Different hepatitis C virus dynamics of free-virions and immune-complexes after initiation of interferon-alpha in patients with chronic hepatitis C.

abstract：:Pre-S1 (large S) proteins are components of the envelope of HBV. The presence of pre-S1 proteins is correlated with viral replication. To test sera of patients with HBV infection for the presence of antibodies against pre-S1 proteins (anti-pre-S1), an E. coli extract containing a pre-S fusion protein covering the grea...

journal_title：Journal of hepatology

authors： Theilmann L,Klinkert MQ,Gmelin K,Kommerell B,Pfaff E

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND/AIMS:Although matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs) play an essential role in liver injury associated with tissue remodeling, the cellular origin of MMPs/TMPs within the liver remains to be clarified. METHODS:Different liver cell populations were analysed with respect to the...

journal_title：Journal of hepatology

authors： Knittel T,Mehde M,Kobold D,Saile B,Dinter C,Ramadori G

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:We evaluated the test performance profile (TPP) of blood tests of liver fibrosis. METHODS:Three hundred and fifty-six patients with C chronic hepatitis were included in two centers. Metavir staging of liver specimens by two independent pathologists and the following tests were evaluated: Fibrotest (FT)...

journal_title：Journal of hepatology

authors： Halfon P,Bacq Y,De Muret A,Penaranda G,Bourliere M,Ouzan D,Tran A,Botta D,Renou C,Bréchot MC,Degott C,Paradis V

更新日期：2007-03-01 00:00:00

abstract：:A monoclonal antibody, designated K-PLC1, has been produced to a tumour-associated antigen on the cell membrane of the PLC/PRF/5 cell line. Using an indirect immunofluorescence technique this antibody produced membrane staining of three hepatocellular carcinoma (HCC) cell lines and it has positively stained 10 of 11 h...

journal_title：Journal of hepatology

authors： Dunk AA,Brown D,Weidmann K,Thomas HC

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND/AIMS:The aim was to study the reproducibility of magnetic resonance velocity mapping, when measuring portal vein and superior mesenteric artery blood flow, under fasting and post-prandial conditions. Magnetic resonance flow measurements for the portal vein were compared with echo-Doppler measurements in the ...

journal_title：Journal of hepatology

authors： Lycklama à Nijeholt GJ,Burggraaf K,Wasser MN,Schultze Kool LJ,Schoemaker RC,Cohen AF,de Roos A

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis B virus (HBV) infection in extrahepatic tissues is controversial. To clarify whether episomal HBV can infect nonhepatic tissues, we investigated the molecular forms of HBV in the lymphatic cells of inactive HBV carriers who lacked viremia, thus avoiding contamination with HBV genomes originati...

journal_title：Journal of hepatology

authors： Umeda M,Marusawa H,Seno H,Katsurada A,Nabeshima M,Egawa H,Uemoto S,Inomata Y,Tanaka K,Chiba T

更新日期：2005-06-01 00:00:00

abstract：:To evaluate the expression of hepatocyte HLA Class I and II antigens and the infiltration of CD8-positive lymphocytes in patients with chronic hepatitis, cells obtained by the technique of fine-needle aspiration were compared with those obtained by percutaneous liver biopsy. In general, correlation between cytological...

journal_title：Journal of hepatology

authors： Krawitt EL,Zannier A,Chossegros P,Gerard F,Chevallier M,Mutin M,Trepo C,Touraine JL

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND/AIMS:The development of cholesterol gallstones, in some patients, has been associated with increased proportions of deoxycholic acid in the bile acid pool. Deoxycholic acid is a microbial product of cholic acid 7alpha-dehydroxylation in the intestines. The levels and activities of bile acid 7alpha-dehydroxyl...

journal_title：Journal of hepatology

authors： Wells JE,Berr F,Thomas LA,Dowling RH,Hylemon PB

更新日期：2000-01-01 00:00:00

abstract：:The oesophageal pH was recorded for 3 h after a test-meal in 27 healthy control subjects (group I), 40 patients with alcoholic cirrhosis (group II), and 22 patients with a normal liver and symptoms of gastro-oesophageal reflux (control refluxers). Gastro-oesophageal reflux was observed in 10 of the cirrhotic patients....

journal_title：Journal of hepatology

authors： Arsene D,Bruley des Varannes S,Galmiche JP,Denis P,Chayvialle JA,Hellot MF,Ducrotte P,Colin R

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND/AIMS:Central nervous system abnormalities such as fatigue and depression occur more frequently in chronic hepatitis C virus (HCV) infection than in many other causes of chronic liver disease. The finding that fatigue is unrelated to activity of hepatitis or mode of infection could indicate an independent eff...

journal_title：Journal of hepatology

authors： Kramer L,Bauer E,Funk G,Hofer H,Jessner W,Steindl-Munda P,Wrba F,Madl C,Gangl A,Ferenci P

