Usefulness of alpha-fetoprotein response in patients treated with sorafenib for advanced hepatocellular carcinoma.


BACKGROUND & AIMS:Tumor shrinkage has been considered a fundamental surrogate efficacy measure for new cancer treatments. However, in patients treated with sorafenib for advanced hepatocellular carcinoma (HCC), tumor shrinkage rarely accompanies increased survival, thereby questioning the prognostic value of imaging-based Response Evaluation Criteria in Solid Tumors (RECIST). We investigated the prognostic usefulness of a decrease in serum alpha-fetoprotein (AFP) and compared it to RECIST. METHODS:In HCC patients treated with sorafenib with baseline AFP >20 ng/ml, AFP response was defined as a >20% decrease in AFP during 8weeks of treatment. Patients were also assessed by RECIST and were categorized as having radiologically proven progressive disease or disease control (consisting of complete or partial responses and stable disease). Comparisons of survival by RECIST and AFP response were corrected for guarantee-time bias by the landmark method. RESULTS:We evaluated 85 patients for AFP response, among them, 82 were also evaluated by RECIST. In the analysis of AFP response, 32 out of 85 patients (37.6%) were responders, whereas 58 out of 82 patients (70.7%) achieved disease control. In landmark analysis, the hazard ratios (HR) for survival according to AFP response and disease control were 0.59 (p=0.040) and 1.03 (p=0.913), respectively. In multivariate analysis, only AFP response (HR=0.52; p=0.009) and Cancer of the Liver Italian Program dichotomized stage (HR=0.42; p=0.002) were prognostic factors of survival. CONCLUSIONS:Assessment of AFP response may be considered as an alternative to RECIST to capture sorafenib activity in HCC.


J Hepatol


Journal of hepatology


Personeni N,Bozzarelli S,Pressiani T,Rimassa L,Tronconi MC,Sclafani F,Carnaghi C,Pedicini V,Giordano L,Santoro A




Has Abstract


2012-07-01 00:00:00














  • Prevalence of GBV-C and hepatitis G virus variants in patients with fulminant hepatic failure in Japan.

    abstract:BACKGROUND/AIMS:Whether GB virus C and hepatitis G virus participate in fulminant hepatic failure is controversial. We studied the prevalence of the viral RNA in 48 patients. There were possible routes of infection, including blood transfusion, in 22 patients (group 1), and no risk factors in the other 26 (group 2). M...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Tanaka M,Nishiguchi S,Tanaka T,Enomoto M,Fukuda K,Takeda T,Nakajima S,Shiomi S,Kuroki T,Monna T,Yano Y,Otani S

    更新日期:1997-12-01 00:00:00

  • Bile acid kinetics and biliary lipid composition in cystic fibrosis.

    abstract:AIMS/METHODS:Bile acid kinetics and biliary lipid composition were studied in seven patients, aged 17-70 years with cystic fibrosis. All patients were of normal height and weight, and were in good clinical condition. Ultrasonography indicated a small gallbladder in one and non-visualized gallbladder in two patients. Se...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Strandvik B,Einarsson K,Lindblad A,Angelin B

    更新日期:1996-07-01 00:00:00

  • Effect of vascular endothelial growth factor on hepatic regenerative activity following partial hepatectomy in rats.

    abstract:BACKGROUND/AIMS:Vascular endothelial growth factor (VEGF) is an angiogenic factor with a growth-promoting effect that is thought to be restricted to vascular endothelial cells. Its essential role during liver regeneration has yet to be determined. The aim of this study was to document the effect of exogenous VEGF admin...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Assy N,Spira G,Paizi M,Shenkar L,Kraizer Y,Cohen T,Neufeld G,Dabbah B,Enat R,Baruch Y

    更新日期:1999-05-01 00:00:00

  • Incidence of non-alcoholic fatty liver disease in Hong Kong: a population study with paired proton-magnetic resonance spectroscopy.

    abstract:BACKGROUND & AIMS:Because abdominal ultrasonography cannot reliably quantify hepatic steatosis, accurate data on the incidence of non-alcoholic fatty liver disease (NAFLD) are lacking. We aimed to study the population incidence of NAFLD with state-of-the-art non-invasive tests. METHODS:This was a prospective cohort st...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Wong VW,Wong GL,Yeung DK,Lau TK,Chan CK,Chim AM,Abrigo JM,Chan RS,Woo J,Tse YK,Chu WC,Chan HL

    更新日期:2015-01-01 00:00:00

  • Modulation of protein kinase C alters hemodynamics and metabolism in the isolated liver in fed and fasted rats.

