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Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat.

Abstract：

BACKGROUND/AIMS:Hepatic stellate cells (HSCs) are known to play a role in hepatic regeneration. We investigated hepatocyte/HSC interaction and HSC activation at various times after 70% partial hepatectomy (PHx) in the rat. METHODS:The hepatic microcirculation was studied using intravital fluorescence microscopy (IVFM). Desmin and alpha-SMA within liver tissue were detected by immunohistochemistry. In isolated parenchymal liver cells (PLCs) and HSCs, double immunostaining was used to identify activated HSC. RESULTS:Using IVFM, hepatocyte-clusters were often seen in vivo at 3 days after PHx (PHx3). Distance between HSC fell from 61.7+/-2.1 microm in controls to 36.1+/-1.4 microm (P<0.001) while the HSC/hepatocyte ratio rose (0.71+/-0.01 to 1.08+/-0.03; P<0.001). In >80% of in vivo microscopic fields in the PHx3 group, clusters of HSCs were observed especially near hepatocyte-clusters. At PHx1 and PHx3, >20% of cells in the PLC-fraction were HSCs which adhered to hepatocytes. At PHx3, in addition to desmin staining, isolated HSCs were also positive for BrdU and alpha-SMA, and formed clusters. HSCs in the HSC-fraction were only positive for desmin which indicated that adherence to hepatocytes is required for HSC activation. CONCLUSIONS:Our data suggest that HSCs are activated by adhering to hepatocytes in the early phase of liver regeneration.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Mabuchi A,Mullaney I,Sheard PW,Hessian PA,Mallard BL,Tawadrous MN,Zimmermann A,Senoo H,Wheatley AM

doi

10.1016/j.jhep.2004.02.005

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

910-6

issue

6

eissn

0168-8278

issn

1600-0641

pii

S0168827804000558

journal_volume

40

pub_type

杂志文章

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