更新日期：2002-09-01 00:00:00

abstract：:Portal vein thrombosis is not uncommon in candidates for transplantation. Partial thrombosis is more common than complete thrombosis. Despite careful screening at evaluation, a number of patients are still found with previously unrecognized thrombosis per-operatively. The objective is to recanalize the portal vein or,...

journal_title：Journal of hepatology

authors： Francoz C,Valla D,Durand F

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND/AIMS:Fulminant hepatic failure (FHF) can be dreadful. When coma sets in, brain edema develops taking FHF into a lethal course. Mechanisms of brain extravasation leading to brain edema remain incompletely understood. Matrix metalloproteinase (MMP)-9 is implicated in various brain injuries. We hypothesized tha...

journal_title：Journal of hepatology

authors： Nguyen JH,Yamamoto S,Steers J,Sevlever D,Lin W,Shimojima N,Castanedes-Casey M,Genco P,Golde T,Richelson E,Dickson D,McKinney M,Eckman CB

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND/AIMS:Intrahepatic cholestasis of pregnancy is characterized by pruritus and increased levels of serum bile acids, and is often associated with premature delivery, fetal distress, and perinatal mortality. The aims of the present study were: (i) to better define the serum bile acid profile in intrahepatic chol...

journal_title：Journal of hepatology

authors： Brites D,Rodrigues CM,Oliveira N,Cardoso M,Graça LM

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis C virus infection is known to play an important role in the pathogenesis of essential mixed cryoglobulinemia type II. Progression of hepatitis C virus infection to mixed cryoglobulinemia may be influenced by host immune response. To analyze the immunogenetic background of mixed cryoglobulinemi...

journal_title：Journal of hepatology

authors： Amoroso A,Berrino M,Canale L,Cornaglia M,Guarrera S,Mazzola G,Savoldi S,Scolari F,Sällberg M,Clementi M,Gabrielli A

更新日期：1998-07-01 00:00:00

abstract：:As growth hormone possesses anabolic properties that are active on protein metabolism, and thus of potential benefit to patients with chronic liver disease, we determined the metabolic effects of recombinant human growth hormone on insulin-like growth factor-I (IGF-I) its specific binding proteins, and liver function....

journal_title：Journal of hepatology

authors： Møller S,Becker U,Grønbaek M,Juul A,Winkler K,Skakkebaek NE

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND & AIMS:Cholangiocarcinoma (CCA) represents a primary hepatic malignancy with incidence and mortality rising globally. Surgical treatment has remained the only potentially curative treatment option, but it is still unclear which patients benefit most from extended liver surgery, highlighting the need for new ...

journal_title：Journal of hepatology

authors： Loosen SH,Roderburg C,Kauertz KL,Pombeiro I,Leyh C,Benz F,Vucur M,Longerich T,Koch A,Braunschweig T,Ulmer TF,Heidenhain C,Tacke F,Binnebösel M,Schmeding M,Trautwein C,Neumann UP,Luedde T

更新日期：2017-10-01 00:00:00

abstract：:Intravascular coagulation is involved in the development of certain types of liver injury, including that induced by dimethylnitrosamine. Nitric oxide inhibits platelet aggregation and adhesion; however, its role in protecting against intravascular coagulation has not been clarified. We therefore investigated the effe...

journal_title：Journal of hepatology

authors： Nagase S,Isobe H,Ayukawa K,Sakai H,Nawata H

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Chronic liver failure resulting from hepatitis C virus infection often necessitates orthotopic liver transplantation. Recurrence of hepatitis C virus infection after transplantation is inevitable, and the infection is usually severe. Interferon and ribavirin have both been used to treat hepatitis C virus inf...

journal_title：Journal of hepatology

authors： Bizollon T,Ducerf C,Trépo C

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND & AIMS:Data on acute exacerbation and reactivation of chronic hepatitis C virus (HCV) infection following chemotherapy are very limited. We sought to characterize the episodes of acute exacerbation and viral reactivation of HCV infection in cancer patients. METHODS:The medical records of HCV-infected patien...

journal_title：Journal of hepatology

authors： Mahale P,Kontoyiannis DP,Chemaly RF,Jiang Y,Hwang JP,Davila M,Torres HA

更新日期：2012-12-01 00:00:00

abstract：:In order to document the incidence of hepatitis delta virus (HDV) replication markers and their relationship to HBV replication, 91 HBsAg chronic carriers were studied. Of these, 51 were anti-HD-positive (19 HBeAg-positive and 32 anti-HBe-positive). Liver HDAg was found in 75% of anti-HD-positive patients. Of the 19 p...

