Assessment of hepatitis B virus DNA levels in chronic HBsAg carriers with or without hepatitis delta virus superinfection.

abstract：:In an attempt to evaluate the prevalence, kinetics and impact of HCV infection in renal transplantation, we analyzed 140 kidney recipients according to the histopathological status of the liver. Thirty-three HBsAg-negative patients had chronic active hepatitis, 73 HBsAg-negative patients had a normal liver, 21 HBsAg-n...

journal_title：Journal of hepatology

authors： Pol S,Legendre C,Saltiel C,Carnot F,Bréchot C,Berthelot P,Mattlinger B,Kreis H

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND/AIMS:Fulminant hepatic failure (FHF) can be dreadful. When coma sets in, brain edema develops taking FHF into a lethal course. Mechanisms of brain extravasation leading to brain edema remain incompletely understood. Matrix metalloproteinase (MMP)-9 is implicated in various brain injuries. We hypothesized tha...

journal_title：Journal of hepatology

authors： Nguyen JH,Yamamoto S,Steers J,Sevlever D,Lin W,Shimojima N,Castanedes-Casey M,Genco P,Golde T,Richelson E,Dickson D,McKinney M,Eckman CB

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND/AIMS:To study the effect of short-term cholestasis on glycogen metabolism. METHODS:Rats were bile duct ligated (BDL) for 4 or 8 days and compared to sham-operated control rats pair-fed to BDL (pair-fed CON) or fed ad libitum (ad libitum-fed CON). RESULTS:Four days after surgery, the hepatic glycogen conten...

journal_title：Journal of hepatology

authors： Lang C,Schäfer M,Varga L,Zimmermann A,Krähenbühl S,Krähenbühl L

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIM:Chronic rejection is an important cause of graft loss following liver transplantation. A number of risk factors for chronic rejection have been identified previously, albeit inconsistently. These include cytomegalovirus infection detected by a number of different techniques, including immunohistochemical...

journal_title：Journal of hepatology

authors： Evans PC,Coleman N,Wreghitt TG,Wight DG,Alexander GJ

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic liver disease is a well-recognised complication of cystic fibrosis. Recent reports suggest that its development is not determined by specific mutations within the cystic fibrosis gene; however, familial clustering of portal hypertension cases and inappropriate immune responses against liver memb...

journal_title：Journal of hepatology

authors： Duthie A,Doherty DG,Donaldson PT,Scott-Jupp R,Tanner MS,Eddleston AL,Mowat AP

更新日期：1995-11-01 00:00:00

abstract：:Ultrastructural changes were observed in 23 consecutive patients who died from fulminant hepatic failure due to hepatitis B virus (4 cases), sporadic non-A, non-B (7), or paracetamol (acetaminophen) overdose (12) and in 3 patients with subacute hepatic necrosis of unknown cause. The findings are described in detail in...

journal_title：Journal of hepatology

authors： McCaul TF,Fagan EA,Tovey G,Portmann B,Williams R,Zuckerman AJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:The purpose of this study was to compare the epidemiological, biochemical, virological and histological characteristics of patients with chronic hepatitis B and C with those of patients suffering from chronic hepatitis C alone. METHODS:Twenty-three patients with chronic hepatitis C, who were anti-HCV p...

journal_title：Journal of hepatology

authors： Zarski JP,Bohn B,Bastie A,Pawlotsky JM,Baud M,Bost-Bezeaux F,Tran van Nhieu J,Seigneurin JM,Buffet C,Dhumeaux D

更新日期：1998-01-01 00:00:00

abstract：:Advances in the management of the pulmonary complications of cystic fibrosis may result in an increasing prevalence of patients with chronic liver disease which may, therefore, become more important in the long-term management of cystic fibrosis patients. However, no simple and reliable test is available for the diagn...

journal_title：Journal of hepatology

authors： Williams SG,Evanson JE,Barrett N,Hodson ME,Boultbee JE,Westaby D

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND & AIMS:Several lipid synthesis pathways play important roles in the development and progression of hepatocellular carcinoma (HCC), although the precise molecular mechanisms remain to be elucidated. Here, we show the relationship between HCC progression and alteration of phospholipid composition regulated by ...

journal_title：Journal of hepatology

authors： Morita Y,Sakaguchi T,Ikegami K,Goto-Inoue N,Hayasaka T,Hang VT,Tanaka H,Harada T,Shibasaki Y,Suzuki A,Fukumoto K,Inaba K,Murakami M,Setou M,Konno H

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND/AIM:Endothelin-1 plays an important role in the regulation of portal hypertension; endothelin antagonists have been extensively studied in portal hypertensive animals. We aimed to evaluate the efficacy of highly selective endothelin antagonists in partial portal vein ligated (PPVL) rats. METHODS:Four groups...

