an animal model by protecting various mitochondrial enzymes most likely through reducing oxidative/nitrosative stress.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Song BJ,Moon KH,Olsson NU,Salem N Jr

doi

10.1016/j.jhep.2008.04.023

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

262-73

issue

2

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(08)00293-6

journal_volume

49

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • YAP activation is an early event and a potential therapeutic target in liver cancer development.

    abstract：BACKGROUND & AIMS:Although the growth suppressing Hippo pathway has been implicated in hepatocellular carcinoma (HCC) pathogenesis, it is unknown at which stage of hepatocarcinogenesis its dysregulation occurs. We investigated in rat and human preneoplastic lesions whether overexpression of the transcriptional co-activ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.06.033

    authors： Perra A,Kowalik MA,Ghiso E,Ledda-Columbano GM,Di Tommaso L,Angioni MM,Raschioni C,Testore E,Roncalli M,Giordano S,Columbano A

    更新日期：2014-11-01 00:00:00

  • Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.

    abstract：BACKGROUND/AIMS:Non-alcoholic fatty liver disease (NAFLD) pathogenesis remains unknown. Due to the emerging role of free cholesterol (FC) in NAFLD, our aim was to examine the correlation between FC accumulation in patients with NAFLD and the expression of enzymes that regulate cholesterol homeostasis. METHODS:Filipin ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.12.016

    authors： Caballero F,Fernández A,De Lacy AM,Fernández-Checa JC,Caballería J,García-Ruiz C

    更新日期：2009-04-01 00:00:00

  • Arsenic and non-cirrhotic portal hypertension. A report of eight cases.

    abstract：:It was discovered that eight patients with complications of non-cirrhotic portal hypertension had received an arsenical preparation for psoriasis as Fowler's solution some years age. Seven of them were admitted for bleeding oesophageal varices. Upon admission, splenomegaly and hypersplenism were present. Liver tests w...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(90)90276-w

    authors： Nevens F,Fevery J,Van Steenbergen W,Sciot R,Desmet V,De Groote J

    更新日期：1990-07-01 00:00:00

  • Can antiviral therapy for hepatitis C reduce the prevalence of HCV among injecting drug user populations? A modeling analysis of its prevention utility.

    abstract：BACKGROUND & AIMS:Hepatitis C virus antiviral treatment is effective for individual patients but few active injecting drug users are treated. We considered the utility of antiviral treatment for primary prevention of hepatitis C. METHODS:A hepatitis C transmission model among injecting drug users was developed, incorp...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.08.029

    authors： Martin NK,Vickerman P,Foster GR,Hutchinson SJ,Goldberg DJ,Hickman M

    更新日期：2011-06-01 00:00:00

  • IL-6 pathway in the liver: From physiopathology to therapy.

    abstract：:Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple functions in the body. In the liver, IL-6 is an important inducer of the acute phase response and infection defense. IL-6 is furthermore crucial for hepatocyte homeostasis and is a potent hepatocyte mitogen. It is not only implicated...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2016.02.004

    authors： Schmidt-Arras D,Rose-John S

    更新日期：2016-06-01 00:00:00

  • Comparison of no-touch multi-bipolar vs. monopolar radiofrequency ablation for small HCC.

    abstract：BACKGROUND & AIMS:The primary aim of this study was to compare the rate of global radiofrequency ablation (RFA) failure between monopolar RFA (MonoRFA) vs. no-touch multi-bipolar RFA (NTmbpRFA) for small hepatocellular carcinoma (HCC) ⩽5cm in cirrhotic patients. METHODS:A total of 362 cirrhotic patients were included ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jhep.2016.07.010

    authors： Hocquelet A,Aubé C,Rode A,Cartier V,Sutter O,Manichon AF,Boursier J,N'kontchou G,Merle P,Blanc JF,Trillaud H,Seror O

    更新日期：2017-01-01 00:00:00

  • The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease.

    abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population and signifies increased risk of liver fibrosis and cirrhosis, type 2 diabetes, and cardiovascular disease. Therapies are limited. Weight loss is of benefit but is difficult to maintain. We aimed at examining the effect of th...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jhep.2013.02.012

    authors： Ryan MC,Itsiopoulos C,Thodis T,Ward G,Trost N,Hofferberth S,O'Dea K,Desmond PV,Johnson NA,Wilson AM

    更新日期：2013-07-01 00:00:00

  • Inhibition of hepatitis C virus gene expression by adenoviral vectors encoding antisense RNA in vitro and in vivo.