    abstract::The activation of protein kinase C (PKC) has been implicated in the pathogenesis of gram-negative sepsis. The effects of PKC modulation on hepatic flow and metabolism were studied using isolated liver perfusion. The liver was isolated from well-fed or overnight-fasted, male Sprague-Dawley rats weighing 250-310 g, and ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Inaba H,Araki M,Numai T

    更新日期:1993-11-01 00:00:00

  • Alterations of leptin during IFN-alpha therapy in patients with chronic viral hepatitis.

    abstract:BACKGROUND/AIMS:Leptin has a particular profibrogenic role in the liver. We investigated whether IFN-alpha influences leptin production in patients with chronic hepatitis B (CHB) and C (CHC). Leptin was determined in serial samples from 63 CHB and 42 CHC IFN-alpha treated patients. Furthermore, we evaluated whether lep...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Zografos TA,Rigopoulou EI,Liaskos C,Togousidis E,Zachou K,Gatselis N,Germenis A,Dalekos GN

    更新日期:2006-05-01 00:00:00

  • GBV-C/HGV is not the major cause of autoimmune hepatitis.

    abstract::Recently, GBV-C and HGV-two isolates of the same new flavivirus-were identified in serum samples of patients with indeterminate hepatitis and posttransfusion hepatitis, respectively. The pathogenic relevance of these viruses is still uncertain. As viral infections are presumed to trigger autoimmune processes, we inves...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Heringlake S,Tillmann HL,Cordes-Temme P,Trautwein C,Hunsmann G,Manns MP

    更新日期:1996-12-01 00:00:00

  • Detection of antibodies against pre-S1 proteins in sera of patients with hepatitis B virus (HBV) infection.

    abstract::Pre-S1 (large S) proteins are components of the envelope of HBV. The presence of pre-S1 proteins is correlated with viral replication. To test sera of patients with HBV infection for the presence of antibodies against pre-S1 proteins (anti-pre-S1), an E. coli extract containing a pre-S fusion protein covering the grea...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Theilmann L,Klinkert MQ,Gmelin K,Kommerell B,Pfaff E

    更新日期:1987-02-01 00:00:00

  • Defective aggregation in cirrhosis is independent of in vivo platelet activation.

    abstract:BACKGROUND/AIMS:Platelet function abnormalities contribute to the hemostatic defect in patients with cirrhosis. In this study we evaluated the occurrence of in vivo platelet activation as a possible mechanism of defective platelet aggregation in patients with cirrhosis. METHODS:Nine patients with severe (Child B-C) ci...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Laffi G,Cinotti S,Filimberti E,Ciabattoni G,Caporale R,Marra F,Melani L,Grossi A,Carloni V,Gentilini P

    更新日期:1996-04-01 00:00:00

  • Treatment of HCV reduces viral hepatitis-associated liver-related mortality in patients: An ERCHIVES study.

    abstract:BACKGROUND & AIMS:Treating HCV infection reduces overall mortality and reduces the risk of multiple extrahepatic complications. Whether the reduction in mortality is primarily due to a reduction in liver-related causes or extrahepatic complications is unknown. METHODS:We identified HCV-positive individuals treated for...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Butt AA,Yan P,Shaikh OS,Lo Re V 3rd,Abou-Samra AB,Sherman KE

    更新日期:2020-08-01 00:00:00

  • Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing.

    abstract:BACKGROUND/AIMS:The aim of our study was to evaluate the proportion of patients with severe alcoholic cirrhosis who would need orthotopic liver transplantation (OLT) and to determine the optimal delay to evaluate an abstinent patient for transplantation. METHODS:Survival without OLT, improvement in liver function and ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Veldt BJ,Lainé F,Guillygomarc'h A,Lauvin L,Boudjema K,Messner M,Brissot P,Deugnier Y,Moirand R

    更新日期:2002-01-01 00:00:00

  • Pregnancy-associated acute liver disease and acute viral hepatitis: differentiation, course and outcome.

    abstract:BACKGROUND/AIMS:Pregnant women with acute viral hepatitis (VH) and those with pregnancy associated acute liver disease (PAALD) including acute fatty liver disease of pregnancy, hemolysis elevated liver enzyme and low platelet syndrome present with similar clinical features and liver tests abnormalities. Accurate differ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Devarbhavi H,Kremers WK,Dierkhising R,Padmanabhan L

    更新日期:2008-12-01 00:00:00

  • Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis.

    abstract:BACKGROUND & AIMS:Mannose-binding lectin (MBL) is a serum lectin synthesized by the liver and involved in innate host defense. MBL deficiency increases the risk of various infectious diseases mostly in immune-deficient conditions. Bacterial infections are a significant cause of morbidity and mortality in liver cirrhosi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Altorjay I,Vitalis Z,Tornai I,Palatka K,Kacska S,Farkas G,Udvardy M,Harsfalvi J,Dinya T,Orosz P,Lombay B Jr,Par G,Par A,Csak T,Osztovits J,Szalay F,Csepregi A,Lakatos PL,Papp M

