当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Effect of HBV polymerase inhibitors on renal function in patients with chronic hepatitis B.

Effect of HBV polymerase inhibitors on renal function in patients with chronic hepatitis B.

Abstract：

BACKGROUND & AIMS:Therapy of chronic hepatitis B with HBV-polymerase inhibitors, in particular tenofovir or adefovir, may affect renal function. To assess renal function more accurately in the normal range, we used the recently validated, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate the estimated glomerular filtration rate (eGFR). METHODS:Patient subgroups included: patients with HBV-monoinfection treated with lamivudine (n=36), adefovir (n=32), entecavir (n=32), or tenofovir (n=37). HBsAg-positive untreated patients (n=60) served as control. For comparison HIV-monoinfected patients treated with tenofovir (n=120) or zidovudine (n=52) based antiretroviral therapy and antiretroviral naive patients (n=109) were assessed. CKD-EPI equation was used to calculate eGFR. In a more sensitive approach, we modeled the individual change in eGFR over time with linear mixed effects models (LME). RESULTS:Yearly predicted median changes in individual eGFR according to the LME model were: HBV untreated -2.05 ml/min, HBV lamivudine -0.92 ml/min, HBV adefovir -1.02 ml/min, HBV entecavir -1.00 ml/min, and HBV tenofovir -0.92 ml/min (p<0.01 for HBV untreated vs. HBV treated). In HIV-monoinfected patients: HIV untreated -0.62 ml/min, HIV treated with tenofovir -2.64 ml/min, HIV treated with zidovudine -1.0 ml/min (p=0.017 for tenofovir vs. no treatment, p<0.001 for tenofovir vs. zidovudine). CONCLUSIONS:Therapy of HBV infection irrespective of medication seems to result in a milder decrease of renal function. In contrast tenofovir as part of HIV combination therapy seems to impair renal function in this Caucasian population.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Mauss S,Berger F,Filmann N,Hueppe D,Henke J,Hegener P,Athmann C,Schmutz G,Herrmann E

doi

10.1016/j.jhep.2011.03.030

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1235-40

issue

6

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(11)00377-1

journal_volume

55

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Met as a therapeutic target in HCC: facts and hopes.

    abstract：:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and its burden is expected to increase further in the next years. In spite of the advances of classical therapies, such as surgery, transplantation, use of radiofrequency and transarterial embolization, the prognosis of this neoplasm ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2013.09.009

    authors： Giordano S,Columbano A

    更新日期：2014-02-01 00:00:00

  • Timing and benefit of liver transplantation in acute liver failure.

    abstract：:The case for using emergency liver transplantation in acute liver failure was made two decades ago by a series of single centre experiences. The development of models identifying a poor prognosis assisted the selection of patients for liver transplantation but none of these delivers both high sensitivity and specifici...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2013.10.024

    authors： O'Grady J

    更新日期：2014-03-01 00:00:00

  • NorUrsodeoxycholic acid ameliorates cholemic nephropathy in bile duct ligated mice.

    abstract：BACKGROUND & AIMS:Severe cholestasis may cause cholemic nephropathy that can be modeled in common bile duct ligated (CBDL) mice. We aimed to explore the therapeutic efficacy and mechanisms of norursodeoxycholic acid (norUDCA) in cholemic nephropathy. METHODS:In 8-week CBDL mice fed with norUDCA (prior or post CBDL) or...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.02.019

    authors： Krones E,Eller K,Pollheimer MJ,Racedo S,Kirsch AH,Frauscher B,Wahlström A,Ståhlman M,Trauner M,Grahammer F,Huber TB,Wagner K,Rosenkranz AR,Marschall HU,Fickert P

    更新日期：2017-07-01 00:00:00

  • Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice.

    abstract：BACKGROUND & AIMS:Excessive trans-fatty acids (TFA) consumption has been thought to be a risk factor mainly for coronary artery diseases while less attention has been paid to liver disease. We aimed to clarify the impact of TFA-rich oil consumption on the hepatic pathophysiology compared to natural oil. METHODS:Mice w...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.02.029

    authors： Obara N,Fukushima K,Ueno Y,Wakui Y,Kimura O,Tamai K,Kakazu E,Inoue J,Kondo Y,Ogawa N,Sato K,Tsuduki T,Ishida K,Shimosegawa T