    abstract：BACKGROUND & AIMS:In this study, adenoviral vectors encoding an antisense RNA complementary to the 5' non-coding region (5'NCR) of the HCV-genome were generated to inhibit HCV-RNA gene expression in cell culture and in vivo. METHODS:First and second-generation (with E4-deletion) adenoviruses encoding the HCV5'NCR in a...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.11.010

    authors： González-Carmona MA,Vogt A,Heinicke T,Quasdorff M,Hoffmann P,Yildiz Y,Schneider C,Serwe M,Bartenschlager R,Sauerbruch T,Caselmann WH

    更新日期：2011-07-01 00:00:00

  • Hepatitis B core-specific memory B cell responses associate with clinical parameters in patients with chronic HBV.

    abstract：BACKGROUND & AIMS:Little is known about the frequency, phenotype and function of HBV-specific B cells during chronic infection. Here we study HBcAg and HBsAg-specific B cells in different clinical phases of a chronic HBV infection. METHODS:We included 118 treatment naïve and 34 nucleos(t)ide analogue-treated patients ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.01.024

    authors： Vanwolleghem T,Groothuismink ZMA,Kreefft K,Hung M,Novikov N,Boonstra A

    更新日期：2020-07-01 00:00:00

  • Tumour suppressors in liver carcinogenesis.

    abstract：:The circuitous cell signalling pathways of hepatocytes comprise several factors that operate to downgrade or even interrupt the transmission of a given signal. These down-regulating influences are essential to keep cell proliferation and cell survival in check and if impaired, can alter a delicate balance in favour of...

    journal_title：Journal of hepatology

    pub_type：

    doi：10.1016/j.jhep.2007.09.003

    authors： Dufour JF,Huber O,Kozma SC,Lu X,Toftgård R

    更新日期：2007-12-01 00:00:00

  • The hydroxyl radical scavengers dimethylsulfoxide and dimethylthiourea protect rats against thioacetamide-induced fulminant hepatic failure.

    abstract：BACKGROUND/AIMS:Reactive oxygen species, proinflammatory cytokines, glutathione depletion and nitric oxide have all been implicated in the pathogenesis of fulminant hepatic failure. The aim of the present study was to examine the respective roles of these factors in the pathogenesis of thioacetamide-induced fulminant h...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80160-3

    authors： Bruck R,Aeed H,Shirin H,Matas Z,Zaidel L,Avni Y,Halpern Z

    更新日期：1999-07-01 00:00:00

  • Incidence of hepatocellular carcinoma in HIV/HBV-coinfected patients on tenofovir therapy: Relevance for screening strategies.

    abstract：BACKGROUND & AIMS:Robust data on hepatocellular carcinoma (HCC) incidence among HIV/hepatitis B virus (HBV)-coinfected individuals on antiretroviral therapy (ART) are needed to inform HCC screening strategies. We aimed to evaluate the incidence and risk factors of HCC among HIV/HBV-coinfected individuals on tenofovir d...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.03.032

    authors： Wandeler G,Mauron E,Atkinson A,Dufour JF,Kraus D,Reiss P,Peters L,Dabis F,Fehr J,Bernasconi E,van der Valk M,Smit C,Gjærde LK,Rockstroh J,Neau D,Bonnet F,Rauch A,Swiss HIV Cohort Study, Athena Observational Cohort Study

    更新日期：2019-08-01 00:00:00

  • Evidence of two major genotypes of hepatitis C virus in France and close relatedness of the predominant one with the prototype virus.

    abstract：:Hepatitis C virus (HCV) cDNA sequence in the nonstructural region NS3 was amplified from the serum of 66% French non-A, non-B hepatitis patients by the nested polymerase chain reaction. A 407 base-pair sequence was determined from four such cases, which revealed the presence of two different virus genotypes F1 (three ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90019-8

    authors： Li JS,Tong SP,Vitvitski L,Lepot D,Trépo C

    更新日期：1991-01-01 00:00:00

  • Alterations of leptin during IFN-alpha therapy in patients with chronic viral hepatitis.

    abstract：BACKGROUND/AIMS:Leptin has a particular profibrogenic role in the liver. We investigated whether IFN-alpha influences leptin production in patients with chronic hepatitis B (CHB) and C (CHC). Leptin was determined in serial samples from 63 CHB and 42 CHC IFN-alpha treated patients. Furthermore, we evaluated whether lep...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.01.025

    authors： Zografos TA,Rigopoulou EI,Liaskos C,Togousidis E,Zachou K,Gatselis N,Germenis A,Dalekos GN

    更新日期：2006-05-01 00:00:00

  • Demographics and outcomes of severe herpes simplex virus hepatitis: a registry-based study.