    更新日期:2010-09-01 00:00:00

  • Association of the IL28B genotype with insulin resistance in patients with chronic hepatitis C.

    abstract:BACKGROUND & AIMS:Insulin resistance, fibrosis and steatosis are established predictors of response to peg-interferon/ribavirin therapy in chronic hepatitis C (CHC). Several host genetic polymorphisms (IL28B, PNPLA3) modify treatment-outcome, the degree of steatosis or fibrosis. The aim of our study was to evaluate the...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Stättermayer AF,Rutter K,Beinhardt S,Scherzer TM,Stadlmayr A,Hofer H,Wrba F,Steindl-Munda P,Krebs M,Datz C,Trauner M,Ferenci P

    更新日期:2012-09-01 00:00:00

  • Hepatitis C virus core protein exerts an inhibitory effect on suppressor of cytokine signaling (SOCS)-1 gene expression.

    abstract:BACKGROUND/AIMS:Suppressor of cytokine signaling (SOCS)-1, a negative feedback regulator of cytokine signaling pathway, also has a tumor suppressor activity, the silencing of its gene by hypermethylation is suggested to contribute to hepatocarcinogenesis. We studied the effect of the core protein of hepatitis C virus (...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Miyoshi H,Fujie H,Shintani Y,Tsutsumi T,Shinzawa S,Makuuchi M,Kokudo N,Matsuura Y,Suzuki T,Miyamura T,Moriya K,Koike K

    更新日期:2005-11-01 00:00:00

  • Demonstration of McCune-Albright mutations in the liver of children with high gammaGT progressive cholestasis.

    abstract::Two patients presented with neonatal cholestasis and acholic stools as first manifestations of McCune-Albright syndrome. Both went through an extensive evaluation including an exploratory laparotomy with peroperative cholangiography which ruled out biliary atresia. One patient presented from the fourth month of life w...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Silva ES,Lumbroso S,Medina M,Gillerot Y,Sultan C,Sokal EM

    更新日期:2000-01-01 00:00:00

  • Low HCV replication levels in end-stage hepatitis C virus-related liver disease.

    abstract:BACKGROUND/AIMS:The relationship between HCV RNA levels and the severity of HCV-related liver disease has been addressed in a few studies, which has led to conflicting results. To clarify this point, we studied serum HCV RNA levels in patients with HCV liver disease at various stages, using a second-generation branched...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Duvoux C,Pawlotsky JM,Bastie A,Cherqui D,Soussy CJ,Dhumeaux D

    更新日期:1999-10-01 00:00:00

  • Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population.

    abstract::Abnormalities of carbohydrate metabolism, including hyperinsulinaemia and insulin resistance, are well recognised complications of cirrhosis. While diabetes mellitus can be explained in many instances on the basis of coincident pancreatic disease, in most the characteristic glucose intolerance of cirrhosis is not read...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Allison ME,Wreghitt T,Palmer CR,Alexander GJ

    更新日期:1994-12-01 00:00:00

  • Quantitative analysis of IgM anti-HBc in chronic hepatitis B patients using a new "gray-zone" for the evaluation of "borderline" values.

    abstract:BACKGROUND/METHODS:In order to define the clinical significance of borderline levels of IgM anti-HBc in chronic hepatitis B patients, we followed up 89 untreated hepatitis B patients (19 HBeAg pos and 70 anti-HBe pos) for 1 year, with monthly monitoring of IgM anti-HBc using a highly sensitive quantitative microparticl...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Colloredo G,Bellati G,Leandro G,Colombatto P,Rho A,Bissoli F,Brunetto MR,Angeli G,Ideo G,Bonino F

    更新日期:1996-11-01 00:00:00

  • DHBV manipulation and prediction of the outcome of infection.

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Vickery K,Cossart Y

    更新日期:1996-10-01 00:00:00

  • Frequent loss of chromosome 3p and hypermethylation of RASSF1A in cholangiocarcinoma.

    abstract:BACKGROUND/AIMS:Cholangiocarcinoma comprises 5-20% of all primary malignant tumors of the liver. However, the lack of information about the genetic basis of cholangiocarcinoma has impeded characterization and understanding of its biological behavior. METHODS:In this study, genome-wide aberrations in 13 cases of cholan...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Wong N,Li L,Tsang K,Lai PB,To KF,Johnson PJ

    更新日期:2002-11-01 00:00:00

  • Acute exacerbation and reactivation of chronic hepatitis C virus infection in cancer patients.