    更新日期：2010-08-01 00:00:00

  • Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis.

    abstract：BACKGROUND/AIMS:Primary sclerosing cholangitis (PSC) is a cholestatic liver disease of unknown etiology. Although the primary defect affects cholangiocytes, cholestatic injury of hepatocytes may promote further liver damage. Since down-regulation of hepatocellular organic anion transporters is implicated in the molecul...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(02)00052-1

    authors： Geier A,Dietrich CG,Lammert F,Orth T,Mayet WJ,Matern S,Gartung C

    更新日期：2002-06-01 00:00:00

  • Prevention of alcoholic fatty liver and mitochondrial dysfunction in the rat by long-chain polyunsaturated fatty acids.

    abstract：BACKGROUND/AIMS:We reported that reduced dietary intake of polyunsaturated fatty acids (PUFA) such as arachidonic (AA,20:4n6,omega-6) and docosahexaenoic (DHA,22:6n3,omega-3) acids led to alcohol-induced fatty liver and fibrosis. This study was aimed at studying the mechanisms by which a DHA/AA-supplemented diet preven...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.04.023

    authors： Song BJ,Moon KH,Olsson NU,Salem N Jr

    更新日期：2008-08-01 00:00:00

  • miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression.

    abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) have been shown to be involved in many biological processes by affecting their target gene expression. miR-122 has been extensively studied in hepatocarcinogenesis. However, the role of miR-122 in liver fibrosis remains unknown. METHODS:The mRNA expression levels of miR-122, prolyl...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.11.011

    authors： Li J,Ghazwani M,Zhang Y,Lu J,Li J,Fan J,Gandhi CR,Li S

    更新日期：2013-03-01 00:00:00

  • The changing scenario of hepatitis D.

    abstract：:The global scenario of hepatitis D is changing with the widespread implementation of vaccination against hepatitis B. In high-income countries that achieved optimal control of HBV, the epidemiology of hepatitis D is dual, consisting of an ageing cohort of domestic patients with advanced liver fibrosis who represent th...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2021.01.014

    authors： Rizzetto M,Hamid S,Negro F

    更新日期：2021-01-20 00:00:00

  • Cost-effectiveness of semi-annual surveillance for hepatocellular carcinoma in cirrhotic patients of the Italian Liver Cancer population.

    abstract：BACKGROUND & AIMS:It was recently shown that semi-annual surveillance for hepatocellular carcinoma (HCC) in cirrhotic patients provides a prognostic advantage over the annual program; however, its cost-effectiveness (CE) in the general cirrhotic population still needs to be defined. METHODS:A Markov model was built to...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jhep.2011.11.022

    authors： Cucchetti A,Trevisani F,Cescon M,Ercolani G,Farinati F,Poggio PD,Rapaccini G,Nolfo MAD,Benvegnù L,Zoli M,Borzio F,Giannini EG,Caturelli E,Chiaramonte M,Pinna AD,Italian Liver Cancer (ITA.LI.CA) Group.

    更新日期：2012-05-01 00:00:00

  • Cyclin D1 is up-regulated in hepatocytes in vivo following cell-cycle block induced by retrorsine.

    abstract：BACKGROUND/AIMS:We reported massive liver repopulation by transplanted hepatocytes in rats given retrorsine (RS), a pyrrolizidine alkaloid which blocks proliferation of resident cells. In these studies, molecular alterations induced by RS on hepatocyte cell cycle were investigated. METHODS:Animals were treated accordi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.03.029

    authors： Pitzalis S,Doratiotto S,Greco M,Montisci S,Pasciu D,Porcu G,Pani P,Laconi S,Laconi E

    更新日期：2005-09-01 00:00:00

  • Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension.