    abstract：BACKGROUND & AIMS:Herpes simplex virus hepatitis is a rare, but severe disease, thus far only documented by case reports and short series. The present study was based on the SRTR registry, and included all listed patients for liver transplantation from 1985 to 2009 with a diagnosis of HSV hepatitis. METHODS:We assesse...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2011.02.029

    authors： Moldovan B,Mentha G,Majno P,Berney T,Morard I,Giostra E,Wildhaber BE,Van Delden C,Morel P,Toso C

    更新日期：2011-12-01 00:00:00

  • Quantitative assessment of hepatitis C virus RNA and IgM antibodies to hepatitis C core in chronic hepatitis C.

    abstract：BACKGROUND/AIMS:IgM antibodies to hepatitis C virus have been found in a variable proportion of patients with chronic hepatitis C. We have evaluated whether IgM anti-core antibodies correlate with viraemia or hepatic injury in chronic hepatitis C. METHODS:Serum from 106 patients with chronic hepatitis C with varying s...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80181-4

    authors： Martinelli AL,Brown D,Braun HB,Michel G,Dusheiko GM

    更新日期：1996-01-01 00:00:00

  • Hepatic oleate regulates liver stress response partially through PGC-1α during high-carbohydrate feeding.

    abstract：BACKGROUND & AIMS:High-carbohydrate diets contribute to the development of liver stress and fatty liver disease. While saturated fatty acids are known to induce liver stress, the role of monounsaturated fatty acids (MUFA), synthesized by the stearoyl-CoA desaturase (SCD) family of enzymes, in regulation of liver functi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2016.03.001

    authors： Liu X,Burhans MS,Flowers MT,Ntambi JM

    更新日期：2016-07-01 00:00:00

  • Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts.

    abstract：BACKGROUND/AIM:Chronic rejection is an important cause of graft loss following liver transplantation. A number of risk factors for chronic rejection have been identified previously, albeit inconsistently. These include cytomegalovirus infection detected by a number of different techniques, including immunohistochemical...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80294-3

    authors： Evans PC,Coleman N,Wreghitt TG,Wight DG,Alexander GJ

    更新日期：1999-11-01 00:00:00

  • miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression.

    abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) have been shown to be involved in many biological processes by affecting their target gene expression. miR-122 has been extensively studied in hepatocarcinogenesis. However, the role of miR-122 in liver fibrosis remains unknown. METHODS:The mRNA expression levels of miR-122, prolyl...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.11.011

    authors： Li J,Ghazwani M,Zhang Y,Lu J,Li J,Fan J,Gandhi CR,Li S

    更新日期：2013-03-01 00:00:00

  • Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice.

    abstract：BACKGROUND & AIMS:Acetaminophen (APAP)-induced liver injury is the most frequent cause of acute liver failure in the US and many other countries. Metabolism of APAP results in formation of APAP protein adducts (APAP-AD) in hepatocytes and triggers mitochondrial dysfunction and necrosis. However, the mechanisms for how ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2016.04.025

    authors： Ni HM,McGill MR,Chao X,Du K,Williams JA,Xie Y,Jaeschke H,Ding WX

    更新日期：2016-08-01 00:00:00

  • Transjugular intrahepatic portosystemic stent-shunt (TIPSS) occlusion and the role of biliary venous fistulae.

    abstract：BACKGROUND/AIM:The aim of this study was to assess the pathology and pathogenic mechanisms involved in the occlusion of transjugular intrahepatic portosystemic stent-shunts. METHODS:Thirty-four patients with transjugular intrahepatic portosystemic stent-shunt who had at least two portographic assessments of shunt func...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0168-8278(96)80026-2

    authors： Jalan R,Harrison DJ,Redhead DN,Hayes PC

    更新日期：1996-02-01 00:00:00

  • Higher risk of renal disease in chronic hepatitis C patients: Antiviral therapy survival benefit in patients on hemodialysis.

    abstract：BACKGROUND & AIMS:Several studies have shown that chronic hepatitis C (CHC) infection has a negative impact on kidney function, as well as survival, in patients with chronic kidney disease (CKD) or on hemodialysis. The aim of this nationwide registry study was to describe renal disease in Swedish patients with CHC. ME...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.12.003

    authors： Söderholm J,Millbourn C,Büsch K,Kövamees J,Schvarcz R,Lindahl K,Bruchfeld A

    更新日期：2018-05-01 00:00:00

  • Myofibroblasts and hepatocellular carcinoma: an in vivo and in vitro study.