journal_title：Journal of hepatology

authors： Bas C,Bartolomé J,La Banda F,Porres JC,Quiroga JA,Mora I,Carreño V

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND/AIMS:Patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) are at risk of early death due to end-stage liver failure. The aim of this study was to compare model of end-stage liver disease (MELD) and Child-Pugh scores as predictors of survival after TIPS. METHODS:We studied 140 cirrhotic p...

journal_title：Journal of hepatology

authors： Salerno F,Merli M,Cazzaniga M,Valeriano V,Rossi P,Lovaria A,Meregaglia D,Nicolini A,Lubatti L,Riggio O

更新日期：2002-04-01 00:00:00

abstract：:Uridine 5'-diphosphate-glucose dolichyl-phosphate glucosyltransferase and bile acid glucosyltransferase were quantitatively determined in subcellular fractions obtained by differential centrifugation of human liver homogenate. Both enzymes were exclusively enriched in the microsomal fraction with a recovery of total e...

journal_title：Journal of hepatology

authors： Gartung C,Matern S,Matern H

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cirrhotic livers exhibit endothelial dysfunction that contributes to the increased hepatic vascular resistance. The present study evaluates the role of cyclooxygenase (COX)-derived prostanoids, implicated in the pathogenesis of endothelial dysfunction in other settings, in the pathogenesis of endothelia...

journal_title：Journal of hepatology

authors： Graupera M,García-Pagán JC,Parés M,Abraldes JG,Roselló J,Bosch J,Rodés J

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic stellate cell (HSC) transdifferentiation into collagen-producing myofibroblasts is a key event in hepatic fibrogenesis, but the transcriptional network that controls the acquisition of the activated phenotype is still poorly understood. In this study, we explored whether the nuclear receptor c...

journal_title：Journal of hepatology

authors： Ceni E,Mello T,Polvani S,Vasseur-Cognet M,Tarocchi M,Tempesti S,Cavalieri D,Beltrame L,Marroncini G,Pinzani M,Milani S,Galli A

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND/AIMS:To study the outcome and the virologic profiles of severe hepatitis exacerbations due to YMDD mutants in lamivudine-treated patients. METHODS:Eighteen lamivudine-treated patients with severe hepatitis exacerbations due to YMDD mutants were recruited. Laboratory and clinical parameters were monitored. V...

journal_title：Journal of hepatology

authors： Yuen MF,Kato T,Mizokami M,Chan AO,Yuen JC,Yuan HJ,Wong DK,Sum SM,Ng IO,Fan ST,Lai CL

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND/AIMS:Despite anti-HBs immunoglobulin therapy, hepatitis B virus (HBV) infection recurs in a high proportion of patients transplanted for HBsAg positive and serum HBV DNA negative chronic liver disease. The contribution of HBV genetic variability to disease recurrence has not been yet thoroughly addressed. We...

journal_title：Journal of hepatology

authors： Brind A,Jiang J,Samuel D,Gigou M,Feray C,Bréchot C,Kremsdorf D

更新日期：1997-02-01 00:00:00

abstract：:Hepatitis A virus (HAV) infection in adults is often symptomatic and disabling. The present article summarizes our experience with phase 2 studies of an inactivated hepatitis A virus vaccine. Pre- and post-exposure prophylaxis with immune globulin (IG) is only effective for 4-6 months. We compared the safety, tolerabi...

journal_title：Journal of hepatology

authors： Shouval D,Ashur Y,Adler R,Lewis JA,Miller W,Kuter B,Brown L,Nalin DR

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND & AIMS:Histopathology is the gold standard in the diagnosis of liver diseases but may be complicated by sampling error and bleeding. Confocal laser endomicroscopy (CLE) is a novel imaging modality providing in vivo histology. Previous studies using CLE for liver microscopy suffered from limited imaging depth...

journal_title：Journal of hepatology

authors： Goetz M,Deris I,Vieth M,Murr E,Hoffman A,Delaney P,Galle PR,Neurath MF,Kiesslich R

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Although bacterial infections are frequent in patients with liver cirrhosis, only isolated cases of bacterial meningitis have been reported. METHODS:We have reviewed a series of 16 cases of bacterial meningitis in patients with cirrhosis, diagnosed in a single hospital over a 30-year period. RESULTS:Thirte...

journal_title：Journal of hepatology

authors： Pauwels A,Pinès E,Abboura M,Chiche I,Lévy VG

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND & AIMS:Given an appreciable risk of adverse-effects, current therapies for chronic hepatitis C virus (HCV) infection pose a dilemma to patients. We explored, via simulation modelling, patient-important benefits of attaining a sustained viral response (SVR). METHODS:We created the HCV Individualised Treatmen...

journal_title：Journal of hepatology

authors： Innes H,Goldberg D,Dusheiko G,Hayes P,Mills PR,Dillon JF,Aspinall E,Barclay ST,Hutchinson SJ

更新日期：2014-06-01 00:00:00