    abstract：BACKGROUND & AIMS:Emricasan, an oral pan-caspase inhibitor, decreased portal pressure in experimental cirrhosis and in an open-label study in patients with cirrhosis and severe portal hypertension, defined as a hepatic venous pressure gradient (HVPG) ≥12 mmHg. We aimed to confirm these results in a placebo-controlled s...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.12.010

    authors： Garcia-Tsao G,Bosch J,Kayali Z,Harrison SA,Abdelmalek MF,Lawitz E,Satapathy SK,Ghabril M,Shiffman ML,Younes ZH,Thuluvath PJ,Berzigotti A,Albillos A,Robinson JM,Hagerty DT,Chan JL,Sanyal AJ,IDN-6556-14 Investigators(‡).

    更新日期：2020-05-01 00:00:00

  • Gene expression regulation for interferon-alpha in hepatocellular carcinoma.

    abstract：:We investigated whether regulation of interferon-alpha gene expression could be involved in liver tumor biology and the role, if any, of hepatitis B virus in the regulation of tumor cytokine gene expression. Gene expression was investigated at the transcriptional level using 'in situ' hybridization of cytokine message...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80215-6

    authors： d'Arville CN,Nouri-Aria KT,Johnson P,Williams R

    更新日期：1993-03-01 00:00:00

  • Mechanism of hepatic fatty acid uptake.

    abstract：:In recent years a new concept of the mechanism of hepatic fatty acid uptake has been described. It was shown that this major class of energy yielding substrates enters hepatocytes by a carrier-mediated uptake system. After the dissociation of the fatty acid-albumin complex at the sinusoidal liver cell plasma membrane,...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/0168-8278(89)90148-7

    authors： Stremmel W

    更新日期：1989-11-01 00:00:00

  • Usefulness of alpha-fetoprotein response in patients treated with sorafenib for advanced hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:Tumor shrinkage has been considered a fundamental surrogate efficacy measure for new cancer treatments. However, in patients treated with sorafenib for advanced hepatocellular carcinoma (HCC), tumor shrinkage rarely accompanies increased survival, thereby questioning the prognostic value of imaging-ba...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.02.016

    authors： Personeni N,Bozzarelli S,Pressiani T,Rimassa L,Tronconi MC,Sclafani F,Carnaghi C,Pedicini V,Giordano L,Santoro A

    更新日期：2012-07-01 00:00:00

  • Alternatively activated macrophages promote resolution of necrosis following acute liver injury.

    abstract：BACKGROUND & AIM:Following acetaminophen (APAP) overdose, acute liver injury (ALI) can occur in patients that present too late for N-acetylcysteine treatment, potentially leading to acute liver failure, systemic inflammation, and death. Macrophages influence the progression and resolution of ALI due to their innate imm...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.02.031

    authors： Starkey Lewis P,Campana L,Aleksieva N,Cartwright JA,Mackinnon A,O'Duibhir E,Kendall T,Vermeren M,Thomson A,Gadd V,Dwyer B,Aird R,Man TY,Rossi AG,Forrester L,Park BK,Forbes SJ

    更新日期：2020-08-01 00:00:00

  • Analysis of T-cell receptor Vbeta repertoire in liver-infiltrating lymphocytes in chronic hepatitis C.

    abstract：BACKGROUND/AIMS:To examine the T-cell repertoire which is involved in the immunopathogenesis of chronic hepatitis, we analyzed the T-cell receptor Vbeta gene usage in liver-infiltrating lymphocytes by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical technique. METHODS:Complementary DNA ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80408-4

    authors： Kashii Y,Shimizu Y,Nambu S,Minemura M,Okada K,Higuchi K,Watanabe A

    更新日期：1997-03-01 00:00:00

  • Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: A pilot study.

    abstract：BACKGROUND & AIMS:To evaluate the hypothesis that increasing T cell frequency and activity may provide durable control of hepatitis B virus (HBV), we administered nivolumab, a programmed death receptor 1 (PD-1) inhibitor, with or without GS-4774, an HBV therapeutic vaccine, in virally suppressed patients with HBV e ant...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.06.028

    authors： Gane E,Verdon DJ,Brooks AE,Gaggar A,Nguyen AH,Subramanian GM,Schwabe C,Dunbar PR