    abstract：BACKGROUND/AIMS:The number of perisinusoidal myofibroblasts has been shown to be increased in hepatocellular carcinoma, as compared to cirrhosis. This increase might suggest a cooperative relationship between tumour cells and myofibroblasts. To assess this relationship, we undertook: (a) an immunohistochemical study to...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(98)80186-4

    authors： Nhieu JT,Brochériou I,Préaux AM,Mallat A,Cherqui D,Zafrani ES,Mavier P

    更新日期：1998-07-01 00:00:00

  • Cellular damage to human hepatocytes through repeated application of 5-aminolevulinic acid.

    abstract：BACKGROUND/AIMS:5-Aminolevulinic acid (ALA), a precursor of porphyrins is used for photodynamic diagnosis and therapy within topical or systemic applications. A potential toxic effect on the human liver is of major interest and therefore we investigated the impact of a repeated application of ALA without illumination o...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(02)00454-3

    authors： Weiss TS,Pahernik S,Scheruebl I,Jauch KW,Thasler WE

    更新日期：2003-04-01 00:00:00

  • Stress management: How the unfolded protein response impacts fatty liver disease.

    abstract：:Induction of the unfolded protein response (UPR) is recognized as central to fatty liver disease (FLD) pathophysiology. This pathway may be a potential therapeutic target for FLD, as well as other diseases. However, fundamental questions as to how UPR contributes to FLD remain unanswered. Conflicting data suggest that...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2012.06.018

    authors： Imrie D,Sadler KC

    更新日期：2012-11-01 00:00:00

  • Prevalence of hepatitis C virus infection in patients with antiphospholipid syndrome.

    abstract：BACKGROUND/AIMS:The aim of this study was to determine the prevalence and clinical significance of hepatitis C virus (HCV) infection in patients with the antiphospholipid syndrome (APS). METHODS:A series of 88 consecutive patients (78 female and 10 male), with a mean age of 39 years (range 15-79), was prospectively st...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80127-5

    authors： Muñoz-Rodríguez FJ,Tàssies D,Font J,Reverter JC,Cervera R,Sánchez-Tapias JM,Mazzara R,Ordinas A,Ingelmo M

    更新日期：1999-05-01 00:00:00

  • Early tacrolimus exposure after liver transplantation: relationship with moderate/severe acute rejection and long-term outcome.

    abstract：BACKGROUND & AIMS:Liver transplant (LT) patients might be overimmunosuppressed as recommendations for tacrolimus trough concentrations (TC) within 4-6 weeks after liver transplantation are set too high (10-15 ng/ml). Early tacrolimus exposure was evaluated in relation to acute rejection and long-term outcomes. METHODS...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.09.019

    authors： Rodríguez-Perálvarez M,Germani G,Papastergiou V,Tsochatzis E,Thalassinos E,Luong TV,Rolando N,Dhillon AP,Patch D,O'Beirne J,Thorburn D,Burroughs AK

    更新日期：2013-02-01 00:00:00

  • Microsteatosis may not interact with macrosteatosis in living donor liver transplantation.

    abstract：BACKGROUND & AIMS:The insignificance of pure microsteatosis (MiS) was reported in living donor liver transplantation (LDLT). However, since steatosis is mostly found in a mixed form of microsteatosis (MiS) and macrosteatosis (MaS), we aimed to determine the importance of MiS mixed with MaS in LDLT. METHODS:Donor match...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.10.027

    authors： Han S,Ha SY,Park CK,Joh JW,Kwon CH,Kwon GY,Kim G,Gwak MS,Jeong WK,Ko JS

    更新日期：2015-03-01 00:00:00

  • Sorafenib attenuates the portal hypertensive syndrome in partial portal vein ligated rats.

    abstract：BACKGROUND/AIMS:Angiogenesis plays a key role in development of portal hypertension (PHT) and represents a potential therapeutic target. We aimed to evaluate the molecular effects of sorafenib, a multiple tyrosine kinase inhibitor, on splanchnic hemodynamics in rats with partial portal vein ligation (PPVL). METHODS:Th...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.06.024

    authors： Reiberger T,Angermayr B,Schwabl P,Rohr-Udilova N,Mitterhauser M,Gangl A,Peck-Radosavljevic M

    更新日期：2009-11-01 00:00:00

  • Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humans.

    abstract：BACKGROUND/AIMS:Little is known about the role of fractalkine (CX3CL1) in the liver. The aim of this study was to investigate the expression patterns of fractalkine and its receptor CX3CR1 in normal human liver and in conditions of injury. METHODS:Distribution and expression of fractalkine and its receptor were invest...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(02)00065-x

    authors： Efsen E,Grappone C,DeFranco RM,Milani S,Romanelli RG,Bonacchi A,Caligiuri A,Failli P,Annunziato F,Pagliai G,Pinzani M,Laffi G,Gentilini P,Marra F

    更新日期：2002-07-01 00:00:00