    abstract:BACKGROUND & AIMS:Data on acute exacerbation and reactivation of chronic hepatitis C virus (HCV) infection following chemotherapy are very limited. We sought to characterize the episodes of acute exacerbation and viral reactivation of HCV infection in cancer patients. METHODS:The medical records of HCV-infected patien...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Mahale P,Kontoyiannis DP,Chemaly RF,Jiang Y,Hwang JP,Davila M,Torres HA

    更新日期:2012-12-01 00:00:00

  • Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: effects on protein-L-isoaspartyl methyltransferase activity.

    abstract:BACKGROUND/AIMS:Protein-L-isoaspartyl methyltransferase (PIMT) is a methyltransferase that plays a crucial role in the repair of damaged proteins. In this study, we investigated whether ethanol exposure causes an accumulation of modified proteins bearing atypical isoaspartyl residues that may be related to impaired PIM...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kharbanda KK,Mailliard ME,Baldwin CR,Sorrell MF,Tuma DJ

    更新日期:2007-06-01 00:00:00

  • Hepatic microvascular features in experimental cirrhosis: a structural and morphometrical study in CCl4-treated rats.

    abstract:BACKGROUND/AIMS:In this study, a detailed morphometrical analysis of the hepatic microvasculature in the different zones of hepatic parenchyma was performed in normal and cirrhotic rat liver (CCl4-induced). The aims were to detect, in CCl4-induced cirrhosis, the real presence of the "capillarization" of hepatic sinusoi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Onori P,Morini S,Franchitto A,Sferra R,Alvaro D,Gaudio E

    更新日期:2000-10-01 00:00:00

  • Visceral adiposity index is not a predictor of liver histology in patients with non-alcoholic fatty liver disease.

    abstract:BACKGROUND & AIMS:Visceral adiposity is associated with hepatic steatosis, inflammation, and fibrosis in non-alcoholic fatty liver disease (NAFLD). The visceral adiposity index (VAI), a novel marker of visceral fat distribution and dysfunction, has been correlated with histology in hepatitis C. We assessed the ability ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Vongsuvanh R,George J,McLeod D,van der Poorten D

    更新日期:2012-08-01 00:00:00

  • Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy.

    abstract:BACKGROUND/AIMS:Intrahepatic cholestasis of pregnancy is characterized by pruritus and increased levels of serum bile acids, and is often associated with premature delivery, fetal distress, and perinatal mortality. The aims of the present study were: (i) to better define the serum bile acid profile in intrahepatic chol...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章


    authors: Brites D,Rodrigues CM,Oliveira N,Cardoso M,Graça LM

    更新日期:1998-01-01 00:00:00

  • Selection for a pre-C stop codon mutation in a hepatitis B virus variant with a pre-C initiation codon mutation during interferon treatment.

    abstract::Hepatitis B virus (HBV) variants with a stop codon, a mutated translation initiation codon or other mutations in the pre-C region which prevent e-antigen expression are highly prevalent in anti-HBe chronic carriers and can be positively selected from a mixed virus infection. Our laboratories recently described pre-C v...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Santantonio T,Jung MC,Schneider R,Pastore G,Pape GR,Will H

    更新日期:1991-11-01 00:00:00

  • Natural history of chronic hepatitis B in Euro-Mediterranean and African countries.

    abstract::Data derived from population, case-control, and cohort studies conducted in several Euro-Mediterranean and African countries disclose impressive similarities in the age and modes of hepatitis B virus (HBV) transmission and in the prevalence, duration, and outcome of the four phases of the natural history of chronic in...

    journal_title:Journal of hepatology

    pub_type: 历史文章,杂志文章,评审


    authors: Hadziyannis SJ

    更新日期:2011-07-01 00:00:00

  • Transplantation of the liver in adults and children with fulminant hepatic failure.

    abstract::Fulminant hepatic failure has a high mortality rate despite intensive medical treatment. Urgent hepatic transplantation was considered over a 3 year period in 26 (36%) of 73 patients with the worst prognostic features of fulminant hepatic failure. The criteria for patient selection were based on the duration of advanc...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Vickers C,Neuberger J,Buckels J,McMaster P,Elias E

    更新日期:1988-10-01 00:00:00

  • Elevation of the serum bilirubin diconjugate fraction provides an early marker for cholestasis in the rat.

    abstract:AIMS/METHODS:During cholestasis, components normally excreted into bile, e.g. bilirubin, accumulate in liver cells and biliary passages. In order to assess the conjugation of bilirubin retained in the hepatocyte during cholestasis, we analyzed the pattern of bilirubin pigments in rat serum and bile, using reversed phas...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Mesa VA,De Vos R,Fevery J

    更新日期:1997-11-01 00:00:00