    更新日期：2019-11-01 00:00:00

  • Quantitation of hepatitis B lamivudine resistant mutants by real-time amplification refractory mutation system PCR.

    abstract：BACKGROUND/AIMS:Lamivudine is an antiviral drug that is used to treat hepatitis B virus (HBV) infection. Long-term therapy does not completely suppress viral replication, and resistant mutants emerge. Resistance is mediated by changes in the tyrosine-methionine-apartate-aspartate (YMDD) motif in the catalytic site of t...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.02.009

    authors： Punia P,Cane P,Teo CG,Saunders N

    更新日期：2004-06-01 00:00:00

  • Inositol phosphate responses in portal veins from portal hypertensive rats: receptor- and nonreceptor-mediated responses.

    abstract：BACKGROUND/AIMS:Venous hyporesponsiveness in portal hypertension has been reported previously by us. The present study was undertaken to investigate possible changes of phosphoinositide signal transduction pathway in the portal veins from portal hypertensive rats METHODS:Portal hypertension was induced by partial port...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80055-4

    authors： Huang YT,Chang SP,Lin HC,Yang MC,Hong CY

    更新日期：1997-02-01 00:00:00

  • Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.

    abstract：BACKGROUND/AIMS:Haematopoietic stem cells (HSC) have previously been shown in some studies to migrate to damaged and diseased liver where a small proportion will engraft. Such cells can promote liver repair in rodent models of liver injury and lead to improved liver function in uncontrolled clinical studies. In order t...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.06.021

    authors： Crosby HA,Lalor PF,Ross E,Newsome PN,Adams DH

    更新日期：2009-10-01 00:00:00

  • IL-1 receptor like 1 protects against alcoholic liver injury by limiting NF-κB activation in hepatic macrophages.

    abstract：BACKGROUND & AIM:Alcohol consumption increases intestinal permeability and causes damage to hepatocytes, leading to the release of pathogen- and damage-associated molecular pattern molecules (PAMPs and DAMPs), stimulating hepatic macrophages and activating NF-κB. The resultant inflammation exacerbates alcoholic liver d...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.08.023

    authors： Wang M,Shen G,Xu L,Liu X,Brown JM,Feng D,Ross RA,Gao B,Liangpunsakul S,Ju C

    更新日期：2017-09-21 00:00:00

  • GBV-C/HGV is not the major cause of autoimmune hepatitis.

    abstract：:Recently, GBV-C and HGV-two isolates of the same new flavivirus-were identified in serum samples of patients with indeterminate hepatitis and posttransfusion hepatitis, respectively. The pathogenic relevance of these viruses is still uncertain. As viral infections are presumed to trigger autoimmune processes, we inves...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80306-0

    authors： Heringlake S,Tillmann HL,Cordes-Temme P,Trautwein C,Hunsmann G,Manns MP

    更新日期：1996-12-01 00:00:00

  • Epidemiology and surveillance for hepatocellular carcinoma: New trends.

    abstract：:The burden of hepatocellular carcinoma (HCC) is highest in East Asia and Africa, although its incidence and mortality are rapidly rising in the United States and Europe. With the implementation of hepatitis B vaccination and hepatitis C treatment programmes worldwide, the epidemiology of HCC is shifting away from a di...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2019.08.025

    authors： Singal AG,Lampertico P,Nahon P

    更新日期：2020-02-01 00:00:00

  • Deterioration of health-related quality of life and fatigue in patients with chronic hepatitis C: Association with demographic factors, inflammatory activity, and degree of fibrosis.

    abstract：BACKGROUND/AIMS:Health-related quality of life (HRQoL) is impaired in patients with chronic hepatitis C. We investigated HRQoL and fatigue in patients with chronic hepatitis C virus (HCV) infection in relation to the degree of fibrosis and inflammation, and controlled for the influence of relevant demographic and medic...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jhep.2008.07.025

    authors： Teuber G,Schäfer A,Rimpel J,Paul K,Keicher C,Scheurlen M,Zeuzem S,Kraus MR