journal_title：Journal of hepatology

authors： De Gottardi A,Shaw S,Sägesser H,Reichen J

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIMS:Interferon (IFN) with ribavirin combination therapy (CT) was proposed for the treatment of hepatitis C recurring in liver transplants. We assessed the efficacy of two protocols of CT in transplanted patients with recurrent severe hepatitis C virus (HCV) hepatitis. METHODS:Fifty-seven patients (68% geno...

journal_title：Journal of hepatology

authors： Lavezzo B,Franchello A,Smedile A,David E,Barbui A,Torrani M,Ottobrelli A,Zamboni F,Fadda M,Bobbio A,Salizzoni M,Rizzetto M

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis C virus (HCV) has been recognized as a major cause of liver disease, but little is known about its diffusion at population level. To estimate the prevalence and incidence of HCV infection and to explore potential risk factors at population level, an epidemiologic study was carried out. METHOD...

journal_title：Journal of hepatology

authors： Osella AR,Misciagna G,Leone A,Di Leo A,Fiore G

更新日期：1997-07-01 00:00:00

abstract：:The present study was conducted to evaluate if the increased rate of apoptosis previously reported in the liver of ethanol-treated rats was accompanied by increased cell renewal. A quantitative analysis of apoptosis was performed in rats fed an ethanol-containing liquid diet for 5 weeks. S-phase cells were demonstrate...

journal_title：Journal of hepatology

authors： Baroni GS,Marucci L,Benedetti A,Mancini R,Jezequel AM,Orlandi F

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND/AIMS:Suppressor of cytokine signaling (SOCS)-1, a negative feedback regulator of cytokine signaling pathway, also has a tumor suppressor activity, the silencing of its gene by hypermethylation is suggested to contribute to hepatocarcinogenesis. We studied the effect of the core protein of hepatitis C virus (...

journal_title：Journal of hepatology

authors： Miyoshi H,Fujie H,Shintani Y,Tsutsumi T,Shinzawa S,Makuuchi M,Kokudo N,Matsuura Y,Suzuki T,Miyamura T,Moriya K,Koike K

更新日期：2005-11-01 00:00:00

abstract：:Alcoholics admitted for detoxification were entered into a double blind placebo controlled trial of oral supplementation with an antioxidant cocktail (vitamin E, beta carotene, vitamin C and selenium) in order to determine the effect of this supplementation on the rate of resolution of a serum marker of free radical a...

journal_title：Journal of hepatology

authors： Butcher GP,Rhodes JM,Walker R,Krasner N,Jackson MJ

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND/AIMS:Interleukin-12 (IL-12), a cytokine with antitumor activity, was examined for the suppressive effect on hepatocellular carcinoma (HCC) in mouse model, and its mechanism of antitumor activity was analyzed. METHODS:Mice implanted with MIH-2 HCC cells were treated with recombinant mouse IL-12 (500 ng/mouse...

journal_title：Journal of hepatology

authors： Komita H,Homma S,Saotome H,Zeniya M,Ohno T,Toda G

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of stages from simple steatosis to non-alcoholic steatohepatitis (NASH). However, disease pathogenesis remains largely unknown. microRNA (miRNA or miR) expression has recently been reported to be altered in human NASH, and modulated by urs...

journal_title：Journal of hepatology

authors： Castro RE,Ferreira DM,Afonso MB,Borralho PM,Machado MV,Cortez-Pinto H,Rodrigues CM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to sequence the precore region of HBV isolated from serum and tumorous and non-tumorous liver tissue from patients with hepatocellular carcinoma to identify mutations that might play a role in malignant transformation. METHODS:HBV DNA was extracted from 62 sera, 14 tumorous and...

journal_title：Journal of hepatology

authors： Kramvis A,Kew MC,Bukofzer S

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hormone replacement therapy (HRT) prevents osteoporosis in postmenopausal women by inhibiting bone resorption, but the benefits of oestrogen therapy in liver transplant patients have not been studied. METHODS:The effect of transdermal HRT was studied in 33 postmenopausal liver transplant women. The mai...

journal_title：Journal of hepatology

authors： Isoniemi H,Appelberg J,Nilsson CG,Mäkelä P,Risteli J,Höckerstedt K

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND/AIMS:Liver carbohydrate metabolism and blood flow are regulated by hepatic nerves and hormones such as glucagon, insulin or catecholamines. Acute and chronic application of alcohol are known to depress the function of central and peripheral nerves. The extent of inhibition of the autonomic nervous system is ...

journal_title：Journal of hepatology

authors： Kucera T,Stümpel F,Jungermann K

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic hepatitis C virus (HCV)-infected patients with cirrhosis are a high-priority population for treatment. To help inform the benefit-risk profile of the all-oral direct-acting antiviral (DAA) combination regimen of ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir (OBV/PTV/r±DSV)...