    更新日期：2008-12-01 00:00:00

  • Targeted vaccination programme successful in reducing acute hepatitis B in men having sex with men in Amsterdam, the Netherlands.

    abstract：BACKGROUND & AIMS:In the Netherlands, transmission of hepatitis B virus occurs mainly within behavioural high-risk groups, such as in men who have sex with men. Therefore, a vaccination programme has targeted these high-risk groups. This study evaluates the impact of the vaccination programme targeting Amsterdam's larg...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.08.002

    authors： van Rijckevorsel G,Whelan J,Kretzschmar M,Siedenburg E,Sonder G,Geskus R,Coutinho R,van den Hoek A

    更新日期：2013-12-01 00:00:00

  • FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency.

    abstract：BACKGROUND & AIMS:The pathogenesis of autoimmune hepatitis (AIH) is not understood, but it was suggested that AIH may be related to a numerical or functional impairment of CD4+CD25+FOXP3+ regulatory T cells (Treg), which are important mediators of immune tolerance to self-antigens. However, the role of Treg in AIH is n...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.02.029

    authors： Peiseler M,Sebode M,Franke B,Wortmann F,Schwinge D,Quaas A,Baron U,Olek S,Wiegard C,Lohse AW,Weiler-Normann C,Schramm C,Herkel J

    更新日期：2012-07-01 00:00:00

  • The apoptosis protector, bcl-2 protein, is downregulated in bile duct epithelial cells of human liver allografts.

    abstract：BACKGROUND/AIMS:Apoptosis of bile duct cells occurs in hepatic allografts and is correlated with acute rejection. bcl-2 protein counteracts apoptosis and prolongs cell survival. We therefore tested the expression of bcl-2 protein in bile ducts of liver grafts in comparison with those of liver cirrhosis. METHODS:115 bi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80418-7

    authors： Gapany C,Zhao M,Zimmermann A

    更新日期：1997-03-01 00:00:00

  • Different hepatitis C virus dynamics of free-virions and immune-complexes after initiation of interferon-alpha in patients with chronic hepatitis C.

    abstract：BACKGROUND/AIMS:To elucidate the mechanisms of action of interferon (IFN) against hepatitis C virus (HCV), we studied the serum HCV dynamics of free-virions (FV) and immune-complexes (IC) in patients treated with IFN. METHODS:FV and IC were separated by immunoprecipitation using anti-human immunoglobulin and quantifie...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00472-0

    authors： Fujita N,Kaito M,Takeo M,Horiike S,Tanaka H,Ikoma J,Watanabe S,Adachi Y

    更新日期：2003-12-01 00:00:00

  • A comparison of fibrosis progression in chronic liver diseases.

    abstract：BACKGROUND/AIMS:No study has compared the liver fibrosis progression rates among chronic liver diseases and the risk factors in order to better organize screening strategies. METHODS:A total of 4852 patients were retrospectively studied (chronic hepatitis C (HCV) [n=2313], human immunodeficiency virus (HIV)-HCV co-inf...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(02)00413-0

    authors： Poynard T,Mathurin P,Lai CL,Guyader D,Poupon R,Tainturier MH,Myers RP,Muntenau M,Ratziu V,Manns M,Vogel A,Capron F,Chedid A,Bedossa P,PANFIBROSIS Group.

    更新日期：2003-03-01 00:00:00

  • Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7.

    abstract：BACKGROUND/AIMS:The oral administration of the major transplant immunosuppressants cyclosporine A and tacrolimus leads to unpredictable drug levels requiring drug monitoring. Hepatic and extrahepatic metabolism of cyclosporine A and tacrolimus by cytochrome P450 proteins has been analyzed but metabolism and inactivatio...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00040-x

    authors： Strassburg CP,Barut A,Obermayer-Straub P,Li Q,Nguyen N,Tukey RH,Manns MP

    更新日期：2001-06-01 00:00:00