journal_title：Journal of hepatology

authors： Poordad F,Nelson DR,Feld JJ,Fried MW,Wedemeyer H,Larsen L,Cohen DE,Cohen E,Mobashery N,Tatsch F,Foster GR

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND & AIMS:The presence of multifocal tumors, developed either from intrahepatic metastasis (IM) or multicentric occurrence (MO), is a distinct feature of hepatocellular carcinoma (HCC). Immunogenomic characterization of multifocal HCC is important for understanding immune escape in different lesions and develop...

journal_title：Journal of hepatology

authors： Dong LQ,Peng LH,Ma LJ,Liu DB,Zhang S,Luo SZ,Rao JH,Zhu HW,Yang SX,Xi SJ,Chen M,Xie FF,Li FQ,Li WH,Ye C,Lin LY,Wang YJ,Wang XY,Gao DM,Zhou H,Yang HM,Wang J,Zhu SD,Wang XD,Cao Y,Zhou J,Fan J,Wu K,Gao

更新日期：2020-05-01 00:00:00

abstract：:The alterations of hepatobiliary transport that occur in cholestasis can be divided into primary defects, such as mutations of transporter genes or acquired dysfunctions of transport systems that cause defective canalicular or cholangiocellular secretion, and secondary defects, which result from biliary obstruction. T...

journal_title：Journal of hepatology

authors： Kullak-Ublick GA,Beuers U,Paumgartner G

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND & AIMS:Histopathology is the gold standard in the diagnosis of liver diseases but may be complicated by sampling error and bleeding. Confocal laser endomicroscopy (CLE) is a novel imaging modality providing in vivo histology. Previous studies using CLE for liver microscopy suffered from limited imaging depth...

journal_title：Journal of hepatology

authors： Goetz M,Deris I,Vieth M,Murr E,Hoffman A,Delaney P,Galle PR,Neurath MF,Kiesslich R

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition and the most common liver disease worldwide, affecting more than one-third of the population. So far there have been no reports on mendelian inheritance in families with NAFLD. METHODS:We performed whole-exome or targeted next-ge...

journal_title：Journal of hepatology

authors： Youssefian L,Vahidnezhad H,Saeidian AH,Pajouhanfar S,Sotoudeh S,Mansouri P,Amirkashani D,Zeinali S,Levine MA,Peris K,Colombo R,Uitto J

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND/AIMS:Not all alcoholics develop liver disease (ALD). Thus, excessive ethanol consumption is necessary, but not sufficient, to induce alcoholic steatohepatitis (ASH) and ALD. Since endotoxemia is present in patients with ALD, it has been proposed that gut-derived, circulating endotoxin is the necessary co-fac...

journal_title：Journal of hepatology

authors： Keshavarzian A,Farhadi A,Forsyth CB,Rangan J,Jakate S,Shaikh M,Banan A,Fields JZ

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Serum carbohydrate deficient transferrin is a marker of chronic alcohol consumption; it increases above normal in healthy individuals after a daily alcohol intake of more than 60 g/d for more than 2 weeks. The influence of liver disease itself on carbohydrate deficient transferrin levels has not been suffici...

journal_title：Journal of hepatology

authors： Radosavljevic M,Temsch E,Hammer J,Pfeffel F,Mayer G,Renner F,Pidlich J,Muller C

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND & AIMS:The therapeutic option for patients with chronic hepatitis delta virus infection (CHD) is limited to interferon alpha with rare curative outcome. Myrcludex B is a first-in-class entry inhibitor inactivating the hepatitis B virus (HBV) and hepatitis D virus (HDV) receptor sodium taurocholate co-transpo...

journal_title：Journal of hepatology

authors： Bogomolov P,Alexandrov A,Voronkova N,Macievich M,Kokina K,Petrachenkova M,Lehr T,Lempp FA,Wedemeyer H,Haag M,Schwab M,Haefeli WE,Blank A,Urban S

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND/AIMS:Interleukin-15 (IL-15) is expressed in many organs. It generally inhibits apoptosis and increases cellular proliferation and differentiation. However, IL-15's roles in liver are unknown. We aimed to determine if IL-15 influences hepatic integrity and regenerative activity. METHODS:Expression of IL-15 a...

journal_title：Journal of hepatology

authors： Suzuki A,McCall S,Choi SS,Sicklick JK,Huang J,Qi Y,Zdanowicz M,Camp T,Li YX,Diehl AM

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND/AIMS:Patients with cholestatic liver disease have 'low-turnover' osteoporosis. Since we reported that bile-duct ligated (BDL) rats develop bone disease with low bone formation and mass, we examined whether their reduced bone mass results in skeletal fragility, and whether the reduction in osteoprogenitor cel...

journal_title：Journal of hepatology

authors： Weinreb M,Pollak RD,Ackerman Z

更新日期：2004-03-01 00:00:00